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Aliases for WNT10A Gene

Aliases for WNT10A Gene

  • Wnt Family Member 10A 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 10A 2 3
  • Protein Wnt-10a 3
  • STHAG4 3
  • OODD 3
  • SSPS 3

External Ids for WNT10A Gene

Previous GeneCards Identifiers for WNT10A Gene

  • GC02P217761
  • GC02P218466
  • GC02P219709
  • GC02P219947
  • GC02P219570
  • GC02P219453
  • GC02P219745
  • GC02P211599

Summaries for WNT10A Gene

Entrez Gene Summary for WNT10A Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT10A Gene

WNT10A (Wnt Family Member 10A) is a Protein Coding gene. Diseases associated with WNT10A include Schopf-Schulz-Passarge Syndrome and Odontoonychodermal Dysplasia. Among its related pathways are DNA Damage Response (only ATM dependent) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT10B.

UniProtKB/Swiss-Prot for WNT10A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.

Gene Wiki entry for WNT10A Gene

Additional gene information for WNT10A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT10A Gene

Genomics for WNT10A Gene

GeneHancer (GH) Regulatory Elements for WNT10A Gene

Promoters and enhancers for WNT10A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I218878 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 552 +5.8 5840 3.3 HDGF ATF1 RB1 ZSCAN4 KLF17 KLF5 GLIS2 ZNF143 ATF7 IKZF2 WNT10A PLCD4 ABCB6 LOC105373882
GH02I218870 Enhancer 0.6 Ensembl 550.8 -1.6 -1610 3.6 MXI1 USF1 SUZ12 EBF1 GABPA ZFHX2 ZNF366 POLR2A ZBTB33 EGR2 WNT10A LINC00608 FEV CRYBA2 RNU6-642P PRKAG3 LOC100129175 MIR375 RNF25 ZNF142
GH02I218886 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 7 +12.1 12077 0.5 HDGF SMAD1 PAX8 EBF1 IRF4 RELA POLR2A NFATC1 ZNF143 ATF7 WNT6 RNU6-642P PRKAG3 LINC00608 FEV CRYBA2 WNT10A CNOT9 LOC105373882
GH02I218891 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.2 +20.8 20825 7.1 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 IRF4 ZNF207 ZNF143 KLF13 LOC105373882 PLCD4 USP37 OBSL1 WNT10A ZNF142 WNT6 CNPPD1 ZFAND2B ANKZF1
GH02I218908 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.3 +35.3 35275 2.4 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B CNOT9 STK36 ZNF142 USP37 AAMP OBSL1 NHEJ1 CDK5R2 ENSG00000235024 ENSG00000269068
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WNT10A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNT10A gene promoter:

Genomic Locations for WNT10A Gene

Genomic Locations for WNT10A Gene
25,259 bases
Plus strand

Genomic View for WNT10A Gene

Genes around WNT10A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT10A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT10A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT10A Gene

Proteins for WNT10A Gene

  • Protein details for WNT10A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wnt-10a
    Protein Accession:
    Secondary Accessions:
    • Q53S44
    • Q96TA7
    • Q9H7S8

    Protein attributes for WNT10A Gene

    417 amino acids
    Molecular mass:
    46444 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT10A Gene

Post-translational modifications for WNT10A Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at isoforms=106 and posLast=363363
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT10A Gene

No data available for DME Specific Peptides for WNT10A Gene

Domains & Families for WNT10A Gene

Gene Families for WNT10A Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for WNT10A Gene

Suggested Antigen Peptide Sequences for WNT10A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Wnt family.
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT10A: view

Function for WNT10A Gene

Molecular function for WNT10A Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.

LifeMap Function Summary for WNT10A Gene

During embryonic development, WNT10A as signaling molecule is secreted from the following cells
It affects the following cells:

Phenotypes From GWAS Catalog for WNT10A Gene

Gene Ontology (GO) - Molecular Function for WNT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005109 frizzled binding IBA --
GO:0048018 receptor ligand activity IDA 28733458
genes like me logo Genes that share ontologies with WNT10A: view
genes like me logo Genes that share phenotypes with WNT10A: view

Human Phenotype Ontology for WNT10A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT10A Gene

MGI Knock Outs for WNT10A:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT10A Gene

Localization for WNT10A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT10A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT10A gene
Compartment Confidence
extracellular 5
nucleus 2
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WNT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with WNT10A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT10A Gene

Pathways & Interactions for WNT10A Gene

genes like me logo Genes that share pathways with WNT10A: view

SIGNOR curated interactions for WNT10A Gene


Gene Ontology (GO) - Biological Process for WNT10A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IMP 17847007
GO:0007275 multicellular organism development IEA --
GO:0010469 regulation of receptor activity IEA --
GO:0010628 positive regulation of gene expression IEA --
GO:0014033 neural crest cell differentiation IEA --
genes like me logo Genes that share ontologies with WNT10A: view

Drugs & Compounds for WNT10A Gene

No Compound Related Data Available

Transcripts for WNT10A Gene

Unigene Clusters for WNT10A Gene

Wingless-type MMTV integration site family, member 10A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT10A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - - -

Relevant External Links for WNT10A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WNT10A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT10A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WNT10A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.4) and Pancreas (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT10A Gene

Protein tissue co-expression partners for WNT10A Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT10A Gene:


SOURCE GeneReport for Unigene cluster for WNT10A Gene:


