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Aliases for INKA2 Gene

Aliases for INKA2 Gene

  • Inka Box Actin Regulator 2 2 3
  • Family With Sequence Similarity 212 Member B 2 3 5
  • FAM212B 3 5
  • Induced In Neural Crest By AP2-Alpha Protein-Related Homolog 3
  • Family With Sequence Similarity 212, Member B 2
  • Chromosome 1 Open Reading Frame 183 2
  • PAK4-Inhibitor INKA2 3
  • Protein FAM212B 3
  • C1orf183 3
  • HInca-R 3

External Ids for INKA2 Gene

Previous HGNC Symbols for INKA2 Gene

  • C1orf183
  • FAM212B

Summaries for INKA2 Gene

GeneCards Summary for INKA2 Gene

INKA2 (Inka Box Actin Regulator 2) is a Protein Coding gene. An important paralog of this gene is INKA1.

Additional gene information for INKA2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for INKA2 Gene

Genomics for INKA2 Gene

GeneHancer (GH) Regulatory Elements for INKA2 Gene

Promoters and enhancers for INKA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J111731 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.3 +19.4 19443 9.1 PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 INKA2 KCND3-AS1 ENSG00000243960 INKA2-AS1 CEPT1 ST7L DDX20 HIGD1AP12 NRBF2P3 LOC105378910
GH01J111754 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.0 23 2.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D DDX20 INKA2 LOC101928718 ST7L DRAM2 DENND2D CAPZA1 CEPT1 INKA2-AS1
GH01J111618 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 +135.2 135213 4.6 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF766 ZNF213 RAP1A ENSG00000243960 CEPT1 RNU6-151P KRT18P57 ATP5PB WDR77 INKA2 UBE2FP3 LINC01160
GH01J111502 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.8 +249.0 248956 8.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ADORA3 C1orf162 RAP1A DDX20 CEPT1 INKA2 DRAM2 TMIGD3
GH01J111591 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.6 +162.6 162562 3.2 HDGF HNRNPUL1 SMAD1 ARNT FEZF1 YBX1 ZNF207 ZNF143 FOS KLF13 DDX20 RAP1A DENND2D TMIGD3 ADORA3 C1orf162 INKA2 OVGP1 LINC01160 GC01P111550
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around INKA2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for INKA2 Gene

Genomic Locations for INKA2 Gene
chr1:111,722,063-111,755,824
(GRCh38/hg38)
Size:
33,762 bases
Orientation:
Minus strand
chr1:112,223,252-112,298,446
(GRCh37/hg19)

Genomic View for INKA2 Gene

Genes around INKA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
INKA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for INKA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for INKA2 Gene

Proteins for INKA2 Gene

  • Protein details for INKA2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A1W2PL72-A0A1W2PL72_HUMAN
    Recommended name:
    PAK4-inhibitor INKA2
    Protein Accession:
    A0A1W2PL72

    Protein attributes for INKA2 Gene

    Size:
    282 amino acids
    Molecular mass:
    30873 Da
    Quaternary structure:
    No Data Available

neXtProt entry for INKA2 Gene

Post-translational modifications for INKA2 Gene

No Post-translational modifications

Other Protein References for INKA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for INKA2 Gene

Domains & Families for INKA2 Gene

Gene Families for INKA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for INKA2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with INKA2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for INKA2 Gene

Function for INKA2 Gene

Phenotypes From GWAS Catalog for INKA2 Gene

Gene Ontology (GO) - Molecular Function for INKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 26607847
GO:0030291 protein serine/threonine kinase inhibitor activity ISS --
genes like me logo Genes that share ontologies with INKA2: view
genes like me logo Genes that share phenotypes with INKA2: view

Animal Models for INKA2 Gene

MGI Knock Outs for INKA2:
  • Inka2 Inka2<tm1a(KOMP)Wtsi>

Animal Model Products

miRNA for INKA2 Gene

miRTarBase miRNAs that target INKA2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for INKA2 Gene

Localization for INKA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for INKA2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for INKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 26607847
genes like me logo Genes that share ontologies with INKA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for INKA2 Gene

Pathways & Interactions for INKA2 Gene

SuperPathways for INKA2 Gene

No Data Available

Interacting Proteins for INKA2 Gene

Gene Ontology (GO) - Biological Process for INKA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071901 negative regulation of protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with INKA2: view

No data available for Pathways by source and SIGNOR curated interactions for INKA2 Gene

Drugs & Compounds for INKA2 Gene

No Compound Related Data Available

Transcripts for INKA2 Gene

mRNA/cDNA for INKA2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for INKA2 Gene

No ASD Table

Relevant External Links for INKA2 Gene

GeneLoc Exon Structure for
INKA2
ECgene alternative splicing isoforms for
INKA2

Expression for INKA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of INKA2 Gene:

INKA2

Evidence on tissue expression from TISSUES for INKA2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with INKA2: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for INKA2 Gene

Orthologs for INKA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for INKA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM212B 33
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia FAM212B 33
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Fam212b 33
  • 80.36 (n)
mouse
(Mus musculus)
Mammalia Fam212b 33
  • 80.13 (n)
Inka2 16
chicken
(Gallus gallus)
Aves C1ORF183 33
  • 62.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam212b 33
  • 54.41 (n)
Str.19495 33
zebrafish
(Danio rerio)
Actinopterygii LOC101886856 33
  • 48.65 (n)
Species where no ortholog for INKA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for INKA2 Gene

ENSEMBL:
Gene Tree for INKA2 (if available)
TreeFam:
Gene Tree for INKA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for INKA2: view image

Paralogs for INKA2 Gene

Paralogs for INKA2 Gene

genes like me logo Genes that share paralogs with INKA2: view

Variants for INKA2 Gene

Sequence variations from dbSNP and Humsavar for INKA2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000037753 -- 111,757,224(-) G/A upstream_transcript_variant
rs1000411220 -- 111,751,935(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000483665 -- 111,744,888(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000501124 -- 111,730,402(-) GTCG/G intron_variant
rs1000511744 -- 111,722,507(-) G/T 3_prime_UTR_variant

Variation tolerance for INKA2 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for INKA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
INKA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for INKA2 Gene

Disorders for INKA2 Gene

Additional Disease Information for INKA2

No disorders were found for INKA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for INKA2 Gene

Publications for INKA2 Gene

  1. Expression profiles of inka2 in the murine nervous system. (PMID: 26292052) Iwasaki Y … Sakakibara S (Gene expression patterns : GEP 2015) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. (PMID: 26607847) Baskaran Y … Robinson RC (Nature communications 2015) 3 58
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58

Products for INKA2 Gene

Sources for INKA2 Gene

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