Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RPS12 Gene

Aliases for RPS12 Gene

  • Ribosomal Protein S12 2 3 5
  • Small Ribosomal Subunit Protein ES12 3 4
  • 40S Ribosomal Protein S12 3
  • S12 3

External Ids for RPS12 Gene

Previous GeneCards Identifiers for RPS12 Gene

  • GC06P132758
  • GC06P132982
  • GC06P133116
  • GC06P133177
  • GC06P130710
  • GC06P133136

Summaries for RPS12 Gene

Entrez Gene Summary for RPS12 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS12 Gene

RPS12 (Ribosomal Protein S12) is a Protein Coding gene. Diseases associated with RPS12 include Robinow Syndrome. Among its related pathways are Viral mRNA Translation and Metabolism. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS12 Gene

Additional gene information for RPS12 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS12 Gene

Genomics for RPS12 Gene

Regulatory Elements for RPS12 Gene

Enhancers for RPS12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H132812 1.5 FANTOM5 ENCODE 27.5 +0.1 140 4 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D SSRP1 ZNF610 RPS12 SLC18B1 SNORA33 VNN1 GC06P132818
GH06H132669 1 Ensembl ENCODE 11.3 -142.5 -142502 4 CTCF FOXA2 MAX RAD21 ZNF366 HNF4G SMC3 ZNF143 ZNF654 L3MBTL2 ENSG00000234484 VNN2 VNN3 SNORA33 RPS12 SNORD100 SNORD101 SLC18B1 VNN1 HLFP1
GH06H132820 0.9 Ensembl ENCODE 10.7 +6.6 6625 0 HNRNPUL1 PAF1 ZNF362 ZBED1 ZNF384 SSRP1 POLR2A IKZF1 MYNN HMBOX1 SLC18B1 RPS12 SNORA33 HMGB1P13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RPS12 on UCSC Golden Path with GeneCards custom track

Promoters for RPS12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000203019 -241 3201 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D SSRP1

Genomic Location for RPS12 Gene

Chromosome:
6
Start:
132,814,441 bp from pter
End:
132,817,564 bp from pter
Size:
3,124 bases
Orientation:
Plus strand

Genomic View for RPS12 Gene

Genes around RPS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS12 Gene

Proteins for RPS12 Gene

  • Protein details for RPS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25398-RS12_HUMAN
    Recommended name:
    40S ribosomal protein S12
    Protein Accession:
    P25398
    Secondary Accessions:
    • Q76M58

    Protein attributes for RPS12 Gene

    Size:
    132 amino acids
    Molecular mass:
    14515 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS12 Gene

neXtProt entry for RPS12 Gene

Post-translational modifications for RPS12 Gene

  • Ubiquitination at isoforms=93, Lys112, and Lys129
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS12 Gene

Domains & Families for RPS12 Gene

Gene Families for RPS12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RPS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25398

UniProtKB/Swiss-Prot:

RS12_HUMAN :
  • Belongs to the eukaryotic ribosomal protein eS12 family.
Family:
  • Belongs to the eukaryotic ribosomal protein eS12 family.
genes like me logo Genes that share domains with RPS12: view

Function for RPS12 Gene

Molecular function for RPS12 Gene

GENATLAS Biochemistry:
60S ribosomal protein S12

Phenotypes From GWAS Catalog for RPS12 Gene

Gene Ontology (GO) - Molecular Function for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with RPS12: view
genes like me logo Genes that share phenotypes with RPS12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS12 Gene

Localization for RPS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RPS12 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RPS12 gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with RPS12: view

Pathways & Interactions for RPS12 Gene

SuperPathways for RPS12 Gene

SuperPathway Contained pathways
1 Viral mRNA Translation
.55
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 rRNA processing in the nucleus and cytosol
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with RPS12: view

Gene Ontology (GO) - Biological Process for RPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006364 rRNA processing TAS --
GO:0006412 translation NAS,IEA 1861993
GO:0006413 translational initiation TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS12: view

No data available for SIGNOR curated interactions for RPS12 Gene

Drugs & Compounds for RPS12 Gene

(4) Drugs for RPS12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RPS12: view

Transcripts for RPS12 Gene

mRNA/cDNA for RPS12 Gene

Unigene Clusters for RPS12 Gene

Ribosomal protein S12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RPS12
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RPS12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6
SP1: -
SP2: - - -
SP3:
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for RPS12 Gene

GeneLoc Exon Structure for
RPS12
ECgene alternative splicing isoforms for
RPS12

Expression for RPS12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RPS12 Gene

