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Aliases for BLMH Gene

Aliases for BLMH Gene

  • Bleomycin Hydrolase 2 3 5
  • BLM Hydrolase 3 4
  • EC 4 58
  • BMH 3 4
  • BH 3 4

External Ids for BLMH Gene

Previous GeneCards Identifiers for BLMH Gene

  • GC17M028328
  • GC17M030481
  • GC17M028720
  • GC17M025599
  • GC17M028575
  • GC17M024785

Summaries for BLMH Gene

Entrez Gene Summary for BLMH Gene

  • Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for BLMH Gene

BLMH (Bleomycin Hydrolase) is a Protein Coding gene. Diseases associated with BLMH include Resistance To Bleomycine In The Treatment Of Testicular Cancer and Testicular Germ Cell Cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. GO annotations related to this gene include peptidase activity and cysteine-type peptidase activity.

UniProtKB/Swiss-Prot for BLMH Gene

  • The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.

Gene Wiki entry for BLMH Gene

Additional gene information for BLMH Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BLMH Gene

Genomics for BLMH Gene

Regulatory Elements for BLMH Gene

Enhancers for BLMH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H030343 2 FANTOM5 Ensembl ENCODE dbSUPER 19.1 -53.0 -53026 4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 BLMH RNU6-1267P TBC1D29 CPD EFCAB5 NSRP1 ENSG00000207132 GC17M030345 GC17P030362
GH17H030336 1.5 Ensembl ENCODE dbSUPER 19.4 -45.1 -45138 2.1 PKNOX1 ATF1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 ZNF143 ATF7 BLMH RNU6-1267P TMIGD1 GC17P030343
GH17H030104 1.3 Ensembl ENCODE 20.9 +187.3 187262 1.5 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 MXD4 CORO6 BLMH SH3GL1P2 NUFIP2 ATAD5 RNU6-1267P GOSR1 DPRXP4 RNF135 ENSG00000264456
GH17H030339 1.2 Ensembl ENCODE 19.7 -48.4 -48361 1.5 PKNOX1 ARID4B ZNF2 YY1 ZNF143 REST PPARG ZNF592 KAT8 NFIL3 BLMH RNU6-1267P SUZ12P1 GC17P030343 TMIGD1
GH17H030331 1.1 Ensembl ENCODE 20.4 -41.0 -41032 3 PKNOX1 FOXA2 RAD21 RARA ETV6 ATF7 RUNX3 CREM IKZF2 MIXL1 BLMH RNU6-1267P CORO6 TMIGD1 LOC105371721
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BLMH on UCSC Golden Path with GeneCards custom track

Promoters for BLMH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092973 366 1601 PKNOX1 ATF1 ARNT SIN3A SLC30A9 GLIS2 ZNF143 FOS ATF7 RUNX3

Genomic Locations for BLMH Gene

Genomic Locations for BLMH Gene
43,972 bases
Minus strand

Genomic View for BLMH Gene

Genes around BLMH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BLMH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BLMH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BLMH Gene

Proteins for BLMH Gene

  • Protein details for BLMH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bleomycin hydrolase
    Protein Accession:
    Secondary Accessions:
    • B2R796
    • Q53F86
    • Q9UER9

    Protein attributes for BLMH Gene

    455 amino acids
    Molecular mass:
    52562 Da
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for BLMH Gene

neXtProt entry for BLMH Gene

Selected DME Specific Peptides for BLMH Gene


Post-translational modifications for BLMH Gene

  • Ubiquitination at Lys42, Lys297, and posLast=391391
  • Modification sites at PhosphoSitePlus

Other Protein References for BLMH Gene

Antibody Products

  • R&D Systems Antibodies for BLMH (BLMH/Bleomycin Hydrolase)
  • Abcam antibodies for BLMH

Domains & Families for BLMH Gene

Gene Families for BLMH Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for BLMH Gene

Suggested Antigen Peptide Sequences for BLMH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with BLMH: view

Function for BLMH Gene

Molecular function for BLMH Gene

GENATLAS Biochemistry:
bleomycin hydrolase,neutral cysteine protease,papain superfamily,widely expressed,maybe involved in bleomycin induced pulmonary fibrosis
UniProtKB/Swiss-Prot CatalyticActivity:
Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.
UniProtKB/Swiss-Prot Function:
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.

Enzyme Numbers (IUBMB) for BLMH Gene

Gene Ontology (GO) - Molecular Function for BLMH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity EXP 9668046
GO:0004180 carboxypeptidase activity TAS 9546396
GO:0004197 cysteine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 11350084
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with BLMH: view
genes like me logo Genes that share phenotypes with BLMH: view

Animal Models for BLMH Gene

MGI Knock Outs for BLMH:

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BLMH Gene

Localization for BLMH Gene

Subcellular locations from UniProtKB/Swiss-Prot for BLMH Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BLMH gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for BLMH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 21630459
GO:0005737 cytoplasm TAS,IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BLMH: view

Pathways & Interactions for BLMH Gene

genes like me logo Genes that share pathways with BLMH: view

Gene Ontology (GO) - Biological Process for BLMH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006508 proteolysis IEA --
GO:0009636 response to toxic substance IEA,IBA --
GO:0042493 response to drug IEA --
GO:0043418 homocysteine catabolic process IBA --
genes like me logo Genes that share ontologies with BLMH: view

No data available for SIGNOR curated interactions for BLMH Gene

Drugs & Compounds for BLMH Gene

(3) Drugs for BLMH Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bleomycin Approved Pharma Enzyme, substrate 161

(2) Additional Compounds for BLMH Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BLMH: view

Transcripts for BLMH Gene

Unigene Clusters for BLMH Gene

Bleomycin hydrolase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BLMH Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a ·
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: - -
SP10: -
SP11: - -
SP12: -

ExUns: 12b ^ 13 ^ 14a · 14b

Relevant External Links for BLMH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BLMH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BLMH Gene

mRNA differential expression in normal tissues according to GTEx for BLMH Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.7) and Skin - Not Sun Exposed (Suprapubic) (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BLMH Gene

NURSA nuclear receptor signaling pathways regulating expression of BLMH Gene:


SOURCE GeneReport for Unigene cluster for BLMH Gene:


Evidence on tissue expression from TISSUES for BLMH Gene

  • Nervous system(4.9)
  • Lung(4.6)
  • Skin(2.9)
  • Kidney(2.7)
  • Blood(2)
genes like me logo Genes that share expression patterns with BLMH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BLMH Gene

Orthologs for BLMH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BLMH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BLMH 33 34
  • 99.78 (n)
(Canis familiaris)
Mammalia BLMH 33 34
  • 93.7 (n)
(Bos Taurus)
Mammalia BLMH 33 34
  • 92.77 (n)
(Mus musculus)
Mammalia Blmh 33 16 34
  • 91.14 (n)
(Rattus norvegicus)
Mammalia Blmh 33
  • 90.92 (n)
(Ornithorhynchus anatinus)
Mammalia BLMH 34
  • 89 (a)
(Monodelphis domestica)
Mammalia BLMH 34
  • 84 (a)
(Gallus gallus)
Aves BLMH 33 34
  • 74.51 (n)
(Anolis carolinensis)
Reptilia BLMH 34
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia blmh 33
  • 72.49 (n)
Str.6189 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9846 33
(Danio rerio)
Actinopterygii blmh 33 34
  • 70.51 (n)
wufb13c01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8256 33
fruit fly
(Drosophila melanogaster)
Insecta CG1440 35 33 34
  • 59.22 (n)
CG13423 35 34
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001341 33
  • 58.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL204W 33
  • 50.39 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAP3 33 34 36
  • 48.46 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08333 33
  • 50.45 (n)
Species where no ortholog for BLMH was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BLMH Gene

Gene Tree for BLMH (if available)
Gene Tree for BLMH (if available)

Paralogs for BLMH Gene

No data available for Paralogs for BLMH Gene

Variants for BLMH Gene

Sequence variations from dbSNP and Humsavar for BLMH Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1050565 Benign 30,249,058(-) CCATT(A/G)TCCTG reference, missense
rs1000030389 -- 30,265,223(+) TTATT(C/T)TCATA intron-variant
rs1000125876 -- 30,255,433(+) ATTTT(-/ATTA)ATAAA intron-variant
rs1000146206 -- 30,265,498(+) ACACA(A/G)AGAGG intron-variant
rs1000213216 -- 30,290,968(+) AAAGA(C/T)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BLMH Gene

Variant ID Type Subtype PubMed ID
nsv2023 CNV insertion 18451855
esv3582599 CNV loss 25503493
esv2478144 CNV deletion 19546169

Variation tolerance for BLMH Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.04; 84.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BLMH Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BLMH Gene

Disorders for BLMH Gene

MalaCards: The human disease database

(6) MalaCards diseases for BLMH Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
resistance to bleomycine in the treatment of testicular cancer
testicular germ cell cancer
  • testicular germ cell tumor
mutagen sensitivity
chromosome 17q11.2 deletion syndrome, 1.4-mb
  • chromosome 17q11.2 deletion syndrome, 1.4mb
pityriasis rubra pilaris
  • devergie's disease
- elite association - COSMIC cancer census association via MalaCards
Search BLMH in MalaCards View complete list of genes associated with diseases

Relevant External Links for BLMH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BLMH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BLMH Gene

Publications for BLMH Gene

  1. Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. (PMID: 18398146) de Haas EC … Gietema JA (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008) 3 22 45 60
  2. Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients. (PMID: 15900213) Nuver J … Gietema JA (Pharmacogenetics and genomics 2005) 3 22 45 60
  3. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. (PMID: 11436125) Prince JA … Brookes AJ (European journal of human genetics : EJHG 2001) 3 22 45 60
  4. Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan. (PMID: 11099722) Hu CJ … Chang JG (Journal of the neurological sciences 2000) 3 22 45 60
  5. Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. (PMID: 10404591) O'Farrell PA … Joshua-Tor L (Structure (London, England : 1993) 1999) 3 4 22 60

Products for BLMH Gene

Sources for BLMH Gene

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