Evidence on tissue expression from TISSUES for WNT10A Gene

  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT10A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • chin
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • scalp
  • skull
  • tongue
  • tooth
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
  • pelvis
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • hair
  • skin
  • spinal column
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with WNT10A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WNT10A Gene

Orthologs for WNT10A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT10A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WNT10A 33 34
  • 99.68 (n)
(Bos Taurus)
Mammalia WNT10A 34
  • 95 (a)
(Canis familiaris)
Mammalia WNT10A 33 34
  • 92.93 (n)
(Mus musculus)
Mammalia Wnt10a 33 16 34
  • 89.05 (n)
(Rattus norvegicus)
Mammalia Wnt10a 33
  • 88.73 (n)
(Monodelphis domestica)
Mammalia WNT10A 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 21 (a)
(Gallus gallus)
Aves WNT10A 33 34
  • 79.82 (n)
(Anolis carolinensis)
Reptilia WNT10A 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt10a 33
  • 74.46 (n)
(Danio rerio)
Actinopterygii wnt10a 33 34
  • 73.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wnt10 35 34
  • 45 (a)
(Caenorhabditis elegans)
Secernentea egl-20 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for WNT10A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT10A Gene

Gene Tree for WNT10A (if available)
Gene Tree for WNT10A (if available)

Paralogs for WNT10A Gene

Paralogs for WNT10A Gene

(10) SIMAP similar genes for WNT10A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WNT10A: view

Variants for WNT10A Gene

Sequence variations from dbSNP and Humsavar for WNT10A Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1027083261 uncertain-significance, Selective tooth agenesis, Odontoonychodermal dysplasia, Schopf-Schulz-Passarge syndrome 218,880,847(+) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1054630 likely-benign, Odontoonychodermal dysplasia, Schopf-Schulz-Passarge syndrome, Selective tooth agenesis 218,893,399(+) T/C 3_prime_UTR_variant
rs1060499588 likely-pathogenic, Odontoonychodermal dysplasia, Schopf-Schulz-Passarge syndrome, Tooth agenesis, selective, 4 218,890,223(+) C/T coding_sequence_variant, intron_variant, stop_gained
rs111903177 benign, Schopf-Schulz-Passarge syndrome, Odontoonychodermal dysplasia, Selective tooth agenesis, Tooth agenesis, selective, 4 218,892,834(+) C/A/T coding_sequence_variant, missense_variant
rs115839019 likely-benign, benign, Selective tooth agenesis, Odontoonychodermal dysplasia, Schopf-Schulz-Passarge syndrome, Tooth agenesis, selective, 4 218,881,080(+) C/T coding_sequence_variant, intron_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for WNT10A Gene

Variant ID Type Subtype PubMed ID
dgv7296n54 CNV loss 21841781
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897
nsv954838 CNV deletion 24416366

Variation tolerance for WNT10A Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT10A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT10A Gene

Disorders for WNT10A Gene

MalaCards: The human disease database

(12) MalaCards diseases for WNT10A Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
schopf-schulz-passarge syndrome
  • ssps
odontoonychodermal dysplasia
  • oodd
tooth agenesis, selective, 4
  • sthag4
hypohidrotic ectodermal dysplasia autosomal recessive
  • anhidrotic ectodermal dysplasia, autosomal recessive
tooth agenesis
  • familial tooth agenesis
- elite association - COSMIC cancer census association via MalaCards


  • Odonto-onycho-dermal dysplasia (OODD) [MIM:257980]: A rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin. {ECO:0000269 PubMed:17847007, ECO:0000269 PubMed:19471313, ECO:0000269 PubMed:19559398, ECO:0000269 PubMed:24458874}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]: A rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms. {ECO:0000269 PubMed:19559398, ECO:0000269 PubMed:21143469}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Tooth agenesis, selective, 4 (STHAG4) [MIM:150400]: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped. Some STHAG4 patients manifest mild features of ectodermal dysplasia, including sparse hair, sparse eyebrows, short eyelashes, abnormalities of the nails, sweating anomalies and dry skin. STHAG4 inheritance is autosomal dominant or autosomal recessive. {ECO:0000269 PubMed:20979233, ECO:0000269 PubMed:21484994, ECO:0000269 PubMed:22581971, ECO:0000269 PubMed:23401279, ECO:0000269 PubMed:24311251, ECO:0000269 PubMed:24449199, ECO:0000269 PubMed:27657131}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for WNT10A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WNT10A: view

No data available for Genatlas for WNT10A Gene

Publications for WNT10A Gene

  1. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. (PMID: 17847007) Adaimy L … Megarbane A (American journal of human genetics 2007) 2 3 4 58
  2. WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. (PMID: 11350055) Kirikoshi H … Katoh M (Biochemical and biophysical research communications 2001) 2 3 4 58
  3. WNT10A mutations also associated with agenesis of the maxillary permanent canines, a separate entity. (PMID: 24311251) Kantaputra P … Kantaputra W (American journal of medical genetics. Part A 2014) 3 4 58
  4. WNT10A mutations account for ¼ of population-based isolated oligodontia and show phenotypic correlations. (PMID: 24449199) Arzoo PS … Dahl N (American journal of medical genetics. Part A 2014) 3 4 58
  5. Tricho-odonto-onycho-dermal dysplasia and WNT10A mutations. (PMID: 24458874) Kantaputra P … Kantaputra W (American journal of medical genetics. Part A 2014) 3 4 58

Products for WNT10A Gene

Sources for WNT10A Gene

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