This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a... See more...

Aliases for SELENOH Gene

Aliases for SELENOH Gene

  • Selenoprotein H 2 3 4 5
  • SELH 2 3 4
  • C11orf31 3 4
  • Chromosome 11 Open Reading Frame 31 2
  • C17orf10 3
  • SELENOH 5
  • SelH 4

External Ids for SELENOH Gene

Previous HGNC Symbols for SELENOH Gene

  • C11orf31

Previous GeneCards Identifiers for SELENOH Gene

  • GC11P057750
  • GC11P057751
  • GC11P057752
  • GC11P057774
  • GC11P057743
  • GC11P057745
  • GC11P057746
  • GC11P057747
  • GC11P057748
  • GC11P057749
  • GC11P057787

Summaries for SELENOH Gene

Entrez Gene Summary for SELENOH Gene

  • This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]

GeneCards Summary for SELENOH Gene

SELENOH (Selenoprotein H) is a Protein Coding gene. Diseases associated with SELENOH include Spina Bifida Occulta and Neural Tube Defects. Among its related pathways are Folate Metabolism.

UniProtKB/Swiss-Prot Summary for SELENOH Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SELENOH Gene

Genomics for SELENOH Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SELENOH Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SELENOH on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SELENOH

Genomic Locations for SELENOH Gene

Latest Assembly
chr11:57,741,250-57,743,554
(GRCh38/hg38)
Size:
2,305 bases
Orientation:
Plus strand

Previous Assembly
chr11:57,508,963-57,511,022
(GRCh37/hg19 by Entrez Gene)
Size:
2,060 bases
Orientation:
Plus strand

chr11:57,508,825-57,510,986
(GRCh37/hg19 by Ensembl)
Size:
2,162 bases
Orientation:
Plus strand

Genomic View for SELENOH Gene

Genes around SELENOH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELENOH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELENOH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELENOH Gene

Proteins for SELENOH Gene

  • Protein details for SELENOH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZQ5-SELH_HUMAN
    Recommended name:
    Selenoprotein H
    Protein Accession:
    Q8IZQ5
    Secondary Accessions:
    • Q8N672

    Protein attributes for SELENOH Gene

    Size:
    122 amino acids
    Molecular mass:
    13453 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SELENOH Gene

Post-translational modifications for SELENOH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SELENOH Gene

No data available for DME Specific Peptides for SELENOH Gene

Domains & Families for SELENOH Gene

Gene Families for SELENOH Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SELENOH Gene

Suggested Antigen Peptide Sequences for SELENOH Gene

GenScript: Design optimal peptide antigens:
  • Selenoprotein H (SELH_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZQ5

UniProtKB/Swiss-Prot:

SELH_HUMAN :
  • Belongs to the SelWTH family.
Family:
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with SELENOH: view

Function for SELENOH Gene

Molecular function for SELENOH Gene

UniProtKB/Swiss-Prot Function:
May be involved in a redox-related process.

Phenotypes From GWAS Catalog for SELENOH Gene

Gene Ontology (GO) - Molecular Function for SELENOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
genes like me logo Genes that share ontologies with SELENOH: view
genes like me logo Genes that share phenotypes with SELENOH: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENOH

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SELENOH Gene

Localization for SELENOH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELENOH gene
Compartment Confidence
nucleus 3
golgi apparatus 3
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SELENOH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IBA 21873635
genes like me logo Genes that share ontologies with SELENOH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SELENOH Gene

Pathways & Interactions for SELENOH Gene

PathCards logo

SuperPathways for SELENOH Gene

SuperPathway Contained pathways
1 Folate Metabolism
genes like me logo Genes that share pathways with SELENOH: view

Pathways by source for SELENOH Gene

1 BioSystems pathway for SELENOH Gene

Interacting Proteins for SELENOH Gene

Gene Ontology (GO) - Biological Process for SELENOH Gene

None

No data available for SIGNOR curated interactions for SELENOH Gene

Drugs & Compounds for SELENOH Gene

No Compound Related Data Available

Transcripts for SELENOH Gene

mRNA/cDNA for SELENOH Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SELENOH

Alternative Splicing Database (ASD) splice patterns (SP) for SELENOH Gene

No ASD Table

Relevant External Links for SELENOH Gene

GeneLoc Exon Structure for
SELENOH

Expression for SELENOH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SELENOH

Evidence on tissue expression from TISSUES for SELENOH Gene

  • Liver(4.5)
  • Nervous system(4.1)
  • Pancreas(3.1)
  • Lung(2.7)
  • Kidney(2.4)
  • Intestine(2.4)
  • Skin(2.3)
  • Spleen(2.2)
  • Thyroid gland(2.2)
  • Heart(2.2)
  • Muscle(2.1)
  • Eye(2)
genes like me logo Genes that share expression patterns with SELENOH: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELENOH Gene

Orthologs for SELENOH Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELENOH Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C11H11orf31 30 31
  • 99.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C18H11orf31 30
  • 88.25 (n)
Cow
(Bos Taurus)
Mammalia C15H11orf31 30
  • 84.7 (n)
Mouse
(Mus musculus)
Mammalia 2700094K13Rik 30 31
  • 81.32 (n)
OneToOne
Selenoh 17
Rat
(Rattus norvegicus)
Mammalia RGD1563348 30
  • 80.46 (n)
Chicken
(Gallus gallus)
Aves LOC100858006 30
  • 65.57 (n)
Lizard
(Anolis carolinensis)
Reptilia C11orf31 31
  • 60 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii seph 30
  • 64.37 (n)
Species where no ortholog for SELENOH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SELENOH Gene

ENSEMBL:
Gene Tree for SELENOH (if available)
TreeFam:
Gene Tree for SELENOH (if available)

Paralogs for SELENOH Gene

No data available for Paralogs for SELENOH Gene

Variants for SELENOH Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SELENOH Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SELENOH Gene

Variant ID Type Subtype PubMed ID
nsv326 CNV insertion 18451855
nsv508633 CNV deletion 20534489
nsv832164 CNV loss 17160897

Variation tolerance for SELENOH Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SELENOH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELENOH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SELENOH Gene

Disorders for SELENOH Gene

MalaCards: The human disease database

(2) MalaCards diseases for SELENOH Gene - From: COP

Disorder Aliases PubMed IDs
spina bifida occulta
  • closed spina bifida
neural tube defects
  • neural tube defects, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SELENOH

genes like me logo Genes that share disorders with SELENOH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELENOH Gene

Publications for SELENOH Gene

  1. Characterization of mammalian selenoproteomes. (PMID: 12775843) Kryukov GV … Gladyshev VN (Science (New York, N.Y.) 2003) 2 3 4
  2. Overexpression of human selenoprotein H in neuronal cells ameliorates ultraviolet irradiation-induced damage by modulating cell signaling pathways. (PMID: 19766117) Mendelev N … Li PA (Experimental neurology 2009) 3 23
  3. Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. (PMID: 17337453) Novoselov SV … Gladyshev VN (The Journal of biological chemistry 2007) 3 23
  4. Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. (PMID: 17526492) Panee J … Berry MJ (The Journal of biological chemistry 2007) 3 23
  5. Overexpression of selenoprotein H reduces Ht22 neuronal cell death after UVB irradiation by preventing superoxide formation. (PMID: 17389926) Ben Jilani KE … Li PA (International journal of biological sciences 2007) 3 23

Products for SELENOH Gene

Sources for SELENOH Gene