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Aliases for DNAJA1 Gene

Aliases for DNAJA1 Gene

  • DnaJ Heat Shock Protein Family (Hsp40) Member A1 2 3 5
  • Neural Precursor Cell Expressed, Developmentally Down-Regulated 7 2 3
  • DnaJ (Hsp40) Homolog, Subfamily A, Member 1 2 3
  • Heat Shock 40 KDa Protein 4 3 4
  • DnaJ Protein Homolog 2 3 4
  • Heat Shock Protein J2 3 4
  • Human DnaJ Protein 2 3 4
  • HSJ-2 3 4
  • HSPF4 3 4
  • HSJ2 3 4
  • HDJ2 3 4
  • HSDJ 3 4
  • DnaJ Homolog Subfamily A Member 1 3
  • Heat Shock Protein, DNAJ-Like 2 3
  • NEDD7 3
  • HDJ-2 3
  • DNAJ2 4
  • HDj-2 4
  • DJ-2 3
  • DjA1 3

External Ids for DNAJA1 Gene

Previous HGNC Symbols for DNAJA1 Gene

  • HSJ2

Previous GeneCards Identifiers for DNAJA1 Gene

  • GC09P033337
  • GC09P033194
  • GC09P033015

Summaries for DNAJA1 Gene

Entrez Gene Summary for DNAJA1 Gene

  • This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

GeneCards Summary for DNAJA1 Gene

DNAJA1 (DnaJ Heat Shock Protein Family (Hsp40) Member A1) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Regulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and chaperone binding. An important paralog of this gene is DNAJA4.

UniProtKB/Swiss-Prot for DNAJA1 Gene

  • Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).

Gene Wiki entry for DNAJA1 Gene

Additional gene information for DNAJA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNAJA1 Gene

Genomics for DNAJA1 Gene

GeneHancer (GH) Regulatory Elements for DNAJA1 Gene

Promoters and enhancers for DNAJA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J033023 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.3 268 4.2 PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B APTX DNAJA1 TOPORS SMU1 ENSG00000223440 ASS1P12 DFFBP1 DDX58 B4GALT1 NOL6
GH09J032999 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.2 -23.8 -23755 2.9 PKNOX1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B E2F8 ZNF207 ZNF143 APTX DNAJA1 LAGE3P1 SMU1 TCEA1P4
GH09J033156 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +137.7 137667 13.1 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 ZNF610 B4GALT1 SMU1 TOPORS NOL6 ASS1P12 ENSG00000228352 DFFBP1 NFX1 UBAP2 TCEA1P4
GH09J032571 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 -452.4 -452388 2.8 HNRNPUL1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 NDUFB6 SMU1 DFFBP1 DDX58 TOPORS B4GALT1 APTX DNAJA1 ASS1P12
GH09J033225 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 +200.6 200604 1 HDGF PKNOX1 ZNF2 RAD21 RFX5 ZNF335 ZNF143 SIRT6 ATF7 FOS B4GALT1-AS1 B4GALT1 SMU1 RNU4ATAC15P APTX DNAJA1 SPINK4 GC09P033251 GC09M033168 GC09M033167
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DNAJA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DNAJA1 gene promoter:
  • FOXD3
  • HEN1
  • HSF2
  • Pax-4a
  • Evi-1
  • ZID
  • COUP
  • MZF-1
  • COUP-TF

Genomic Locations for DNAJA1 Gene

Genomic Locations for DNAJA1 Gene
chr9:33,025,211-33,039,907
(GRCh38/hg38)
Size:
14,697 bases
Orientation:
Plus strand
chr9:33,025,209-33,039,905
(GRCh37/hg19)
Size:
14,697 bases
Orientation:
Plus strand

Genomic View for DNAJA1 Gene

Genes around DNAJA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNAJA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNAJA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNAJA1 Gene

Proteins for DNAJA1 Gene

  • Protein details for DNAJA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31689-DNJA1_HUMAN
    Recommended name:
    DnaJ homolog subfamily A member 1
    Protein Accession:
    P31689
    Secondary Accessions:
    • Q5T7Q0
    • Q86TL9

    Protein attributes for DNAJA1 Gene

    Size:
    397 amino acids
    Molecular mass:
    44868 Da
    Quaternary structure:
    • Identified in a complex with HSPA1B and BAX (PubMed:14752510). Interacts with RNF207 (PubMed:25281747).

