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Aliases for TSPAN17 Gene

Aliases for TSPAN17 Gene

  • Tetraspanin 17 2 3 5
  • F-Box Only Protein 23, Transmembrane 4 Superfamily Member 17 2 3
  • Tetraspan Protein SB134 3 4
  • TM4SF17 3 4
  • FBXO23 3 4
  • Transmembrane 4 Superfamily Member 17 4
  • F-Box Only Protein 23 4
  • Tetraspanin-17 3
  • Tspan-17 4
  • FBX23 3

External Ids for TSPAN17 Gene

Previous HGNC Symbols for TSPAN17 Gene

  • FBXO23
  • TM4SF17

Previous GeneCards Identifiers for TSPAN17 Gene

  • GC05P176008
  • GC05P176074
  • GC05P170998

Summaries for TSPAN17 Gene

Entrez Gene Summary for TSPAN17 Gene

  • This gene encodes a member of the transmembrane 4 superfamily. It is characterized by four tetraspanin transmembrane segments. The function of this gene has not yet been determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for TSPAN17 Gene

TSPAN17 (Tetraspanin 17) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include enzyme binding and ubiquitin-protein transferase activity. An important paralog of this gene is TSPAN5.

UniProtKB/Swiss-Prot for TSPAN17 Gene

  • Regulates ADAM10 maturation.

Additional gene information for TSPAN17 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN17 Gene

Genomics for TSPAN17 Gene

GeneHancer (GH) Regulatory Elements for TSPAN17 Gene

Promoters and enhancers for TSPAN17 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I176646 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 580.9 +0.5 540 3 HDGF PKNOX1 SMAD1 ATF1 ARNT SIN3A ZNF48 YY1 TCF12 POLR2B TSPAN17 GPRIN1 HK3 EIF4E1B ENSG00000248484
GH05I176657 Enhancer 0.9 Ensembl ENCODE 27.2 +11.4 11354 1.8 CTCF SAP130 ZNF2 IRF4 RAD21 ZFHX2 CTBP1 SMC3 ZNF143 ZNF444 TSPAN17 ENSG00000248484
GH05I176653 Enhancer 0.8 ENCODE 27.3 +6.0 6026 0.8 HDGF PKNOX1 SMAD1 BACH1 BMI1 BATF ZFHX2 ZBTB48 EGR1 NFATC1 TSPAN17 PRELID1 ENSG00000248484
GH05I176992 Enhancer 1.5 FANTOM5 Ensembl ENCODE 10.4 +347.8 347759 5.3 HDGF PKNOX1 FOXA2 ARNT ZNF766 CBX5 E2F8 ZNF143 FOS REST ZNF346 UIMC1 FAM193B NSD1 TSPAN17 FGFR4 RAB24 HK3 GRK6 GC05M176982
GH05I176816 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.8 +170.1 170063 2.7 ZNF335 SCRT2 IKZF2 EGR2 SP3 ZBTB11 ZNF398 IKZF1 ZNF341 ZBTB26 HK3 TSPAN17 UNC5A EIF4E1B GC05M176812
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TSPAN17 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TSPAN17 gene promoter:

Genomic Locations for TSPAN17 Gene

Genomic Locations for TSPAN17 Gene
11,672 bases
Plus strand

Genomic View for TSPAN17 Gene

Genes around TSPAN17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN17 Gene

Proteins for TSPAN17 Gene

  • Protein details for TSPAN17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6NXF7
    • Q96S98
    • Q9UKB9

    Protein attributes for TSPAN17 Gene

    270 amino acids
    Molecular mass:
    30264 Da
    Quaternary structure:
    • Interacts with ADAM10.
    • Sequence=AAF04524.1; Type=Frameshift; Positions=66, 81, 83; Evidence={ECO:0000305};

    Alternative splice isoforms for TSPAN17 Gene


neXtProt entry for TSPAN17 Gene

Post-translational modifications for TSPAN17 Gene

  • Glycosylation at posLast=5151 and isoforms=3, 4171

No data available for DME Specific Peptides for TSPAN17 Gene

Domains & Families for TSPAN17 Gene

Gene Families for TSPAN17 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TSPAN17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN17: view

Function for TSPAN17 Gene

Molecular function for TSPAN17 Gene

UniProtKB/Swiss-Prot Function:
Regulates ADAM10 maturation.

