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Aliases for CTRB1 Gene

Aliases for CTRB1 Gene

  • Chymotrypsinogen B1 2 3 5
  • CTRB 3 4
  • Chymotrypsinogen B 3
  • EC 4

External Ids for CTRB1 Gene

Previous HGNC Symbols for CTRB1 Gene

  • CTRB

Previous GeneCards Identifiers for CTRB1 Gene

  • GC16M066168
  • GC16P076213
  • GC16P074991
  • GC16P075032
  • GC16P075003
  • GC16P073810
  • GC16P075252
  • GC16P061006

Summaries for CTRB1 Gene

Entrez Gene Summary for CTRB1 Gene

  • This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This gene is located adjacent to a related chymotrypsinogen gene. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]

GeneCards Summary for CTRB1 Gene

CTRB1 (Chymotrypsinogen B1) is a Protein Coding gene. Among its related pathways are Metabolism and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRB2.

Additional gene information for CTRB1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB1 Gene

Genomics for CTRB1 Gene

GeneHancer (GH) Regulatory Elements for CTRB1 Gene

Promoters and enhancers for CTRB1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J075215 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 650.7 -0.8 -836 5.1 MYRF IRF2 AHR TFAP4 FOXA2 EBF1 BATF IRF4 THRB TEAD3 CTRB1 CTRB2 BCAR1 ENSG00000261783 CFDP1
GH16J075198 Enhancer 0.7 Ensembl ENCODE 13.1 -20.6 -20618 0.6 SP1 KLF1 CTBP1 GABPB1 NRF1 ZNF133 BCAR1 CTRB1 ENSG00000240338 ENSG00000252122 CTRB2 ZFP1 RPS4Y1P1
GH16J075206 Promoter/Enhancer 1.1 EPDnew ENCODE dbSUPER 0.4 -11.5 -11541 1 ZFHX2 EGR2 CTRB2 BCAR1 ENSG00000261783 CTRB1
GH16J075222 Enhancer 0.6 ENCODE dbSUPER 0.7 +3.6 3572 0.2 L3MBTL2 MAX MGA ENSG00000240338 CTRB1
GH16J075223 Enhancer 0.2 dbSUPER 0.7 +4.5 4479 1.4 ENSG00000240338 CTRB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CTRB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTRB1 gene promoter:
  • Tal-1beta
  • ITF-2
  • PPAR-gamma2
  • PPAR-gamma1
  • NF-1
  • GATA-1
  • GATA-2
  • GATA-3
  • SREBP-1a
  • SREBP-1b

Genomic Locations for CTRB1 Gene

Genomic Locations for CTRB1 Gene
7,353 bases
Plus strand
5,939 bases
Plus strand

Genomic View for CTRB1 Gene

Genes around CTRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB1 Gene

Proteins for CTRB1 Gene

  • Protein details for CTRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsinogen B
    Protein Accession:

    Protein attributes for CTRB1 Gene

    263 amino acids
    Molecular mass:
    27713 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB1 Gene

Post-translational modifications for CTRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB1 Gene

No data available for DME Specific Peptides for CTRB1 Gene

Domains & Families for CTRB1 Gene

Gene Families for CTRB1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CTRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase S1 family.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRB1: view

Function for CTRB1 Gene

Molecular function for CTRB1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.
GENATLAS Biochemistry:
chymotrypsinogen B1

Enzyme Numbers (IUBMB) for CTRB1 Gene

Phenotypes From GWAS Catalog for CTRB1 Gene

Gene Ontology (GO) - Molecular Function for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTRB1: view
genes like me logo Genes that share phenotypes with CTRB1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CTRB1

CRISPR Products

miRNA for CTRB1 Gene

miRTarBase miRNAs that target CTRB1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTRB1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTRB1 Gene

Localization for CTRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB1 Gene

Secreted, extracellular space.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTRB1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTRB1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTRB1 Gene

Pathways & Interactions for CTRB1 Gene

genes like me logo Genes that share pathways with CTRB1: view

Gene Ontology (GO) - Biological Process for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion IEA --
GO:0009235 cobalamin metabolic process TAS --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with CTRB1: view

No data available for SIGNOR curated interactions for CTRB1 Gene

Drugs & Compounds for CTRB1 Gene

(16) Drugs for CTRB1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Investigational, Withdrawn Pharma Target Inhibitor of bovine pancreatic trypsin 25
(2S) N-acetyl-L-alanyl-αL-phenylalanyl-chloroethylketone Experimental Pharma Target 0
(3S)-3-Amino-1-chloro-4-phenyl-2-butanone Experimental Pharma Target 0
genes like me logo Genes that share compounds with CTRB1: view

Transcripts for CTRB1 Gene

mRNA/cDNA for CTRB1 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(154) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTRB1 Gene

Chymotrypsinogen B1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CTRB1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB1 Gene

No ASD Table

Relevant External Links for CTRB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTRB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTRB1 Gene

mRNA differential expression in normal tissues according to GTEx for CTRB1 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CTRB1 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTRB1 Gene

