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Aliases for PABPC3 Gene

Aliases for PABPC3 Gene

  • Poly(A) Binding Protein Cytoplasmic 3 2 3 5
  • Poly(A)-Binding Protein 3 3 4
  • Testis PABP 2 3
  • PABPL3 3 4
  • PABP-3 3 4
  • PABP3 3 4
  • Testis-Specific Poly(A)-Binding Protein (PABP) 3
  • Testis-Specific Poly(A)-Binding Protein 3 3
  • Testis-Specific Poly(A)-Binding Protein 4
  • Poly(A)-Binding Protein, Cytoplasmic 3 2
  • Polyadenylate-Binding Protein 3 3
  • Poly(A)-Binding Protein-Like 3 3
  • TPABP 3

External Ids for PABPC3 Gene

Previous HGNC Symbols for PABPC3 Gene

  • PABPL3

Previous GeneCards Identifiers for PABPC3 Gene

  • GC13P023650
  • GC13P019650
  • GC13P024600
  • GC13P023468
  • GC13P024568
  • GC13P025670
  • GC13P006483

Summaries for PABPC3 Gene

Entrez Gene Summary for PABPC3 Gene

  • Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]

GeneCards Summary for PABPC3 Gene

PABPC3 (Poly(A) Binding Protein Cytoplasmic 3) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for PABPC3 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

Gene Wiki entry for PABPC3 Gene

Additional gene information for PABPC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC3 Gene

Genomics for PABPC3 Gene

GeneHancer (GH) Regulatory Elements for PABPC3 Gene

Promoters and enhancers for PABPC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J026048 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 5 +955.1 955098 4.3 ZSCAN4 SIN3A FEZF1 ZNF335 GLIS2 SCRT2 ZNF143 REST ZFP69B GLIS1 SHISA2 PABPC3 LINC00415 PIR56473
GH13J025892 Enhancer 0.3 dbSUPER 5.6 +796.7 796664 0.4 CREB1 PABPC3 GC13P025866 PIR50437 RN7SL741P ATP8A2
GH13J024910 Enhancer 1.1 FANTOM5 ENCODE 1.4 -184.6 -184563 1.4 PKNOX1 ATF1 FOXA2 CHAMP1 FOS USF2 ZNF592 MEF2D SMARCA4 IKZF1 NUP58 MTMR6 PARP4 PABPC3 CENPJ PIR31198 GC13P024800
GH13J025899 Enhancer 0.2 dbSUPER 5.6 +803.8 803767 1.1 PABPC3 GC13P025866 PIR50437 RN7SL741P ATP8A2
GH13J025113 Enhancer 0.7 ENCODE 0.4 +18.7 18695 1.5 CTCF PKNOX1 TFAP4 RB1 SIN3A RAD21 GATA3 SMC3 ZNF143 RUNX3 AMER2 LINC01053 LINC00463 PABPC3 LOC105370120 ENSG00000279695
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PABPC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PABPC3 gene promoter:

Genomic Locations for PABPC3 Gene

Genomic Locations for PABPC3 Gene
chr13:25,095,868-25,099,254
(GRCh38/hg38)
Size:
3,387 bases
Orientation:
Plus strand
chr13:25,670,276-25,673,389
(GRCh37/hg19)

Genomic View for PABPC3 Gene

Genes around PABPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC3 Gene

Proteins for PABPC3 Gene

  • Protein details for PABPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H361-PABP3_HUMAN
    Recommended name:
    Polyadenylate-binding protein 3
    Protein Accession:
    Q9H361
    Secondary Accessions:
    • Q8NHV0
    • Q9H086

    Protein attributes for PABPC3 Gene

    Size:
    631 amino acids
    Molecular mass:
    70031 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PABPC3 Gene

neXtProt entry for PABPC3 Gene

Post-translational modifications for PABPC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC3 Gene

Domains & Families for PABPC3 Gene

Gene Families for PABPC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q9H361

UniProtKB/Swiss-Prot:

PABP3_HUMAN :
  • Belongs to the polyadenylate-binding protein type-1 family.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC3: view

Function for PABPC3 Gene

Molecular function for PABPC3 Gene

UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.
GENATLAS Biochemistry:
poly(A) binding protein,cytoplasmic 3

