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Aliases for GSTP1 Gene

Aliases for GSTP1 Gene

  • Glutathione S-Transferase Pi 1 2 3 5
  • GST Class-Pi 3 4
  • EC 2.5.1.18 4 56
  • GSTP1-1 3 4
  • FAEES3 3 4
  • GST3 3 4
  • Fatty Acid Ethyl Ester Synthase III 3
  • Epididymis Secretory Protein Li 22 3
  • Glutathione S-Transferase P 3
  • Deafness, X-Linked 7 3
  • HEL-S-22 3
  • DFN7 3
  • GSTP 3
  • PI 3

External Ids for GSTP1 Gene

Previous HGNC Symbols for GSTP1 Gene

  • FAEES3
  • GST3

Previous GeneCards Identifiers for GSTP1 Gene

  • GC11P069874
  • GC11P069047
  • GC11P067601
  • GC11P067126
  • GC11P067107
  • GC11P067351
  • GC11P063681

Summaries for GSTP1 Gene

Entrez Gene Summary for GSTP1 Gene

  • Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

CIViC summary for GSTP1 Gene

GeneCards Summary for GSTP1 Gene

GSTP1 (Glutathione S-Transferase Pi 1) is a Protein Coding gene. Diseases associated with GSTP1 include Oral Mucosa Leukoplakia and Prostate Cancer. Among its related pathways are Innate Immune System and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity and kinase regulator activity. An important paralog of this gene is GSTM3.

UniProtKB/Swiss-Prot for GSTP1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Gene Wiki entry for GSTP1 Gene

PharmGKB "VIP" Summary for GSTP1 Gene

Additional gene information for GSTP1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for GSTP1 Gene

Genomics for GSTP1 Gene

GeneHancer (GH) Regulatory Elements for GSTP1 Gene

Promoters and enhancers for GSTP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I067579 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 742 10.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A GSTP1 ENSG00000255119 NUDT8 PTPRCAP NDUFV1 C11orf72 DOC2GP RHOD LRP5 ALDH3B2
GH11I067572 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.4 -10.6 -10585 1.4 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B ZNF2 TCF12 ZNF143 FOS NDUFV1 RBM14 RBM4B ENSG00000255119 C11orf72 DOC2GP NUDT8 TBX10 KDM2A PPP6R3
GH11I067557 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -24.7 -24695 2.7 TFAP4 PKNOX1 ZFP64 EBF1 BATF RELA ZNF316 ATF7 ZSCAN29 NFE2 PTPRCAP ALDH3B2 NDUFV1 NUDT8 CDK2AP2 GC11M067541 GSTP1
GH11I067560 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.3 -20.7 -20711 3.9 PKNOX1 ATF1 IRF4 YY1 ZNF766 ZNF207 ATF7 FOS RUNX3 DEK PTPRCAP AIP KMT5B NDUFV1 ENSG00000258297 PPP6R3 RBM14 CABP2 C11orf72 ENSG00000255119
GH11I067544 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.3 -38.7 -38683 1.4 CTCF MEIS2 FOXA2 PKNOX1 USF1 ATF1 TAF1 RAD21 RARA YY1 PTPRCAP ALDH3B2 FAM86C2P GC11M067541 GSTP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GSTP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GSTP1 gene promoter:

Genomic Locations for GSTP1 Gene

Genomic Locations for GSTP1 Gene
chr11:67,583,595-67,586,660
(GRCh38/hg38)
Size:
3,066 bases
Orientation:
Plus strand
chr11:67,351,066-67,354,131
(GRCh37/hg19)

Genomic View for GSTP1 Gene

Genes around GSTP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GSTP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GSTP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GSTP1 Gene

Proteins for GSTP1 Gene

  • Protein details for GSTP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09211-GSTP1_HUMAN
    Recommended name:
    Glutathione S-transferase P
    Protein Accession:
    P09211
    Secondary Accessions:
    • O00460
    • Q15690
    • Q5TZY3

    Protein attributes for GSTP1 Gene

    Size:
    210 amino acids
    Molecular mass:
    23356 Da
    Quaternary structure:
    • Homodimer. Interacts with CDK5.

