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Aliases for SIRT4 Gene

Aliases for SIRT4 Gene

  • Sirtuin 4 2 3 5
  • NAD-Dependent ADP-Ribosyltransferase Sirtuin-4 3 4
  • NAD-Dependent Protein Deacetylase Sirtuin-4 3 4
  • Regulatory Protein SIR2 Homolog 4 3 4
  • SIR2-Like Protein 4 3 4
  • EC 3.5.1.- 4 4
  • SIR2L4 3 4
  • Sirtuin (Silent Mating Type Information Regulation 2, S. Cerevisiae, Homolog) 4 2
  • Sirtuin (Silent Mating Type Information Regulation 2 Homolog) 4 (S. Cerevisiae) 2
  • NAD-Dependent Protein Lipoamidase Sirtuin-4, Mitochondrial 3
  • Sirtuin Type 4 3
  • Sir2-Like 4 3
  • EC 2.4.2.- 4

External Ids for SIRT4 Gene

Previous GeneCards Identifiers for SIRT4 Gene

  • GC12P119613
  • GC12P120266
  • GC12P120522
  • GC12P119152
  • GC12P119203
  • GC12P120740
  • GC12P117748

Summaries for SIRT4 Gene

Entrez Gene Summary for SIRT4 Gene

  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

GeneCards Summary for SIRT4 Gene

SIRT4 (Sirtuin 4) is a Protein Coding gene. Among its related pathways are DNA damage_NHEJ mechanisms of DSBs repair and p53 Signaling. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity and NAD-dependent protein deacetylase activity. An important paralog of this gene is SIRT5.

UniProtKB/Swiss-Prot for SIRT4 Gene

  • Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of Lys-471 of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). Down-regulates insulin secretion.

Tocris Summary for SIRT4 Gene

  • Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Gene Wiki entry for SIRT4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIRT4 Gene

Genomics for SIRT4 Gene

Regulatory Elements for SIRT4 Gene

Enhancers for SIRT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G120223 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.2 -60.6 -60615 16.0 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PXN SIRT4 RPLP0 RNU4-2 RNU4-1 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
GH12G120239 2.1 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -42.7 -42669 19.3 CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GCN1 SIRT4 RNU4-2 RNU4-1 RNU6-1088P PLA2G1B PXN BICDL1 RNF10 RAB35
GH12G120316 1.6 Ensembl ENCODE dbSUPER 13.2 +25.3 25336 1.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 SIRT4 RPL31P52 C12orf43 MSI1 COQ5 RNU6-1088P PLA2G1B
GH12G120290 1.5 ENCODE dbSUPER 12.6 +0.0 31 3.4 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 GCN1 RAB35 SRSF9 SIRT4 PRKAB1 RPL31P52 C12orf43 NME2P1 MSI1 RNU4-1
GH12G120376 0.7 dbSUPER 22.5 +85.2 85241 1.1 ZSCAN4 ZNF23 ZFHX2 SCRT2 PRDM10 EGR2 SCRT1 HLF OSR2 PRDM6 SIRT4 PLA2G1B RNU6-1088P ENSG00000111780 COX6A1 TRIAP1 RPL31P52 DYNLL1 SRSF9 RPS27P25
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SIRT4 on UCSC Golden Path with GeneCards custom track

Promoters for SIRT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058293 201 2401 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for SIRT4 Gene

Chromosome:
12
Start:
120,292,199 bp from pter
End:
120,313,249 bp from pter
Size:
21,051 bases
Orientation:
Plus strand

Genomic View for SIRT4 Gene

Genes around SIRT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIRT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIRT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIRT4 Gene

Proteins for SIRT4 Gene

  • Protein details for SIRT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6E7-SIR4_HUMAN
    Recommended name:
    NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
    Protein Accession:
    Q9Y6E7
    Secondary Accessions:
    • O43346
    • Q32M33

    Protein attributes for SIRT4 Gene

    Size:
    314 amino acids
    Molecular mass:
    35188 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with GLUD1, IDE and SLC25A5 (PubMed:16959573, PubMed:17715127). Interacts with DLAT and PDHX (PubMed:25525879).
    Miscellaneous:
    • According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
    • Expression is down-regulated in a number of cancers, while overexpression reduces cell proliferation, transformation, and tumor development (PubMed:23562301, PubMed:23663782).
    SequenceCaution:
    • Sequence=AAB95634.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SIRT4 Gene

