Aliases for DNAJC8 Gene

Aliases for DNAJC8 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member C8 2 3 5
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 8 2 3
  • DnaJ Homolog Subfamily C Member 8 3 4
  • Splicing Protein Spf31 3 4
  • SPF31 3 4
  • HSPC331 3

External Ids for DNAJC8 Gene

Previous GeneCards Identifiers for DNAJC8 Gene

  • GC01P026900
  • GC01M027537
  • GC01M027760
  • GC01M028131
  • GC01M028211
  • GC01M028399
  • GC01M028526
  • GC01M026783

Summaries for DNAJC8 Gene

GeneCards Summary for DNAJC8 Gene

DNAJC8 (DnaJ Heat Shock Protein Family (Hsp40) Member C8) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot Summary for DNAJC8 Gene

  • Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716).

Additional gene information for DNAJC8 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DNAJC8 Gene

Genomics for DNAJC8 Gene

GeneHancer (GH) Regulatory Elements for DNAJC8 Gene

Promoters and enhancers for DNAJC8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJC8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJC8 gene promoter:
  • c-Myb
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CREB
  • deltaCREB
  • HSF2
  • NF-Y

Genomic Locations for DNAJC8 Gene

Genomic Locations for DNAJC8 Gene
chr1:28,199,456-28,233,031
(GRCh38/hg38)
Size:
33,576 bases
Orientation:
Minus strand
chr1:28,525,967-28,559,542
(GRCh37/hg19)
Size:
33,576 bases
Orientation:
Minus strand

Genomic View for DNAJC8 Gene

Genes around DNAJC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJC8 Gene

Proteins for DNAJC8 Gene

  • Protein details for DNAJC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75937-DNJC8_HUMAN
    Recommended name:
    DnaJ homolog subfamily C member 8
    Protein Accession:
    O75937
    Secondary Accessions:
    • B4DUU4
    • D3DPM0
    • Q6IBA4
    • Q8N4Z5
    • Q9P051
    • Q9P067

    Protein attributes for DNAJC8 Gene

    Size:
    253 amino acids
    Molecular mass:
    29842 Da
    Quaternary structure:
    • Interacts with SRPK1 (PubMed:19240134). Interacts with HSP70 (HSPA1A or HSPA1B) (PubMed:27133716).
    SequenceCaution:
    • Sequence=AAC35352.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAG33181.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for DNAJC8 Gene

Post-translational modifications for DNAJC8 Gene

  • Ubiquitination at Lys108 and Lys210
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJC8 Gene

Domains & Families for DNAJC8 Gene

Gene Families for DNAJC8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DNAJC8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNAJC8 Gene

GenScript: Design optimal peptide antigens:
  • Splicing protein spf31 (DNJC8_HUMAN)
genes like me logo Genes that share domains with DNAJC8: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DNAJC8 Gene

Function for DNAJC8 Gene

Molecular function for DNAJC8 Gene

UniProtKB/Swiss-Prot Function:
Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells (PubMed:27133716).

Phenotypes From GWAS Catalog for DNAJC8 Gene

Gene Ontology (GO) - Molecular Function for DNAJC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28298427
GO:0030544 Hsp70 protein binding IPI 27133716
genes like me logo Genes that share ontologies with DNAJC8: view
genes like me logo Genes that share phenotypes with DNAJC8: view

Animal Models for DNAJC8 Gene

MGI Knock Outs for DNAJC8:
  • Dnajc8 Dnajc8<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for DNAJC8 Gene

miRTarBase miRNAs that target DNAJC8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJC8 Gene

Localization for DNAJC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJC8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJC8 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DNAJC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 27133716
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with DNAJC8: view

Pathways & Interactions for DNAJC8 Gene

genes like me logo Genes that share pathways with DNAJC8: view

Pathways by source for DNAJC8 Gene

Gene Ontology (GO) - Biological Process for DNAJC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
genes like me logo Genes that share ontologies with DNAJC8: view

No data available for SIGNOR curated interactions for DNAJC8 Gene

Drugs & Compounds for DNAJC8 Gene

No Compound Related Data Available

Transcripts for DNAJC8 Gene

mRNA/cDNA for DNAJC8 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJC8 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - - - - -
SP7: -

Relevant External Links for DNAJC8 Gene

GeneLoc Exon Structure for
DNAJC8
ECgene alternative splicing isoforms for
DNAJC8

Expression for DNAJC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNAJC8 Gene

This gene is overexpressed in Lavage (11.5), Lymph node (9.7), and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJC8 Gene



Protein tissue co-expression partners for DNAJC8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJC8 Gene:

DNAJC8

SOURCE GeneReport for Unigene cluster for DNAJC8 Gene:

Hs.433540

mRNA Expression by UniProt/SwissProt for DNAJC8 Gene:

O75937-DNJC8_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DNAJC8 Gene

  • Blood(4.4)
  • Liver(4.4)
  • Nervous system(3.6)
  • Lung(3.3)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with DNAJC8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJC8 Gene

Orthologs for DNAJC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNAJC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNAJC8 33 32
  • 99.87 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJC8 33
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJC8 33
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJC8 33 32
  • 94.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DNAJC8 33 32
  • 94.47 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dnajc8 17 33 32
  • 90.78 (n)
rat
(Rattus norvegicus)
Mammalia Dnajc8 32
  • 90.51 (n)
chicken
(Gallus gallus)
Aves DNAJC8 33 32
  • 83.55 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJC8 33
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc8 32
  • 78.49 (n)
Str.10589 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.24686 32
zebrafish
(Danio rerio)
Actinopterygii dnajc8 33 32
  • 74.33 (n)
OneToOne
-- 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005298 32
  • 56.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10375 33 34 32
  • 54.65 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnj-30 33 32
  • 55.12 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 51 (a)
OneToOne
Species where no ortholog for DNAJC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNAJC8 Gene

ENSEMBL:
Gene Tree for DNAJC8 (if available)
TreeFam:
Gene Tree for DNAJC8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJC8: view image

Paralogs for DNAJC8 Gene

genes like me logo Genes that share paralogs with DNAJC8: view

No data available for Paralogs for DNAJC8 Gene

Variants for DNAJC8 Gene

Sequence variations from dbSNP and Humsavar for DNAJC8 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000008142 -- 28,206,812(-) G/A intron_variant
rs1000019079 -- 28,221,425(-) G/T intron_variant
rs1000071480 -- 28,221,185(-) A/G intron_variant
rs1000082193 -- 28,220,980(-) G/A/C/T intron_variant
rs1000276010 -- 28,211,447(-) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJC8 Gene

Variant ID Type Subtype PubMed ID
esv2674175 CNV deletion 23128226
esv3559959 CNV deletion 23714750
esv3585575 CNV loss 21293372
nsv545916 CNV gain 21841781
nsv945854 CNV duplication 23825009

Variation tolerance for DNAJC8 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJC8 Gene

Disorders for DNAJC8 Gene

Additional Disease Information for DNAJC8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNAJC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJC8 Gene

Publications for DNAJC8 Gene

  1. A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner. (PMID: 27133716) Ito N … Torigoe T (Biochemical and biophysical research communications 2016) 3 4 56
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. (PMID: 11147971) Ohtsuka K … Hata M (Cell stress & chaperones 2000) 2 3 56

Products for DNAJC8 Gene

Sources for DNAJC8 Gene