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Aliases for SLC35A3 Gene

Aliases for SLC35A3 Gene

  • Solute Carrier Family 35 Member A3 2 3 4 5
  • Solute Carrier Family 35 (UDP-N-Acetylglucosamine (UDP-GlcNAc) Transporter), Member A3 2 3
  • Solute Carrier Family 35 (UDP-N-Acetylglucosamine (UDP-GlcNAc) Transporter), Member 3 2 3
  • Golgi UDP-GlcNAc Transporter 3 4
  • UDP-N-Acetylglucosamine Transporter 3
  • AMRS 3

External Ids for SLC35A3 Gene

Previous GeneCards Identifiers for SLC35A3 Gene

  • GC01P101231
  • GC01P099569
  • GC01P099726
  • GC01P099898
  • GC01P100147
  • GC01P100208
  • GC01P100435
  • GC01P098557

Summaries for SLC35A3 Gene

Entrez Gene Summary for SLC35A3 Gene

  • This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for SLC35A3 Gene

SLC35A3 (Solute Carrier Family 35 Member A3) is a Protein Coding gene. Diseases associated with SLC35A3 include Arthrogryposis, Mental Retardation, And Seizures and Autism Spectrum Disorder. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. GO annotations related to this gene include sugar:proton symporter activity and UDP-N-acetylglucosamine transmembrane transporter activity. An important paralog of this gene is SLC35A2.

UniProtKB/Swiss-Prot for SLC35A3 Gene

  • Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides.

Additional gene information for SLC35A3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35A3 Gene

Genomics for SLC35A3 Gene

Regulatory Elements for SLC35A3 Gene

Enhancers for SLC35A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H099943 1.2 Ensembl ENCODE 11.8 -25.0 -24998 1.6 HDAC1 PKNOX1 ATF1 ARNT CHAMP1 TCF12 GATA2 ZSCAN5C ATF7 NCOA1 LRRC39 SLC35A3 ENSG00000228084 FRRS1 GC01P099965 AGL
GH01H100130 1.2 ENCODE 8 +163.2 163182 4.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 RTCA SASS6 SLC35A3 ENSG00000226952
GH01H099969 1.2 ENCODE 5.9 +1.6 1589 2.9 HDGF FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SASS6 ENSG00000227034 MFSD14A TRMT13 HNRNPA1P68 RTCA BRI3P1 SLC30A7 SLC35A3 GPR88
GH01H099557 1.1 Ensembl ENCODE dbSUPER 4.9 -410.9 -410948 1.3 FOSL1 JUND JUN MAFG FOS MAFK PALMD SLC35A3 BRI3P1 LINC01708 ENSG00000233983
GH01H100178 0.5 ENCODE 10 +209.4 209413 0.2 MEF2D L3MBTL2 ZNF354B TRMT13 RTCA HNRNPA1P68 SASS6 SLC30A7 MFSD14A SLC35A3 LRRC39 RPL23AP90
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010605 1413 1800 HDGF FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for SLC35A3 Gene

Genomic Locations for SLC35A3 Gene
66,751 bases
Plus strand

Genomic View for SLC35A3 Gene

Genes around SLC35A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35A3 Gene

Proteins for SLC35A3 Gene

  • Protein details for SLC35A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-N-acetylglucosamine transporter
    Protein Accession:
    Secondary Accessions:
    • A8K3F8
    • D3DT54
    • Q68CR2
    • Q9BSB7

    Protein attributes for SLC35A3 Gene

    325 amino acids
    Molecular mass:
    35985 Da
    Quaternary structure:
    • Interacts with SLC35A2.

    Alternative splice isoforms for SLC35A3 Gene


neXtProt entry for SLC35A3 Gene

Post-translational modifications for SLC35A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC35A3 Gene

Domains & Families for SLC35A3 Gene

Gene Families for SLC35A3 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35A3 Gene

Suggested Antigen Peptide Sequences for SLC35A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
genes like me logo Genes that share domains with SLC35A3: view

Function for SLC35A3 Gene

Molecular function for SLC35A3 Gene

GENATLAS Biochemistry:
solute carrier family 35,member A3,UDP N-acetylglucosamine transporter,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides.

Gene Ontology (GO) - Molecular Function for SLC35A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IEA --
GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 23089177
genes like me logo Genes that share ontologies with SLC35A3: view
genes like me logo Genes that share phenotypes with SLC35A3: view

Human Phenotype Ontology for SLC35A3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35A3 Gene

Localization for SLC35A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35A3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35A3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC35A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus TAS 10393322
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35A3 Gene

Pathways & Interactions for SLC35A3 Gene

genes like me logo Genes that share pathways with SLC35A3: view

Gene Ontology (GO) - Biological Process for SLC35A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006047 UDP-N-acetylglucosamine metabolic process TAS 10393322
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015788 UDP-N-acetylglucosamine transport TAS,IMP 23089177
GO:0015992 proton transport IEA --
genes like me logo Genes that share ontologies with SLC35A3: view

No data available for SIGNOR curated interactions for SLC35A3 Gene

Drugs & Compounds for SLC35A3 Gene

(1) Additional Compounds for SLC35A3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
  • UDP-a-D-N-Acetylglucosamine
  • UDP-Acetyl-D-glucosamine
  • UDP-Acetyl-delta-glucosamine
  • UDP-Acetylglucosamine
genes like me logo Genes that share compounds with SLC35A3: view

Transcripts for SLC35A3 Gene

Unigene Clusters for SLC35A3 Gene

Solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP3: - - - - - -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for SLC35A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35A3 Gene

This gene is overexpressed in Nasal epithelium (57.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC35A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35A3 Gene:


SOURCE GeneReport for Unigene cluster for SLC35A3 Gene:


Evidence on tissue expression from TISSUES for SLC35A3 Gene

  • Kidney(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35A3 Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • nervous
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • chin
  • face
  • head
  • jaw
  • mandible
  • skull
  • pelvis
  • ankle
  • digit
  • elbow
  • femur
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • thigh
  • toe
  • upper limb
  • wrist
genes like me logo Genes that share expression patterns with SLC35A3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC35A3 Gene

Orthologs for SLC35A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35A3 33 34
  • 99.69 (n)
(Canis familiaris)
Mammalia SLC35A3 33 34
  • 94.05 (n)
(Bos Taurus)
Mammalia SLC35A3 33 34
  • 93.74 (n)
(Mus musculus)
Mammalia Slc35a3 33 16 34
  • 89.85 (n)
(Rattus norvegicus)
Mammalia Slc35a3 33
  • 89.54 (n)
(Monodelphis domestica)
Mammalia SLC35A3 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SLC35A3 34
  • 80 (a)
(Gallus gallus)
Aves SLC35A3 33 34
  • 75.16 (n)
(Anolis carolinensis)
Reptilia SLC35A3 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35a3.2 33
  • 70.67 (n)
MGC75571 33
(Danio rerio)
Actinopterygii SLC35A3 (1 of 2) 34
  • 77 (a)
si:ch211-228b23.2 33
  • 68.21 (n)
SLC35A3 (2 of 2) 34
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2501 33
fruit fly
(Drosophila melanogaster)
Insecta Csat 35
  • 48 (a)
(Caenorhabditis elegans)
Secernentea nstp-4 33 34
  • 58.61 (n)
C03H5.2 35
  • 47 (a)
B0212.4a 35
  • 40 (a)
B0212.4b 35
  • 40 (a)
ZK370.7 35
  • 39 (a)
ZK896.9 35
  • 39 (a)
F44C8.7 35
  • 38 (a)
ZC250.3 35
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8816 34
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13887 33
Species where no ortholog for SLC35A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35A3 Gene

Gene Tree for SLC35A3 (if available)
Gene Tree for SLC35A3 (if available)

Paralogs for SLC35A3 Gene

Paralogs for SLC35A3 Gene

(3) SIMAP similar genes for SLC35A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC35A3: view

Variants for SLC35A3 Gene

Sequence variations from dbSNP and Humsavar for SLC35A3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs141952252 Pathogenic 100,017,814(+) CAACC(A/G)GGTAA intron-variant, reference, missense
rs398122524 Pathogenic 100,011,413(+) GTTCT(C/T)AATTT reference, stop-gained
rs1000023518 -- 99,975,064(+) TAGCC(C/T)CCCAA intron-variant, utr-variant-5-prime
rs1000028546 -- 100,014,466(+) ATTCT(C/T)CTGCT intron-variant
rs1000181834 -- 99,974,374(+) CAGAG(A/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35A3 Gene

Variant ID Type Subtype PubMed ID
nsv546888 CNV loss 21841781
nsv526047 CNV gain 19592680
nsv428146 CNV gain 18775914
nsv1137786 CNV deletion 24896259
nsv10406 CNV gain 18304495
nsv1003259 CNV loss 25217958
esv2758952 CNV loss 17122850
esv2567165 CNV deletion 19546169

Variation tolerance for SLC35A3 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35A3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35A3 Gene

Disorders for SLC35A3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC35A3 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
arthrogryposis, mental retardation, and seizures
  • arthrogryposis, mental retardation and seizures
autism spectrum disorder
  • pervasive developmental disorder
- elite association - COSMIC cancer census association via MalaCards


  • Arthrogryposis, mental retardation, and seizures (AMRS) [MIM:615553]: A disease characterized by arthrogryposis, mental retardation, autism spectrum disorder, and epilepsy. Additional features include limb malformations, distal joint involvement, microcephaly, retromicrognathia, and general muscle hypotonia. {ECO:0000269 PubMed:24031089}. Note=The disease is caused by mutations affecting the gene represented in this entry. In Golgi vesicles isolated from patient fibroblasts the transport of the respective nucleotide sugar is significantly reduced causing a massive decrease in the content of cell surface expressed highly branched N-glycans and a concomitant sharp increase of lower branched glycoforms.

Relevant External Links for SLC35A3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC35A3: view

No data available for Genatlas for SLC35A3 Gene

Publications for SLC35A3 Gene

  1. Molecular cloning and functional expression of the human Golgi UDP-N-acetylglucosamine transporter. (PMID: 10393322) Ishida N … Kawakita M (Journal of biochemistry 1999) 2 3 4 60
  2. Mutations in SLC35A3 cause autism spectrum disorder, epilepsy and arthrogryposis. (PMID: 24031089) Edvardson S … Elpeleg O (Journal of medical genetics 2013) 3 4 60
  3. UDP-N-acetylglucosamine transporter and UDP-galactose transporter form heterologous complexes in the Golgi membrane. (PMID: 23089177) Maszczak-Seneczko D … Olczak M (FEBS letters 2012) 3 4 60
  4. UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats). (PMID: 25944901) Maszczak-Seneczko D … Olczak M (The Journal of biological chemistry 2015) 3 60
  5. UDP-Gal/UDP-GlcNAc chimeric transporter complements mutation defect in mammalian cells deficient in UDP-Gal transporter. (PMID: 23583405) Olczak M … Olczak T (Biochemical and biophysical research communications 2013) 3 60

Products for SLC35A3 Gene

Sources for SLC35A3 Gene

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