Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR51E1 Gene

Aliases for OR51E1 Gene

  • Olfactory Receptor Family 51 Subfamily E Member 1 2 3 5
  • Olfactory Receptor, Family 51, Subfamily E, Member 1 Pseudogene 2 3
  • Prostate-Specific G Protein-Coupled Receptor 2 3 4
  • G-Protein Coupled Receptor 164 3 4
  • Olfactory Receptor 51E1 3 4
  • Olfactory Receptor 52A3 3 4
  • OR51E1P 3 4
  • OR52A3P 3 4
  • D-GPCR 3 4
  • GPR136 2 3
  • GPR164 3 4
  • PSGR2 3 4
  • POGR 3 4
  • Olfactory Receptor, Family 52, Subfamily A, Member 3 Pseudogene 3
  • Olfactory Receptor, Family 51, Subfamily E, Member 1 2
  • Prostate Overexpressed G Protein-Coupled Receptor 3
  • Prostate-Overexpressed G Protein-Coupled Receptor 4
  • Dresden-G-Protein-Coupled Receptor 3
  • Olfactory Receptor OR11-15 3
  • OR51E1 5
  • DGPCR 3

External Ids for OR51E1 Gene

Previous HGNC Symbols for OR51E1 Gene

  • OR51E1P
  • OR52A3P
  • GPR164

Previous GeneCards Identifiers for OR51E1 Gene

  • GC11U990519
  • GC00U920624
  • GC11P004622

Summaries for OR51E1 Gene

Entrez Gene Summary for OR51E1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR51E1 Gene

OR51E1 (Olfactory Receptor Family 51 Subfamily E Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR51E2.

UniProtKB/Swiss-Prot Summary for OR51E1 Gene

Gene Wiki entry for OR51E1 Gene

Additional gene information for OR51E1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR51E1 Gene

Genomics for OR51E1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR51E1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J004641 Enhancer 0.3 Ensembl 600.7 -1.9 -1919 0.2 TEAD4 TEAD3 OR51E1 TRIM68 OR51D1
GH11J004643 Promoter 0.3 Ensembl 610.3 +0.8 780 1.2 OR51E1 OR51A9P OR51E2
GH11J004642 Enhancer 0.2 Ensembl 600.7 -1.0 -1019 0.4 OR51E1 TRIM68 OR51D1
GH11J004609 Promoter/Enhancer 0.8 Ensembl ENCODE 10.4 -33.4 -33388 1.7 IRF2 SPI1 IKZF1 ETV6 IKZF2 TRIM68 lnc-C11orf40-2 OR51D1 OR51E1 piR-39858-065
GH11J004658 Enhancer 0.7 Ensembl 8.4 +15.7 15680 0.6 LEF1 IKZF1 DPF2 HDAC1 SOX6 TCF12 EP300 CBX3 HMBOX1 CTBP1 OR51E2 OR51F1 OR51E1 OR51A9P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR51E1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR51E1

Top Transcription factor binding sites by QIAGEN in the OR51E1 gene promoter:
  • AML1a
  • CUTL1
  • Evi-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OR51E1 Gene

Genomic Locations for OR51E1 Gene
chr11:4,643,420-4,655,488
(GRCh38/hg38)
Size:
12,069 bases
Orientation:
Plus strand
chr11:4,664,650-4,676,718
(GRCh37/hg19)
Size:
12,069 bases
Orientation:
Plus strand

Genomic View for OR51E1 Gene

Genes around OR51E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR51E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR51E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR51E1 Gene

Proteins for OR51E1 Gene

  • Protein details for OR51E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCB6-O51E1_HUMAN
    Recommended name:
    Olfactory receptor 51E1
    Protein Accession:
    Q8TCB6
    Secondary Accessions:
    • A8KAM6
    • Q5S4P5
    • Q66X57
    • Q6IF93

    Protein attributes for OR51E1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35271 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAU07996.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=DAA04767.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR51E1 Gene

Post-translational modifications for OR51E1 Gene

  • Glycosylation at Asn7 and Asn90

Other Protein References for OR51E1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR51E1 Gene

Domains & Families for OR51E1 Gene

Gene Families for OR51E1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR51E1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR51E1 Gene

GenScript: Design optimal peptide antigens:
  • Prostate-specific G protein-coupled receptor 2 (O51E1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TCB6

