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Aliases for SLCO4A1 Gene

Aliases for SLCO4A1 Gene

  • Solute Carrier Organic Anion Transporter Family Member 4A1 2 3 5
  • Solute Carrier Family 21 (Organic Anion Transporter), Member 12 2 3
  • Organic Anion Transporter Polypeptide-Related Protein 1 3 4
  • Sodium-Independent Organic Anion Transporter E 3 4
  • Solute Carrier Family 21 Member 12 3 4
  • Colon Organic Anion Transporter 3 4
  • SLC21A12 3 4
  • OATP-RP1 3 4
  • OATP4A1 3 4
  • OATPRP1 3 4
  • OATP-E 3 4
  • OATP1 3 4
  • OATPE 3 4
  • POAT 3 4
  • Solute Carrier Organic Anion Transporter Family, Member 4A1 2
  • Organic Anion Transporting Polypeptide E 3
  • Organic Anion-Transporting Polypeptide E 4

External Ids for SLCO4A1 Gene

Previous HGNC Symbols for SLCO4A1 Gene

  • SLC21A12

Previous GeneCards Identifiers for SLCO4A1 Gene

  • GC20P062000
  • GC20P060744
  • GC20P061273
  • GC20P057991
  • GC20P062655
  • GC20P062702
  • GC20P062716
  • GC20P062751
  • GC20P062783
  • GC20P062792
  • GC20P062806

Summaries for SLCO4A1 Gene

GeneCards Summary for SLCO4A1 Gene

SLCO4A1 (Solute Carrier Organic Anion Transporter Family Member 4A1) is a Protein Coding gene. Diseases associated with SLCO4A1 include Mucinous Cystadenocarcinoma and Aneurysmal Bone Cysts. Among its related pathways are Hepatic ABC Transporters and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is SLCO4C1.

UniProtKB/Swiss-Prot for SLCO4A1 Gene

  • Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

Gene Wiki entry for SLCO4A1 Gene

Additional gene information for SLCO4A1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLCO4A1 Gene

Genomics for SLCO4A1 Gene

GeneHancer (GH) Regulatory Elements for SLCO4A1 Gene

Promoters and enhancers for SLCO4A1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I062708 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.4 +68.5 68480 4.3 PKNOX1 ATF1 RB1 NFIB KLF17 SIN3A YY1 ZNF766 GLIS2 SCRT2 NTSR1 RTEL1 ARFGAP1 TNFRSF6B YTHDF1 ARFRP1 ENSG00000223669 OGFR OGFR-AS1 SLCO4A1-AS1
GH20I062727 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.2 +85.8 85756 2 POLR2A MAX ZFP36 ZBTB33 MYC LINC00659 SLCO4A1 ENSG00000232121 ENSG00000229882 OGFR-AS1 OGFR ENSG00000223669 NTSR1
GH20I062715 Enhancer 0.7 ENCODE dbSUPER 11.4 +74.0 73964 1 FOSL1 L3MBTL2 MGA ZNF395 OGFR OGFR-AS1 LINC00659 SLCO4A1-AS1 SLCO4A1 MIR133A2 MRGBP ENSG00000229882 ENSG00000232121 NTSR1
GH20I062752 Enhancer 0.6 Ensembl 11.7 +110.1 110056 0.6 SMARCE1 USF1 L3MBTL2 MAX MNT ZNF48 ZNF335 FOSL1 IKZF1 PRDM10 GC20M062750 NTSR1 LINC00659 SLCO4A1-AS1 SLCO4A1 MIR133A2 TCFL5 ENSG00000223669
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLCO4A1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLCO4A1 gene promoter:

Genomic Locations for SLCO4A1 Gene

Genomic Locations for SLCO4A1 Gene
43,386 bases
Plus strand

Genomic View for SLCO4A1 Gene

Genes around SLCO4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLCO4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLCO4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLCO4A1 Gene

Proteins for SLCO4A1 Gene

  • Protein details for SLCO4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier organic anion transporter family member 4A1
    Protein Accession:
    Secondary Accessions:
    • Q9H4T7
    • Q9H4T8
    • Q9H8P2
    • Q9NWX8
    • Q9UI35
    • Q9UIG7

