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Aliases for WDR1 Gene

Aliases for WDR1 Gene

  • WD Repeat Domain 1 2 3 5
  • Actin-Interacting Protein 1 3 4
  • NORI-1 3 4
  • AIP1 3 4
  • Epididymis Secretory Protein Li 52 3
  • WD Repeat-Containing Protein 1 3
  • HEL-S-52 3

External Ids for WDR1 Gene

Previous GeneCards Identifiers for WDR1 Gene

  • GC04M009744
  • GC04M010026
  • GC04M009826
  • GC04M009752
  • GC04M009685
  • GC04M009409

Summaries for WDR1 Gene

Entrez Gene Summary for WDR1 Gene

  • This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR1 Gene

WDR1 (WD Repeat Domain 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Hypertrophy Model. Gene Ontology (GO) annotations related to this gene include actin binding.

UniProtKB/Swiss-Prot for WDR1 Gene

  • Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).

Gene Wiki entry for WDR1 Gene

Additional gene information for WDR1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR1 Gene

Genomics for WDR1 Gene

GeneHancer (GH) Regulatory Elements for WDR1 Gene

Promoters and enhancers for WDR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J010114 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 654.5 -2.6 -2630 10.6 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 WDR1 PIR47312 PIR56274 PIR50505 PIR50532 PIR59771 PIR61386 PIR45151 PIR37236 PIR52457
GH04J010179 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.4 -65.7 -65717 6.2 HDGF HNRNPUL1 PKNOX1 SMAD1 ATF1 ARNT NCOA2 TCF12 POLR2B GATA2 ENSG00000261490 SLC2A9 WDR1 LOC105374476 ENSG00000251296 LOC100129344
GH04J010157 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.6 -41.4 -41402 1.7 ARNT RAD21 ARID2 ZNF143 ATF7 CREM ZNF654 NCOA1 REST ZNF148 GC04P012296 PIR51281 LOC105374478 SLC2A9 WDR1 RNA5SP155
GH04J010087 Enhancer 0.7 ENCODE dbSUPER 13.4 +27.8 27815 3.2 CTCF POLR2A ZNF143 ZIC2 RAD21 SLC2A9 WDR1 RNA5SP155 ENSG00000261490 LOC105374476 GC04M010099 MIR3138
GH04J010074 Enhancer 0.7 dbSUPER 12.2 +38.8 38780 7 CTCF RXRA SMAD5 JUN ZMYM3 RAD21 RARA FOSL1 POLR2A IKZF1 MIR3138 SLC2A9 WDR1 RNA5SP155 ENSG00000261490 GC04M010074
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WDR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR1 gene promoter:
  • Olf-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for WDR1 Gene

Genomic Locations for WDR1 Gene
chr4:10,074,339-10,116,949
(GRCh38/hg38)
Size:
42,611 bases
Orientation:
Minus strand
chr4:10,075,963-10,118,573
(GRCh37/hg19)
Size:
42,611 bases
Orientation:
Minus strand

Genomic View for WDR1 Gene

Genes around WDR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR1 Gene

Proteins for WDR1 Gene

  • Protein details for WDR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75083-WDR1_HUMAN
    Recommended name:
    WD repeat-containing protein 1
    Protein Accession:
    O75083
    Secondary Accessions:
    • A8K6E9
    • A8MPU4
    • O75313
    • Q8N6E5
    • Q9UG05
    • Q9UG78
    • Q9UQE0

    Protein attributes for WDR1 Gene

    Size:
    606 amino acids
    Molecular mass:
    66194 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD05045.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR1 Gene

Post-translational modifications for WDR1 Gene

  • Ubiquitination at posLast=489489, posLast=484484, posLast=480480, isoforms=3437, isoforms=3405, posLast=362362, isoforms=3334, isoforms=155, isoforms=126, posLast=9090, posLast=8181, isoforms=338, and posLast=77
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR1 Gene

No data available for DME Specific Peptides for WDR1 Gene

Domains & Families for WDR1 Gene

Gene Families for WDR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O75083

UniProtKB/Swiss-Prot:

WDR1_HUMAN :
  • Belongs to the WD repeat AIP1 family.
Family:
  • Belongs to the WD repeat AIP1 family.
genes like me logo Genes that share domains with WDR1: view

Function for WDR1 Gene

Molecular function for WDR1 Gene

UniProtKB/Swiss-Prot Function:
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).
GENATLAS Biochemistry:
WD repeat domain 1,homolog to a chick gene upregulated in the acoustically chick basilar papilla

Phenotypes From GWAS Catalog for WDR1 Gene

Gene Ontology (GO) - Molecular Function for WDR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IEA --
GO:0051015 actin filament binding IBA,ISS --
genes like me logo Genes that share ontologies with WDR1: view
genes like me logo Genes that share phenotypes with WDR1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR1 Gene

Localization for WDR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR1 Gene

Cytoplasm, cytoskeleton. Cell projection, podosome. Cell junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR1 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IEA --
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with WDR1: view

Pathways & Interactions for WDR1 Gene

genes like me logo Genes that share pathways with WDR1: view

Pathways by source for WDR1 Gene

Gene Ontology (GO) - Biological Process for WDR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002446 neutrophil mediated immunity IEA --
GO:0002576 platelet degranulation TAS --
GO:0007605 sensory perception of sound TAS 10036186
GO:0008360 regulation of cell shape IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with WDR1: view

