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Aliases for IGLC7 Gene

Aliases for IGLC7 Gene

  • Immunoglobulin Lambda Constant 7 2 3 5
  • Ig Lambda-7 Chain C Region 4
  • C7 3

External Ids for IGLC7 Gene

Previous GeneCards Identifiers for IGLC7 Gene

  • GC22U990186
  • GC22P021589
  • GC22P021597
  • GC22P021607
  • GC22P021617
  • GC22P021627
  • GC22P021638
  • GC22P021649
  • GC22P021662
  • GC22P021674
  • GC22P023269
  • GC22P006232
  • GC22P023274
  • GC22P023280
  • GC22P023285
  • GC22P023290
  • GC22P023294
  • GC22P023310
  • GC22P023325
  • GC22P022925
  • GC22P022935
  • GC22P022984
  • GC22P023091
  • GC22P023138
  • GC22P023195

Summaries for IGLC7 Gene

GeneCards Summary for IGLC7 Gene

IGLC7 (Immunoglobulin Lambda Constant 7) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGLC1.

UniProtKB/Swiss-Prot for IGLC7 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLC7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLC7 Gene

Genomics for IGLC7 Gene

GeneHancer (GH) Regulatory Elements for IGLC7 Gene

Promoters and enhancers for IGLC7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I022923 Enhancer 0.6 dbSUPER 550.8 +1.6 1609 1.1 SMARCA5 HNRNPUL1 KLF1 MCM3 TSC22D4 MCM5 YBX1 MCM2 ZBTB5 MCM7 IGLC7 LOC105372947 TOP3B MIF-AS1 MMP11 ZNF70 SMARCB1 IGLC2 IGLV7-43 IGLC3
GH22I022926 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +9.5 9516 10.9 HDGF PKNOX1 ATF1 SMAD1 IRF4 ZNF143 ATF7 RUNX3 ZNF263 MCM3 TOP3B IGLV5-52 ENSG00000272578 ENSG00000234630 MIF-AS1 ZNF70 IGLV3-4 IGLV2-5 MMP11 SMARCB1
GH22I022901 Enhancer 1 ENCODE dbSUPER 9.2 -19.8 -19764 2.8 HNRNPUL1 RB1 BMI1 IRF4 EGR1 BCLAF1 IKZF2 MCM3 PHF21A SMAD5 IGLC2 TOP3B ZNF70 MIF-AS1 MMP11 IGLV2-5 IGLV3-4 SMARCB1 IGLC7 IGLV10-54
GH22I022898 Enhancer 0.6 dbSUPER 9.2 -23.1 -23096 3.2 KLF1 SMAD5 CEBPB MCM5 ZBTB5 MCM7 IRF9 CTBP1 PBX2 MLLT1 IGLC2 IGLJ2 IGLV2-5 IGLV3-4 TOP3B MIF-AS1 IGLC7 LOC105372948 IGL
GH22I022914 Enhancer 0.5 ENCODE dbSUPER 10.2 -7.5 -7473 0.3 ID3 IGLC5 IGLJ5 IGLC7 LOC105372948 IGL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGLC7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGLC7 Gene

Genomic Locations for IGLC7 Gene
chr22:22,922,594-22,923,034
(GRCh38/hg38)
Size:
441 bases
Orientation:
Plus strand
chr22:23,264,766-23,265,203
(GRCh37/hg19)

Genomic View for IGLC7 Gene

Genes around IGLC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC7 Gene

Proteins for IGLC7 Gene

  • Protein details for IGLC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0M8Q6-IGLC7_HUMAN
    Recommended name:
    Immunoglobulin lambda constant 7
    Protein Accession:
    A0M8Q6
    Secondary Accessions:
    • A0A075B6L1

    Protein attributes for IGLC7 Gene

    Size:
    106 amino acids
    Molecular mass:
    11254 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    Miscellaneous:
    • Displays the following serological isotype: Ke+, Oz- and two of the three characteristic amino acids of Mgc-isotype: Ala-6 and Ser-8 but instead of Thr-57 it displays Lys-57. Ke+ has Gly-46 and Oz- has Arg-83.
    SequenceCaution:
    • Sequence=BAA20016.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA36053.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59556.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for IGLC7 Gene

Post-translational modifications for IGLC7 Gene

No Post-translational modifications

Other Protein References for IGLC7 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC7 Gene

Domains & Families for IGLC7 Gene

Gene Families for IGLC7 Gene

Protein Domains for IGLC7 Gene

Suggested Antigen Peptide Sequences for IGLC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLC7: view

No data available for UniProtKB/Swiss-Prot for IGLC7 Gene

Function for IGLC7 Gene

Molecular function for IGLC7 Gene

GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 7 (Ke marker)
UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGLC7: view

Animal Model Products

miRNA for IGLC7 Gene

miRTarBase miRNAs that target IGLC7

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC7 Gene

Localization for IGLC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLC7 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA --
GO:0042571 immunoglobulin complex, circulating IBA --
GO:0072562 blood microparticle IBA --
genes like me logo Genes that share ontologies with IGLC7: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLC7 Gene

Pathways & Interactions for IGLC7 Gene

SuperPathways for IGLC7 Gene

No Data Available

Interacting Proteins for IGLC7 Gene

Gene Ontology (GO) - Biological Process for IGLC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLC7: view

No data available for Pathways by source and SIGNOR curated interactions for IGLC7 Gene

Drugs & Compounds for IGLC7 Gene

No Compound Related Data Available

Transcripts for IGLC7 Gene

mRNA/cDNA for IGLC7 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC7 Gene

No ASD Table

Relevant External Links for IGLC7 Gene

GeneLoc Exon Structure for
IGLC7
ECgene alternative splicing isoforms for
IGLC7

Expression for IGLC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLC7 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC7 Gene

This gene is overexpressed in Spleen (x18.4), Minor Salivary Gland (x7.6), and Colon - Transverse (x6.1).

Protein differential expression in normal tissues from HIPED for IGLC7 Gene

This gene is overexpressed in Skin (50.2) and Serum (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC7 Gene



NURSA nuclear receptor signaling pathways regulating expression of IGLC7 Gene:

IGLC7
genes like me logo Genes that share expression patterns with IGLC7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLC7 Gene

Orthologs for IGLC7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGLC7 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
ManyToMany
-- 34
  • 87 (a)
ManyToMany
-- 34
  • 72 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
-- 34
  • 59 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 34
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 42 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
-- 34
  • 9 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 34 (a)
ManyToMany
IGLL1 34
  • 34 (a)
ManyToMany
VPREB 34
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 34
  • 10 (a)
ManyToMany
Species where no ortholog for IGLC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC7 Gene

ENSEMBL:
Gene Tree for IGLC7 (if available)
TreeFam:
Gene Tree for IGLC7 (if available)

Paralogs for IGLC7 Gene

Variants for IGLC7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC7 Gene

IGLC7_HUMAN-A0M8Q6
There are several alleles. The sequence shown is that of IMGT allele IGLC7*03.

Sequence variations from dbSNP and Humsavar for IGLC7 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
VAR_077896 -- p.Asn34Tyr

Additional Variant Information for IGLC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC7

No data available for Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC7 Gene

Disorders for IGLC7 Gene

Additional Disease Information for IGLC7

Genetic Association Database
(GAD)

No disorders were found for IGLC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLC7 Gene

Publications for IGLC7 Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 4 58
  2. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek TJ … Leder P (The Journal of experimental medicine 1990) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58

Products for IGLC7 Gene

Sources for IGLC7 Gene

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