    Three dimensional structures from OCA and Proteopedia for GSTP1 Gene

neXtProt entry for GSTP1 Gene

Selected DME Specific Peptides for GSTP1 Gene

P09211:
  • CLYGQLPKF
  • RMLLADQ
  • ISFADYNL
  • LLADQGQSWKEEV
  • FPLLSAYV
  • DGDLTLYQSN
  • NDGVEDLR
  • GLYGKDQ

Post-translational modifications for GSTP1 Gene

  • Ubiquitination at isoforms=45, posLast=5555, posLast=121121, and isoforms=191
  • Modification sites at PhosphoSitePlus

Other Protein References for GSTP1 Gene

Domains & Families for GSTP1 Gene

Gene Families for GSTP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P09211

UniProtKB/Swiss-Prot:

GSTP1_HUMAN :
  • Belongs to the GST superfamily. Pi family.
Family:
  • Belongs to the GST superfamily. Pi family.
genes like me logo Genes that share domains with GSTP1: view

Function for GSTP1 Gene

Molecular function for GSTP1 Gene

GENATLAS Biochemistry:
glutathione S-transferase pi class,susceptibility factor in squamous-cell carcinoma of the esophagus and in Barretts esophagus carcinoma,involved in the DNA methylation of cpG island in prostate cancer and other cancer
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Enzyme Numbers (IUBMB) for GSTP1 Gene

Gene Ontology (GO) - Molecular Function for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IEA,TAS --
GO:0004602 glutathione peroxidase activity IDA 16624487
GO:0005515 protein binding IPI 16636664
GO:0008144 drug binding IEA --
GO:0008432 JUN kinase binding ISS --
genes like me logo Genes that share ontologies with GSTP1: view
genes like me logo Genes that share phenotypes with GSTP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GSTP1 Gene

Localization for GSTP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GSTP1 Gene

Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GSTP1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 5
plasma membrane 4
nucleus 4
peroxisome 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Mitochondria (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA,IDA 22664934
GO:0005622 intracellular IDA 18962899
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm TAS 16130169
genes like me logo Genes that share ontologies with GSTP1: view

Pathways & Interactions for GSTP1 Gene

genes like me logo Genes that share pathways with GSTP1: view

SIGNOR curated interactions for GSTP1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for GSTP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species ISS --
GO:0002674 negative regulation of acute inflammatory response NAS 18962899
GO:0006469 negative regulation of protein kinase activity IEA,IDA 16636664
GO:0006749 glutathione metabolic process IDA 1540159
GO:0006805 xenobiotic metabolic process IEA,IDA 1540159
genes like me logo Genes that share ontologies with GSTP1: view

Drugs & Compounds for GSTP1 Gene

(106) Drugs for GSTP1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Enzyme, inhibitor 434,438
Cisplatin Approved Pharma Enzyme, substrate Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 2906
Oxaliplatin Approved, Investigational Pharma Enzyme, substrate Antitumor agent, Platinum 1560
Clomipramine Approved, Investigational, Vet_approved Pharma Target, inhibitor 24
Chlorambucil Approved Pharma Enzyme, substrate 54

(107) Additional Compounds for GSTP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(2) ApexBio Compounds for GSTP1 Gene

Compound Action Cas Number
Ezatiostat (GST) P1-1 inhibitor 168682-53-9
Ezatiostat hydrochloride GST inhibitor 286942-97-0
genes like me logo Genes that share compounds with GSTP1: view

Drug Products

Transcripts for GSTP1 Gene

Unigene Clusters for GSTP1 Gene

Glutathione S-transferase pi 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GSTP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6:

Relevant External Links for GSTP1 Gene

GeneLoc Exon Structure for
GSTP1
ECgene alternative splicing isoforms for
GSTP1

Expression for GSTP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GSTP1 Gene

mRNA differential expression in normal tissues according to GTEx for GSTP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.9).

Protein differential expression in normal tissues from HIPED for GSTP1 Gene

This gene is overexpressed in Amniocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GSTP1 Gene



Protein tissue co-expression partners for GSTP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of GSTP1 Gene:

GSTP1

SOURCE GeneReport for Unigene cluster for GSTP1 Gene:

Hs.523836

Evidence on tissue expression from TISSUES for GSTP1 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Blood(4.6)
  • Intestine(4.6)
  • Lung(4.4)
  • Eye(4.3)
  • Pancreas(3.7)
  • Skin(3.4)
  • Kidney(3)
  • Stomach(3)
  • Lymph node(2.9)
  • Muscle(2.9)
  • Thyroid gland(2.9)
  • Bone marrow(2.8)
  • Gall bladder(2.6)
  • Heart(2.6)
  • Adrenal gland(2.1)
  • Spleen(2.1)
  • Urine(2.1)
genes like me logo Genes that share expression patterns with GSTP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GSTP1 Gene