Phenotypes From GWAS Catalog for TSPAN17 Gene

Gene Ontology (GO) - Molecular Function for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity NAS 10531035
GO:0019899 enzyme binding IPI 23091066
genes like me logo Genes that share ontologies with TSPAN17: view
genes like me logo Genes that share phenotypes with TSPAN17: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN17

CRISPR Products

miRNA for TSPAN17 Gene

miRTarBase miRNAs that target TSPAN17

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN17 Gene

Localization for TSPAN17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN17 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN17 gene
Compartment Confidence
plasma membrane 5
nucleus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 10531035
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN17: view

Pathways & Interactions for TSPAN17 Gene

SuperPathways for TSPAN17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TSPAN17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0016567 protein ubiquitination NAS 10531035
GO:0072594 establishment of protein localization to organelle IDA 23091066
genes like me logo Genes that share ontologies with TSPAN17: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN17 Gene

Drugs & Compounds for TSPAN17 Gene

No Compound Related Data Available

Transcripts for TSPAN17 Gene

Unigene Clusters for TSPAN17 Gene

Tetraspanin 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN17 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: -
SP7: - - - - - - -

Relevant External Links for TSPAN17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TSPAN17 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN17 Gene:


Evidence on tissue expression from TISSUES for TSPAN17 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with TSPAN17: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN17 Gene

Orthologs for TSPAN17 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN17 33 34
  • 99.29 (n)
(Bos Taurus)
Mammalia TSPAN17 33 34
  • 95.56 (n)
(Monodelphis domestica)
Mammalia TSPAN17 34
  • 93 (a)
(Mus musculus)
Mammalia Tspan17 33 16 34
  • 91.36 (n)
(Rattus norvegicus)
Mammalia Tspan17 33
  • 91.36 (n)
(Canis familiaris)
Mammalia TSPAN17 33 34
  • 90.83 (n)
(Ornithorhynchus anatinus)
Mammalia TSPAN17 34
  • 69 (a)
(Anolis carolinensis)
Reptilia TSPAN17 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan17 33
  • 78.27 (n)
(Danio rerio)
Actinopterygii tspan17 33
  • 78.02 (n)
TSPAN17 34
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tsp26A 33 34
  • 57.16 (n)
(Caenorhabditis elegans)
Secernentea tsp-12 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for TSPAN17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TSPAN17 Gene

Gene Tree for TSPAN17 (if available)
Gene Tree for TSPAN17 (if available)

Paralogs for TSPAN17 Gene Pseudogenes for TSPAN17 Gene

genes like me logo Genes that share paralogs with TSPAN17: view

Variants for TSPAN17 Gene

Sequence variations from dbSNP and Humsavar for TSPAN17 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000153661 -- 176,648,525(+) C/T intron_variant
rs1000214522 -- 176,653,799(+) T/C intron_variant
rs1000275022 -- 176,651,335(+) A/G intron_variant
rs1000401913 -- 176,646,544(+) C/T upstream_transcript_variant
rs1000486767 -- 176,659,273(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TSPAN17 Gene

Variant ID Type Subtype PubMed ID
nsv462556 CNV loss 19166990
nsv600346 CNV loss 21841781
nsv600347 CNV loss 21841781

Variation tolerance for TSPAN17 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TSPAN17 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN17 Gene

Disorders for TSPAN17 Gene

Additional Disease Information for TSPAN17

No disorders were found for TSPAN17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TSPAN17 Gene

Publications for TSPAN17 Gene

  1. Identification of a family of human F-box proteins. (PMID: 10531035) Cenciarelli C … Pagano M (Current biology : CB 1999) 2 3 4 58
  2. A family of mammalian F-box proteins. (PMID: 10531037) Winston JT … Harper JW (Current biology : CB 1999) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration. (PMID: 28600292) Reyat JS … Tomlinson MG (Journal of immunology (Baltimore, Md. : 1950) 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TSPAN17 Gene

Sources for TSPAN17 Gene

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