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Aliases for SLC51A Gene

Aliases for SLC51A Gene

  • Solute Carrier Family 51 Alpha Subunit 2 3 5
  • Organic Solute Transporter, Alpha Subunit 2 3
  • Solute Carrier Family 51 Subunit Alpha 3 4
  • OST-Alpha 3 4
  • OSTA 3 4
  • Organic Solute Transporter Subunit Alpha 3
  • Solute Carrier Family 51, Alpha Subunit 2
  • Organic Solute Transporter Alpha 3
  • OSTalpha 3

External Ids for SLC51A Gene

Previous GeneCards Identifiers for SLC51A Gene

  • GC03P195939

Summaries for SLC51A Gene

GeneCards Summary for SLC51A Gene

SLC51A (Solute Carrier Family 51 Alpha Subunit) is a Protein Coding gene. Diseases associated with SLC51A include Bone Resorption Disease and Bone Remodeling Disease. Among its related pathways are Bile secretion and Drug Induction of Bile Acid Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transporter activity.

UniProtKB/Swiss-Prot for SLC51A Gene

  • Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.

Gene Wiki entry for SLC51A Gene

Additional gene information for SLC51A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC51A Gene

Genomics for SLC51A Gene

GeneHancer (GH) Regulatory Elements for SLC51A Gene

Promoters and enhancers for SLC51A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I196213 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 555.9 +4.1 4100 3.6 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 YY1 SLC30A9 RXRA SLC51A ZDHHC19 PCYT1A ENSG00000228028 TFRC LOC105374304 GC03P196178
GH03I196210 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 560.2 -0.3 -292 1 PKNOX1 IKZF1 ZNF341 EBF1 NR2F6 KDM1A SLC51A ZDHHC19 ENSG00000222335 GC03P196178
GH03I196212 Enhancer 0.2 ENCODE 550.8 +0.9 938 0.2 SLC51A ZDHHC19 LOC105374304 GC03P196178
GH03I196316 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 +106.6 106594 2.8 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B E2F8 ZNF143 ZNF207 TCTEX1D2 ENSG00000272741 TM4SF19-AS1 SDHAP1 SDHAP2 UBXN7 LINC00969 RNU6ATAC24P RNF168 ENSG00000271662
GH03I196285 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 +75.8 75782 3.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PCYT1A TM4SF19 WDR53 RNF168 ACAP2 ENSG00000260261 NCBP2 SLC51A ENSG00000231443 ENSG00000228028
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC51A on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC51A Gene

Genomic Locations for SLC51A Gene
chr3:196,211,487-196,243,178
(GRCh38/hg38)
Size:
31,692 bases
Orientation:
Plus strand
chr3:195,938,358-195,970,049
(GRCh37/hg19)

Genomic View for SLC51A Gene

Genes around SLC51A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC51A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC51A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC51A Gene

Proteins for SLC51A Gene

  • Protein details for SLC51A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UW1-OSTA_HUMAN
    Recommended name:
    Organic solute transporter subunit alpha
    Protein Accession:
    Q86UW1
    Secondary Accessions:
    • Q6ZMC7

    Protein attributes for SLC51A Gene

    Size:
    340 amino acids
    Molecular mass:
    37735 Da
    Quaternary structure:
    • Interacts with SLC51B. The Ost-alpha/Ost-beta complex is a heterodimer composed of alpha (SLC51A) and beta (SLC51B) subunit (By similarity).

neXtProt entry for SLC51A Gene

Post-translational modifications for SLC51A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC51A Gene

No data available for DME Specific Peptides for SLC51A Gene

Domains & Families for SLC51A Gene

Gene Families for SLC51A Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for SLC51A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC51A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UW1

UniProtKB/Swiss-Prot:

OSTA_HUMAN :
  • Belongs to the OST-alpha family.
Family:
  • Belongs to the OST-alpha family.
genes like me logo Genes that share domains with SLC51A: view

Function for SLC51A Gene

Molecular function for SLC51A Gene

UniProtKB/Swiss-Prot Function:
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids.
UniProtKB/Swiss-Prot Induction:
Positively regulated via NR1H4/FXR in adrenal gland, kidney and intestine.

Phenotypes From GWAS Catalog for SLC51A Gene

Gene Ontology (GO) - Molecular Function for SLC51A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015125 bile acid transmembrane transporter activity IEA --
GO:0022857 transmembrane transporter activity IEA --
GO:0042803 protein homodimerization activity ISS,IEA --
GO:0046982 protein heterodimerization activity ISS,IEA --
genes like me logo Genes that share ontologies with SLC51A: view
genes like me logo Genes that share phenotypes with SLC51A: view

Animal Models for SLC51A Gene

MGI Knock Outs for SLC51A:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC51A

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC51A Gene

Localization for SLC51A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC51A Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC51A gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for SLC51A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane ISS,IBA --
GO:0005886 plasma membrane IDA 12719432
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,ISS --
GO:0016323 basolateral plasma membrane IDA,IEA 16317684
genes like me logo Genes that share ontologies with SLC51A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC51A Gene

Pathways & Interactions for SLC51A Gene

genes like me logo Genes that share pathways with SLC51A: view

Pathways by source for SLC51A Gene

1 BioSystems pathway for SLC51A Gene
1 KEGG pathway for SLC51A Gene

Interacting Proteins for SLC51A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296327%0d%0a9606.ENSP00000335292%0d%0a
Selected Interacting proteins: Q86UW1-OSTA_HUMAN ENSP00000296327 for SLC51A Gene via IID STRING