No data available for SIGNOR curated interactions for WDR1 Gene

Drugs & Compounds for WDR1 Gene

No Compound Related Data Available

Transcripts for WDR1 Gene

mRNA/cDNA for WDR1 Gene

Unigene Clusters for WDR1 Gene

WD repeat domain 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR1 Gene

No ASD Table

Relevant External Links for WDR1 Gene

GeneLoc Exon Structure for
WDR1
ECgene alternative splicing isoforms for
WDR1

Expression for WDR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR1 Gene



Protein tissue co-expression partners for WDR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR1 Gene:

WDR1

SOURCE GeneReport for Unigene cluster for WDR1 Gene:

Hs.128548

Evidence on tissue expression from TISSUES for WDR1 Gene

  • Nervous system(5)
  • Intestine(4.8)
  • Blood(4.6)
  • Eye(4.5)
  • Kidney(4.4)
  • Liver(4.4)
  • Skin(4.4)
  • Lung(4)
  • Pancreas(2.5)
  • Stomach(2.4)
  • Heart(2.3)
  • Muscle(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with WDR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR1 Gene

Orthologs for WDR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR1 34 33
  • 98.9 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR1 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR1 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR1 34 33
  • 89.38 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WDR1 34 33
  • 89.38 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr1 33
  • 88.17 (n)
mouse
(Mus musculus)
Mammalia Wdr1 16 34 33
  • 87.68 (n)
chicken
(Gallus gallus)
Aves WDR1 34 33
  • 77.17 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr1 33
  • 73.76 (n)
Str.11460 33
zebrafish
(Danio rerio)
Actinopterygii wdr1 33
  • 73.73 (n)
WDR1 34
  • 64 (a)
OneToOne
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002509 33
  • 56.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta flr 34 33
  • 56.51 (n)
OneToOne
CG10724 35
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea aipl-1 34 33
  • 48.71 (n)
OneToMany
K08F9.2 35
  • 42 (a)
unc-78 34 35
  • 39 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL043W 33
  • 44.43 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F13750g 33
  • 44.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIP1 36 34 33
  • 43.97 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18060 33
  • 48.96 (n)
rice
(Oryza sativa)
Liliopsida Os01g0125800 33
  • 47.34 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03944 33
  • 49.11 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC9G1.05 33
  • 44.93 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9254 34
  • 38 (a)
OneToOne
Species where no ortholog for WDR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR1 Gene

ENSEMBL:
Gene Tree for WDR1 (if available)
TreeFam:
Gene Tree for WDR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for WDR1: view image

Paralogs for WDR1 Gene

No data available for Paralogs for WDR1 Gene

Variants for WDR1 Gene

Sequence variations from dbSNP and Humsavar for WDR1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000009735 -- 10,090,041(-) G/T intron_variant
rs1000119594 -- 10,115,770(-) G/A/T intron_variant
rs1000165031 -- 10,074,603(-) G/A 3_prime_UTR_variant
rs1000223487 -- 10,088,362(-) A/G coding_sequence_variant, synonymous_variant
rs1000281065 -- 10,117,518(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR1 Gene

Variant ID Type Subtype PubMed ID
dgv5117n100 CNV gain 25217958
esv24360 CNV gain+loss 19812545
esv2752052 CNV gain 17911159
esv2759222 CNV gain+loss 17122850
esv3575678 CNV gain 25503493
esv3599589 CNV gain 21293372
esv3599598 CNV gain 21293372
esv989430 CNV deletion 20482838
nsv1003286 CNV gain 25217958
nsv1005698 CNV gain 25217958
nsv1013487 CNV gain 25217958
nsv1014335 CNV gain 25217958
nsv1074689 CNV deletion 25765185
nsv428438 CNV gain 18775914
nsv469621 CNV loss 16826518
nsv524687 CNV gain 19592680
nsv525589 CNV loss 19592680
nsv829857 CNV gain 17160897

Variation tolerance for WDR1 Gene

Residual Variation Intolerance Score: 7.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR1 Gene

Human Gene Mutation Database (HGMD)
WDR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR1 Gene

Disorders for WDR1 Gene

Additional Disease Information for WDR1

No disorders were found for WDR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR1 Gene

Publications for WDR1 Gene

  1. Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells. (PMID: 18494608) Kato A … Mizuno K (The Biochemical journal 2008) 3 4 22 58
  2. AIP1/WDR1 supports mitotic cell rounding. (PMID: 15629458) Fujibuchi T … Kito K (Biochemical and biophysical research communications 2005) 3 4 22 58
  3. A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein. (PMID: 10036186) Adler HJ … Lomax MI (Genomics 1999) 2 3 4 58
  4. Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions. (PMID: 25792565) Lechuga S … Ivanov AI (American journal of physiology. Gastrointestinal and liver physiology 2015) 3 4 58
  5. Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. (PMID: 18179892) Wallace C … Munroe PB (American journal of human genetics 2008) 3 44 58

Products for WDR1 Gene

Sources for WDR1 Gene

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