Protein differential expression in normal tissues from HIPED for RPS12 Gene

This gene is overexpressed in Amniocyte (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RPS12 Gene



Protein tissue co-expression partners for RPS12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RPS12 Gene:

RPS12

SOURCE GeneReport for Unigene cluster for RPS12 Gene:

Hs.546289

Evidence on tissue expression from TISSUES for RPS12 Gene

  • Liver(4.9)
  • Skin(4.7)
  • Nervous system(4.3)
  • Intestine(3.2)
  • Heart(2.9)
  • Pancreas(2.8)
  • Muscle(2.7)
  • Lymph node(2.6)
  • Spleen(2.6)
  • Bone marrow(2.5)
  • Eye(2.5)
  • Lung(2.5)
  • Stomach(2.4)
  • Adrenal gland(2.3)
  • Gall bladder(2.3)
  • Thyroid gland(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RPS12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RPS12 Gene

Orthologs for RPS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS12 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RPS12 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RPS12 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RPS12 34 33
  • 99.49 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RPS12 33 34
  • 95.71 (n)
cow
(Bos Taurus)
Mammalia RPS12 33
  • 94.44 (n)
-- 34
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rps12 16 34 33
  • 91.41 (n)
rat
(Rattus norvegicus)
Mammalia Rps12 33
  • 91.41 (n)
chicken
(Gallus gallus)
Aves RPS12 34 33
  • 83.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RPS12 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps12 33
  • 86.87 (n)
Str.17155 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68529 33
zebrafish
(Danio rerio)
Actinopterygii rps12 34 33
  • 81.31 (n)
OneToOne
wufa95a02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8526 33
fruit fly
(Drosophila melanogaster)
Insecta RpS12 35 34
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-12 35 33 34
  • 58.06 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS12 33 34 36
  • 55.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR412C 33
  • 55.07 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00352g 33
  • 53.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G15930 33
  • 58.69 (n)
rice
(Oryza sativa)
Liliopsida Os07g0150200 33
  • 62.81 (n)
Os.22993 33
barley
(Hordeum vulgare)
Liliopsida Hv.7997 33
wheat
(Triticum aestivum)
Liliopsida Ta.22961 33
corn
(Zea mays)
Liliopsida Zm.6239 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4620 34
  • 66 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps1201 33
  • 62.06 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06432 33
  • 56.35 (n)
Species where no ortholog for RPS12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS12 Gene

ENSEMBL:
Gene Tree for RPS12 (if available)
TreeFam:
Gene Tree for RPS12 (if available)

Paralogs for RPS12 Gene

No data available for Paralogs for RPS12 Gene

Variants for RPS12 Gene

Sequence variations from dbSNP and Humsavar for RPS12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000421697 -- 132,814,751(+) AACTT(C/T)ACCCG upstream-variant-2KB, utr-variant-5-prime
rs1000519286 -- 132,814,207(+) TGGTG(G/T)GGAAA upstream-variant-2KB
rs1001612348 -- 132,813,329(+) AGCGC(C/T)GGCAC nc-transcript-variant, upstream-variant-2KB
rs1002374186 -- 132,815,044(+) CACGA(G/T)GGCCT upstream-variant-2KB, reference, missense
rs1002516999 -- 132,814,168(+) GGAGG(C/G)TGGGT nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RPS12 Gene

Variant ID Type Subtype PubMed ID
dgv1830e212 CNV loss 25503493
nsv970166 CNV duplication 23825009
nsv970167 CNV duplication 23825009

Variation tolerance for RPS12 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 7.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RPS12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS12 Gene

Disorders for RPS12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RPS12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
robinow syndrome
  • acral dysostosis with facial and genital abnormalities
- elite association - COSMIC cancer census association via MalaCards
Search RPS12 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RPS12

Human Genome Epidemiology (HuGE) Navigator
RPS12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS12
genes like me logo Genes that share disorders with RPS12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RPS12 Gene

Publications for RPS12 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N … Page DC (Genome research 1998) 2 3 4 60
  2. cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17. (PMID: 1861993) Hérault Y … Brun G (Nucleic acids research 1991) 2 3 4 60
  3. The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. (PMID: 11875025) Yoshihama M … Kenmochi N (Genome research 2002) 3 4 60
  4. Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. (PMID: 11870519) Cheng Q … Hui KM (British journal of cancer 2002) 3 22 60
  5. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. (PMID: 8706699) Vladimirov SN … Otto A (European journal of biochemistry 1996) 3 4 60

Products for RPS12 Gene

Sources for RPS12 Gene

Content
Loading form....