Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PIK3R6 Gene

Aliases for PIK3R6 Gene

  • Phosphoinositide-3-Kinase Regulatory Subunit 6 2 3 5
  • P84 PI3K Adapter Protein 3 4
  • P84 PIKAP 3 4
  • C17orf38 3 4
  • P87PIKAP 3 4
  • P87 Phosphoinositide 3-Kinase Gamma (PI3Kg) Adapter Protein 3
  • Phosphoinositide 3-Kinase Gamma Adapter Protein Of 87 KDa 4
  • Phosphoinositide-3-Kinase, Regulatory Subunit 6 2
  • Phosphoinositide 3-Kinase Regulatory Subunit 6 3
  • Chromosome 17 Open Reading Frame 38 2
  • PI3Kgamma Adapter Protein Of 87 KDa 3
  • P87 PI3K Adapter Protein 4
  • P87(PIKAP) 3
  • HsT41028 3

External Ids for PIK3R6 Gene

Previous HGNC Symbols for PIK3R6 Gene

  • C17orf38

Previous GeneCards Identifiers for PIK3R6 Gene

  • GC17M008647
  • GC17M008706

Summaries for PIK3R6 Gene

Entrez Gene Summary for PIK3R6 Gene

  • Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for PIK3R6 Gene

PIK3R6 (Phosphoinositide-3-Kinase Regulatory Subunit 6) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include 1-phosphatidylinositol-3-kinase regulator activity and phosphatidylinositol-4,5-bisphosphate 3-kinase activity. An important paralog of this gene is PIK3R5.

UniProtKB/Swiss-Prot for PIK3R6 Gene

  • Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Additional gene information for PIK3R6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIK3R6 Gene

Genomics for PIK3R6 Gene

Regulatory Elements for PIK3R6 Gene

Enhancers for PIK3R6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H008856 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.4 +8.2 8242 5 HDGF PKNOX1 TBL1XR1 BMI1 YBX1 BATF ETS1 EGR1 ZNF143 ATF7 PIK3R6 PFAS PIK3R5 RPL26 CTC1 SPDYE4 CNTROB NDEL1 MFSD6L
GH17H008866 1.2 Ensembl ENCODE dbSUPER 20.3 +0.4 370 1 HDGF ZNF687 MAZ SMAD5 CBFB MAX BACH1 ZNF16 EBF1 ZNF217 PIK3R6 ENSG00000265749 RPL26 PFAS CNTROB MFSD6L
GH17H008412 1.5 FANTOM5 Ensembl ENCODE 9.1 +454.7 454716 1 HDAC1 KLF1 ATF1 TBL1XR1 ZBTB21 ZNF473 JUN CEBPG RAD21 FOSL1 WRAP53 RPL26 KRBA2 ZBTB4 SLC25A35 RANGRF PFAS NDEL1 PIK3R6 CNTROB
GH17H008849 0.7 dbSUPER 19.2 +16.3 16271 4 PKNOX1 EBF1 BATF RUNX3 IKZF2 ZNF687 NR2F1 JUNB DPF2 ZNF592 PIK3R6 PIK3R5 SPDYE4 MFSD6L
GH17H008863 0.5 dbSUPER 21.8 +3.5 3508 1 HDGF RB1 NBN MLLT1 PIK3R6 SPDYE4 MFSD6L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIK3R6 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIK3R6 Gene

Chromosome:
17
Start:
8,802,722 bp from pter
End:
8,867,697 bp from pter
Size:
64,976 bases
Orientation:
Minus strand

Genomic View for PIK3R6 Gene

Genes around PIK3R6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIK3R6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIK3R6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIK3R6 Gene

Proteins for PIK3R6 Gene

  • Protein details for PIK3R6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5UE93-PI3R6_HUMAN
    Recommended name:
    Phosphoinositide 3-kinase regulatory subunit 6
    Protein Accession:
    Q5UE93
    Secondary Accessions:
    • Q658R3

