Aliases for SCO1 Gene
External Ids for SCO1 Gene
Previous HGNC Symbols for SCO1 Gene
Previous GeneCards Identifiers for SCO1 Gene
Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SCO1 Gene
SCO1 (SCO1, Cytochrome C Oxidase Assembly Protein) is a Protein Coding gene. Diseases associated with SCO1 include Mitochondrial Complex Iv Deficiency and Fatal Infantile Cytochrome C Oxidase Deficiency. Among its related pathways are Gene Expression and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and antioxidant activity. An important paralog of this gene is ENSG00000284194.
UniProtKB/Swiss-Prot for SCO1 Gene
Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15659396, PubMed:16735468, PubMed:17189203, PubMed:19336478, PubMed:15229189). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity).