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Aliases for SLCO1A2 Gene

Aliases for SLCO1A2 Gene

  • Solute Carrier Organic Anion Transporter Family Member 1A2 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 3 2 3
  • Sodium-Independent Organic Anion Transporter 3 4
  • Organic Anion-Transporting Polypeptide 1 3 4
  • Solute Carrier Family 21 Member 3 3 4
  • SLC21A3 3 4
  • OATP1A2 3 4
  • OATP-1 3 4
  • OATP-A 3 4
  • OATP 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 1A2 2
  • Organic Anion Transporting Polypeptide A 3
  • OATP1 4

External Ids for SLCO1A2 Gene

Previous HGNC Symbols for SLCO1A2 Gene

  • SLC21A3

Previous GeneCards Identifiers for SLCO1A2 Gene

  • GC12M021313
  • GC12M021417

Summaries for SLCO1A2 Gene

Entrez Gene Summary for SLCO1A2 Gene

  • This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

GeneCards Summary for SLCO1A2 Gene

SLCO1A2 (Solute Carrier Organic Anion Transporter Family Member 1A2) is a Protein Coding gene. Diseases associated with SLCO1A2 include Intrahepatic Cholestasis and Aneurysmal Bone Cysts. Among its related pathways are Metabolism and Bile secretion. Gene Ontology (GO) annotations related to this gene include transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLCO1C1.

UniProtKB/Swiss-Prot for SLCO1A2 Gene

  • Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.

Gene Wiki entry for SLCO1A2 Gene

Additional gene information for SLCO1A2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO1A2 Gene

Genomics for SLCO1A2 Gene

GeneHancer (GH) Regulatory Elements for SLCO1A2 Gene

Promoters and enhancers for SLCO1A2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I021395 Promoter 0.9 EPDnew 550.3 +24.1 24069 0.1 SMARCE1 HDAC1 SMAD5 TAF9B SOX6 NFRKB CTBP1 FOXK2 NCOR1 POLR2A SLCO1A2 IAPP
GH12I021357 Promoter 0.7 EPDnew 550.2 +62.5 62485 0.1 MITF IKZF1 SLCO1A2 IAPP
GH12I021275 Enhancer 0.2 FANTOM5 4.6 +143.5 143546 0.1 PIR55925 GYS2 SLCO1B1 SLCO1A2 SLCO1B3 KCNJ8 GC12P021259
GH12I020906 Enhancer 0.2 FANTOM5 1.9 +513.1 513134 0.3 SLCO1B1 SLCO1B7 SLCO1B3 SLCO1A2 GC12M020897 GC12P020879 ENSG00000257046
GH12I021416 Enhancer 0.3 ENCODE 0.8 +2.9 2912 0.2 SP1 SLCO1A2 IAPP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLCO1A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLCO1A2 gene promoter:

Genomic Locations for SLCO1A2 Gene

Genomic Locations for SLCO1A2 Gene
154,995 bases
Minus strand

Genomic View for SLCO1A2 Gene

Genes around SLCO1A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO1A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO1A2 Gene

Proteins for SLCO1A2 Gene

  • Protein details for SLCO1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 1A2
    Protein Accession:
    Secondary Accessions:
    • Q9UGP7
    • Q9UL38

    Protein attributes for SLCO1A2 Gene

    670 amino acids
    Molecular mass:
    74145 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLCO1A2 Gene


neXtProt entry for SLCO1A2 Gene

Post-translational modifications for SLCO1A2 Gene

  • Glycosylation at isoforms=2124, isoforms=2135, isoforms=2412, and isoforms=2419

No data available for DME Specific Peptides for SLCO1A2 Gene

Domains & Families for SLCO1A2 Gene

Gene Families for SLCO1A2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO1A2: view

Function for SLCO1A2 Gene

Molecular function for SLCO1A2 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.

Phenotypes From GWAS Catalog for SLCO1A2 Gene

Gene Ontology (GO) - Molecular Function for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008514 organic anion transmembrane transporter activity TAS 9007731
GO:0015125 bile acid transmembrane transporter activity TAS --
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLCO1A2: view
genes like me logo Genes that share phenotypes with SLCO1A2: view

Animal Models for SLCO1A2 Gene

MGI Knock Outs for SLCO1A2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLCO1A2 Gene

Localization for SLCO1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO1A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO1A2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO1A2: view

Pathways & Interactions for SLCO1A2 Gene

genes like me logo Genes that share pathways with SLCO1A2: view

Gene Ontology (GO) - Biological Process for SLCO1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015711 organic anion transport TAS 9007731
GO:0015721 bile acid and bile salt transport TAS --
GO:0043252 sodium-independent organic anion transport TAS --
genes like me logo Genes that share ontologies with SLCO1A2: view

No data available for SIGNOR curated interactions for SLCO1A2 Gene

Drugs & Compounds for SLCO1A2 Gene

(79) Drugs for SLCO1A2 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifampin Approved Pharma Agonist, Target, Transporter, inhibitor, binder 376
Rocuronium Approved Pharma Transporter, substrate TGF-βR I kinase inhibitor, Neuromuscular blocker for anaesthesia;aminosteroid 319
Probenecid Approved, Investigational Pharma Inhibition, Inhibitor, Transporter, inhibitor 35
Bumetanide Approved Pharma Agonist, Transporter, substrate NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 19
cholic acid Approved Pharma Full agonist, Agonist, Transporter, substrate, inhibitor, inducer 0

(84) Additional Compounds for SLCO1A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
genes like me logo Genes that share compounds with SLCO1A2: view

Transcripts for SLCO1A2 Gene

Unigene Clusters for SLCO1A2 Gene

Solute carrier organic anion transporter family, member 1A2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO1A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP3: -
SP4: -

Relevant External Links for SLCO1A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO1A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLCO1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLCO1A2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.9), Brain - Substantia nigra (x7.3), Brain - Hippocampus (x6.8), Brain - Amygdala (x6.3), Brain - Putamen (basal ganglia) (x5.0), and Brain - Hypothalamus (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of SLCO1A2 Gene:


SOURCE GeneReport for Unigene cluster for SLCO1A2 Gene:


Evidence on tissue expression from TISSUES for SLCO1A2 Gene

  • Liver(4.6)
  • Nervous system(4.5)
  • Intestine(2.5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SLCO1A2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO1A2 Gene

Orthologs for SLCO1A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLCO1A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLCO1A2 33 34
  • 99.3 (n)
(Canis familiaris)
Mammalia SLCO1A2 33
  • 89.65 (n)
  • 87 (a)
(Bos Taurus)
Mammalia SLCO1A2 33 34
  • 87.64 (n)
(Mus musculus)
Mammalia Slco1a5 33 16 34
  • 78.11 (n)
Slco1a4 34
  • 73 (a)
Slco1a1 34
  • 69 (a)
Gm6614 34
  • 67 (a)
Gm5724 34
  • 66 (a)
Slco1a6 34
  • 66 (a)
(Rattus norvegicus)
Mammalia Slco1a5 33
  • 77.66 (n)
(Monodelphis domestica)
Mammalia SLCO1A2 34
  • 69 (a)
(Gallus gallus)
Aves SLCO1A2 33
  • 65.53 (n)
-- 34
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68666 33
Species where no ortholog for SLCO1A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLCO1A2 Gene

Gene Tree for SLCO1A2 (if available)
Gene Tree for SLCO1A2 (if available)

Paralogs for SLCO1A2 Gene

Variants for SLCO1A2 Gene

Sequence variations from dbSNP and Humsavar for SLCO1A2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
VAR_036409 A colorectal cancer sample p.Val220Ile
rs1000045618 -- 21,375,788(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000051866 -- 21,271,144(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000055614 -- 21,395,718(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000069224 -- 21,355,596(-) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO1A2 Gene

Variant ID Type Subtype PubMed ID
nsv557740 CNV loss 21841781
nsv557739 CNV loss 21841781
nsv557738 CNV loss 21841781
nsv557737 CNV loss 21841781
nsv557736 CNV loss 21841781
nsv557735 CNV loss 21841781
nsv557734 CNV loss 21841781
nsv519603 CNV gain+loss 19592680
nsv515735 CNV gain+loss 19592680
nsv475260 CNV novel sequence insertion 20440878
nsv470274 CNV loss 18288195
nsv469162 CNV loss 19166990
nsv469161 CNV loss 19166990
nsv1115426 CNV duplication 24896259
nsv1040888 CNV loss 25217958
esv3628806 CNV loss 21293372
esv3628799 CNV loss 21293372
esv2750499 CNV gain 17666407
esv1146701 CNV insertion 17803354
dgv1404n100 CNV loss 25217958

Variation tolerance for SLCO1A2 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.36; 70.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO1A2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO1A2 Gene

Disorders for SLCO1A2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLCO1A2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
intrahepatic cholestasis
  • intrahepatic cholestasis of pregnancy
aneurysmal bone cysts
  • aneurysmal bone cyst
extrahepatic cholestasis
  • extrahepatic biliary stasis
bile duct disease
  • bile duct disorder nos
biliary tract disease
  • biliary tract abnormality
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLCO1A2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLCO1A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO1A2 Gene

Publications for SLCO1A2 Gene

  1. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. (PMID: 15632119) Lee W … Kim RB (The Journal of biological chemistry 2005) 3 4 22 44 58
  2. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. (PMID: 7557095) Kullak-Ublick GA … Meier PJ (Gastroenterology 1995) 3 4 25 58
  3. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. (PMID: 21685912) Höglinger GU … Schellenberg GD (Nature genetics 2011) 3 44 58
  4. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics. (PMID: 19890249) Picard N … Marquet P (Clinical pharmacology and therapeutics 2010) 3 44 58
  5. HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms. (PMID: 20051929) Hartkoorn RC … Owen A (Pharmacogenetics and genomics 2010) 3 22 58

Products for SLCO1A2 Gene

Sources for SLCO1A2 Gene

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