    Protein attributes for SLCO4A1 Gene

    722 amino acids
    Molecular mass:
    77193 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91247.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLCO4A1 Gene


neXtProt entry for SLCO4A1 Gene

Post-translational modifications for SLCO4A1 Gene

  • Ubiquitination at isoforms=2, 3, 466 and posLast=353353
  • Glycosylation at posLast=499499 and isoforms=2, 4557
  • Modification sites at PhosphoSitePlus

Other Protein References for SLCO4A1 Gene

No data available for DME Specific Peptides for SLCO4A1 Gene

Domains & Families for SLCO4A1 Gene

Gene Families for SLCO4A1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLCO4A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the organo anion transporter (TC 2.A.60) family.
  • Belongs to the organo anion transporter (TC 2.A.60) family.
genes like me logo Genes that share domains with SLCO4A1: view

Function for SLCO4A1 Gene

Molecular function for SLCO4A1 Gene

UniProtKB/Swiss-Prot Function:
Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

Phenotypes From GWAS Catalog for SLCO4A1 Gene

Gene Ontology (GO) - Molecular Function for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015347 sodium-independent organic anion transmembrane transporter activity IBA --
GO:0015349 thyroid hormone transmembrane transporter activity TAS,IBA --
genes like me logo Genes that share ontologies with SLCO4A1: view
genes like me logo Genes that share phenotypes with SLCO4A1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLCO4A1

CRISPR Products

miRNA for SLCO4A1 Gene

miRTarBase miRNAs that target SLCO4A1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLCO4A1 Gene

Localization for SLCO4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLCO4A1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLCO4A1: view

Pathways & Interactions for SLCO4A1 Gene

genes like me logo Genes that share pathways with SLCO4A1: view

Gene Ontology (GO) - Biological Process for SLCO4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0043252 sodium-independent organic anion transport TAS --
GO:0055085 transmembrane transport IEA --
GO:0070327 thyroid hormone transport IBA --
genes like me logo Genes that share ontologies with SLCO4A1: view

No data available for SIGNOR curated interactions for SLCO4A1 Gene

Drugs & Compounds for SLCO4A1 Gene

(19) Drugs for SLCO4A1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Liotrix Approved Pharma Transporter, substrate, inhibitor 0
Penicillin G Approved, Vet_approved Pharma Transporter, substrate 33
conjugated estrogens Approved Pharma Transporter, substrate 0
Dextrothyroxine Approved, Investigational Pharma Transporter 0
Digoxin Approved Pharma Transporter, substrate 146

(80) Additional Compounds for SLCO4A1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxy-5b-Cholanoate
  • 1,3,12-Trihydroxy-5b-Cholanoic acid
  • 1,3,12-Trihydroxy-Cholan-24-oate
  • 1,3,12-Trihydroxy-Cholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-oate
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oate
  • 1,3,7,12-Tetrahydroxy-Cholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-oate
  • 1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-oic acid
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-Chola-4,6-dienic acid
  • 12a-Hydroxy-3-oxochola-4,6-dienate
12b-Hydroxy-5b-cholanoic acid
  • 12-Hydroxy-(5b,12b)-Cholan-24-oate
  • 12-Hydroxy-(5b,12b)-Cholan-24-oic acid
  • 12b-Hydroxy-5b-Cholan-24-oate
  • 12b-Hydroxy-5b-Cholan-24-oic acid
  • 12b-Hydroxy-5b-cholanic acid
genes like me logo Genes that share compounds with SLCO4A1: view

Transcripts for SLCO4A1 Gene

Unigene Clusters for SLCO4A1 Gene

Solute carrier organic anion transporter family, member 4A1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLCO4A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - - - -
SP2: - - - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: -

Relevant External Links for SLCO4A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLCO4A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLCO4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLCO4A1 Gene

This gene is overexpressed in Placenta (65.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLCO4A1 Gene

Protein tissue co-expression partners for SLCO4A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLCO4A1 Gene:


SOURCE GeneReport for Unigene cluster for SLCO4A1 Gene:


mRNA Expression by UniProt/SwissProt for SLCO4A1 Gene:

Tissue specificity: Ubiquitous, with the exception of spleen and leukocytes.

