Aliases for SPOCK3 Gene
External Ids for SPOCK3 Gene
Previous GeneCards Identifiers for SPOCK3 Gene
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for SPOCK3 Gene
SPOCK3 (SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 3) is a Protein Coding gene. Diseases associated with SPOCK3 include Adult T-Cell Leukemia. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is SPOCK1.
UniProtKB/Swiss-Prot for SPOCK3 Gene
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.