Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51E2 Gene

Aliases for OR51E2 Gene

  • Olfactory Receptor Family 51 Subfamily E Member 2 2 3 5
  • PSGR 2 3 4
  • Prostate-Specific G-Protein Coupled Receptor 3 4
  • Olfactory Receptor OR11-16 3 4
  • Olfactory Receptor 51E2 3 4
  • HPRAJ 3 4
  • Olfactory Receptor, Family 51, Subfamily E, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 51, Subfamily E, Member 2 2
  • Olfactory Receptor, Family 52, Subfamily A, Member 2 3
  • OR51E3P 3
  • OR52A2 3
  • OR51E2 5

External Ids for OR51E2 Gene

Previous GeneCards Identifiers for OR51E2 Gene

  • GC11M005267
  • GC11M005003
  • GC11M004660
  • GC11M004665
  • GC11M004657
  • GC11M004701

Summaries for OR51E2 Gene

Entrez Gene Summary for OR51E2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51E2 Gene

OR51E2 (Olfactory Receptor Family 51 Subfamily E Member 2) is a Protein Coding gene. Diseases associated with OR51E2 include Prostate Cancer and Gnathodiaphyseal Dysplasia. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and steroid hormone receptor activity. An important paralog of this gene is OR51E1.

UniProtKB/Swiss-Prot Summary for OR51E2 Gene

  • Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is propably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity).

Gene Wiki entry for OR51E2 Gene

Additional gene information for OR51E2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51E2 Gene

Genomics for OR51E2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR51E2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004658 Enhancer 0.7 Ensembl 10 +38.8 38754 0.6 LEF1 IKZF1 DPF2 HDAC1 SOX6 TCF12 EP300 CBX3 HMBOX1 CTBP1 OR51E2 OR51F1 OR51E1 OR51A9P
GH11J004647 Enhancer 0.3 Ensembl 10.1 +50.5 50453 0.4 ATF2 JUN OR51F2 OR51E2 TRIM68 OR51F1 C11orf40 OR51E1 OR51A9P
GH11J004718 Enhancer 0.2 Ensembl 11 -20.9 -20947 0.4 OR51C4P OR51E2 OR51F1 KRT8P49 MMP26
GH11J004648 Enhancer 0.2 Ensembl 10.1 +49.9 49853 0.4 OR51F2 OR51E2 TRIM68 OR51F1 C11orf40 OR51E1 OR51A9P
GH11J004703 Enhancer 0.6 Ensembl ENCODE 0.4 -6.9 -6923 1.6 PKNOX1 ZBTB40 TAF1 ZNF652 MMP26 OR51E1 OR51E2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51E2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51E2

Top Transcription factor binding sites by QIAGEN in the OR51E2 gene promoter:
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4

Genomic Locations for OR51E2 Gene

Genomic Locations for OR51E2 Gene
chr11:4,680,171-4,697,854
(GRCh38/hg38)
Size:
17,684 bases
Orientation:
Minus strand
chr11:4,701,401-4,719,084
(GRCh37/hg19)
Size:
17,684 bases
Orientation:
Minus strand

Genomic View for OR51E2 Gene

Genes around OR51E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51E2 Gene

Proteins for OR51E2 Gene

  • Protein details for OR51E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H255-O51E2_HUMAN
    Recommended name:
    Olfactory receptor 51E2
    Protein Accession:
    Q9H255
    Secondary Accessions:
    • B2RA63
    • Q6IF94

    Protein attributes for OR51E2 Gene

    Size:
    320 amino acids
    Molecular mass:
    35493 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR51E2 Gene

Post-translational modifications for OR51E2 Gene

  • Glycosylation at Asn5

Other Protein References for OR51E2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51E2 Gene

Domains & Families for OR51E2 Gene

Gene Families for OR51E2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for OR51E2 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR51E2 Gene

GenScript: Design optimal peptide antigens:
  • Prostate-specific G-protein coupled receptor (O51E2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H255

UniProtKB/Swiss-Prot:

O51E2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51E2: view

Function for OR51E2 Gene

Molecular function for OR51E2 Gene

UniProtKB/Swiss-Prot Function:
Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is propably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in prostate cancer.