    Protein attributes for PIK3R6 Gene

    Size:
    754 amino acids
    Molecular mass:
    84258 Da
    Quaternary structure:
    • Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG. Interacts with beta-gamma G protein dimers. Interacts with PDE3B; the interaction allows recruitment of the PI3K gamma complex to a PDE3B:RAPGEF3 complex.

neXtProt entry for PIK3R6 Gene

Post-translational modifications for PIK3R6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PIK3R6 Gene

Domains & Families for PIK3R6 Gene

Gene Families for PIK3R6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PIK3R6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIK3R6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIK3R6: view

No data available for UniProtKB/Swiss-Prot for PIK3R6 Gene

Function for PIK3R6 Gene

Molecular function for PIK3R6 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Gene Ontology (GO) - Molecular Function for PIK3R6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21393242
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS,IEA --
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity ISS --
genes like me logo Genes that share ontologies with PIK3R6: view
genes like me logo Genes that share phenotypes with PIK3R6: view

Animal Models for PIK3R6 Gene

MGI Knock Outs for PIK3R6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PIK3R6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PIK3R6 Gene

Localization for PIK3R6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIK3R6 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Translocated to the plasma membrane in a Ras-dependent manner. {ECO:0000250 UniProtKB:Q3U6Q4}.

Gene Ontology (GO) - Cellular Components for PIK3R6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0005942 phosphatidylinositol 3-kinase complex IBA --
GO:0005944 phosphatidylinositol 3-kinase complex, class IB ISS --
genes like me logo Genes that share ontologies with PIK3R6: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PIK3R6 Gene

Pathways & Interactions for PIK3R6 Gene

genes like me logo Genes that share pathways with PIK3R6: view

Interacting Proteins for PIK3R6 Gene

Gene Ontology (GO) - Biological Process for PIK3R6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA,ISS --
GO:0014065 phosphatidylinositol 3-kinase signaling IBA --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with PIK3R6: view

No data available for SIGNOR curated interactions for PIK3R6 Gene

Drugs & Compounds for PIK3R6 Gene

(21) Drugs for PIK3R6 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
SF1126 Investigational Pharma inhibitor Kinase Inhibitors 0
BAY80-6946 Pharma Inhibition, Biomarker, inhibitor PI3K Inhibitors, Kinase Inhibitors 0
BEZ235 Pharma Inhibition, inhibitor PI3K/mTOR inhibitor, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors, PI3K/mTOR Inhibitors 0
BGJ398 Pharma Inhibition, inhibitor FGFR inhibitor ,potent and selective, Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 0
BKM120 Pharma Inhibition, inhibitor Inhibitor of pan-Class I PI3K, pan-PI3K inhibitor, Kinase Inhibitors, Phosphatidylinositol-3- kinase (PI-3K) inhibitors 0
genes like me logo Genes that share compounds with PIK3R6: view

Transcripts for PIK3R6 Gene

mRNA/cDNA for PIK3R6 Gene

(12) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIK3R6 Gene

Phosphoinositide-3-kinase, regulatory subunit 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PIK3R6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PIK3R6 Gene

No ASD Table

Relevant External Links for PIK3R6 Gene

GeneLoc Exon Structure for
PIK3R6
ECgene alternative splicing isoforms for
PIK3R6

Expression for PIK3R6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIK3R6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIK3R6 Gene

This gene is overexpressed in Liver, secretome (41.0), Peripheral blood mononuclear cells (21.6), and Platelet (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIK3R6 Gene



Protein tissue co-expression partners for PIK3R6 Gene

NURSA nuclear receptor signaling pathways regulating expression of PIK3R6 Gene:

PIK3R6

SOURCE GeneReport for Unigene cluster for PIK3R6 Gene:

Hs.255809
genes like me logo Genes that share expression patterns with PIK3R6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIK3R6 Gene