Gene Ontology (GO) - Biological Process for SLC51A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015721 bile acid and bile salt transport IEA,ISS --
GO:0032782 bile acid secretion IPI 16317684
GO:0055085 transmembrane transport IEA --
GO:0071702 organic substance transport IEA --
genes like me logo Genes that share ontologies with SLC51A: view

No data available for SIGNOR curated interactions for SLC51A Gene

Drugs & Compounds for SLC51A Gene

(7) Drugs for SLC51A Gene - From: DrugBank, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Digoxin Approved Pharma Transporter, substrate 146
conjugated estrogens Approved Pharma Transporter, substrate 0
Dinoprostone Approved Pharma Transporter, substrate 99
Premarin Approved July of 2003 Pharma 0
Taurocholic acid Experimental Pharma Transporter, substrate 0

(2) Additional Compounds for SLC51A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC51A: view

Transcripts for SLC51A Gene

Unigene Clusters for SLC51A Gene

Solute carrier family 51, alpha subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC51A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - - - - -
SP2:
SP3: - -
SP4: -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for SLC51A Gene

GeneLoc Exon Structure for
SLC51A
ECgene alternative splicing isoforms for
SLC51A

Expression for SLC51A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC51A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC51A Gene

This gene is overexpressed in Liver (x17.6), Whole Blood (x5.7), Small Intestine - Terminal Ileum (x5.5), and Colon - Transverse (x4.4).

Protein differential expression in normal tissues from HIPED for SLC51A Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC51A Gene



Protein tissue co-expression partners for SLC51A Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC51A Gene:

SLC51A

SOURCE GeneReport for Unigene cluster for SLC51A Gene:

Hs.630585

mRNA Expression by UniProt/SwissProt for SLC51A Gene:

Q86UW1-OSTA_HUMAN
Tissue specificity: Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.

Evidence on tissue expression from TISSUES for SLC51A Gene

  • Liver(4.5)
  • Intestine(4.4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with SLC51A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC51A Gene

Orthologs for SLC51A Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC51A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC51A 33 34
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia SLC51A 33 34
  • 86.96 (n)
cow
(Bos Taurus)
Mammalia SLC51A 33 34
  • 85.79 (n)
mouse
(Mus musculus)
Mammalia Slc51a 33 16 34
  • 84.51 (n)
rat
(Rattus norvegicus)
Mammalia Slc51a 33
  • 84.31 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC51A 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC51A 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC424916 33
  • 67.08 (n)
SLC51A 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC51A 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc51a 33
  • 61.3 (n)
zebrafish
(Danio rerio)
Actinopterygii slc51a 34
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToMany
-- 34
  • 13 (a)
OneToMany
Species where no ortholog for SLC51A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC51A Gene

ENSEMBL:
Gene Tree for SLC51A (if available)
TreeFam:
Gene Tree for SLC51A (if available)

Paralogs for SLC51A Gene

(1) SIMAP similar genes for SLC51A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC51A: view

No data available for Paralogs for SLC51A Gene

Variants for SLC51A Gene

Sequence variations from dbSNP and Humsavar for SLC51A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000010696 -- 196,228,047(+) C/T intron_variant
rs1000047318 -- 196,219,465(+) G/A intron_variant
rs1000307330 -- 196,233,508(+) C/T downstream_transcript_variant
rs1000755994 -- 196,216,863(+) A/G intron_variant
rs1000915693 -- 196,231,916(+) A/C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC51A Gene

Variant ID Type Subtype PubMed ID
dgv8848n54 CNV loss 21841781
esv2668764 CNV deletion 23128226
esv26725 CNV loss 19812545
esv2759213 CNV gain+loss 17122850
esv3563176 CNV deletion 23714750
esv3569221 CNV loss 25503493
esv3599275 CNV loss 21293372
esv3599276 CNV loss 21293372
esv3599277 CNV gain 21293372
esv3599278 CNV gain 21293372
nsv1008512 CNV gain 25217958
nsv1009811 CNV gain 25217958
nsv10387 CNV loss 18304495
nsv1117364 CNV tandem duplication 24896259
nsv521280 CNV loss 19592680
nsv593071 CNV gain 21841781
nsv593072 CNV loss 21841781
nsv593073 CNV loss 21841781
nsv997797 CNV gain 25217958

Variation tolerance for SLC51A Gene

Residual Variation Intolerance Score: 53.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.23; 92.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC51A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC51A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC51A Gene

Disorders for SLC51A Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC51A Gene - From: DISEASES

Disorder Aliases PubMed IDs
bone resorption disease
  • bone resorption
bone remodeling disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC51A

genes like me logo Genes that share disorders with SLC51A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC51A Gene

Publications for SLC51A Gene

  1. Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. (PMID: 12719432) Seward DJ … Ballatori N (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. (PMID: 16251721) Lee H … Edwards PA (Journal of lipid research 2006) 3 4 22 58
  3. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. (PMID: 16269519) Landrier JF … Kullak-Ublick GA (American journal of physiology. Gastrointestinal and liver physiology 2006) 3 4 22 58
  4. Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism. (PMID: 20538072) Dawson PA … Rao A (Biochimica et biophysica acta 2010) 2 3 58
  5. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. (PMID: 16423920) Boyer JL … Ballatori N (American journal of physiology. Gastrointestinal and liver physiology 2006) 3 22 58

Products for SLC51A Gene

Sources for SLC51A Gene

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