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Aliases for SPOCK3 Gene

Aliases for SPOCK3 Gene

  • SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 3 2 3
  • SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 3 2 3 5
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 3 2 3
  • TICN3 3 4
  • SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 3 4
  • Testican-3 3
  • HSAJ1454 3
  • TES-3 3

External Ids for SPOCK3 Gene

Previous GeneCards Identifiers for SPOCK3 Gene

  • GC04M168064
  • GC04M168238
  • GC04M168350
  • GC04M168029
  • GC04M167891
  • GC04M167654
  • GC04M163410

Summaries for SPOCK3 Gene

Entrez Gene Summary for SPOCK3 Gene

  • This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPOCK3 Gene

SPOCK3 (SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 3) is a Protein Coding gene. Diseases associated with SPOCK3 include Adult T-Cell Leukemia and T-Cell Leukemia. Among its related pathways are ERK Signaling and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is SPOCK1.

UniProtKB/Swiss-Prot for SPOCK3 Gene

  • May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.

Additional gene information for SPOCK3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK3 Gene

Genomics for SPOCK3 Gene

GeneHancer (GH) Regulatory Elements for SPOCK3 Gene

Promoters and enhancers for SPOCK3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J167234 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 650.7 +0.3 296 1 MXI1 L3MBTL2 SIN3A ZNF398 DPF2 BATF POLR2A IKZF1 ZBTB26 RUNX3 SPOCK3 GC04M167102
GH04J167232 Enhancer 0.2 FANTOM5 651.9 +1.8 1751 0.3 SPOCK3 GC04M167102
GH04J167030 Enhancer 0.6 ENCODE 18.6 +202.8 202780 2.2 JUN CEBPB REST EP300 ATF2 SP1 CREB1 STAT3 ATF7 SPOCK3 GC04P167098 RNA5SP171 GC04M166919
GH04J167021 Enhancer 0.5 ENCODE 10.8 +213.1 213051 0.1 CTCF GATA3 ZNF654 TRIM22 SMC3 ZNF143 RAD21 SPOCK3 GC04P167098 RNA5SP171 GC04M166919
GH04J166988 Enhancer 0.3 FANTOM5 15.5 +245.7 245742 0.2 MAFK SPOCK3 GC04M166919 RNA5SP171 GC04P167098
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPOCK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPOCK3 gene promoter:
  • NCX
  • HNF-1A
  • HNF-1
  • Egr-3
  • Ik-3
  • LHX3b
  • Lhx3a
  • FOXD1
  • E4BP4
  • En-1

Genomic Locations for SPOCK3 Gene

Genomic Locations for SPOCK3 Gene
501,413 bases
Minus strand
501,413 bases
Minus strand

Genomic View for SPOCK3 Gene

Genes around SPOCK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK3 Gene

Proteins for SPOCK3 Gene

  • Protein details for SPOCK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R7M7
    • B3KR67
    • B4DGK5
    • B4DHB4
    • B4DHV3
    • B4DI46
    • B4DJY3
    • E7EP61
    • F5H099
    • O75705
    • Q6UW53
    • Q96Q26

    Protein attributes for SPOCK3 Gene

    436 amino acids
    Molecular mass:
    49429 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG58995.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCK3 Gene

neXtProt entry for SPOCK3 Gene

Post-translational modifications for SPOCK3 Gene

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
  • Glycosylation at isoforms=3, 4, 5, 6, 7, 8389 and isoforms=3, 4, 5, 6, 7, 8384
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SPOCK3 (Testican 3/SPOCK3)
  • Abcam antibodies for SPOCK3
  • Boster Bio Antibodies for SPOCK3

No data available for DME Specific Peptides for SPOCK3 Gene

Domains & Families for SPOCK3 Gene

Gene Families for SPOCK3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPOCK3: view

No data available for UniProtKB/Swiss-Prot for SPOCK3 Gene

Function for SPOCK3 Gene

Molecular function for SPOCK3 Gene

UniProtKB/Swiss-Prot Function:
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.

