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Aliases for ADAM8 Gene

Aliases for ADAM8 Gene

  • ADAM Metallopeptidase Domain 8 2 3 5
  • A Disintegrin And Metalloproteinase Domain 8 2 3
  • Cell Surface Antigen MS2 3 4
  • MS2 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 8 3
  • Human Leukocyte Differentiation Antigen 3
  • CD156a Antigen 4
  • EC 3.4.24.- 4
  • CD156a 3
  • ADAM 8 4
  • CD156 3

External Ids for ADAM8 Gene

Previous GeneCards Identifiers for ADAM8 Gene

  • GC10M133990
  • GC10M134205
  • GC10M134992
  • GC10M134549
  • GC10M134964
  • GC10M134925
  • GC10M135075
  • GC10M128622

Summaries for ADAM8 Gene

Entrez Gene Summary for ADAM8 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

GeneCards Summary for ADAM8 Gene

ADAM8 (ADAM Metallopeptidase Domain 8) is a Protein Coding gene. Diseases associated with ADAM8 include Asthma and Retinitis Pigmentosa 7. Among its related pathways are Innate Immune System and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is ADAM19.

UniProtKB/Swiss-Prot for ADAM8 Gene

  • Possible involvement in extravasation of leukocytes.

Gene Wiki entry for ADAM8 Gene

Additional gene information for ADAM8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM8 Gene

Genomics for ADAM8 Gene

GeneHancer (GH) Regulatory Elements for ADAM8 Gene

Promoters and enhancers for ADAM8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J133273 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 679.5 -0.3 -299 7.5 HDGF PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A ZBTB7B IRF4 ZNF207 ADAM8 TUBGCP2 ECHS1 VENTX ENSG00000235245 CFAP46 GC10P133285 PIR44208
GH10J133257 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +16.5 16484 6.6 HDGF CLOCK SIN3A ZNF766 ZNF143 FOS KLF13 ZNF263 SP3 REST TUBGCP2 ENSG00000235245 SCART1 VENTX ZNF511 ADAM8 ECHS1 ENSG00000273980
GH10J133012 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +263.6 263555 1.7 CTCF ATF1 ZNF680 BHLHE40 JUN ELF1 ATF2 FOSL1 IKZF1 CREB1 LINC01168 ADAM8 INPP5A ADGRA1 GC10P132846
GH10J133234 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 5 +40.1 40077 4 SUZ12 NRF1 MAX ZBTB7A SP1 EGR1 PHF20 GABPB1 VEZF1 CREB1 VENTX TUBGCP2 ADAM8 UTF1
GH10J133304 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.4 -30.6 -30581 5.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 TUBGCP2 ZNF511 ZNF511-PRAP1 ECHS1 VENTX ADAM8 GC10P133300
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAM8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAM8 gene promoter:

Genomic Locations for ADAM8 Gene

Genomic Locations for ADAM8 Gene
chr10:133,262,403-133,276,903
(GRCh38/hg38)
Size:
14,501 bases
Orientation:
Minus strand
chr10:135,075,907-135,090,407
(GRCh37/hg19)

Genomic View for ADAM8 Gene

Genes around ADAM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM8 Gene

Proteins for ADAM8 Gene

  • Protein details for ADAM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78325-ADAM8_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 8
    Protein Accession:
    P78325
    Secondary Accessions:
    • B4DVM6
    • H0YL36
    • H0YLR0
    • H0YN39

    Protein attributes for ADAM8 Gene

    Size:
    824 amino acids
    Molecular mass:
    88771 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with FST3.

    Three dimensional structures from OCA and Proteopedia for ADAM8 Gene

    Alternative splice isoforms for ADAM8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM8 Gene

Post-translational modifications for ADAM8 Gene

  • Glycosylation at posLast=612612, Asn436, Asn91, and posLast=6767
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADAM8 Gene

Domains & Families for ADAM8 Gene

Gene Families for ADAM8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAM8: view

No data available for UniProtKB/Swiss-Prot for ADAM8 Gene

Function for ADAM8 Gene

Molecular function for ADAM8 Gene

UniProtKB/Swiss-Prot Function:
Possible involvement in extravasation of leukocytes.
GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 8,membrane anchored cell surface adhesion protein (antigen MS2),expressed in granulocyte,monocyte,macrophage,involved in cell-cell and cell-matrix interactions

Enzyme Numbers (IUBMB) for ADAM8 Gene

Gene Ontology (GO) - Molecular Function for ADAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IPI 12777399
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with ADAM8: view
genes like me logo Genes that share phenotypes with ADAM8: view

Animal Models for ADAM8 Gene

MGI Knock Outs for ADAM8:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM8

miRNA for ADAM8 Gene

miRTarBase miRNAs that target ADAM8

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM8 Gene

Localization for ADAM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM8 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAM8 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
lysosome 4
extracellular 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ADAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IDA 15220135
GO:0005737 cytoplasm IDA 18397961
GO:0005886 plasma membrane TAS,IDA --
GO:0005887 integral component of plasma membrane IDA 18397961
GO:0009986 cell surface IDA 17548643
genes like me logo Genes that share ontologies with ADAM8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAM8 Gene

