Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SGK2 Gene

Aliases for SGK2 Gene

  • SGK2, Serine/Threonine Kinase 2 2 3 5
  • Serum/Glucocorticoid Regulated Kinase 2 2 3
  • Serum/Glucocorticoid-Regulated Kinase 2 4
  • Serine/Threonine-Protein Kinase Sgk2 3
  • EC 2.7.11.1 4
  • DJ138B7.2 3
  • H-SGK2 3

External Ids for SGK2 Gene

Previous GeneCards Identifiers for SGK2 Gene

  • GC20P041916
  • GC20P042826
  • GC20P042873
  • GC20P041621
  • GC20P042187
  • GC20P038923

Summaries for SGK2 Gene

Entrez Gene Summary for SGK2 Gene

  • This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for SGK2 Gene

SGK2 (SGK2, Serine/Threonine Kinase 2) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SGK1.

UniProtKB/Swiss-Prot for SGK2 Gene

  • Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.

Gene Wiki entry for SGK2 Gene

Additional gene information for SGK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGK2 Gene

Genomics for SGK2 Gene

GeneHancer (GH) Regulatory Elements for SGK2 Gene

Promoters and enhancers for SGK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J043555 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 657.1 -0.4 -353 6.2 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 SP5 SGK2 IFT52 SRSF6 RNU6-1251P ENSG00000226143 ENSG00000277611
GH20J043565 Promoter 0.6 EPDnew 650.4 +6.2 6237 0.1 ZBTB33 SGK2 IFT52 GC20P043584 ENSG00000277611
GH20J043567 Promoter 0.5 EPDnew 650.4 +9.0 9016 0.1 SGK2 IFT52 GC20P043584 ENSG00000277611
GH20J044173 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +622.8 622818 15.7 HDGF PKNOX1 MLX YBX1 DMAP1 ZNF48 TCF12 ZNF121 ZNF207 MCM5 JPH2 SRSF6 OSER1 L3MBTL1 FITM2 IFT52 SGK2 OSER1-DT GC20P044130
GH20J043656 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 10.3 +98.7 98711 2.8 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 MYBL2 GC20P043655 IFT52 OSER1 SRSF6 SGK2 L3MBTL1 GC20M043632
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SGK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SGK2 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • USF-1
  • USF1
  • FAC1
  • NF-1
  • NF-1/L

Genomic Locations for SGK2 Gene

Genomic Locations for SGK2 Gene
chr20:43,558,968-43,588,237
(GRCh38/hg38)
Size:
29,270 bases
Orientation:
Plus strand
chr20:42,187,608-42,216,877
(GRCh37/hg19)
Size:
29,270 bases
Orientation:
Plus strand

Genomic View for SGK2 Gene

Genes around SGK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGK2 Gene

Proteins for SGK2 Gene

  • Protein details for SGK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBY8-SGK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Sgk2
    Protein Accession:
    Q9HBY8
    Secondary Accessions:
    • Q52PK5
    • Q5H8Y6
    • Q5H8Z1
    • Q5TZR3
    • Q9UKG6

    Protein attributes for SGK2 Gene

    Size:
    427 amino acids
    Molecular mass:
    47604 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SGK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SGK2 Gene

Post-translational modifications for SGK2 Gene

  • Activated by phosphorylation on Ser-416 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-253.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SGK2 Gene

Domains & Families for SGK2 Gene

Gene Families for SGK2 Gene

Suggested Antigen Peptide Sequences for SGK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBY8

UniProtKB/Swiss-Prot:

SGK2_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SGK2: view

Function for SGK2 Gene

Molecular function for SGK2 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation.

Enzyme Numbers (IUBMB) for SGK2 Gene

Phenotypes From GWAS Catalog for SGK2 Gene

Gene Ontology (GO) - Molecular Function for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IBA --
GO:0005246 calcium channel regulator activity IBA --
GO:0005524 ATP binding IEA --
GO:0015459 potassium channel regulator activity IDA 12397388
genes like me logo Genes that share ontologies with SGK2: view
genes like me logo Genes that share phenotypes with SGK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SGK2

Clone Products

  • Addgene plasmids for SGK2

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SGK2 Gene

Localization for SGK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGK2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGK2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SGK2: view

Pathways & Interactions for SGK2 Gene

genes like me logo Genes that share pathways with SGK2: view

Pathways by source for SGK2 Gene

1 BioSystems pathway for SGK2 Gene
2 KEGG pathways for SGK2 Gene
1 Cell Signaling Technology pathway for SGK2 Gene

SIGNOR curated interactions for SGK2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SGK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth TAS 20919962
GO:0006468 protein phosphorylation NAS 12397388
GO:0006979 response to oxidative stress TAS 10548550
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA --
genes like me logo Genes that share ontologies with SGK2: view