Evidence on tissue expression from TISSUES for SLCO4A1 Gene

  • Kidney(4.4)
  • Pancreas(4.1)
  • Nervous system(4.1)
  • Intestine(2.8)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with SLCO4A1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLCO4A1 Gene

Orthologs for SLCO4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLCO4A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLCO4A1 33 34
  • 98.59 (n)
(Bos Taurus)
Mammalia SLCO4A1 33 34
  • 83.55 (n)
(Canis familiaris)
Mammalia SLCO4A1 33 34
  • 83.05 (n)
(Mus musculus)
Mammalia Slco4a1 33 16 34
  • 79.66 (n)
(Rattus norvegicus)
Mammalia Slco4a1 33
  • 78.87 (n)
(Monodelphis domestica)
Mammalia SLCO4A1 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SLCO4A1 34
  • 68 (a)
(Gallus gallus)
Aves SLCO4A1 33 34
  • 70.18 (n)
(Anolis carolinensis)
Reptilia SLCO4A1 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slco4a1 33
  • 66.12 (n)
(Danio rerio)
Actinopterygii slco4a1 33 34
  • 64.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Oatp26F 33 34
  • 56.11 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008712 33
  • 55.95 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y70G10A.3 33
  • 46.75 (n)
Y70G10A.3 34
  • 33 (a)
K02G10.5 34
  • 27 (a)
F53B1.8 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
Species where no ortholog for SLCO4A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLCO4A1 Gene

Gene Tree for SLCO4A1 (if available)
Gene Tree for SLCO4A1 (if available)

Paralogs for SLCO4A1 Gene

(13) SIMAP similar genes for SLCO4A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLCO4A1: view

Variants for SLCO4A1 Gene

Sequence variations from dbSNP and Humsavar for SLCO4A1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000055912 -- 62,644,491(+) T/G intron_variant
rs1000187702 -- 62,654,533(+) C/T intron_variant
rs1000213019 -- 62,680,396(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000241589 -- 62,686,522(+) G/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000261581 -- 62,660,840(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLCO4A1 Gene

Variant ID Type Subtype PubMed ID
esv1387013 CNV deletion 17803354
esv2422398 CNV duplication 17116639
esv2722820 CNV deletion 23290073
esv2722821 CNV deletion 23290073
esv994234 CNV deletion 20482838
nsv1121582 CNV deletion 24896259
nsv1125917 CNV deletion 24896259
nsv1133514 CNV deletion 24896259
nsv1143192 CNV deletion 24896259
nsv1145774 CNV deletion 26484159
nsv428380 CNV loss 18775914
nsv459065 CNV gain 19166990
nsv476766 CNV novel sequence insertion 20440878
nsv481306 CNV novel sequence insertion 20440878
nsv586496 CNV gain 21841781
nsv586502 CNV loss 21841781
nsv586503 CNV gain 21841781
nsv586504 CNV loss 21841781
nsv834026 CNV loss 17160897
nsv953302 CNV deletion 24416366
nsv9822 CNV gain 18304495

Variation tolerance for SLCO4A1 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.17; 75.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLCO4A1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLCO4A1 Gene

Disorders for SLCO4A1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLCO4A1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mucinous cystadenocarcinoma
  • mucinous cystadenocarcinoma nos
aneurysmal bone cysts
  • aneurysmal bone cyst
chronic cholangitis
  • cystadenocarcinoma nos
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLCO4A1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SLCO4A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLCO4A1 Gene

Publications for SLCO4A1 Gene

  1. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. (PMID: 11316767) Fujiwara K … Abe T (Endocrinology 2001) 3 4 22 25 58
  2. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (PMID: 10873595) Tamai I … Tsuji A (Biochemical and biophysical research communications 2000) 2 3 4 25 58
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLCO4A1 Gene

Sources for SLCO4A1 Gene

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