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Aliases for KRT38 Gene

Aliases for KRT38 Gene

  • Keratin 38 2 3 5
  • Keratin, Hair, Acidic, 8 2 3
  • Hair Keratin, Type I Ha8 3 4
  • Keratin 38, Type I 2 3
  • KRTHA8 3 4
  • HHa8 3 4
  • K38 3 4
  • Keratin, Type I Cuticular Ha8 3
  • Keratin-38 4
  • HKA8 4
  • HA8 3

External Ids for KRT38 Gene

Previous HGNC Symbols for KRT38 Gene

  • KRTHA8

Previous GeneCards Identifiers for KRT38 Gene

  • GC17M036847
  • GC17M039592
  • GC17M035356

Summaries for KRT38 Gene

Entrez Gene Summary for KRT38 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT38 Gene

KRT38 (Keratin 38) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT37.

Additional gene information for KRT38 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT38 Gene

Genomics for KRT38 Gene

GeneHancer (GH) Regulatory Elements for KRT38 Gene

Promoters and enhancers for KRT38 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I041440 Promoter 0.5 EPDnew 550.8 +0.4 408 0.1 KRT38 KRT37
GH17I041338 Enhancer 1 Ensembl ENCODE dbSUPER 20.6 +100.3 100333 6 PKNOX1 YBX1 EBF1 RELA GATA3 NBN ZNF24 EZH2 KRT38 KRTAP16-1 KRTAP29-1 KRT31 LOC100505782 KRTAP17-1 KRTAP9-6 KRT37 ENSG00000234477 RNU2-32P
GH17I041401 Enhancer 1.1 Ensembl ENCODE 18.1 +37.7 37672 3.4 PKNOX1 FOXA2 FEZF1 GLIS2 FOS JUNB REST TSHZ1 ZNF518A NFIL3 LOC100505782 KRT34 KRT38 ENSG00000267758 KRT36 KRT41P
GH17I041377 Enhancer 0.8 Ensembl ENCODE 19.3 +61.4 61375 5.5 SREBF1 JUND JUN STAT3 CEBPB FOXP2 EP300 RFX5 KRT34 KRT38 KRT32 KRT36 KRT33B
GH17I040908 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9 +528.4 528369 8.7 FOXA2 MLX ARID4B SIN3A IRF4 ZNF48 ETS1 ZNF213 ARID2 ZNF143 KRT23 KRTAP3-2 MSL1 KRT20 TMEM99 KRT37 KRT28 KRT40 LOC100505782 KRT31
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT38 gene promoter:

Genomic Locations for KRT38 Gene

Genomic Locations for KRT38 Gene
chr17:41,436,369-41,441,344
(GRCh38/hg38)
Size:
4,976 bases
Orientation:
Minus strand
chr17:39,592,621-39,597,596
(GRCh37/hg19)

Genomic View for KRT38 Gene

Genes around KRT38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT38 Gene

Proteins for KRT38 Gene

  • Protein details for KRT38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76015-KRT38_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha8
    Protein Accession:
    O76015
    Secondary Accessions:
    • A2RRM5
    • Q6A164

    Protein attributes for KRT38 Gene

    Size:
    456 amino acids
    Molecular mass:
    50480 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT38 Gene

Post-translational modifications for KRT38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT38 Gene

Domains & Families for KRT38 Gene

Gene Families for KRT38 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76015

UniProtKB/Swiss-Prot:

KRT38_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT38: view

Function for KRT38 Gene

Gene Ontology (GO) - Molecular Function for KRT38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT38: view

Phenotypes for KRT38 Gene

genes like me logo Genes that share phenotypes with KRT38: view

miRNA for KRT38 Gene

miRTarBase miRNAs that target KRT38

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT38 Gene

Localization for KRT38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT38 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KRT38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome IDA,HDA 23533145
genes like me logo Genes that share ontologies with KRT38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT38 Gene

Pathways & Interactions for KRT38 Gene

SuperPathways for KRT38 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT38: view