Phenotypes From GWAS Catalog for PABPC3 Gene

Gene Ontology (GO) - Molecular Function for PABPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008143 poly(A) binding IDA 11328870
genes like me logo Genes that share ontologies with PABPC3: view
genes like me logo Genes that share phenotypes with PABPC3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPC3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC3 Gene

Localization for PABPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PABPC3 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PABPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11328870
GO:0005829 cytosol IDA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PABPC3: view

Pathways & Interactions for PABPC3 Gene

genes like me logo Genes that share pathways with PABPC3: view

Pathways by source for PABPC3 Gene

3 KEGG pathways for PABPC3 Gene

Gene Ontology (GO) - Biological Process for PABPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016071 mRNA metabolic process NAS 11328870
genes like me logo Genes that share ontologies with PABPC3: view

No data available for SIGNOR curated interactions for PABPC3 Gene

Drugs & Compounds for PABPC3 Gene

No Compound Related Data Available

Transcripts for PABPC3 Gene

mRNA/cDNA for PABPC3 Gene

(32) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC3 Gene

Poly(A) binding protein, cytoplasmic 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PABPC3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC3 Gene

No ASD Table

Relevant External Links for PABPC3 Gene

GeneLoc Exon Structure for
PABPC3
ECgene alternative splicing isoforms for
PABPC3

Expression for PABPC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PABPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PABPC3 Gene

This gene is overexpressed in Testis (x43.9).

Protein differential expression in normal tissues from HIPED for PABPC3 Gene

This gene is overexpressed in Brain (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PABPC3 Gene



Protein tissue co-expression partners for PABPC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PABPC3 Gene:

PABPC3

SOURCE GeneReport for Unigene cluster for PABPC3 Gene:

Hs.458280

mRNA Expression by UniProt/SwissProt for PABPC3 Gene:

Q9H361-PABP3_HUMAN
Tissue specificity: Testis specific.

Evidence on tissue expression from TISSUES for PABPC3 Gene

  • Spleen(2.5)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with PABPC3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PABPC3 Gene

Orthologs for PABPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PABPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC3 34 33
  • 99 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
ManyToMany
-- 34
  • 83 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pabpc2 34
  • 75 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PABPC1 34
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 86 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pabpc1a 34 33
  • 73.75 (n)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta pAbp 35
  • 54 (a)
CG4612 35
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea pab-2 35
  • 54 (a)
pab-1 35
  • 50 (a)
Species where no ortholog for PABPC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PABPC3 Gene

ENSEMBL:
Gene Tree for PABPC3 (if available)
TreeFam:
Gene Tree for PABPC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PABPC3: view image

Paralogs for PABPC3 Gene

(15) SIMAP similar genes for PABPC3 Gene using alignment to 3 proteins:

  • PABP3_HUMAN
  • Q3ZCS4_HUMAN
  • Q5VX58_HUMAN

Pseudogenes.org Pseudogenes for PABPC3 Gene

genes like me logo Genes that share paralogs with PABPC3: view

Variants for PABPC3 Gene

Sequence variations from dbSNP and Humsavar for PABPC3 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000034110 -- 25,094,767(+) C/T upstream_transcript_variant
rs1000635311 -- 25,096,005(+) G/A/T upstream_transcript_variant
rs1002673588 -- 25,096,048(+) C/A upstream_transcript_variant
rs1003216540 -- 25,094,897(+) T/C upstream_transcript_variant
rs1003621733 -- 25,094,608(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC3 Gene

Variant ID Type Subtype PubMed ID
dgv7e24 CNV loss 17666407
esv2659512 CNV deletion 23128226
esv2747161 CNV deletion 23290073
nsv1047876 CNV gain 25217958
nsv435952 OTHER inversion 17901297
nsv983566 CNV duplication 23825009

Variation tolerance for PABPC3 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PABPC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PABPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC3 Gene

Disorders for PABPC3 Gene

Additional Disease Information for PABPC3

No disorders were found for PABPC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC3 Gene

Publications for PABPC3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  3. Human testis expresses a specific poly(A)-binding protein. (PMID: 11328870) Féral C … Pawlak A (Nucleic acids research 2001) 3 4 58
  4. Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PMID: 10543404) Féral C … Guellaën G (Human genetics 1999) 2 3 58
  5. Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization. (PMID: 8432538) Morris CM … Bodger MP (Genomics 1993) 2 3 58

Products for PABPC3 Gene

Sources for PABPC3 Gene

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