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Aliases for CTF1 Gene

Aliases for CTF1 Gene

  • Cardiotrophin 1 2 3 5
  • CT-1 3 4
  • Cardiotrophin-1 3
  • Cardiophin 1 3
  • CT1 3

External Ids for CTF1 Gene

Previous GeneCards Identifiers for CTF1 Gene

  • GC16M9B0154
  • GC16P031404
  • GC16P030904
  • GC16P030943
  • GC16P030815
  • GC16P028471

Summaries for CTF1 Gene

Entrez Gene Summary for CTF1 Gene

  • The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for CTF1 Gene

CTF1 (Cardiotrophin 1) is a Protein Coding gene. Diseases associated with CTF1 include Neonatal Stroke and Hypertensive Heart Disease. Among its related pathways are Physiological and Pathological Hypertrophy of the Heart and Interleukin-6 family signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and leukemia inhibitory factor receptor binding.

UniProtKB/Swiss-Prot for CTF1 Gene

  • Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Additional gene information for CTF1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTF1 Gene

Genomics for CTF1 Gene

GeneHancer (GH) Regulatory Elements for CTF1 Gene

Promoters and enhancers for CTF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J030892 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.6 -643 5.1 MLX ZFP64 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZNF610 ZNF585B BCL7C ENSG00000262721 CTF1 MIR762 ENSG00000260267 SRCAP INO80E SETD1A FUS SMG1P5
GH16J030872 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 12.3 -20.9 -20943 5.3 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D MIR762HG MIR4519 RNF40 INO80E SETD1A SRCAP ENSG00000260267 FBRS BCL7C ZNF764
GH16J030813 Enhancer 1.6 FANTOM5 Ensembl ENCODE 11.7 -81.6 -81636 2.1 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC ENSG00000274848 HSD3B7 ZNF629 MIR762 CTF1 BCL7C
GH16J030805 Enhancer 1.3 Ensembl ENCODE 11.4 -89.5 -89512 2.6 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 INO80E SRCAP RNF40 SETD1A FUS FBRS ZNF764 C16orf58 SMG1P5 ZNF646
GH16J030939 Enhancer 1.1 Ensembl ENCODE 11.3 +45.7 45708 3.6 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZNF48 YY1 GLIS2 ELK1 ZNF416 HSD3B7 ZNF668 KAT8 SETD1A ZNF646 CTF1 MIR762 BCL7C RNF40 CCDC189
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTF1 gene promoter:

Genomic Locations for CTF1 Gene

Genomic Locations for CTF1 Gene
chr16:30,895,828-30,903,560
(GRCh38/hg38)
Size:
7,733 bases
Orientation:
Plus strand
chr16:30,907,928-30,914,881
(GRCh37/hg19)

Genomic View for CTF1 Gene

Genes around CTF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTF1 Gene

Proteins for CTF1 Gene

  • Protein details for CTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16619-CTF1_HUMAN
    Recommended name:
    Cardiotrophin-1
    Protein Accession:
    Q16619
    Secondary Accessions:
    • A8MVX4
    • Q5U5Y7

    Protein attributes for CTF1 Gene

    Size:
    201 amino acids
    Molecular mass:
    21227 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CTF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTF1 Gene

Post-translational modifications for CTF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTF1 Gene

No data available for DME Specific Peptides for CTF1 Gene

Domains & Families for CTF1 Gene

Gene Families for CTF1 Gene

Protein Domains for CTF1 Gene

Suggested Antigen Peptide Sequences for CTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16619

UniProtKB/Swiss-Prot:

CTF1_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with CTF1: view

Function for CTF1 Gene

Molecular function for CTF1 Gene

UniProtKB/Swiss-Prot Function:
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
GENATLAS Biochemistry:
cardiotrophin 1,21.5kDa,interleukin-6 cytokine family member,expressed in adult human heart,skeletal muscle,ovary,colon,testis,fetal kidney and lung,also expressed in dilated cardiomyopathy

Phenotypes From GWAS Catalog for CTF1 Gene

Gene Ontology (GO) - Molecular Function for CTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA --
GO:0005146 leukemia inhibitory factor receptor binding TAS,IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CTF1: view
genes like me logo Genes that share phenotypes with CTF1: view

Animal Models for CTF1 Gene

MGI Knock Outs for CTF1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CTF1 Gene

Localization for CTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTF1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTF1 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA,TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CTF1 Gene