Post-translational modifications for SIRT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SIRT4 Gene

Antibody Products

  • Abcam antibodies for SIRT4

No data available for DME Specific Peptides for SIRT4 Gene

Domains & Families for SIRT4 Gene

Gene Families for SIRT4 Gene

Suggested Antigen Peptide Sequences for SIRT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6E7

UniProtKB/Swiss-Prot:

SIR4_HUMAN :
  • Belongs to the sirtuin family. Class II subfamily.
Family:
  • Belongs to the sirtuin family. Class II subfamily.
genes like me logo Genes that share domains with SIRT4: view

Function for SIRT4 Gene

Molecular function for SIRT4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=719 uM for a peptide of H3 biotinylated at Lys-9 {ECO:0000269 PubMed:25525879}; KM=814 uM for a peptide of H3 lipoylated at Lys-9 {ECO:0000269 PubMed:25525879}; KM=239 uM for a peptide of DLAT lipoylated at Lys-259 {ECO:0000269 PubMed:25525879}; Note=kcat is 0.0019 sec(-1) for the delipoylation of H3 Lys-9. kcat is 0.0005 sec(-1) for the debiotinylation of H3 Lys-9. kcat is 0.0018 sec(-1) for the delipoylation of DLAT Lys-259. {ECO:0000269 PubMed:25525879};
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + a protein = nicotinamide + an N-(ADP-D-ribosyl)-protein.
UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein.
UniProtKB/Swiss-Prot Function:
Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of Lys-471 of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). Down-regulates insulin secretion.
UniProtKB/Swiss-Prot Induction:
Induced by glutamine (at protein level).

Enzyme Numbers (IUBMB) for SIRT4 Gene

Gene Ontology (GO) - Molecular Function for SIRT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IDA,TAS 17456799
GO:0005515 protein binding IPI 16959573
GO:0016740 transferase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0034979 NOT NAD-dependent protein deacetylase activity IDA 17715127
genes like me logo Genes that share ontologies with SIRT4: view
genes like me logo Genes that share phenotypes with SIRT4: view

Animal Models for SIRT4 Gene

MGI Knock Outs for SIRT4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SIRT4

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SIRT4 Gene

Localization for SIRT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIRT4 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIRT4 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SIRT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 16079181
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS,IEA --
genes like me logo Genes that share ontologies with SIRT4: view

Pathways & Interactions for SIRT4 Gene

genes like me logo Genes that share pathways with SIRT4: view

Pathways by source for SIRT4 Gene

1 Sino Biological pathway for SIRT4 Gene
2 GeneGo (Thomson Reuters) pathways for SIRT4 Gene
2 Qiagen pathways for SIRT4 Gene

Gene Ontology (GO) - Biological Process for SIRT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000820 regulation of glutamine family amino acid metabolic process IEA --
GO:0006342 chromatin silencing TAS 10381378
GO:0006471 protein ADP-ribosylation TAS 17456799
GO:0006541 glutamine metabolic process IEA,ISS --
GO:0006974 cellular response to DNA damage stimulus ISS --
genes like me logo Genes that share ontologies with SIRT4: view

No data available for SIGNOR curated interactions for SIRT4 Gene

Drugs & Compounds for SIRT4 Gene

(7) Drugs for SIRT4 Gene - From: ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Panobinostat Approved, Investigational Pharma Inhibition, inhibitor Histone deacetylase (HDAC)inhibitors 135
Nicotinamide Approved Nutra 919,923
Splitomicin Pharma 0
NAD Pharma Full agonist, Agonist 0
AGK 2 Pharma Selective SIRT2 inhibitor 0

(3) Additional Compounds for SIRT4 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
O-acetyl-ADP-ribose
EX 527
49843-98-3
SirReal 2
709002-46-0

(5) Tocris Compounds for SIRT4 Gene

Compound Action Cas Number
AGK 2 Selective SIRT2 inhibitor 304896-28-4
EX 527 Selective SIRT1 inhibitor 49843-98-3
Salermide SIRT1 and SIRT2 inhibitor 1105698-15-4
SirReal 2 Selective inhibitor of SIRT2 709002-46-0
Sirtinol Selective sirtuin family deacetylase inhibitor 410536-97-9

(1) ApexBio Compounds for SIRT4 Gene

Compound Action Cas Number
Splitomicin 5690-03-9
genes like me logo Genes that share compounds with SIRT4: view

