Aliases for PIK3R6 Gene
External Ids for PIK3R6 Gene
Previous HGNC Symbols for PIK3R6 Gene
Previous GeneCards Identifiers for PIK3R6 Gene
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for PIK3R6 Gene
PIK3R6 (Phosphoinositide-3-Kinase Regulatory Subunit 6) is a Protein Coding gene. Among its related pathways are Apelin signaling pathway and G beta-gamma signalling through PI3Kgamma. Gene Ontology (GO) annotations related to this gene include 1-phosphatidylinositol-3-kinase regulator activity and phosphatidylinositol-4,5-bisphosphate 3-kinase activity. An important paralog of this gene is PIK3R5.
UniProtKB/Swiss-Prot for PIK3R6 Gene
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.