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Aliases for FAM3A Gene

Aliases for FAM3A Gene

  • Family With Sequence Similarity 3 Member A 2 3 5
  • Cytokine-Like Protein 2-19 3 4
  • 2.19 3 4
  • Family With Sequence Similarity 3, Member A 2
  • Protein FAM3A 3
  • DXS560S 3
  • XAP-7 3
  • 2-19 4
  • DLD 3

External Ids for FAM3A Gene

Previous GeneCards Identifiers for FAM3A Gene

  • GC0XM147792
  • GC0XM150115
  • GC0XM151320
  • GC0XM152202
  • GC0XM153298
  • GC0XM153387
  • GC0XM153734
  • GC0XM142310

Summaries for FAM3A Gene

Entrez Gene Summary for FAM3A Gene

  • This gene encodes a cytokine-like protein. The expression of this gene may be regulated by peroxisome proliferator-activated receptor gamma, and the encoded protein may be involved in the regulation of glucose and lipid metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for FAM3A Gene

FAM3A (Family With Sequence Similarity 3 Member A) is a Protein Coding gene. An important paralog of this gene is FAM3D.

UniProtKB/Swiss-Prot for FAM3A Gene

  • May act as a defensin against invading fungal microorganisms.

Additional gene information for FAM3A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FAM3A Gene

Genomics for FAM3A Gene

GeneHancer (GH) Regulatory Elements for FAM3A Gene

Promoters and enhancers for FAM3A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154514 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 713.7 -0.4 -392 3.7 HDGF PKNOX1 ARID4B SIN3A FEZF1 YY1 POLR2B GLIS2 ELK1 ZNF143 FAM3A ENSG00000261773
GH0XJ154540 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE 68.7 -26.1 -26091 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 IKBKG FAM3A F8A1 F8A2 GAB3 MECP2 MPP1 EMD DNASE1L1 IRAK1
GH0XJ154483 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 55.6 +30.4 30413 3.8 PKNOX1 ATF1 ARNT SIN3A ZBTB7B POLR2B ZNF766 GLIS2 FOS ATF7 UBL4A LAGE3 FAM3A FAM50A GDI1 CH17-340M24.3 ATP6AP1 GC0XM154482 SLC10A3
GH0XJ154488 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 43.5 +26.0 25965 2.8 PKNOX1 ATF1 ARID4B NEUROD1 SIN3A YY1 POLR2B GLIS2 ELK1 ATF7 SLC10A3 FAM3A H2AFB1 TMEM187 PIR45081
GH0XJ154599 Enhancer 0.9 Ensembl ENCODE 68 -84.6 -84640 2 MXI1 ZSCAN26 ZNF473 JUN FOSL1 POLR2A FOS TCF7L2 SMARCC1 ZNF621 FAM3A GAB3 MECP2 PLXNA3 ENSG00000232155 CTAG1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FAM3A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FAM3A gene promoter:
  • HNF-4alpha1
  • p53
  • HNF-4alpha2
  • RelA
  • STAT1beta
  • STAT1
  • STAT1alpha

Genomic Locations for FAM3A Gene

Genomic Locations for FAM3A Gene
10,089 bases
Minus strand
11,244 bases
Minus strand

Genomic View for FAM3A Gene

Genes around FAM3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FAM3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FAM3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FAM3A Gene

Proteins for FAM3A Gene

  • Protein details for FAM3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAM3A
    Protein Accession:
    Secondary Accessions:
    • A6QRH6
    • B2RBI7
    • B4DFI8
    • D3DWX4
    • Q5HY76
    • Q96H51

    Protein attributes for FAM3A Gene

    230 amino acids
    Molecular mass:
    25152 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FAM3A Gene


neXtProt entry for FAM3A Gene

Post-translational modifications for FAM3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FAM3A Gene

Domains & Families for FAM3A Gene

Gene Families for FAM3A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FAM3A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FAM3 family.
  • Belongs to the FAM3 family.
genes like me logo Genes that share domains with FAM3A: view

Function for FAM3A Gene

Molecular function for FAM3A Gene

UniProtKB/Swiss-Prot Function:
May act as a defensin against invading fungal microorganisms.