Drugs & Compounds for SGK2 Gene

(2) Drugs for SGK2 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0
GSK 650394 Pharma SGK1 inhibitor 0

(1) Additional Compounds for SGK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(1) ApexBio Compounds for SGK2 Gene

Compound Action Cas Number
GSK 650394 SGK1 inhibitor 890842-28-1
genes like me logo Genes that share compounds with SGK2: view

Drug Products

Transcripts for SGK2 Gene

mRNA/cDNA for SGK2 Gene

Unigene Clusters for SGK2 Gene

Serum/glucocorticoid regulated kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for SGK2

Alternative Splicing Database (ASD) splice patterns (SP) for SGK2 Gene

No ASD Table

Relevant External Links for SGK2 Gene

GeneLoc Exon Structure for
SGK2
ECgene alternative splicing isoforms for
SGK2

Expression for SGK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SGK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SGK2 Gene

This gene is overexpressed in Liver (x11.4), Kidney - Cortex (x8.1), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for SGK2 Gene

This gene is overexpressed in Nasal epithelium (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SGK2 Gene



Protein tissue co-expression partners for SGK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SGK2 Gene:

SGK2

SOURCE GeneReport for Unigene cluster for SGK2 Gene:

Hs.300863

mRNA Expression by UniProt/SwissProt for SGK2 Gene:

Q9HBY8-SGK2_HUMAN
Tissue specificity: Highly expressed in liver, kidney and pancreas, and at lower levels in brain.

Evidence on tissue expression from TISSUES for SGK2 Gene

  • Intestine(4.3)
  • Nervous system(4.2)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with SGK2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SGK2 Gene

Orthologs for SGK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGK2 34 33
  • 99.27 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SGK2 34 33
  • 90.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SGK2 33
  • 90.9 (n)
mouse
(Mus musculus)
Mammalia Sgk2 16 34 33
  • 89.16 (n)
rat
(Rattus norvegicus)
Mammalia Sgk2 33
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia SGK2 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SGK2 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SGK2 34 33
  • 76.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGK2 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgk2 33
  • 74.4 (n)
Str.5294 33
zebrafish
(Danio rerio)
Actinopterygii sgk2a 34 33
  • 68.83 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9898 33
worm
(Caenorhabditis elegans)
Secernentea W10G6.2 35
  • 54 (a)
sgk-1 34
  • 39 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL028W 33
  • 54.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12716g 33
  • 53.4 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPK1 36 34 33
  • 52.67 (n)
YPK2 34
  • 27 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU07280 33
  • 55.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gad8 33
  • 52.1 (n)
Species where no ortholog for SGK2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGK2 Gene

ENSEMBL:
Gene Tree for SGK2 (if available)
TreeFam:
Gene Tree for SGK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SGK2: view image

Paralogs for SGK2 Gene

genes like me logo Genes that share paralogs with SGK2: view

Variants for SGK2 Gene

Sequence variations from dbSNP and Humsavar for SGK2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
VAR_041074 A lung adenocarcinoma sample p.Glu259Lys
rs1000185640 -- 43,561,770(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000198552 -- 43,567,539(+) G/A intron_variant
rs1000231614 -- 43,584,646(+) G/C intron_variant
rs1000370024 -- 43,581,166(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SGK2 Gene

Variant ID Type Subtype PubMed ID
nsv1057847 CNV loss 25217958

Variation tolerance for SGK2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SGK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGK2 Gene

Disorders for SGK2 Gene

Additional Disease Information for SGK2

No disorders were found for SGK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SGK2 Gene

Publications for SGK2 Gene

  1. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase. (PMID: 10548550) Kobayashi T … Cohen P (The Biochemical journal 1999) 2 3 4 58
  2. Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2. (PMID: 26740304) Wang H … You G (Biochemical pharmacology 2016) 2 3 58
  3. Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis. (PMID: 26392083) Gotoh S … Negishi M (Scientific reports 2015) 2 3 58
  4. The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19. (PMID: 20511718) Böhmer C … Palmada M (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010) 3 4 58
  5. Second AKT: the rise of SGK in cancer signalling. (PMID: 20919962) Bruhn MA … Sheppard KE (Growth factors (Chur, Switzerland) 2010) 3 4 58

Products for SGK2 Gene

  • Addgene plasmids for SGK2

Sources for SGK2 Gene

Content
Loading form....