Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TNFSF15 Gene

Aliases for TNFSF15 Gene

  • TNF Superfamily Member 15 2 3 5
  • Vascular Endothelial Cell Growth Inhibitor 2 3 4
  • TNF Ligand-Related Molecule 1 2 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 15 2 3
  • Vascular Endothelial Growth Inhibitor-192A 2 3
  • TNF Superfamily Ligand TL1A 2 3
  • VEGI 3 4
  • TL1 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 15 3
  • Tumor Necrosis Factor Superfamily Member 15 3
  • Tumor Necrosis Factor Ligand 1B 3
  • VEGI192A 3
  • TNLG1B 3
  • TL1A 3

External Ids for TNFSF15 Gene

Previous GeneCards Identifiers for TNFSF15 Gene

  • GC09M108349
  • GC09M109283
  • GC09M111005
  • GC09M112927
  • GC09M114632
  • GC09M116591
  • GC09M117551
  • GC09M087156

Summaries for TNFSF15 Gene

Entrez Gene Summary for TNFSF15 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFSF15 Gene

TNFSF15 (TNF Superfamily Member 15) is a Protein Coding gene. Diseases associated with TNFSF15 include Diverticulitis and Primary Biliary Cholangitis. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF14.

UniProtKB/Swiss-Prot for TNFSF15 Gene

  • Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Gene Wiki entry for TNFSF15 Gene

Additional gene information for TNFSF15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF15 Gene

Genomics for TNFSF15 Gene

GeneHancer (GH) Regulatory Elements for TNFSF15 Gene

Promoters and enhancers for TNFSF15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I114803 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 564.7 +0.8 794 4.5 FOXA2 RARA FOS IKZF2 RUNX3 ELK4 RXRA MIER2 REST NR2F2 TNFSF15 DEC1 WHRN ENSG00000274919
GH09I114892 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 34.9 -88.6 -88551 3.5 FOXA2 INSM2 SIN3A BATF BRCA1 ZBTB40 ETS1 RFX5 ELK1 ZNF366 TNFSF15 TNFSF8 ATP6V1G1 WHRN GC09P114903 LOC645266
GH09I114906 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.6 -102.5 -102489 5 PKNOX1 CLOCK FOXA2 NEUROD1 SIN3A ZBTB7B YY1 ELK1 ZNF207 ZNF143 TNFSF15 TNFSF8 ATP6V1G1 WHRN GC09P114903
GH09I114483 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.8 +321.7 321712 2.5 HDGF ATF1 ARNT IRF4 ZNF143 ATF7 FOS RUNX3 DEK NCOA1 WHRN TNFSF15 TNFSF8 ATP6V1G1 LOC100131877 AKNA
GH09I114884 Enhancer 1.3 FANTOM5 Ensembl ENCODE 21.5 -79.0 -78955 1.1 ELF3 FOXA2 SIN3A BMI1 DNMT3B RARA YY1 ATF7 CREM THAP11 TNFSF15 ATP6V1G1 TNFSF8 GC09P114903 LOC645266
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TNFSF15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNFSF15 gene promoter:

Genomic Locations for TNFSF15 Gene

Genomic Locations for TNFSF15 Gene
chr9:114,784,635-114,806,128
(GRCh38/hg38)
Size:
21,494 bases
Orientation:
Minus strand
chr9:117,546,915-117,568,408
(GRCh37/hg19)

Genomic View for TNFSF15 Gene

Genes around TNFSF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFSF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFSF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF15 Gene

Proteins for TNFSF15 Gene

  • Protein details for TNFSF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95150-TNF15_HUMAN
    Recommended name:
    Tumor necrosis factor ligand superfamily member 15
    Protein Accession:
    O95150
    Secondary Accessions:
    • Q3SX69
    • Q5VJK8
    • Q5VWH1
    • Q8NFE9

    Protein attributes for TNFSF15 Gene

    Size:
    251 amino acids
    Molecular mass:
    28087 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for TNFSF15 Gene

    Alternative splice isoforms for TNFSF15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNFSF15 Gene

Post-translational modifications for TNFSF15 Gene

  • Glycosylation at isoforms=2, 3133 and posLast=229229

Other Protein References for TNFSF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Abcam proteins for TNFSF15

No data available for DME Specific Peptides for TNFSF15 Gene

Domains & Families for TNFSF15 Gene

Gene Families for TNFSF15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TNFSF15 Gene

Suggested Antigen Peptide Sequences for TNFSF15 Gene

Graphical View of Domain Structure for InterPro Entry

O95150

UniProtKB/Swiss-Prot:

TNF15_HUMAN :
  • Belongs to the tumor necrosis factor family.
Family:
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF15: view

Function for TNFSF15 Gene

Molecular function for TNFSF15 Gene

GENATLAS Biochemistry:
tumor necrosis factor (ligand) superfamily,member 15,expressed in hematopoietic cells
UniProtKB/Swiss-Prot Function:
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL1A/interleukin-1 alpha and TNF.