Pathways & Interactions for CTF1 Gene

genes like me logo Genes that share pathways with CTF1: view

SIGNOR curated interactions for CTF1 Gene

Activates:

Gene Ontology (GO) - Biological Process for CTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007267 cell-cell signaling TAS 7862649
GO:0007399 nervous system development TAS 7738033
GO:0007517 muscle organ development TAS 7862649
GO:0008283 cell proliferation TAS 7738033
genes like me logo Genes that share ontologies with CTF1: view

Drugs & Compounds for CTF1 Gene

(2) Additional Compounds for CTF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTF1: view

Transcripts for CTF1 Gene

mRNA/cDNA for CTF1 Gene

Unigene Clusters for CTF1 Gene

Cardiotrophin 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTF1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -
SP3:

Relevant External Links for CTF1 Gene

GeneLoc Exon Structure for
CTF1
ECgene alternative splicing isoforms for
CTF1

Expression for CTF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTF1 Gene

This gene is overexpressed in Liver, secretome (19.7), Prostate (13.7), and Uterus (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTF1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CTF1 Gene:

CTF1

SOURCE GeneReport for Unigene cluster for CTF1 Gene:

Hs.483811

mRNA Expression by UniProt/SwissProt for CTF1 Gene:

Q16619-CTF1_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for CTF1 Gene

  • Heart(4.6)
  • Nervous system(4.4)
  • Lung(4.3)
  • Muscle(2.8)
genes like me logo Genes that share expression patterns with CTF1: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTF1 Gene

Orthologs for CTF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTF1 34 33
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CTF1 34 33
  • 89.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CTF1 34 33
  • 87.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ctf1 16 34 33
  • 82.26 (n)
rat
(Rattus norvegicus)
Mammalia Ctf1 33
  • 82.09 (n)
oppossum
(Monodelphis domestica)
Mammalia CTF1 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTF1 34
  • 62 (a)
OneToOne
Species where no ortholog for CTF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CTF1 Gene

ENSEMBL:
Gene Tree for CTF1 (if available)
TreeFam:
Gene Tree for CTF1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CTF1: view image

Paralogs for CTF1 Gene

No data available for Paralogs for CTF1 Gene

Variants for CTF1 Gene

Sequence variations from dbSNP and Humsavar for CTF1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1034195402 uncertain-significance, Dilated Cardiomyopathy, Dominant 30,902,522(+) C/A coding_sequence_variant, missense_variant
rs1046276 likely-benign, Dilated Cardiomyopathy, Dominant 30,903,305(+) T/C 3_prime_UTR_variant
rs114618084 likely-benign, Dilated Cardiomyopathy, Dominant 30,903,018(+) T/G 3_prime_UTR_variant
rs117210898 likely-benign, Dilated Cardiomyopathy, Dominant 30,902,821(+) C/T 3_prime_UTR_variant
rs1870292 likely-benign, Dilated Cardiomyopathy, Dominant 30,903,074(+) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CTF1 Gene

Variant ID Type Subtype PubMed ID
dgv35n68 CNV loss 17160897
nsv457483 CNV loss 19166990
nsv571820 CNV loss 21841781
nsv833189 CNV loss 17160897
nsv953802 CNV deletion 24416366

Variation tolerance for CTF1 Gene

Gene Damage Index Score: 0.20; 4.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTF1 Gene

Human Gene Mutation Database (HGMD)
CTF1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTF1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTF1 Gene

Disorders for CTF1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CTF1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neonatal stroke
  • neonatal ischemic stroke
hypertensive heart disease
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
motor neuron disease
  • motor neuron diseases
heart disease
  • congestive heart failure
- elite association - COSMIC cancer census association via MalaCards
Search CTF1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CTF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CTF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTF1 Gene

Publications for CTF1 Gene

  1. Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. (PMID: 8833032) Pennica D … Wood WI (Cytokine 1996) 2 3 4 22 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 44 58
  4. Protective effect of the 1742(C/G) polymorphism of human cardiotrophin-1 against left ventricular hypertrophy in essential hypertension. (PMID: 20683337) Robador PA … Díez J (Journal of hypertension 2010) 3 44 58
  5. A novel custom resequencing array for dilated cardiomyopathy. (PMID: 20474083) Zimmerman RS … Funke BH (Genetics in medicine : official journal of the American College of Medical Genetics 2010) 3 44 58

Products for CTF1 Gene

Sources for CTF1 Gene

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