Phenotypes From GWAS Catalog for SPOCK3 Gene

Gene Ontology (GO) - Molecular Function for SPOCK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0008191 metalloendopeptidase inhibitor activity TAS 12810672
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SPOCK3: view
genes like me logo Genes that share phenotypes with SPOCK3: view

Animal Models for SPOCK3 Gene

MGI Knock Outs for SPOCK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPOCK3

CRISPR Products

miRNA for SPOCK3 Gene

miRTarBase miRNAs that target SPOCK3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPOCK3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPOCK3 Gene

Localization for SPOCK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOCK3 gene
Compartment Confidence
extracellular 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPOCK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPOCK3: view

Pathways & Interactions for SPOCK3 Gene

genes like me logo Genes that share pathways with SPOCK3: view

Gene Ontology (GO) - Biological Process for SPOCK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0010951 negative regulation of endopeptidase activity TAS 12810672
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA --
GO:2000146 negative regulation of cell motility TAS 12810672
genes like me logo Genes that share ontologies with SPOCK3: view

No data available for SIGNOR curated interactions for SPOCK3 Gene

Drugs & Compounds for SPOCK3 Gene

No Compound Related Data Available

Transcripts for SPOCK3 Gene

Unigene Clusters for SPOCK3 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SPOCK3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK3 Gene

No ASD Table

Relevant External Links for SPOCK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPOCK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPOCK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.5), Brain - Substantia nigra (x6.0), Brain - Putamen (basal ganglia) (x5.7), Brain - Hippocampus (x5.2), Brain - Caudate (basal ganglia) (x5.0), Brain - Nucleus accumbens (basal ganglia) (x4.3), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for SPOCK3 Gene

This gene is overexpressed in Vitreous humor (58.2) and Frontal cortex (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPOCK3 Gene

Protein tissue co-expression partners for SPOCK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPOCK3 Gene:


SOURCE GeneReport for Unigene cluster for SPOCK3 Gene:


mRNA Expression by UniProt/SwissProt for SPOCK3 Gene:

Tissue specificity: Expressed in brain.

Evidence on tissue expression from TISSUES for SPOCK3 Gene

  • Nervous system(5)
  • Lung(4)
  • Muscle(4)
genes like me logo Genes that share expression patterns with SPOCK3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOCK3 Gene

Orthologs for SPOCK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPOCK3 34 33
  • 99.39 (n)
(Canis familiaris)
Mammalia SPOCK3 34 33
  • 91.1 (n)
(Mus musculus)
Mammalia Spock3 16 34 33
  • 89.72 (n)
(Rattus norvegicus)
Mammalia Spock3 33
  • 89.39 (n)
(Monodelphis domestica)
Mammalia SPOCK3 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SPOCK3 34
  • 65 (a)
(Gallus gallus)
Aves SPOCK3 34 33
  • 83.04 (n)
(Anolis carolinensis)
Reptilia SPOCK3 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spock3 33
  • 76.07 (n)
(Danio rerio)
Actinopterygii spock3 34 33
  • 66.57 (n)
Dr.12941 33
fruit fly
(Drosophila melanogaster)
Insecta CG13830 34
  • 19 (a)
(Caenorhabditis elegans)
Secernentea C54E4.2 34 33
  • 52.08 (n)
Species where no ortholog for SPOCK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPOCK3 Gene

Gene Tree for SPOCK3 (if available)
Gene Tree for SPOCK3 (if available)
Evolutionary constrained regions (ECRs) for SPOCK3: view image

Paralogs for SPOCK3 Gene

Paralogs for SPOCK3 Gene

(4) SIMAP similar genes for SPOCK3 Gene using alignment to 12 proteins:

  • B4DG04_HUMAN
  • E7EQ24_HUMAN
  • H0YA19_HUMAN
  • L8E8K0_HUMAN
genes like me logo Genes that share paralogs with SPOCK3: view

