Aliases for SPOCK3 Gene
External Ids for SPOCK3 Gene
Previous GeneCards Identifiers for SPOCK3 Gene
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for SPOCK3 Gene
SPOCK3 (SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 3) is a Protein Coding gene. Diseases associated with SPOCK3 include Adult T-Cell Leukemia. Among its related pathways are Phospholipase-C Pathway and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is SPOCK1.
UniProtKB/Swiss-Prot for SPOCK3 Gene
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.