    Three dimensional structures from OCA and Proteopedia for DNAJA1 Gene

    Alternative splice isoforms for DNAJA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNAJA1 Gene

Post-translational modifications for DNAJA1 Gene

  • Ubiquitination at posLast=350350, Lys344, Lys301, Lys296, posLast=246246, Lys144, Lys143, posLast=136136, Lys105, posLast=4646, Lys37, and posLast=1414
  • Modification sites at PhosphoSitePlus

Other Protein References for DNAJA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNAJA1 Gene

Domains & Families for DNAJA1 Gene

Gene Families for DNAJA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNAJA1: view

No data available for UniProtKB/Swiss-Prot for DNAJA1 Gene

Function for DNAJA1 Gene

Molecular function for DNAJA1 Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).
UniProtKB/Swiss-Prot Induction:
Up-regulated by heat shock.

Phenotypes From GWAS Catalog for DNAJA1 Gene

Gene Ontology (GO) - Molecular Function for DNAJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 12150907
GO:0001671 ATPase activator activity IDA 24318877
GO:0005515 protein binding IPI 22085931
GO:0005524 ATP binding IEA --
GO:0030544 Hsp70 protein binding IDA 14752510
genes like me logo Genes that share ontologies with DNAJA1: view
genes like me logo Genes that share phenotypes with DNAJA1: view

Animal Models for DNAJA1 Gene

MGI Knock Outs for DNAJA1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DNAJA1 Gene

Localization for DNAJA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNAJA1 Gene

Membrane; Lipid-anchor. Cytoplasm. Microsome. Nucleus. Cytoplasm, perinuclear region. Mitochondrion. Note=Primarily associated with microsomes. A minor proportion is associated with mitochondria (By similarity). Primarily cytoplasmic. A minor proportion is associated with nuclei. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNAJA1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
mitochondrion 4
nucleus 4
endoplasmic reticulum 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubules (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DNAJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 colocalizes_with ubiquitin ligase complex IDA 12150907
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with DNAJA1: view

Pathways & Interactions for DNAJA1 Gene

genes like me logo Genes that share pathways with DNAJA1: view

Pathways by source for DNAJA1 Gene

Gene Ontology (GO) - Biological Process for DNAJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,TAS --
GO:0006986 response to unfolded protein TAS 8334160
GO:0007283 spermatogenesis IEA --
GO:0009408 response to heat IEA --
GO:0030317 flagellated sperm motility IEA --
genes like me logo Genes that share ontologies with DNAJA1: view

No data available for SIGNOR curated interactions for DNAJA1 Gene

Drugs & Compounds for DNAJA1 Gene

No Compound Related Data Available

Transcripts for DNAJA1 Gene

mRNA/cDNA for DNAJA1 Gene

Unigene Clusters for DNAJA1 Gene

DnaJ (Hsp40) homolog, subfamily A, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNAJA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: - -
SP3: - - - - - - - - - - - - - - -
SP4: - - -
SP5: - -
SP6: - - - - - - - - -
SP7: - - -
SP8: - - -
SP9:
SP10: - - - - - -

Relevant External Links for DNAJA1 Gene

GeneLoc Exon Structure for
DNAJA1
ECgene alternative splicing isoforms for
DNAJA1

Expression for DNAJA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNAJA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DNAJA1 Gene



Protein tissue co-expression partners for DNAJA1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNAJA1 Gene:

DNAJA1

SOURCE GeneReport for Unigene cluster for DNAJA1 Gene:

Hs.445203

mRNA Expression by UniProt/SwissProt for DNAJA1 Gene:

P31689-DNJA1_HUMAN
Tissue specificity: Ubiquitous. Isoform 2 is highly expressed in testis and lung, but detected at low levels in thymus, prostate, colon and liver.