Pathways & Interactions for ADAM8 Gene

genes like me logo Genes that share pathways with ADAM8: view

Gene Ontology (GO) - Biological Process for ADAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis ISS --
GO:0001525 angiogenesis ISS --
GO:0002523 leukocyte migration involved in inflammatory response ISS --
GO:0002675 positive regulation of acute inflammatory response ISS --
GO:0002693 positive regulation of cellular extravasation IEA --
genes like me logo Genes that share ontologies with ADAM8: view

No data available for SIGNOR curated interactions for ADAM8 Gene

Drugs & Compounds for ADAM8 Gene

(1) Additional Compounds for ADAM8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM8: view

Transcripts for ADAM8 Gene

Unigene Clusters for ADAM8 Gene

ADAM metallopeptidase domain 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^
SP1:
SP2:
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:
SP8:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c
SP1: -
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ADAM8 Gene

GeneLoc Exon Structure for
ADAM8
ECgene alternative splicing isoforms for
ADAM8

Expression for ADAM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAM8 Gene

This gene is overexpressed in Whole Blood (x34.0).

Protein differential expression in normal tissues from HIPED for ADAM8 Gene

This gene is overexpressed in NK cells (37.1), Peripheral blood mononuclear cells (23.7), and CD8 Tcells (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM8 Gene



Protein tissue co-expression partners for ADAM8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAM8 Gene:

ADAM8

SOURCE GeneReport for Unigene cluster for ADAM8 Gene:

Hs.501574

mRNA Expression by UniProt/SwissProt for ADAM8 Gene:

P78325-ADAM8_HUMAN
Tissue specificity: Expressed on neutrophils and monocytes.

Evidence on tissue expression from TISSUES for ADAM8 Gene

  • Blood(4.6)
  • Spleen(4.4)
  • Heart(2.7)
  • Nervous system(2.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with ADAM8: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM8 Gene

Orthologs for ADAM8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM8 33
  • 95.86 (n)
cow
(Bos Taurus)
Mammalia ADAM8 34 33
  • 75.92 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam8 33
  • 72.43 (n)
mouse
(Mus musculus)
Mammalia Adam8 16 34 33
  • 72.3 (n)
dog
(Canis familiaris)
Mammalia ADAM8 34
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAM8 34
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ADAM8 34 33
  • 57.81 (n)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adam8b 34 33
  • 49.47 (n)
OneToMany
adam8a 34
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mmd 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
Species where no ortholog for ADAM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAM8 Gene

ENSEMBL:
Gene Tree for ADAM8 (if available)
TreeFam:
Gene Tree for ADAM8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAM8: view image

Paralogs for ADAM8 Gene

Paralogs for ADAM8 Gene

(7) SIMAP similar genes for ADAM8 Gene using alignment to 4 proteins:

  • ADAM8_HUMAN
  • H0YKZ1_HUMAN
  • H0YMT6_HUMAN
  • Q14C66_HUMAN
genes like me logo Genes that share paralogs with ADAM8: view

Variants for ADAM8 Gene

Sequence variations from dbSNP and Humsavar for ADAM8 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000143110 -- 133,275,409(-) G/A intron_variant
rs1000248904 -- 133,270,265(-) G/A intron_variant
rs1000431446 -- 133,275,213(-) G/A intron_variant
rs1001187199 -- 133,265,663(-) C/T genic_downstream_transcript_variant, intron_variant
rs1001426999 -- 133,267,156(-) G/A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM8 Gene

Variant ID Type Subtype PubMed ID
dgv122n27 CNV loss 19166990
dgv1475n54 CNV loss 21841781
dgv2e196 CNV duplication 17116639
dgv3e196 CNV duplication 17116639
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv3144981 CNV deletion 24192839
esv3625030 CNV gain 21293372
esv3625037 CNV gain 21293372
esv3891901 CNV loss 25118596
nsv1037772 CNV gain 25217958
nsv1159784 CNV deletion 26073780
nsv1159785 CNV deletion 26073780
nsv1159786 CNV deletion 26073780
nsv428243 CNV gain 18775914
nsv470980 CNV loss 18288195
nsv509381 CNV insertion 20534489
nsv516968 CNV loss 19592680
nsv528260 CNV loss 19592680
nsv552587 CNV loss 21841781
nsv552589 CNV gain 21841781
nsv552590 CNV loss 21841781
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832039 CNV loss 17160897
nsv952705 CNV deletion 24416366

Variation tolerance for ADAM8 Gene

Residual Variation Intolerance Score: 98.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM8 Gene

Disorders for ADAM8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADAM8 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
retinitis pigmentosa 7
  • rp7
- elite association - COSMIC cancer census association via MalaCards
Search ADAM8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADAM8

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADAM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAM8 Gene

Publications for ADAM8 Gene

  1. CD156 (human ADAM8): expression, primary amino acid sequence, and gene location. (PMID: 9126482) Yoshiyama K … Yamamoto S (Genomics 1997) 2 3 4 22 58
  2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  3. ADAM8 and its single nucleotide polymorphism 2662 T/G are associated with advanced atherosclerosis and fatal myocardial infarction: Tampere vascular study. (PMID: 19575316) Levula M … Lehtimäki T (Annals of medicine 2009) 3 44 58
  4. Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction. (PMID: 18397961) Ainola M … Konttinen YT (Annals of the rheumatic diseases 2009) 3 22 58
  5. Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion. (PMID: 19284887) Ma GF … Konttinen YT (BMC microbiology 2009) 3 22 58

Products for ADAM8 Gene

Sources for ADAM8 Gene

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