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Aliases for UBAP2L Gene

Aliases for UBAP2L Gene

  • Ubiquitin Associated Protein 2 Like 2 3 5
  • Protein NICE-4 3 4
  • NICE4 3 4
  • Ubiquitin-Associated Protein 2-Like 3
  • Ubiquitin Associated Protein 2-Like 2
  • KIAA0144 4
  • NICE-4 3

External Ids for UBAP2L Gene

Previous GeneCards Identifiers for UBAP2L Gene

  • GC01P151006
  • GC01P152459
  • GC01P125556

Summaries for UBAP2L Gene

GeneCards Summary for UBAP2L Gene

UBAP2L (Ubiquitin Associated Protein 2 Like) is a Protein Coding gene. An important paralog of this gene is UBAP2.

UniProtKB/Swiss-Prot for UBAP2L Gene

  • Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).

Gene Wiki entry for UBAP2L Gene

Additional gene information for UBAP2L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAP2L Gene

Genomics for UBAP2L Gene

GeneHancer (GH) Regulatory Elements for UBAP2L Gene

Promoters and enhancers for UBAP2L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J154218 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 673.8 +0.8 764 5 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 NFYC UBAP2L C1orf43 CREB3L4 CHTOP INTS3 THBS3 SLC27A3 KRTCAP2 CRTC2 MIR4258
GH01J154225 Promoter/Enhancer 0.8 EPDnew dbSUPER 650.4 +5.1 5104 0.1 PRDM1 UBAP2L C1orf43 SNORA58B
GH01J154255 Promoter 0.5 EPDnew 650.3 +35.3 35324 0.1 UBAP2L SNORA58B C1orf43
GH01J154257 Promoter 0.5 EPDnew 650.3 +37.1 37115 0.1 UBAP2L SNORA58B C1orf43
GH01J154998 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 101.9 +784.5 784500 11.3 CLOCK MLX YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 ZBTB7B GON4L CLK2 UBAP2L KHDC4 ENSG00000271267 THBS3 RUSC1-AS1 SHC1 MSTO1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UBAP2L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBAP2L gene promoter:
  • E47
  • c-Myc
  • Max1
  • AREB6
  • Hand1
  • Pax-4a

Genomic Locations for UBAP2L Gene

Genomic Locations for UBAP2L Gene
51,560 bases
Plus strand
51,332 bases
Plus strand

Genomic View for UBAP2L Gene

Genes around UBAP2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBAP2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBAP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAP2L Gene

Proteins for UBAP2L Gene

  • