Aliases for SMAD2 Gene
Aliases for SMAD2 Gene
External Ids for SMAD2 Gene
- HGNC: 6768
- Entrez Gene: 4087
- Ensembl: ENSG00000175387
- OMIM: 601366
- UniProtKB: Q15796
Previous HGNC Symbols for SMAD2 Gene
- MADH2
Previous GeneCards Identifiers for SMAD2 Gene
- GC18M043620
- GC18M043621
- GC18M045357
- GC18M042208
Summaries for SMAD2 Gene
-
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for SMAD2 Gene
SMAD2 (SMAD Family Member 2) is a Protein Coding gene. Diseases associated with SMAD2 include Keloids and Ureteral Disease. Among its related pathways are Toll-like receptor signaling pathway and TGF-beta Receptor Signaling (WikiPathways). Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is SMAD3.
UniProtKB/Swiss-Prot for SMAD2 Gene
-
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMAD2 Gene
Genomics for SMAD2 Gene
GeneHancer (GH) Regulatory Elements for SMAD2 Gene
Promoters and enhancers for SMAD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SMAD2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the SMAD2 gene promoter:
Regulatory Element Products
Genomic Locations for SMAD2 Gene
Genomic Locations for SMAD2 Gene
- chr18:47,808,957-47,931,193
- (GRCh38/hg38)
- Size:
- 122,237 bases
- Orientation:
- Minus strand
- chr18:45,357,922-45,457,515
- (GRCh37/hg19)
Genomic View for SMAD2 Gene
Genes around SMAD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.1 by Ensembl
- 18q21.1 by Entrez Gene
- 18q21.1 by HGNC
SMAD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SMAD2 Gene
Proteins for SMAD2 Gene
-
Protein details for SMAD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15796-SMAD2_HUMAN
- Recommended name:
- Mothers against decapentaplegic homolog 2
- Protein Accession:
- Q15796
Protein attributes for SMAD2 Gene
- Size:
- 467 amino acids
- Molecular mass:
- 52306 Da
- Quaternary structure:
-
- Monomer; the absence of TGF-beta. Heterodimer; in the presence of TGF-beta. Forms a heterodimer with co-SMAD, SMAD4, in the nucleus to form the transactivation complex SMAD2/SMAD4. Interacts with AIP1, HGS, PML and WWP1 (By similarity). Interacts with NEDD4L in response to TGF-beta (By similarity). Found in a complex with SMAD3 and TRIM33 upon addition of TGF-beta. Interacts with ACVR1B, SMAD3 and TRIM33. Interacts (via the MH2 domain) with ZFYVE9; may form trimers with the SMAD4 co-SMAD. Interacts with FOXH1, homeobox protein TGIF, PEBP2-alpha subunit, CREB-binding protein (CBP), EP300, SKI and SNW1. Interacts with SNON; when phosphorylated at Ser-465/467. Interacts with SKOR1 and SKOR2. Interacts with PRDM16. Interacts (via MH2 domain) with LEMD3. Interacts with RBPMS. Interacts with WWP1. Interacts (dephosphorylated form, via the MH1 and MH2 domains) with RANBP3 (via its C-terminal R domain); the interaction results in the export of dephosphorylated SMAD3 out of the nucleus and termination of the TGF-beta signaling. Interacts with PDPK1 (via PH domain). Interacts with DAB2; the interactions are enhanced upon TGF-beta stimulation. Interacts with USP15. Interacts with PPP5C. Interacts with ZNF580. Interacts with LDLRAD4 (via the SMAD interaction motif). Interacts (via MH2 domain) with PMEPA1 (via the SMAD interaction motif). Interacts with ZFHX3. Interacts with ZNF451 (PubMed:24324267). Identified in a complex that contains at least ZNF451, SMAD2, SMAD3 and SMAD4 (PubMed:24324267). Interacts weakly with ZNF8 (By similarity). Interacts (when phosphorylated) with RNF111; RNF111 acts as an enhancer of the transcriptional responses by mediating ubiquitination and degradation of SMAD2 inhibitors (By similarity).
Three dimensional structures from OCA and Proteopedia for SMAD2 Gene
Protein Expression for SMAD2 Gene
Post-translational modifications for SMAD2 Gene
- Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. Isoform short: Acetylation increases DNA binding activity in vitro and enhances its association with target promoters in vivo. Acetylation in the nucleus by EP300 is enhanced by TGF-beta.
- In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding (By similarity). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (PubMed:21947082). Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are in use are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover (By similarity).
- Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases. TGF-beta-induced Ser-465/467 phosphorylation declines progressively in a KMT5A-dependent manner. Able to interact with SMURF2 when phosphorylated on Ser-465/467, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for SMAD2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for SMAD2 (Smad2)
-
Custom Antibody ServicesOriGene Antibodies for SMAD2
- AM06653SU-N
- AP08073PU-N
- AP08072PU-S
- AP08072PU-N
- AP08026PU-S
- AP08026PU-N
- AP08025PU-S
- AP08025PU-N
- AP06413PU-N
- AP01355PU-N
- AM31101PU-N
- CF501777
- TA501777
- CF501728
- TA501728
- TA347047
- TA336363
- TA325851
- TA325850
- TA325849
- TA325848
- TA324933
- TA324932
- TA321257
- TA321256
- TA321255
- TA319186
- TA312261
- TA312260
- TA312259
- TA312258
- TA310020
- TA302690
- SP1399P
- AP55880PU-S
- AP55880PU-N
- AP55851PU-S
- AP55851PU-N
- AP23361PU-N
- AP21096PU-N
- AP21095PU-N
- AP21054PU-N
- AP20361PU-N
- AP08464PU-N
- AP08073PU-S
- Novus Biologicals Antibodies for SMAD2
-
Abcam antibodies for SMAD2
-
Cloud-Clone Corp. Antibodies for SMAD2
- Invitrogen Antibodies for SMAD2
- antibodies-online: Search results for 428 available SMAD2 Antibodies ranked by validation data
- Compare Top SMAD2 Antibodies
-
Recommended
- 344 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 193 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 167 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IF/ICC Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- 344 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 193 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 2 IF Antibodies (anti-mouse)
- 1 IF/ICC Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 167 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 2 IF Antibodies (anti-rat)
- 1 IF/ICC Antibody (anti-rat)
- 1 IHC Antibody (anti-rat)
- GeneTex SMAD2 antibody for SMAD2
-
Santa Cruz Biotechnology (SCBT) Antibodies for SMAD2
- Sino Biological Antibodies for SMAD2
Protein Products
-
OriGene Purified Proteins for SMAD2
- Search Origene for MassSpec and Protein Over-expression Lysates for SMAD2
- Origene Custom Protein Services for SMAD2
- Sino Biological Recombinant Proteins for SMAD2
- Sino Biological Cell Lysates for SMAD2
- ProSpec Recombinant Proteins for SMAD2
-
Cloud-Clone Corp. Proteins for SMAD2
- Search GeneTex for Proteins for SMAD2
-
ProSci Proteins for SMAD2
-
Abcam proteins for SMAD2
Assay Products
No data available for DME Specific Peptides for SMAD2 Gene
Domains & Families for SMAD2 Gene
Gene Families for SMAD2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Transcription factors
Protein Domains for SMAD2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SMAD2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15796- Family:
-
- Belongs to the dwarfin/SMAD family.