Orthologs for PIK3R6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIK3R6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIK3R6 33
  • 98.94 (n)
dog
(Canis familiaris)
Mammalia PIK3R6 33
  • 86.39 (n)
cow
(Bos Taurus)
Mammalia PIK3R6 33
  • 85.93 (n)
mouse
(Mus musculus)
Mammalia Pik3r6 33 16
  • 82.64 (n)
rat
(Rattus norvegicus)
Mammalia Pik3r6 33
  • 82.06 (n)
chicken
(Gallus gallus)
Aves PIK3R6 33
  • 64.48 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia pik3r6 33
  • 58.71 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100007492 33
  • 51.47 (n)
Species where no ortholog for PIK3R6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIK3R6 Gene

ENSEMBL:
Gene Tree for PIK3R6 (if available)
TreeFam:
Gene Tree for PIK3R6 (if available)

Paralogs for PIK3R6 Gene

Paralogs for PIK3R6 Gene

genes like me logo Genes that share paralogs with PIK3R6: view

Variants for PIK3R6 Gene

Sequence variations from dbSNP and Humsavar for PIK3R6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000026905 -- 8,846,256(+) GTCAA(A/C)GATCA intron-variant
rs1000040677 -- 8,815,283(+) CAGGC(A/G)GACCA intron-variant
rs1000105792 -- 8,853,121(+) AATTA(C/T)GGTGT intron-variant
rs1000121405 -- 8,869,866(+) CCCCT(A/T)TTGCC intron-variant
rs1000243982 -- 8,818,024(+) CTGCA(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIK3R6 Gene

Variant ID Type Subtype PubMed ID
dgv534e199 CNV deletion 23128226
esv2530577 CNV insertion 19546169
esv2656928 CNV deletion 23128226
esv2661814 CNV deletion 23128226
esv2668684 CNV deletion 23128226
esv2677297 CNV deletion 23128226
esv2715619 CNV deletion 23290073
esv2715620 CNV deletion 23290073
esv3440912 CNV duplication 20981092
esv3554109 CNV deletion 23714750
esv3639892 CNV loss 21293372
esv3639893 CNV loss 21293372
esv3639894 CNV loss 21293372
esv994892 CNV deletion 20482838
nsv1070387 CNV deletion 25765185
nsv1071335 CNV deletion 25765185
nsv1071369 CNV deletion 25765185
nsv1071370 CNV deletion 25765185
nsv1116187 CNV deletion 24896259
nsv1134596 CNV deletion 24896259
nsv1138497 CNV deletion 24896259
nsv1138498 CNV deletion 24896259
nsv1969 CNV deletion 18451855
nsv1970 CNV deletion 18451855
nsv480842 CNV novel sequence insertion 20440878
nsv518675 CNV gain 19592680
nsv521208 CNV loss 19592680
nsv953828 CNV deletion 24416366

Variation tolerance for PIK3R6 Gene

Gene Damage Index Score: 4.02; 60.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIK3R6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIK3R6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIK3R6 Gene

Disorders for PIK3R6 Gene

Relevant External Links for PIK3R6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIK3R6

No disorders were found for PIK3R6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIK3R6 Gene

Publications for PIK3R6 Gene

  1. Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B. (PMID: 16476736) Voigt P … Schaefer M (The Journal of biological chemistry 2006) 2 3 4 60
  2. A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells. (PMID: 21393242) Wilson LS … Maurice DH (The Journal of biological chemistry 2011) 3 4 60
  3. p84 forms a negative regulatory complex with p110γ to control PI3Kγ signalling during cell migration. (PMID: 25753393) Turvey ME … McColl SR (Immunology and cell biology 2015) 3 60
  4. p87 and p101 subunits are distinct regulators determining class IB phosphoinositide 3-kinase (PI3K) specificity. (PMID: 24014027) Shymanets A … Nürnberg B (The Journal of biological chemistry 2013) 3 60
  5. GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. (PMID: 22728827) Suire S … Stephens L (The EMBO journal 2012) 3 60

Products for PIK3R6 Gene

Sources for PIK3R6 Gene

Content
Loading form....