Phenotypes From GWAS Catalog for TNFSF15 Gene

Gene Ontology (GO) - Molecular Function for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9434163
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
genes like me logo Genes that share ontologies with TNFSF15: view
genes like me logo Genes that share phenotypes with TNFSF15: view

Human Phenotype Ontology for TNFSF15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TNFSF15 Gene

MGI Knock Outs for TNFSF15:

Animal Model Products

  • Taconic Biosciences Mouse Models for TNFSF15

miRNA for TNFSF15 Gene

miRTarBase miRNAs that target TNFSF15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TNFSF15 Gene

Localization for TNFSF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF15 Gene

Membrane; Single-pass type II membrane protein.
Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNFSF15 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS,IDA --
GO:0005887 integral component of plasma membrane TAS 9872942
genes like me logo Genes that share ontologies with TNFSF15: view

Pathways & Interactions for TNFSF15 Gene

genes like me logo Genes that share pathways with TNFSF15: view

Pathways by source for TNFSF15 Gene

1 Sino Biological pathway for TNFSF15 Gene
1 BioSystems pathway for TNFSF15 Gene
1 KEGG pathway for TNFSF15 Gene
1 GeneGo (Thomson Reuters) pathway for TNFSF15 Gene
1 Qiagen pathway for TNFSF15 Gene
1 Cell Signaling Technology pathway for TNFSF15 Gene

SIGNOR curated interactions for TNFSF15 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TNFSF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 11911831
GO:0006955 immune response IEA --
GO:0007165 signal transduction NAS,IEA 9872942
GO:0007250 activation of NF-kappaB-inducing kinase activity IDA 11911831
genes like me logo Genes that share ontologies with TNFSF15: view

Drugs & Compounds for TNFSF15 Gene

(1) Drugs for TNFSF15 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pomalidomide (CC-4047) Pharma Immunomodulator,antumor/anti-angiogenic 0

(1) ApexBio Compounds for TNFSF15 Gene

Compound Action Cas Number
Pomalidomide (CC-4047) Immunomodulator,antumor/anti-angiogenic 19171-19-8
genes like me logo Genes that share compounds with TNFSF15: view

Drug Products

Transcripts for TNFSF15 Gene

mRNA/cDNA for TNFSF15 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TNFSF15 Gene

Tumor necrosis factor (ligand) superfamily, member 15:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF15 Gene

No ASD Table

Relevant External Links for TNFSF15 Gene

GeneLoc Exon Structure for
TNFSF15
ECgene alternative splicing isoforms for
TNFSF15

Expression for TNFSF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNFSF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TNFSF15 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x5.7), Minor Salivary Gland (x5.6), Prostate (x4.8), Colon - Sigmoid (x4.7), Bladder (x4.3), and Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for TNFSF15 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFSF15 Gene



Protein tissue co-expression partners for TNFSF15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNFSF15 Gene:

TNFSF15

SOURCE GeneReport for Unigene cluster for TNFSF15 Gene:

Hs.23349

mRNA Expression by UniProt/SwissProt for TNFSF15 Gene:

O95150-TNF15_HUMAN
Tissue specificity: Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Evidence on tissue expression from TISSUES for TNFSF15 Gene

  • Blood(2)
  • Intestine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TNFSF15 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • lymphatic
Regions:
Abdomen:
  • biliary tract
  • liver
  • spleen
General:
  • blood
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with TNFSF15: view

Orthologs for TNFSF15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNFSF15 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia TNFSF15 33 34
  • 87.33 (n)
cow
(Bos Taurus)
Mammalia TNFSF15 33 34
  • 86.27 (n)
rat
(Rattus norvegicus)
Mammalia Tnfsf15 33
  • 79.35 (n)
mouse
(Mus musculus)
Mammalia Tnfsf15 33 16 34
  • 78.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TNFSF15 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TNFSF15 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNFSF15 33
  • 63.92 (n)
CHTL1A 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TNFSF15 34
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnfsf15 33
  • 52.43 (n)
Species where no ortholog for TNFSF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TNFSF15 Gene

ENSEMBL:
Gene Tree for TNFSF15 (if available)
TreeFam:
Gene Tree for TNFSF15 (if available)

Paralogs for TNFSF15 Gene

Paralogs for TNFSF15 Gene

genes like me logo Genes that share paralogs with TNFSF15: view

Variants for TNFSF15 Gene

Sequence variations from dbSNP and Humsavar for TNFSF15 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000085413 -- 114,788,000(-) C/T 3_prime_UTR_variant
rs1000105084 -- 114,793,350(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000136502 -- 114,792,999(-) TCTATTAGTTCT/TCT genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000313447 -- 114,805,129(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000470964 -- 114,804,383(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TNFSF15 Gene

Variant ID Type Subtype PubMed ID
nsv831695 CNV gain 17160897

Variation tolerance for TNFSF15 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNFSF15 Gene

Human Gene Mutation Database (HGMD)
TNFSF15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNFSF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF15 Gene

Disorders for TNFSF15 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TNFSF15 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diverticulitis
primary biliary cholangitis
  • pbc
keshan disease
  • caused by deficiency of selenium in the diet
ulcerative colitis
  • left-sided ulcerative colitis
crohn's disease
  • crohn disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TNFSF15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TNFSF15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TNFSF15 Gene

Publications for TNFSF15 Gene

  1. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. (PMID: 19262684) Michelsen KS … Targan SR (PloS one 2009) 3 22 44 58
  2. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. (PMID: 11911831) Migone TS … Wei P (Immunity 2002) 3 4 22 58
  3. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. (PMID: 9434163) Tan KB … Truneh A (Gene 1997) 2 3 4 58
  4. Decoy strategies: the structure of TL1A:DcR3 complex. (PMID: 21300286) Zhan C … Almo SC (Structure (London, England : 1993) 2011) 3 4 58
  5. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 44 58

Products for TNFSF15 Gene

Sources for TNFSF15 Gene

Content
Loading form....