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Aliases for ACTRT1 Gene

Aliases for ACTRT1 Gene

  • Actin Related Protein T1 2 3 5
  • ARPT1 3 4
  • Actin-Related Protein T1 3
  • ARP-T1 4
  • ARIP1 3
  • HSD27 3
  • AIP1 3

External Ids for ACTRT1 Gene

Previous GeneCards Identifiers for ACTRT1 Gene

  • GC0XM124030
  • GC0XM125129
  • GC0XM125890
  • GC0XM126910
  • GC0XM127012
  • GC0XM127184
  • GC0XM116588

Summaries for ACTRT1 Gene

Entrez Gene Summary for ACTRT1 Gene

  • This gene encodes a protein related to the cytoskeletal protein beta-actin. This protein is a major component of the calyx in the perinuclear theca of mammalian sperm heads, and it therefore likely functions in spermatid formation. This gene is intronless and is similar to a related gene located on chromosome 1. A related pseudogene has also been identified approximately 75 kb downstream of this gene on chromosome X. [provided by RefSeq, May 2010]

GeneCards Summary for ACTRT1 Gene

ACTRT1 (Actin Related Protein T1) is a Protein Coding gene. An important paralog of this gene is ACTRT2.

Additional gene information for ACTRT1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTRT1 Gene

Genomics for ACTRT1 Gene

GeneHancer (GH) Regulatory Elements for ACTRT1 Gene

Promoters and enhancers for ACTRT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ128020 Enhancer 0.7 ENCODE 0.3 +31.4 31406 1 NCOA3 SIX4 CLOCK JUN NEUROD1 ZBTB40 HIC1 CTBP1 GATA3 FOSL2 ACTRT1 GC0XM127969
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTRT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACTRT1 gene promoter:
  • AML1a
  • Hand1
  • E47
  • deltaCREB
  • CREB
  • RORalpha1
  • Nkx5-1
  • RFX1

Genomic Locations for ACTRT1 Gene

Genomic Locations for ACTRT1 Gene
1,442 bases
Minus strand
1,442 bases
Minus strand

Genomic View for ACTRT1 Gene

Genes around ACTRT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTRT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTRT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTRT1 Gene

Proteins for ACTRT1 Gene

  • Protein details for ACTRT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein T1
    Protein Accession:
    Secondary Accessions:
    • Q6X7C1
    • Q96L10

    Protein attributes for ACTRT1 Gene

    376 amino acids
    Molecular mass:
    41696 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTRT1 Gene

Post-translational modifications for ACTRT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTRT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTRT1 Gene

Domains & Families for ACTRT1 Gene

Gene Families for ACTRT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACTRT1 Gene


Suggested Antigen Peptide Sequences for ACTRT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTRT1: view

Function for ACTRT1 Gene

genes like me logo Genes that share phenotypes with ACTRT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTRT1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACTRT1 Gene

Localization for ACTRT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTRT1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTRT1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for ACTRT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTRT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACTRT1 Gene

Pathways & Interactions for ACTRT1 Gene

SuperPathways for ACTRT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTRT1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ACTRT1 Gene

Drugs & Compounds for ACTRT1 Gene

No Compound Related Data Available

Transcripts for ACTRT1 Gene

mRNA/cDNA for ACTRT1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTRT1 Gene

Actin-related protein T1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTRT1

Alternative Splicing Database (ASD) splice patterns (SP) for ACTRT1 Gene

No ASD Table

Relevant External Links for ACTRT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTRT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTRT1 Gene

mRNA differential expression in normal tissues according to GTEx for ACTRT1 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for ACTRT1 Gene

This gene is overexpressed in Testis (51.5), Spleen (9.3), and Prostate (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACTRT1 Gene

Protein tissue co-expression partners for ACTRT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACTRT1 Gene:


SOURCE GeneReport for Unigene cluster for ACTRT1 Gene:

genes like me logo Genes that share expression patterns with ACTRT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTRT1 Gene

Orthologs for ACTRT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTRT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTRT1 34 33
  • 99.11 (n)
(Canis familiaris)
Mammalia ACTRT1 34 33
  • 84.49 (n)
(Bos Taurus)
Mammalia ACTRT1 34 33
  • 83.51 (n)
(Mus musculus)
Mammalia Actrt1 16 34 33
  • 75.29 (n)
(Rattus norvegicus)
Mammalia Actrt1 33
  • 74.31 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
(Gallus gallus)
Aves -- 34
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp53D 34
  • 43 (a)
Species where no ortholog for ACTRT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTRT1 Gene

Gene Tree for ACTRT1 (if available)
Gene Tree for ACTRT1 (if available)
Evolutionary constrained regions (ECRs) for ACTRT1: view image

Paralogs for ACTRT1 Gene

(24) SIMAP similar genes for ACTRT1 Gene using alignment to 1 proteins:

  • ACTT1_HUMAN Pseudogenes for ACTRT1 Gene

genes like me logo Genes that share paralogs with ACTRT1: view

Variants for ACTRT1 Gene

Sequence variations from dbSNP and Humsavar for ACTRT1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000763724 -- 128,050,538(-) A/G downstream_transcript_variant
rs1000974791 -- 128,050,972(-) A/G 3_prime_UTR_variant
rs1002844271 -- 128,052,385(-) T/G 5_prime_UTR_variant
rs1003105812 -- 128,054,344(-) G/A upstream_transcript_variant
rs1006593521 -- 128,053,422(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTRT1 Gene

Variant ID Type Subtype PubMed ID
esv2666298 CNV deletion 23128226
esv2758892 CNV loss 17122850
esv3574538 CNV loss 25503493

Variation tolerance for ACTRT1 Gene

Residual Variation Intolerance Score: 84.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTRT1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTRT1 Gene

Disorders for ACTRT1 Gene

Additional Disease Information for ACTRT1

No disorders were found for ACTRT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTRT1 Gene

Publications for ACTRT1 Gene

  1. Novel actin-related proteins Arp-T1 and Arp-T2 as components of the cytoskeletal calyx of the mammalian sperm head. (PMID: 12243744) Heid H … Franke W (Experimental cell research 2002) 2 3 4 22 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas. (PMID: 28869610) Bal E … Smahi A (Nature medicine 2017) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for ACTRT1 Gene

Sources for ACTRT1 Gene

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