Drug Products

Transcripts for SIRT4 Gene

Unigene Clusters for SIRT4 Gene

Sirtuin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SIRT4

Alternative Splicing Database (ASD) splice patterns (SP) for SIRT4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for SIRT4 Gene

GeneLoc Exon Structure for
SIRT4
ECgene alternative splicing isoforms for
SIRT4

Expression for SIRT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIRT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SIRT4 Gene:

SIRT4

SOURCE GeneReport for Unigene cluster for SIRT4 Gene:

Hs.50861

mRNA Expression by UniProt/SwissProt for SIRT4 Gene:

Q9Y6E7-SIR4_HUMAN
Tissue specificity: Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus.
genes like me logo Genes that share expression patterns with SIRT4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SIRT4 Gene

Orthologs for SIRT4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SIRT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SIRT4 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia SIRT4 34 35
  • 88.39 (n)
dog
(Canis familiaris)
Mammalia SIRT4 34 35
  • 88 (n)
mouse
(Mus musculus)
Mammalia Sirt4 34 16 35
  • 83.23 (n)
rat
(Rattus norvegicus)
Mammalia Sirt4 34
  • 82.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SIRT4 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves SIRT4 34 35
  • 73.33 (n)
lizard
(Anolis carolinensis)
Reptilia SIRT4 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sirt4 34
  • 62.37 (n)
Str.4552 34
zebrafish
(Danio rerio)
Actinopterygii sirt4 34 35
  • 64.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013148 34
  • 52.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sirt4 34 35
  • 51.67 (n)
CG3187 36
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea sir-2.2 36 34 35
  • 50.78 (n)
sir-2.3 36 35
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HST1 35
  • 13 (a)
ManyToMany
SIR2 35
  • 11 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SRT2 34
  • 50.61 (n)
rice
(Oryza sativa)
Liliopsida Os12g0179800 34
  • 50.54 (n)
Species where no ortholog for SIRT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SIRT4 Gene

ENSEMBL:
Gene Tree for SIRT4 (if available)
TreeFam:
Gene Tree for SIRT4 (if available)

Paralogs for SIRT4 Gene

Paralogs for SIRT4 Gene

genes like me logo Genes that share paralogs with SIRT4: view

Variants for SIRT4 Gene

Sequence variations from dbSNP and Humsavar for SIRT4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000114305 -- 120,291,906(+) GCTGG(A/G)AAGGT upstream-variant-2KB
rs1000241736 -- 120,291,202(+) CCAAG(A/G)AGGCG upstream-variant-2KB
rs1000250371 -- 120,302,494(+) ACTGA(C/T)GCACG intron-variant
rs1000295953 -- 120,310,154(+) GCTAG(G/T)CGTGG intron-variant
rs1000421232 -- 120,308,586(+) GTCTG(A/G)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SIRT4 Gene

Variant ID Type Subtype PubMed ID
esv2763006 CNV loss 21179565
esv3549882 CNV deletion 23714750
esv3630921 CNV loss 21293372
nsv518764 CNV loss 19592680
nsv560435 CNV loss 21841781
nsv832530 CNV loss 17160897

Variation tolerance for SIRT4 Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SIRT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIRT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIRT4 Gene

Disorders for SIRT4 Gene

Relevant External Links for SIRT4

Genetic Association Database (GAD)
SIRT4
Human Genome Epidemiology (HuGE) Navigator
SIRT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SIRT4

No disorders were found for SIRT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIRT4 Gene

Publications for SIRT4 Gene

  1. Regulation of insulin secretion by SIRT4, a mitochondrial ADP- ribosyltransferase. (PMID: 17715127) Ahuja N. … Verdin E. (J. Biol. Chem. 2007) 3 4 22 64
  2. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. (PMID: 10381378) Frye R.A. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 64
  3. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. (PMID: 25525879) Mathias R.A. … Cristea I.M. (Cell 2014) 3 4 64
  4. SIRT4 represses peroxisome proliferator-activated receptor alpha activity to suppress hepatic fat oxidation. (PMID: 24043310) Laurent G. … Haigis M.C. (Mol. Cell. Biol. 2013) 3 4 64
  5. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. (PMID: 23663782) Csibi A. … Blenis J. (Cell 2013) 3 4 64

Products for SIRT4 Gene

  • Addgene plasmids for SIRT4

Sources for SIRT4 Gene

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