Function for SMAD2 Gene
Molecular function for SMAD2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Phenotypes From GWAS Catalog for SMAD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 9389648 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 9389648 |
| GO:0003677 | contributes_to DNA binding | IDA | 9389648 |
| GO:0003682 | chromatin binding | IEA | -- |
| GO:0003690 | double-stranded DNA binding | ISS | -- |
Phenotypes for SMAD2 Gene
- MGI mutant phenotypes for SMAD2:
-
inferred from 22 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- taste/olfaction phenotype
- GenomeRNAi human phenotypes for SMAD2:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with vaccinia virus (VACV) infection
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased shRNA abundance (Z-score < -2)
- Increased mitotic index
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased vesicular stomatitis virus (VSV) infection
Animal Models for SMAD2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SMAD2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SMAD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SMAD2 gene
- Search ViGene Biosciences for SMAD2
CRISPR Products
-
OriGene CRISPR knockouts for SMAD2
- genomics-online: gRNA clones - Search results for 141 available SMAD2 gene related products
- Overview of 141 available SMAD2 gene related products
- Applied Biological Materials CRISPR for SMAD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SMAD2
- GenScript: Design CRISPR guide RNA sequences for SMAD2
miRNA for SMAD2 Gene
- miRTarBase miRNAs that target SMAD2
-
- hsa-mir-155-5p (MIRT005872)
- hsa-mir-200a-3p (MIRT007290)
- hsa-mir-200b-3p (MIRT007322)
- hsa-mir-652-3p (MIRT039468)
- hsa-mir-484 (MIRT042141)
- hsa-mir-324-5p (MIRT043212)
- hsa-mir-624-3p (MIRT053419)
- hsa-mir-148a-3p (MIRT053560)
- hsa-mir-181a-5p (MIRT053687)
- hsa-mir-188-5p (MIRT053699)
- hsa-let-7g-5p (MIRT054664)
- hsa-mir-146a-5p (MIRT054772)
- hsa-mir-18a-5p (MIRT387526)
- hsa-mir-18b-5p (MIRT387527)
- hsa-mir-192-3p (MIRT495410)
- hsa-mir-6501-5p (MIRT495411)
- hsa-mir-3613-3p (MIRT495412)
- hsa-mir-495-5p (MIRT495414)
- hsa-mir-6891-3p (MIRT612462)
- hsa-mir-6072 (MIRT612463)
- hsa-mir-1228-3p (MIRT612464)
- hsa-mir-8485 (MIRT612465)
- hsa-mir-329-3p (MIRT612466)
- hsa-mir-362-3p (MIRT612467)
- hsa-mir-503-5p (MIRT628988)
- hsa-mir-642a-5p (MIRT666206)
- hsa-mir-196a-3p (MIRT666207)
- hsa-mir-4469 (MIRT666208)
- hsa-mir-372-5p (MIRT666209)
- hsa-mir-371a-5p (MIRT666210)
- hsa-mir-2276-5p (MIRT666211)
- hsa-mir-6892-3p (MIRT666212)
- hsa-mir-106a-3p (MIRT699167)
- hsa-mir-937-5p (MIRT699168)
- hsa-mir-505-3p (MIRT699169)
- hsa-mir-5702 (MIRT699170)
- hsa-mir-203a-3p (MIRT699171)
- hsa-mir-1324 (MIRT699172)
- hsa-mir-5680 (MIRT699173)
- hsa-mir-548g-3p (MIRT699174)
- hsa-mir-548av-3p (MIRT699175)
- hsa-mir-374a-3p (MIRT724464)
- hsa-mir-5089-3p (MIRT724465)
- hsa-mir-361-5p (MIRT724466)
- hsa-mir-6744-3p (MIRT724467)
- hsa-mir-4757-5p (MIRT724468)
- hsa-mir-4502 (MIRT724469)
- hsa-mir-2115-3p (MIRT724470)
- hsa-mir-27a-3p (MIRT726493)
- hsa-mir-27b-3p (MIRT726494)
- hsa-mir-323a-3p (MIRT731256)
- hsa-mir-128-3p (MIRT731928)
- hsa-mir-425-5p (MIRT732219)
- hsa-mir-486-5p (MIRT732557)
- hsa-mir-206 (MIRT732612)
- hsa-mir-503-3p (MIRT733758)
- hsa-mir-15b-5p (MIRT733877)
- hsa-mir-205-5p (MIRT734288)
- hsa-mir-125a-5p (MIRT735098)
- hsa-mir-145-5p (MIRT735099)
- hsa-mir-212-3p (MIRT735157)
- hsa-mir-132-3p (MIRT735158)
- hsa-let-7a-3p (MIRT760967)
- hsa-let-7b-3p (MIRT760980)
- hsa-let-7f-1-3p (MIRT761025)
- hsa-let-7f-2-3p (MIRT761027)
- hsa-mir-1185-1-3p (MIRT761205)
- hsa-mir-1185-2-3p (MIRT761207)
- hsa-mir-1266-3p (MIRT761744)
- hsa-mir-1267 (MIRT761761)
- hsa-mir-300 (MIRT764400)
- hsa-mir-381-3p (MIRT767547)
- hsa-mir-4666a-3p (MIRT770827)
- hsa-mir-4789-5p (MIRT772346)
- hsa-mir-7152-5p (MIRT781534)
- hsa-mir-944 (MIRT782981)
- hsa-mir-98-3p (MIRT783007)
Targeted motifs for SMAD2 Gene
HOMER Transcription Factor Regulatory Elements motif SMAD2
- Consensus sequence: CTGTCTGG Submotif: canonical Cell Type: ES GEO ID: GSE29422
miRNA Products
- Search ViGene Biosciences for SMAD2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SMAD2
- Browse OriGene Inhibitory RNA Products For SMAD2
- genomics-online: shRNA clones - Search results for 141 available SMAD2 gene related products
- Overview of 141 available SMAD2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SMAD2 gene
Clone Products
-
OriGene ORF clones in human for SMAD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SMAD2
- VectorBuilder custom plasmid, inducible vectors for SMAD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SMAD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SMAD2
- Applied Biological Materials Clones for SMAD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SMAD2
-
ViGene Biosciences adenoviral particle packaged cDNA for SMAD2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SMAD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SMAD2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for SMAD2 Gene
Localization for SMAD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SMAD2 Gene
- Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). {ECO:0000269 PubMed:16751101, ECO:0000269 PubMed:19289081, ECO:0000269 PubMed:9865696}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
- Cytosol (3)
- Nucleoli (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 21828274 |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA,IEA | 8980228 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | IDA | 17438144 |
Pathways & Interactions for SMAD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | SMAD2/3 MH2 Domain Mutants in Cancer | ||
| 2 | Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer | ||
| 3 | TGF-beta receptor signaling activates SMADs | ||
| 4 | Gastric cancer |
.62
|
|
| 5 | Th17 cell differentiation | ||
Pathways by source for SMAD2 Gene
1 Sino Biological pathway for SMAD2 Gene
2 GeneTex pathways for SMAD2 Gene
17 BioSystems pathways for SMAD2 Gene
27 Reactome pathways for SMAD2 Gene
21 KEGG pathways for SMAD2 Gene
5 GeneGo (Thomson Reuters) pathways for SMAD2 Gene
2 R&D Systems pathways for SMAD2 Gene
10 Qiagen pathways for SMAD2 Gene
1 Cell Signaling Technology pathway for SMAD2 Gene
Interacting Proteins for SMAD2 Gene
Selected Interacting proteins:
ENSP00000262160
Q15796-SMAD2_HUMAN
for SMAD2 Gene via
STRING
MINT
IID
UniProtKB
SIGNOR curated interactions for SMAD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | TAS | -- |
| GO:0001657 | ureteric bud development | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001706 | endoderm formation | IEA | -- |
| GO:0001707 | mesoderm formation | ISS | -- |
Drugs & Compounds for SMAD2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pirfenidone | Approved, Investigational | Pharma | TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo | 65 | ||
| phosphoserine | Experimental | Pharma | Target | 0 | ||
| LDN193189 Hydrochloride | Pharma | ALK inhibitor,potent and selective | 0 | |||
| LY364947 | Pharma | 0 | ||||
| RepSox | Pharma | ALK5 inhibitor,potent and selective, Potent and selective inhibitor of TGF-betaRI | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(4) ApexBio Compounds for SMAD2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| LDN193189 Hydrochloride | ALK inhibitor,potent and selective | 1062368-62-0 |
| LY364947 | 396129-53-6 | |
| Pirfenidone | TGF-β production inhibitor | 53179-13-8 |
| RepSox | ALK5 inhibitor,potent and selective | 446859-33-2 |
Transcripts for SMAD2 Gene
mRNA/cDNA for SMAD2 Gene
- (13) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (247) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SMAD2 Gene
- SMAD family member 2:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for SMAD2
- genomics-online: gRNA clones - Search results for 141 available SMAD2 gene related products
- Overview of 141 available SMAD2 gene related products
- Applied Biological Materials CRISPR for SMAD2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SMAD2
- GenScript: Design CRISPR guide RNA sequences for SMAD2
miRNA Products
- Search ViGene Biosciences for SMAD2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SMAD2
- Browse OriGene Inhibitory RNA Products For SMAD2
- genomics-online: shRNA clones - Search results for 141 available SMAD2 gene related products
- Overview of 141 available SMAD2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SMAD2 gene
Clone Products
-
OriGene ORF clones in human for SMAD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for SMAD2
- VectorBuilder custom plasmid, inducible vectors for SMAD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SMAD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SMAD2
