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Aliases for C8orf31 Gene

Subcategory (RNA class) for C8orf31 Gene

ncRNA

Quality Score for this RNA gene is

13

Aliases for C8orf31 Gene

  • Chromosome 8 Open Reading Frame 31 (Putative) 2 3 5
  • Chromosome 8 Open Reading Frame 31 2
  • Uncharacterized Protein C8orf31 3

External Ids for C8orf31 Gene

Previous GeneCards Identifiers for C8orf31 Gene

  • GC08P144193
  • GC08P139374
  • GC08P144120

Summaries for C8orf31 Gene

GeneCards Summary for C8orf31 Gene

C8orf31 (Chromosome 8 Open Reading Frame 31 (Putative)) is an RNA Gene, and is affiliated with the ncRNA class.

Additional gene information for C8orf31 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C8orf31 Gene

Genomics for C8orf31 Gene

GeneHancer (GH) Regulatory Elements for C8orf31 Gene

Promoters and enhancers for C8orf31 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J143038 Promoter/Enhancer 1.4 Ensembl ENCODE 669 +0.2 208 1.7 HDAC1 ELF3 PKNOX1 NFIB ZFP64 ARID4B YBX1 TCF12 ZNF766 GATA2 C8orf31 ENSG00000243328 GC08P143054
GH08J142667 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10 -369.3 -369269 5.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 E2F8 JRK PSCA LY6K ZNF623 SLURP1 ZC3H3 C8orf31 ENSG00000255050 PIR47130
GH08J142990 Enhancer 1 FANTOM5 ENCODE 18.4 -46.2 -46209 4.4 PKNOX1 KLF1 NFIB CEBPG ZFHX2 CTBP1 GATA3 EGR1 RCOR1 EGR2 C8orf31 LY6E-DT CYP11B2 LY6D ENSG00000253715 TSNARE1 LYPD2 CDC42P3 LOC105375794
GH08J143047 Enhancer 1 Ensembl ENCODE 17.2 +9.1 9066 1.3 PKNOX1 SIN3A IRF4 RAD21 RFX5 ZNF143 BCLAF1 MIXL1 ZNF362 ZNF654 C8orf31 ENSG00000243328 GC08P143054 LOC105375795
GH08J143042 Enhancer 0.7 ENCODE 20.8 +3.7 3655 1.4 SOX13 SAP130 ARID4B ZNF48 ZSCAN9 RARA ZNF7 GATAD1 POLR2A IKZF5 C8orf31 ENSG00000243328 GC08P143054 LOC105375795
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C8orf31 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C8orf31 gene promoter:
  • LUN-1
  • C/EBPalpha
  • AREB6
  • c-Rel
  • Lmo2
  • LCR-F1
  • IRF-1
  • En-1
  • NCX

Genomic Locations for C8orf31 Gene

Genomic Locations for C8orf31 Gene
chr8:143,039,209-143,059,942
(GRCh38/hg38)
Size:
20,734 bases
Orientation:
Plus strand
chr8:144,120,626-144,141,359
(GRCh37/hg19)
Size:
20,734 bases
Orientation:
Plus strand

Genomic View for C8orf31 Gene

Genes around C8orf31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C8orf31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C8orf31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C8orf31 Gene

Proteins for C8orf31 Gene

  • Protein details for C8orf31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9H6-CH031_HUMAN
    Recommended name:
    Putative uncharacterized protein C8orf31
    Protein Accession:
    Q8N9H6
    Secondary Accessions:
    • Q6GMU7

    Protein attributes for C8orf31 Gene

    Size:
    132 amino acids
    Molecular mass:
    14527 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C8orf31 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C8orf31 Gene

Post-translational modifications for C8orf31 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C8orf31 Gene

Domains & Families for C8orf31 Gene

Protein Domains for C8orf31 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C8orf31: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C8orf31 Gene

Function for C8orf31 Gene

Phenotypes From GWAS Catalog for C8orf31 Gene

genes like me logo Genes that share phenotypes with C8orf31: view

Animal Model Products

miRNA for C8orf31 Gene

miRTarBase miRNAs that target C8orf31

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C8orf31 Gene

Localization for C8orf31 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C8orf31 gene
Compartment Confidence
mitochondrion 2
nucleus 2
extracellular 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C8orf31 Gene

Pathways & Interactions for C8orf31 Gene

SuperPathways for C8orf31 Gene

No Data Available

Interacting Proteins for C8orf31 Gene

Gene Ontology (GO) - Biological Process for C8orf31 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C8orf31 Gene

Drugs & Compounds for C8orf31 Gene

No Compound Related Data Available

Transcripts for C8orf31 Gene

mRNA/cDNA for C8orf31 Gene

(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(10) RNA Central transcripts :

Unigene Clusters for C8orf31 Gene

Chromosome 8 open reading frame 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C8orf31 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: -
SP2: - -
SP3: -

Relevant External Links for C8orf31 Gene

GeneLoc Exon Structure for
C8orf31
ECgene alternative splicing isoforms for
C8orf31

Expression for C8orf31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C8orf31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of C8orf31 Gene:

C8orf31

SOURCE GeneReport for Unigene cluster for C8orf31 Gene:

Hs.660382
genes like me logo Genes that share expression patterns with C8orf31: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C8orf31 Gene

Orthologs for C8orf31 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C8orf31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8orf31 34
  • 96 (a)
OneToOne
C8H8orf31 33
  • 93.89 (n)
Species where no ortholog for C8orf31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C8orf31 Gene

ENSEMBL:
Gene Tree for C8orf31 (if available)
TreeFam:
Gene Tree for C8orf31 (if available)

Paralogs for C8orf31 Gene

No data available for Paralogs for C8orf31 Gene

Variants for C8orf31 Gene

Sequence variations from dbSNP and Humsavar for C8orf31 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000090940 -- 143,038,108(+) A/G upstream_transcript_variant
rs1000119730 -- 143,054,798(+) A/G downstream_transcript_variant
rs1000161755 -- 143,039,621(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000278669 -- 143,054,694(+) G/T downstream_transcript_variant
rs1000373376 -- 143,043,728(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C8orf31 Gene

Variant ID Type Subtype PubMed ID
esv1451224 CNV insertion 17803354
esv25583 CNV loss 19812545
esv2670756 CNV deletion 23128226
esv2737948 CNV deletion 23290073
esv2861234 CNV insertion 24192839
esv33872 CNV gain 17666407
esv3619096 CNV loss 21293372
nsv465991 CNV loss 19166990
nsv512976 CNV insertion 21212237
nsv612717 CNV loss 21841781
nsv6437 CNV insertion 18451855

Variation tolerance for C8orf31 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C8orf31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C8orf31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C8orf31 Gene

Disorders for C8orf31 Gene

Additional Disease Information for C8orf31

No disorders were found for C8orf31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C8orf31 Gene

Publications for C8orf31 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C8orf31 Gene

Sources for C8orf31 Gene

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