Orthologs for GSTP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GSTP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GSTP1 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia GSTP1 33 34
  • 87.78 (n)
dog
(Canis familiaris)
Mammalia GSTP1 33 34
  • 86.83 (n)
-- 34
  • 85 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gstp2 34
  • 84 (a)
OneToMany
Gstp1 33 34
  • 83.49 (n)
BC021614 34
  • 70 (a)
OneToMany
Gstp-ps 16
rat
(Rattus norvegicus)
Mammalia Gstp1 33
  • 82.7 (n)
oppossum
(Monodelphis domestica)
Mammalia GSTP1 34
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GSTP1 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gstp1 33
  • 57.26 (n)
zebrafish
(Danio rerio)
Actinopterygii gstp1 33 34
  • 63.14 (n)
gstp2 34
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gst-1 35 34
  • 39 (a)
gst-23 34
  • 38 (a)
ManyToMany
gst-25 34
  • 35 (a)
ManyToMany
Species where no ortholog for GSTP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GSTP1 Gene

ENSEMBL:
Gene Tree for GSTP1 (if available)
TreeFam:
Gene Tree for GSTP1 (if available)

Paralogs for GSTP1 Gene

Paralogs for GSTP1 Gene

(8) SIMAP similar genes for GSTP1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for GSTP1 Gene

genes like me logo Genes that share paralogs with GSTP1: view

Variants for GSTP1 Gene

Sequence variations from dbSNP and Humsavar for GSTP1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1695 drug-response, not-provided, fluorouracil and oxaliplatin response - Efficacy, cyclophosphamide and epirubicin response - Efficacy, Toxicity/ADR, Platinum compounds response - Toxicity/ADR, Colorectal Neoplasms 67,585,218(+) A/G coding_sequence_variant, missense_variant
rs1000411337 -- 67,582,233(+) C/T upstream_transcript_variant
rs1000615502 -- 67,582,409(+) G/A upstream_transcript_variant
rs1001448524 -- 67,586,322(+) G/C intron_variant
rs1001516756 -- 67,582,500(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GSTP1 Gene

Variant ID Type Subtype PubMed ID
dgv1214n100 CNV gain 25217958
dgv1981n54 CNV gain 21841781
esv2422195 CNV duplication 17116639
nsv468606 CNV gain 19166990

Variation tolerance for GSTP1 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GSTP1 Gene

Human Gene Mutation Database (HGMD)
GSTP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GSTP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GSTP1 Gene

Disorders for GSTP1 Gene

MalaCards: The human disease database

(31) MalaCards diseases for GSTP1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oral mucosa leukoplakia
  • leukoplakia, oral
prostate cancer
  • prostate cancer, susceptibility to
squamous cell carcinoma
  • epidermoid carcinoma
larynx cancer
  • laryngeal benign neoplasm
hepatocellular adenoma
- elite association - COSMIC cancer census association via MalaCards
Search GSTP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GSTP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with GSTP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GSTP1 Gene

Publications for GSTP1 Gene

  1. Influence of GST gene polymorphisms on busulfan pharmacokinetics in children. (PMID: 19584821) Ansari M … Krajinovic M (Bone marrow transplantation 2010) 3 22 44 58
  2. Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinoma. (PMID: 19922504) Chen YC … Wang WS (Cancer science 2010) 3 22 44 58
  3. Estrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents. (PMID: 20197727) Woo HY … Lim SW (The Korean journal of laboratory medicine 2010) 3 22 44 58
  4. Glutathione-S-transferase genotypes influence the risk of chemotherapy-related toxicities and prognosis in Korean patients with diffuse large B-cell lymphoma. (PMID: 20303013) Cho HJ … Kong SY (Cancer genetics and cytogenetics 2010) 3 22 44 58
  5. Associations between glutathione S-transferase pi Ile105Val and glyoxylate aminotransferase Pro11Leu and Ile340Met polymorphisms and early-onset oxaliplatin-induced neuropathy. (PMID: 20308030) Kanai M … Matsuda F (Cancer epidemiology 2010) 3 22 44 58

Products for GSTP1 Gene

Sources for GSTP1 Gene

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