- Applied Biological Materials Clones for SMAD2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - |
| ExUns: | 15 | ^ | 16 | ^ | 17a | · | 17b |
|---|---|---|---|---|---|---|---|
| SP1: | |||||||
| SP2: | |||||||
| SP3: | |||||||
| SP4: | |||||||
| SP5: | |||||||
| SP6: | |||||||
| SP7: | |||||||
| SP8: | |||||||
| SP9: | |||||||
| SP10: | |||||||
| SP11: | |||||||
| SP12: | |||||||
| SP13: |
Expression for SMAD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Primitive Streak (Early Embryonic Tissues)
- Primitive Streak Cells Anterior Primitive Streak
- Endoderm Progenitor Cells Anterior Primitive Streak
- Extraembryonic Mural Cells Extraembryonic Mesoderm
-
Epiblast (Early Embryo)
- Primitive Streak Cells Anterior Primitive Streak
- Extraembryonic Mural Cells Extraembryonic Mesoderm
- Brain (Nervous System)
-
Endoderm (Gastrulation Derivatives)
- Endoderm Progenitor Cells Anterior Primitive Streak
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Mural Cells Extraembryonic Mesoderm
- Neural Tube (Nervous System)
- Liver (Hepatobiliary System)
-
Colon (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Breast (27.7) and Peripheral blood mononuclear cells (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SMAD2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SMAD2 Gene:
SMAD2SOURCE GeneReport for Unigene cluster for SMAD2 Gene:
Hs.12253mRNA Expression by UniProt/SwissProt for SMAD2 Gene:
Q15796-SMAD2_HUMAN
Tissue specificity:
Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Evidence on tissue expression from TISSUES for SMAD2 Gene
- Kidney(4.6)
- Pancreas(4.4)
- Spleen(4.4)
- Nervous system(4)
- Muscle(3.4)
- Lung(3.2)
- Heart(3.1)
- Skin(2.9)
- Blood(2.8)
- Liver(2.8)
- Intestine(2.7)
- Bone marrow(2.2)
- Eye(2.2)
- Lymph node(2.2)
- Stomach(2.1)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for SMAD2
-
OriGene qPCR primer pairs and template standards for SMAD2
- genomics-online: primer clones - Search results for 141 available SMAD2 gene related products
- Overview of 141 available SMAD2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMAD2 Gene
Orthologs for SMAD2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | SMAD2 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | SMAD2 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SMAD2 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | SMAD2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SMAD2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Smad2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Smad2 33 |
|
||
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| MADH2 34 |
|
OneToMany | |||
| SMAD2 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | SMAD2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | smad2 33 |
|
||
| Str.11098 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.85 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | smad2 33 34 |
|
||
| madh2 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3591 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Smox 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | sma-2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.560 33 |
|
- Species where no ortholog for SMAD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SMAD2 Gene
(6) SIMAP similar genes for SMAD2 Gene using alignment to 7 proteins:
Variants for SMAD2 Gene
| SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs397509416 | uncertain-significance, Variant of unknown significance | 47,851,273(-) | C/T | genic_downstream_transcript_variant, splice_donor_variant | |
| rs797044882 | pathogenic, Inborn genetic diseases | 47,848,537(-) | C/G | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| VAR_011375 | A colorectal carcinoma sample | p.Arg133Cys | |||
| VAR_011377 | A colorectal carcinoma sample | p.Leu440Arg | |||
| VAR_011378 | A colorectal carcinoma sample | p.Pro445His |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1593n106 | CNV | deletion | 24896259 |
| dgv3347n100 | CNV | loss | 25217958 |
| dgv3348n100 | CNV | gain | 25217958 |
| dgv3349n100 | CNV | loss | 25217958 |
| dgv3350n100 | CNV | loss | 25217958 |
| dgv3351n100 | CNV | loss | 25217958 |
| dgv3352n100 | CNV | loss | 25217958 |
| dgv3353n100 | CNV | loss | 25217958 |
| dgv3354n100 | CNV | loss | 25217958 |
| dgv3355n100 | CNV | loss | 25217958 |
| esv1323042 | CNV | insertion | 17803354 |
