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Aliases for TRAV29DV5 Gene

Aliases for TRAV29DV5 Gene

  • T Cell Receptor Alpha Variable 29/Delta Variable 5 (Gene/Pseudogene) 2 3 5
  • T-Cell Receptor Alpha Chain V Region CTL-L17 3
  • T Cell Receptor Alpha/Delta Variable 29/DV5 3
  • TRAV29/DV5 3
  • TCRAV21S1 3
  • HADV29S1 3
  • TCRA 3

External Ids for TRAV29DV5 Gene

Previous GeneCards Identifiers for TRAV29DV5 Gene

  • GC14U990290
  • GC14P020622
  • GC14P020623
  • GC14P021701
  • GC14P022633
  • GC14P022651
  • GC14P022738
  • GC14P022844

Summaries for TRAV29DV5 Gene

Entrez Gene Summary for TRAV29DV5 Gene

  • T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

GeneCards Summary for TRAV29DV5 Gene

TRAV29DV5 (T Cell Receptor Alpha Variable 29/Delta Variable 5 (Gene/Pseudogene)) is a Protein Coding gene. An important paralog of this gene is TRAV23DV6.

UniProtKB/Swiss-Prot for TRAV29DV5 Gene

  • V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Additional gene information for TRAV29DV5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAV29DV5 Gene

Genomics for TRAV29DV5 Gene

GeneHancer (GH) Regulatory Elements for TRAV29DV5 Gene

Promoters and enhancers for TRAV29DV5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J022164 Enhancer 0.7 ENCODE 650.7 +1.6 1572 0.1 NCOA3 PKNOX1 ESRRA NFIB NEUROD1 BMI1 CTBP1 GATA3 RCOR1 FOS TRAV29DV5 TRAV30 TRA
GH14J022158 Enhancer 0.4 Ensembl ENCODE 0.7 -3.2 -3181 2.8 TRAV26-2 TRAV28 TRAV29DV5 TRA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAV29DV5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRAV29DV5 Gene

Genomic Locations for TRAV29DV5 Gene
chr14:22,163,238-22,163,870
(GRCh38/hg38)
Size:
633 bases
Orientation:
Plus strand
chr14:22,631,134-22,631,766
(GRCh37/hg19)
Size:
633 bases
Orientation:
Plus strand

Genomic View for TRAV29DV5 Gene

Genes around TRAV29DV5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAV29DV5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAV29DV5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAV29DV5 Gene

Proteins for TRAV29DV5 Gene

  • Protein details for TRAV29DV5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04437-TVA29_HUMAN
    Recommended name:
    T cell receptor alpha variable 29/delta variable 5
    Protein Accession:
    P04437
    Secondary Accessions:
    • A0JD25

    Protein attributes for TRAV29DV5 Gene

    Size:
    119 amino acids
    Molecular mass:
    13438 Da
    Quaternary structure:
    • Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.
    SequenceCaution:
    • Sequence=AAA60627.1; Type=Miscellaneous discrepancy; Note=Chimeric mRNA corresponding to regions V and J of T cell receptor (TR) alpha chain.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRAV29DV5 Gene

neXtProt entry for TRAV29DV5 Gene

Post-translational modifications for TRAV29DV5 Gene

No Post-translational modifications

Other Protein References for TRAV29DV5 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TRAV29DV5 Gene

Domains & Families for TRAV29DV5 Gene

Gene Families for TRAV29DV5 Gene

Protein Domains for TRAV29DV5 Gene

Suggested Antigen Peptide Sequences for TRAV29DV5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRAV29DV5: view

No data available for UniProtKB/Swiss-Prot for TRAV29DV5 Gene

Function for TRAV29DV5 Gene

Molecular function for TRAV29DV5 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).

Gene Ontology (GO) - Molecular Function for TRAV29DV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042287 MHC protein binding NAS 2426193
GO:0042605 peptide antigen binding NAS 2426193
genes like me logo Genes that share ontologies with TRAV29DV5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRAV29DV5 Gene

Localization for TRAV29DV5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAV29DV5 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for TRAV29DV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TRAV29DV5: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TRAV29DV5 Gene

Pathways & Interactions for TRAV29DV5 Gene

SuperPathways for TRAV29DV5 Gene

No Data Available

Interacting Proteins for TRAV29DV5 Gene

Selected Interacting proteins: P04437-TVA29_HUMAN for TRAV29DV5 Gene via IID

Symbol External ID(s) Details
HLA-A

Gene Ontology (GO) - Biological Process for TRAV29DV5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0006955 immune response NAS 2426193
GO:0031295 T cell costimulation TAS --
GO:0050776 regulation of immune response TAS --
GO:0050852 T cell receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TRAV29DV5: view

No data available for Pathways by source and SIGNOR curated interactions for TRAV29DV5 Gene

Drugs & Compounds for TRAV29DV5 Gene

No Compound Related Data Available

Transcripts for TRAV29DV5 Gene

mRNA/cDNA for TRAV29DV5 Gene

(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAV29DV5 Gene

No ASD Table

Relevant External Links for TRAV29DV5 Gene

GeneLoc Exon Structure for
TRAV29DV5
ECgene alternative splicing isoforms for
TRAV29DV5

Expression for TRAV29DV5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAV29DV5 Gene

mRNA differential expression in normal tissues according to GTEx for TRAV29DV5 Gene

This gene is overexpressed in Whole Blood (x30.9), Spleen (x4.9), and Small Intestine - Terminal Ileum (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TRAV29DV5 Gene:

TRAV29DV5
genes like me logo Genes that share expression patterns with TRAV29DV5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAV29DV5 Gene

Orthologs for TRAV29DV5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRAV29DV5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRAV29DV5 34
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trav19 34
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRAV29DV5 34
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
ManyToMany
-- 34
  • 48 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
OneToMany
Species where no ortholog for TRAV29DV5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRAV29DV5 Gene

ENSEMBL:
Gene Tree for TRAV29DV5 (if available)
TreeFam:
Gene Tree for TRAV29DV5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRAV29DV5: view image

Paralogs for TRAV29DV5 Gene

genes like me logo Genes that share paralogs with TRAV29DV5: view

Variants for TRAV29DV5 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TRAV29DV5 Gene

TVA29_HUMAN-P04437
There are several alleles. The sequence shown is that of IMGT allele TRAV29/DV5*01.

Additional Variant Information for TRAV29DV5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAV29DV5

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for TRAV29DV5 Gene

Disorders for TRAV29DV5 Gene

No disorders were found for TRAV29DV5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for TRAV29DV5 Gene

Publications for TRAV29DV5 Gene

  1. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3 58
  2. The complete primary structure of the T-cell receptor genes from an alloreactive cytotoxic human T-lymphocyte clone. (PMID: 2426193) Leiden JM … Strominger JL (Immunogenetics 1986) 3 4 58
  3. T cell antigen receptor recognition of antigen-presenting molecules. (PMID: 25493333) Rossjohn J … McCluskey J (Annual review of immunology 2015) 4 58
  4. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
  5. T cell receptor signalling networks: branched, diversified and bounded. (PMID: 23524462) Brownlie RJ … Zamoyska R (Nature reviews. Immunology 2013) 4 58

Products for TRAV29DV5 Gene

Sources for TRAV29DV5 Gene

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