Pathways by source for KRT38 Gene

2 Reactome pathways for KRT38 Gene

Gene Ontology (GO) - Biological Process for KRT38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT38: view

No data available for SIGNOR curated interactions for KRT38 Gene

Drugs & Compounds for KRT38 Gene

No Compound Related Data Available

Transcripts for KRT38 Gene

mRNA/cDNA for KRT38 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT38 Gene

Keratin 38:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT38 Gene

No ASD Table

Relevant External Links for KRT38 Gene

GeneLoc Exon Structure for
KRT38
ECgene alternative splicing isoforms for
KRT38

Expression for KRT38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT38 Gene

mRNA differential expression in normal tissues according to GTEx for KRT38 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x47.3).

Protein differential expression in normal tissues from HIPED for KRT38 Gene

This gene is overexpressed in Stomach (19.9), Breast (15.9), Esophagus (10.2), Hair follicle (9.5), and Skin (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT38 Gene



NURSA nuclear receptor signaling pathways regulating expression of KRT38 Gene:

KRT38

SOURCE GeneReport for Unigene cluster for KRT38 Gene:

Hs.248188

Evidence on tissue expression from TISSUES for KRT38 Gene

  • Skin(4.4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT38 Gene

Orthologs for KRT38 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT38 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia KRT38 33
  • 83.6 (n)
-- 34
  • 74 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
ManyToMany
-- 34
  • 69 (a)
ManyToMany
-- 34
  • 65 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii wu:fb17f05 34
  • 39 (a)
ManyToMany
zgc:92061 34
  • 38 (a)
ManyToMany
cyt1 34
  • 37 (a)
ManyToMany
cyt1l 34
  • 37 (a)
ManyToMany
krt17 34
  • 36 (a)
ManyToMany
zgc:109868 34
  • 36 (a)
ManyToMany
zgc:153629 34
  • 35 (a)
ManyToMany
krt15 34
  • 34 (a)
ManyToMany
zgc:136902 34
  • 34 (a)
ManyToMany
zgc:92035 34
  • 34 (a)
ManyToMany
krt1-19d 34
  • 33 (a)
ManyToMany
si:dkeyp-113d7.4 34
  • 31 (a)
ManyToMany
BX469912.1 34
  • 19 (a)
ManyToMany
zgc:92533 34
  • 19 (a)
ManyToMany
Species where no ortholog for KRT38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT38 Gene

ENSEMBL:
Gene Tree for KRT38 (if available)
TreeFam:
Gene Tree for KRT38 (if available)

Paralogs for KRT38 Gene

Pseudogenes.org Pseudogenes for KRT38 Gene

genes like me logo Genes that share paralogs with KRT38: view

Variants for KRT38 Gene

Sequence variations from dbSNP and Humsavar for KRT38 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000143898 -- 41,437,632(-) A/G intron_variant
rs1001820607 -- 41,441,598(-) A/C/G upstream_transcript_variant
rs1002011815 -- 41,440,180(-) C/T coding_sequence_variant, missense_variant
rs1002068367 -- 41,441,304(-) C/T 5_prime_UTR_variant
rs1002126661 -- 41,442,708(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT38 Gene

Variant ID Type Subtype PubMed ID
esv2715932 CNV deletion 23290073
esv2758690 CNV gain+loss 17122850
nsv1071383 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789
nsv960489 CNV duplication 23825009

Variation tolerance for KRT38 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT38

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT38 Gene

Disorders for KRT38 Gene

Additional Disease Information for KRT38

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KRT38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT38 Gene

Publications for KRT38 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 2 3 4 58
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  3. Keratin 8 Y54H and G62C mutations are not associated with inflammatory bowel disease. (PMID: 15248378) Büning C … Witt H (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2004) 3 44 58
  4. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers MA … Schweizer J (Differentiation; research in biological diversity 2004) 3 4 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for KRT38 Gene

Sources for KRT38 Gene

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