Gene Ontology (GO) - Molecular Function for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IDA 19389702
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IMP 29249973
GO:0038023 signaling receptor activity ISS --
genes like me logo Genes that share ontologies with OR51E2: view
genes like me logo Genes that share phenotypes with OR51E2: view

Animal Models for OR51E2 Gene

MGI Knock Outs for OR51E2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51E2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OR51E2 Gene

Localization for OR51E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51E2 Gene

Cell membrane. Multi-pass membrane protein. Early endosome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51E2 gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031901 early endosome membrane IEA,IDA 27226631
genes like me logo Genes that share ontologies with OR51E2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51E2 Gene

Pathways & Interactions for OR51E2 Gene

genes like me logo Genes that share pathways with OR51E2: view

Pathways by source for OR51E2 Gene

Gene Ontology (GO) - Biological Process for OR51E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0016477 cell migration IMP 29249973
GO:0030318 melanocyte differentiation IMP 27226631
genes like me logo Genes that share ontologies with OR51E2: view

No data available for SIGNOR curated interactions for OR51E2 Gene

Drugs & Compounds for OR51E2 Gene

No Compound Related Data Available

Transcripts for OR51E2 Gene

mRNA/cDNA for OR51E2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51E2

Alternative Splicing Database (ASD) splice patterns (SP) for OR51E2 Gene

No ASD Table

Relevant External Links for OR51E2 Gene

GeneLoc Exon Structure for
OR51E2

Expression for OR51E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51E2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR51E2 Gene

This gene is overexpressed in Prostate (x20.5), Colon - Sigmoid (x9.6), Artery - Tibial (x8.3), and Colon - Transverse (x4.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51E2

SOURCE GeneReport for Unigene cluster for OR51E2 Gene:

Hs.501758

mRNA Expression by UniProt/SwissProt for OR51E2 Gene:

Q9H255-O51E2_HUMAN
Tissue specificity: Highly expressed in the prostate (PubMed:11707321). Also expressed in spleen, liver, olfactory epithelium, retinal pigment epithelium and medulla oblongata (PubMed:29249973, PubMed:11707321, PubMed:16491480). In the retinal pigment epithelium expression is restricted to the pigment cells and choroid (at protein level) (PubMed:29249973). Expressed in epidermal melanocytes (at protein level) (PubMed:27226631).
genes like me logo Genes that share expression patterns with OR51E2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51E2 Gene

Orthologs for OR51E2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51E2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OR51E2 31
  • 100 (a)
OneToOne
LOC466344 30
  • 99.17 (n)
Dog
(Canis familiaris)
Mammalia LOC100856052 30
  • 89.79 (n)
OR51E2 31
  • 82 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR51E2 30 31
  • 89.37 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or51e2 46 Olfr78 30 17 31
  • 86.94 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olr59 30
  • 86.83 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR51E2 31
  • 81 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OR51E2 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia or51e1 30
  • 62.84 (n)
Zebrafish
(Danio rerio)
Actinopterygii CABZ01018874.1 31
  • 31 (a)
ManyToMany
or112-1 31
  • 30 (a)
ManyToMany
Species where no ortholog for OR51E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR51E2 Gene

ENSEMBL:
Gene Tree for OR51E2 (if available)
TreeFam:
Gene Tree for OR51E2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51E2: view image

Paralogs for OR51E2 Gene

(420) SIMAP similar genes for OR51E2 Gene using alignment to 2 proteins:

  • O51E2_HUMAN
  • E9PPJ8_HUMAN

Pseudogenes.org Pseudogenes for OR51E2 Gene

genes like me logo Genes that share paralogs with OR51E2: view

Variants for OR51E2 Gene

Additional dbSNP identifiers (rs#s) for OR51E2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR51E2 Gene

Variant ID Type Subtype PubMed ID
esv3891914 CNV gain 25118596
nsv1054847 CNV gain 25217958
nsv832055 CNV loss 17160897
nsv832056 CNV gain 17160897

Variation tolerance for OR51E2 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51E2 Gene

Disorders for OR51E2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OR51E2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
gnathodiaphyseal dysplasia
  • gdd
retinal arteries, tortuosity of
  • rator
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with OR51E2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR51E2 Gene

Publications for OR51E2 Gene

  1. PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer. (PMID: 11118034) Xu LL … Srivastava S (Cancer research 2000) 2 3 4 23
  2. Activation of an olfactory receptor inhibits proliferation of prostate cancer cells. (PMID: 19389702) Neuhaus EM … Hatt H (The Journal of biological chemistry 2009) 3 4 23
  3. The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase. (PMID: 16491480) Wang J … Ittmann M (The Prostate 2006) 3 4 23
  4. Odorant Receptor 51E2 Agonist β-ionone Regulates RPE Cell Migration and Proliferation. (PMID: 29249973) Jovancevic N … Hatt H (Frontiers in physiology 2017) 3 4
  5. Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes. (PMID: 27226631) Gelis L … Hatt H (The Journal of biological chemistry 2016) 3 4

Products for OR51E2 Gene

  • Signalway Proteins for OR51E2

Sources for OR51E2 Gene