Aliases for STEAP3 Gene
External Ids for STEAP3 Gene
Previous GeneCards Identifiers for STEAP3 Gene
This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
GeneCards Summary for STEAP3 Gene
STEAP3 (STEAP3 Metalloreductase) is a Protein Coding gene. Diseases associated with STEAP3 include Anemia, Hypochromic Microcytic, With Iron Overload 2 and Hypochromic Microcytic Anemia With Iron Overload. Among its related pathways are Gene Expression and Ferroptosis. Gene Ontology (GO) annotations related to this gene include cupric reductase activity and ferric-chelate reductase activity. An important paralog of this gene is STEAP2.
UniProtKB/Swiss-Prot for STEAP3 Gene
Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.