Evidence on tissue expression from TISSUES for DNAJA1 Gene

  • Nervous system(5)
  • Lung(3.8)
  • Kidney(3.2)
  • Eye(2.9)
  • Intestine(2.6)
  • Liver(2.6)
  • Heart(2.3)
  • Skin(2.3)
  • Spleen(2.3)
  • Blood(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with DNAJA1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNAJA1 Gene

Orthologs for DNAJA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNAJA1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToMany
-- 34
  • 96 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
DNAJA1 33
  • 94.46 (n)
-- 34
  • 93 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia DNAJA1 34 33
  • 99.58 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNAJA1 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNAJA1 34 33
  • 94.21 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dnaja1 16 34 33
  • 92.02 (n)
rat
(Rattus norvegicus)
Mammalia Dnaja1 33
  • 91.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DNAJA1 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNAJA1 34 33
  • 78.17 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNAJA1 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnaja1 33
  • 76.91 (n)
zebrafish
(Danio rerio)
Actinopterygii dnaja1 34 33
  • 68.11 (n)
OneToOne
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Droj2 34
  • 62 (a)
OneToMany
CG8863 35
  • 59 (a)
DnaJ-H 35
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea dnj-12 34
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YDJ1 34
  • 47 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.12175 33
wheat
(Triticum aestivum)
Liliopsida Ta.357 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10384 34
  • 63 (a)
OneToMany
Species where no ortholog for DNAJA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNAJA1 Gene

ENSEMBL:
Gene Tree for DNAJA1 (if available)
TreeFam:
Gene Tree for DNAJA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DNAJA1: view image

Paralogs for DNAJA1 Gene

Paralogs for DNAJA1 Gene

(10) SIMAP similar genes for DNAJA1 Gene using alignment to 2 proteins:

  • DNJA1_HUMAN
  • B7Z5C0_HUMAN
genes like me logo Genes that share paralogs with DNAJA1: view

Variants for DNAJA1 Gene

Sequence variations from dbSNP and Humsavar for DNAJA1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000398217 -- 33,027,951(+) G/A intron_variant
rs1000411612 -- 33,024,341(+) G/A upstream_transcript_variant
rs1000566336 -- 33,034,452(+) A/T intron_variant
rs1000583178 -- 33,031,959(+) AAAAA/AAAA intron_variant
rs1000682896 -- 33,029,308(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DNAJA1 Gene

Variant ID Type Subtype PubMed ID
esv3620303 CNV gain 21293372
nsv1137437 CNV deletion 24896259
nsv1161856 CNV duplication 26073780
nsv614143 CNV gain 21841781
nsv8438 CNV gain 18304495
nsv950853 CNV duplication 24416366

Variation tolerance for DNAJA1 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DNAJA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DNAJA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNAJA1 Gene

Disorders for DNAJA1 Gene

Additional Disease Information for DNAJA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DNAJA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNAJA1 Gene

Publications for DNAJA1 Gene

  1. Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein. (PMID: 8334160) Chellaiah A … Mohanakumar T (Biochimica et biophysica acta 1993) 2 3 4 22 58
  2. hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. (PMID: 14752510) Gotoh T … Mori M (Cell death and differentiation 2004) 3 4 22 58
  3. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. (PMID: 24318877) Rauch JN … Gestwicki JE (The Journal of biological chemistry 2014) 3 4 58
  4. RING finger protein RNF207, a novel regulator of cardiac excitation. (PMID: 25281747) Roder K … Koren G (The Journal of biological chemistry 2014) 3 4 58
  5. Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. (PMID: 24512202) Stark JL … Powers R (Biochemistry 2014) 3 4 58

Products for DNAJA1 Gene

Sources for DNAJA1 Gene

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