Aliases for RAB7B Gene
External Ids for RAB7B Gene
Previous GeneCards Identifiers for RAB7B Gene
GeneCards Summary for RAB7B Gene
RAB7B (RAB7B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and RAB GEFs exchange GTP for GDP on RABs. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB7A.
UniProtKB/Swiss-Prot for RAB7B Gene
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.