UniProtKB/Swiss-Prot:

O51E1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR51E1: view

Function for OR51E1 Gene

Molecular function for OR51E1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR51E1 Gene

Gene Ontology (GO) - Molecular Function for OR51E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR51E1: view
genes like me logo Genes that share phenotypes with OR51E1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51E1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR51E1 Gene

Localization for OR51E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR51E1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR51E1 gene
Compartment Confidence
plasma membrane 4
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OR51E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR51E1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR51E1 Gene

Pathways & Interactions for OR51E1 Gene

genes like me logo Genes that share pathways with OR51E1: view

Pathways by source for OR51E1 Gene

Gene Ontology (GO) - Biological Process for OR51E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR51E1: view

No data available for SIGNOR curated interactions for OR51E1 Gene

Drugs & Compounds for OR51E1 Gene

No Compound Related Data Available

Transcripts for OR51E1 Gene

mRNA/cDNA for OR51E1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR51E1

Alternative Splicing Database (ASD) splice patterns (SP) for OR51E1 Gene

No ASD Table

Relevant External Links for OR51E1 Gene

GeneLoc Exon Structure for
OR51E1

Expression for OR51E1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR51E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR51E1 Gene

This gene is overexpressed in Prostate (x7.0), Artery - Tibial (x6.6), and Heart - Left Ventricle (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR51E1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR51E1

SOURCE GeneReport for Unigene cluster for OR51E1 Gene:

Hs.470038

mRNA Expression by UniProt/SwissProt for OR51E1 Gene:

Q8TCB6-O51E1_HUMAN
Tissue specificity: Highly expressed in prostate. Very low levels may be detected in some other tissues, such as placenta, skeletal muscle, heart, ovary and testis. Up-regulated in prostate cancers.

Evidence on tissue expression from TISSUES for OR51E1 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with OR51E1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR51E1 Gene

Orthologs for OR51E1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR51E1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466342 30
  • 99.26 (n)
OR51E1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OR51E1 31
  • 92 (a)
OneToOne
LOC485235 30
  • 88.61 (n)
Cow
(Bos Taurus)
Mammalia OR51E1 30 31
  • 89.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Or51e1 46 Olfr558 30 17 31
  • 87.87 (n)
OneToOne
Or51ah3 46 Olfr615
  • chr7:103,560,479-103,561,417
Rat
(Rattus norvegicus)
Mammalia Olr63 30
  • 87.62 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR51E1 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OR51E1 31
  • 69 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii CABZ01018874.1 31
  • 32 (a)
ManyToMany
or112-1 31
  • 31 (a)
ManyToMany
Species where no ortholog for OR51E1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OR51E1 Gene

ENSEMBL:
Gene Tree for OR51E1 (if available)
TreeFam:
Gene Tree for OR51E1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR51E1: view image

Paralogs for OR51E1 Gene

(427) SIMAP similar genes for OR51E1 Gene using alignment to 2 proteins:

  • O51E1_HUMAN
  • E9PKL6_HUMAN
genes like me logo Genes that share paralogs with OR51E1: view

Variants for OR51E1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR51E1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs17224476 -. - p.Ser10Asnp.Ser9Asn

Additional dbSNP identifiers (rs#s) for OR51E1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR51E1 Gene

Variant ID Type Subtype PubMed ID
dgv1025n100 CNV loss 25217958
dgv1586n54 CNV loss 21841781
esv2670201 CNV deletion 23128226
esv3891914 CNV gain 25118596
nsv1041633 CNV gain 25217958
nsv1054705 CNV loss 25217958
nsv1054847 CNV gain 25217958
nsv476526 CNV novel sequence insertion 20440878
nsv832055 CNV loss 17160897
nsv832056 CNV gain 17160897

Variation tolerance for OR51E1 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR51E1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR51E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR51E1 Gene

Disorders for OR51E1 Gene

Additional Disease Information for OR51E1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for OR51E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR51E1 Gene

Publications for OR51E1 Gene

  1. PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer. (PMID: 16206286) Weng J … Liu M (International journal of cancer 2006) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  5. D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate. (PMID: 15313197) Weigle B … Rieber EP (Biochemical and biophysical research communications 2004) 3 4

Products for OR51E1 Gene

Sources for OR51E1 Gene