| esv2627568 | CNV | deletion | 19546169 |
| esv2667321 | CNV | deletion | 23128226 |
| esv2717053 | CNV | deletion | 23290073 |
| esv3325292 | CNV | insertion | 20981092 |
| esv3555341 | CNV | deletion | 23714750 |
| nsv1057072 | CNV | loss | 25217958 |
| nsv1057722 | CNV | gain | 25217958 |
| nsv1062318 | CNV | gain+loss | 25217958 |
| nsv1072265 | CNV | deletion | 25765185 |
| nsv1072266 | CNV | deletion | 25765185 |
| nsv1112727 | CNV | deletion | 24896259 |
| nsv1127630 | CNV | deletion | 24896259 |
| nsv1146886 | CNV | deletion | 26484159 |
| nsv132205 | CNV | deletion | 16902084 |
| nsv2288 | CNV | insertion | 18451855 |
| nsv961048 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.43% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SMAD2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMAD2 Gene
Disorders for SMAD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| keloids |
|
|
| ureteral disease |
|
|
| hypertrophic scars |
|
|
| buschke-ollendorff syndrome |
|
|
| melorheostosis |
|
|
Search SMAD2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SMAD2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SMAD2 Gene
Publications for SMAD2 Gene
- Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240. (PMID: 11879191) Abdel-Wahab N … Chantry A (The Biochemical journal 2002) 3 4 22 58
- Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. (PMID: 12193595) Funaba M … Mathews LS (The Journal of biological chemistry 2002) 3 4 22 58
- Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3. (PMID: 9873005) Yagi K … Miyazono K (The Journal of biological chemistry 1999) 3 4 22 58
- Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway. (PMID: 9503010) Takenoshita S … Hagiwara K (Genomics 1998) 3 4 22 58
- SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. (PMID: 9865696) Tsukazaki T … Wrana JL (Cell 1998) 3 4 22 58
Products for SMAD2 Gene
- R&D Systems Antibodies for SMAD2 (Smad2)
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- AM06653SU-N
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- AP08026PU-N
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- AP08072PU-N
- AP08072PU-S
- AP08073PU-N
- AP08073PU-S
- AP08464PU-N
- AP20361PU-N
- AP21054PU-N
- AP21095PU-N
- AP21096PU-N
- AP23361PU-N
- AP55851PU-N
- AP55851PU-S
- AP55880PU-N
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- SP1399P
- TA302690
- TA310020
- TA312258
- TA312259
- TA312260
- TA312261
- TA319186
- TA321255
- TA321256
- TA321257
- TA324932
- TA324933
- TA325848
- TA325849
- TA325850
- TA325851
- TA336363
- TA347047
- TA501728
- CF501728
- TA501777
- CF501777
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- Novus Biologicals Tissue Microarrays
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- Abcam antibodies for SMAD2
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- Browse Primary Antibodies
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- ApexBio compounds for SMAD2
- Cyagen custom Knockout/knockin (KOKI) mouse models for SMAD2
- VectorBuilder custom plasmid, inducible vectors for SMAD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SMAD2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SMAD2
- antibodies-online: Search results for 428 available SMAD2 Antibodies ranked by validation data
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- Recommended
- 344 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 12 IF Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 1 IHC Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 193 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
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- 1 IF/ICC Antibody (anti-mouse)
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- 167 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
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- antibodies-online: Search results for 43 available SMAD2 Elisa Kits ranked by validation data
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- GeneTex SMAD2 antibody for SMAD2
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- Search ViGene Biosciences for SMAD2
- Santa Cruz Biotechnology (SCBT) Antibodies for SMAD2
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- genomics-online: cdna clones - Search results for 141 available SMAD2 gene related products
- Overview of 141 available SMAD2 gene related products
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