Protein tissue co-expression partners for CTRB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CTRB1 Gene:


SOURCE GeneReport for Unigene cluster for CTRB1 Gene:


Evidence on tissue expression from TISSUES for CTRB1 Gene

  • Pancreas(5)
genes like me logo Genes that share expression patterns with CTRB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTRB1 Gene

Orthologs for CTRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTRB1 34 33
  • 96.7 (n)
(Bos Taurus)
Mammalia CTRB1 33
  • 87.2 (n)
-- 34
  • 69 (a)
(Canis familiaris)
Mammalia CTRB2 33
  • 87.2 (n)
-- 34
  • 86 (a)
-- 34
  • 74 (a)
(Mus musculus)
Mammalia Ctrb1 34
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
-- 34
  • 55 (a)
-- 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
(Gallus gallus)
Aves -- 34
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733231 33
  • 64.26 (n)
LOC394984 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64417 33
(Danio rerio)
Actinopterygii zgc:136461 34
  • 68 (a)
ctrb1 34
  • 38 (a)
wufb61f07 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1189 33
fruit fly
(Drosophila melanogaster)
Insecta CG31728 33
  • 51.72 (n)
CG11836 35
  • 40 (a)
Sb 35
  • 37 (a)
CG8213 35
  • 36 (a)
mas 35
  • 35 (a)
Jon99Ciii 34
  • 32 (a)
Jon99Cii 34
  • 32 (a)
CG8172 35
  • 32 (a)
Jon99Fi 34
  • 31 (a)
Jon44E 34
  • 31 (a)
Jon99Fii 34
  • 31 (a)
Jon66Cii 34
  • 31 (a)
CG8952 34
  • 30 (a)
Jon65Aii 34
  • 30 (a)
Jon25Bi 34
  • 30 (a)
yip7 34
  • 30 (a)
Jon25Biii 34
  • 30 (a)
CG10469 34
  • 30 (a)
Jon66Ci 34
  • 30 (a)
CG7542 34
  • 29 (a)
CG18179 34
  • 28 (a)
Jon65Aiii 34
  • 28 (a)
Jon25Bii 34
  • 28 (a)
Jon65Ai 34
  • 28 (a)
CG10472 34 35
  • 28 (a)
Jon99Ci 34
  • 28 (a)
CG18180 34
  • 27 (a)
CG8329 34
  • 27 (a)
CG10477 34
  • 27 (a)
CG11529 34
  • 27 (a)
Jon65Aiv 34
  • 27 (a)
CG3088 34
  • 27 (a)
CG6462 34
  • 24 (a)
sphinx2 34
  • 21 (a)
sphinx1 34
  • 20 (a)
Jon74E 34
  • 18 (a)
CG6592 34
  • 17 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD2 33
  • 49.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
Species where no ortholog for CTRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB1 Gene

Gene Tree for CTRB1 (if available)
Gene Tree for CTRB1 (if available)
Evolutionary constrained regions (ECRs) for CTRB1: view image

Paralogs for CTRB1 Gene

Paralogs for CTRB1 Gene

genes like me logo Genes that share paralogs with CTRB1: view

Variants for CTRB1 Gene

Sequence variations from dbSNP and Humsavar for CTRB1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs193920783 uncertain-significance, Malignant tumor of prostate 75,224,707(+) C/T coding_sequence_variant, synonymous_variant
rs1000089786 -- 75,221,789(+) A/G intron_variant
rs1000463830 -- 75,219,670(+) T/C intron_variant
rs1000486996 -- 75,223,319(+) G/A intron_variant
rs1000754737 -- 75,223,719(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CTRB1 Gene

Variant ID Type Subtype PubMed ID
dgv1638e59 OTHER inversion 20981092
dgv20n50 OTHER inversion 21212237
dgv25n47 OTHER inversion 21111241
dgv51n16 OTHER inversion 17901297
esv1000574 OTHER inversion 20482838
esv1356452 OTHER inversion 17803354
esv2504659 OTHER inversion 19546169
esv2668023 CNV deletion 23128226
esv3582319 CNV loss 25503493
esv3582320 CNV loss 25503493
esv3639087 CNV loss 21293372
nsv1116159 CNV deletion 24896259
nsv1127514 CNV deletion 24896259
nsv149 OTHER inversion 15895083
nsv482198 CNV gain 20164927
nsv516504 CNV gain+loss 19592680
nsv523405 CNV loss 19592680
nsv7286 OTHER inversion 18451855
nsv833282 CNV gain+loss 17160897

Variation tolerance for CTRB1 Gene

Gene Damage Index Score: 2.48; 43.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTRB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRB1 Gene

Disorders for CTRB1 Gene

Additional Disease Information for CTRB1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CTRB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTRB1 Gene

Publications for CTRB1 Gene

  1. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N … Matsubara K (Biochemical and biophysical research communications 1989) 2 3 4 58
  2. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z … Genest J (European journal of human genetics : EJHG 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou DX … Soeda E (The Japanese journal of human genetics 1993) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CTRB1 Gene

Sources for CTRB1 Gene

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