Variants for SPOCK3 Gene

Sequence variations from dbSNP and Humsavar for SPOCK3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000005138 -- 167,022,805(-) G/A intron_variant
rs1000007019 -- 167,061,261(-) C/A intron_variant
rs1000007830 -- 167,077,628(-) C/G intron_variant
rs1000019649 -- 167,110,209(-) C/T intron_variant
rs1000021581 -- 166,754,056(-) G/A/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCK3 Gene

Variant ID Type Subtype PubMed ID
dgv1543e212 CNV loss 25503493
dgv9375n54 CNV loss 21841781
dgv9376n54 CNV loss 21841781
dgv97n16 CNV deletion 17901297
dgv990e199 CNV deletion 23128226
esv1003468 CNV gain 20482838
esv1005052 CNV deletion 20482838
esv2120481 CNV deletion 18987734
esv2432618 CNV deletion 19546169
esv24658 CNV gain 19812545
esv2475463 OTHER inversion 19546169
esv2510827 CNV deletion 19546169
esv2540605 CNV loss 19546169
esv2619228 CNV loss 19546169
esv2664916 CNV deletion 23128226
esv2673273 CNV deletion 23128226
esv2675353 CNV deletion 23128226
esv2728699 CNV deletion 23290073
esv2728700 CNV deletion 23290073
esv2728701 CNV deletion 23290073
esv2759300 CNV gain 17122850
esv28141 CNV gain+loss 19812545
esv29919 CNV gain 19812545
esv3353887 CNV insertion 20981092
esv3361505 CNV insertion 20981092
esv3564953 CNV deletion 23714750
esv3564954 CNV deletion 23714750
esv3564955 CNV deletion 23714750
esv3564958 CNV deletion 23714750
esv3603050 CNV loss 21293372
esv3603051 CNV loss 21293372
esv3603052 CNV loss 21293372
esv3603055 CNV loss 21293372
esv3603056 CNV gain 21293372
esv3603057 CNV loss 21293372
esv3603060 CNV loss 21293372
esv3603061 CNV gain 21293372
esv3603062 CNV loss 21293372
esv3603063 CNV gain 21293372
esv3603064 CNV gain 21293372
esv3603065 CNV gain 21293372
esv3863 CNV loss 18987735
esv8954 CNV loss 19470904
nsv1018209 CNV gain 25217958
nsv1029108 CNV gain 25217958
nsv1031070 CNV loss 25217958
nsv1073389 CNV deletion 25765185
nsv1073390 CNV deletion 25765185
nsv1114596 CNV deletion 24896259
nsv1120493 CNV tandem duplication 24896259
nsv293099 CNV insertion 16902084
nsv436416 CNV deletion 17901297
nsv436442 CNV deletion 17901297
nsv436877 CNV insertion 17901297
nsv4593 CNV deletion 18451855
nsv475978 CNV novel sequence insertion 20440878
nsv499072 CNV loss 21111241
nsv508329 CNV deletion 20534489
nsv513177 CNV loss 21212237
nsv528717 CNV loss 19592680
nsv596067 CNV loss 21841781
nsv596068 CNV loss 21841781
nsv820858 CNV deletion 20802225
nsv822822 CNV gain 20364138
nsv822823 CNV loss 20364138
nsv949843 CNV deletion 24416366
nsv955651 CNV deletion 24416366
nsv956350 CNV deletion 24416366
nsv956909 CNV deletion 24416366
nsv964110 CNV duplication 23825009
nsv964111 CNV duplication 23825009

Variation tolerance for SPOCK3 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPOCK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK3 Gene

Disorders for SPOCK3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPOCK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adult t-cell leukemia
  • adult t-cell leukemia/lymphoma
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SPOCK3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SPOCK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPOCK3 Gene

Publications for SPOCK3 Gene

  1. Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. (PMID: 11751414) Nakada M … Sato H (Cancer research 2001) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for SPOCK3 Gene

Sources for SPOCK3 Gene

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