Phenotypes From GWAS Catalog for FAM3A Gene

Gene Ontology (GO) - Molecular Function for FAM3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with FAM3A: view
genes like me logo Genes that share phenotypes with FAM3A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FAM3A

miRNA for FAM3A Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FAM3A Gene

Localization for FAM3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for FAM3A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FAM3A gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FAM3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FAM3A: view

Pathways & Interactions for FAM3A Gene

SuperPathways for FAM3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for FAM3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019732 antifungal humoral response IDA 18212107
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA 18212107
GO:1905035 negative regulation of antifungal innate immune response IDA 18212107
genes like me logo Genes that share ontologies with FAM3A: view

No data available for Pathways by source and SIGNOR curated interactions for FAM3A Gene

Drugs & Compounds for FAM3A Gene

No Compound Related Data Available

Transcripts for FAM3A Gene

Unigene Clusters for FAM3A Gene

Family with sequence similarity 3, member A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FAM3A Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP6: -
SP7: -

Relevant External Links for FAM3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FAM3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FAM3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FAM3A Gene

This gene is overexpressed in Nasal epithelium (59.3) and Bone (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FAM3A Gene

NURSA nuclear receptor signaling pathways regulating expression of FAM3A Gene:


SOURCE GeneReport for Unigene cluster for FAM3A Gene:


mRNA Expression by UniProt/SwissProt for FAM3A Gene:

Tissue specificity: In similar amounts in testis, pancreas, adrenal, placenta, brain, fetal brain, liver, kidney, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for FAM3A Gene

  • Nervous system(4.8)
  • Pancreas(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with FAM3A: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FAM3A Gene

Orthologs for FAM3A Gene

This gene was present in the common ancestor of animals.

Orthologs for FAM3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM3A 34 33
  • 99.63 (n)
(Canis familiaris)
Mammalia FAM3A 34 33
  • 89.23 (n)
(Rattus norvegicus)
Mammalia Fam3a 33
  • 87.37 (n)
(Bos Taurus)
Mammalia FAM3A 34 33
  • 86.99 (n)
(Mus musculus)
Mammalia Fam3a 16 34 33
  • 86.32 (n)
(Ornithorhynchus anatinus)
Mammalia FAM3A 34
  • 84 (a)
(Monodelphis domestica)
Mammalia FAM3A 34
  • 77 (a)
(Anolis carolinensis)
Reptilia FAM3A 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam3a 33
  • 68.29 (n)
Str.6172 33
African clawed frog
(Xenopus laevis)
Amphibia fam3a-prov 33
(Danio rerio)
Actinopterygii fam3a 34 33
  • 66.07 (n)
zgc73350 33
(Caenorhabditis elegans)
Secernentea Y73B3A.3 34
  • 7 (a)
M70.4 34
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.67 34
  • 28 (a)
Species where no ortholog for FAM3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FAM3A Gene

Gene Tree for FAM3A (if available)
Gene Tree for FAM3A (if available)
Evolutionary constrained regions (ECRs) for FAM3A: view image

Paralogs for FAM3A Gene

Paralogs for FAM3A Gene

genes like me logo Genes that share paralogs with FAM3A: view

Variants for FAM3A Gene

Sequence variations from dbSNP and Humsavar for FAM3A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000343705 -- 154,515,305(-) C/T genic_upstream_transcript_variant, intron_variant
rs1001789813 -- 154,506,474(-) G/A 3_prime_UTR_variant
rs1002018459 -- 154,513,561(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002516830 -- 154,514,075(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002679643 -- 154,509,568(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FAM3A Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv508816 CNV insertion 20534489
nsv519042 CNV gain 19592680

Variation tolerance for FAM3A Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FAM3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FAM3A Gene

Disorders for FAM3A Gene

Additional Disease Information for FAM3A

No disorders were found for FAM3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FAM3A Gene

Publications for FAM3A Gene

  1. Cloning, expression, and initial characterization of a novel cytokine-like gene family. (PMID: 12160727) Zhu Y … Young PR (Genomics 2002) 3 4 22 58
  2. Transcriptional regulation analysis of FAM3A gene and its effect on adipocyte differentiation. (PMID: 27688071) Kang T … Lei M (Gene 2016) 2 3 58
  3. FAM3A attenuates ER stress-induced mitochondrial dysfunction and apoptosis via CHOP-Wnt pathway. (PMID: 26939760) Song Q … Zhang R (Neurochemistry international 2016) 2 3 58
  4. FAM3A Protects HT22 Cells Against Hydrogen Peroxide-Induced Oxidative Stress Through Activation of PI3K/Akt but not MEK/ERK Pathway. (PMID: 26492522) Song Q … Zhang R (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015) 2 3 58
  5. GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases. (PMID: 16406369) Guo J … Yu L (FEBS letters 2006) 3 22 58

Products for FAM3A Gene

Sources for FAM3A Gene

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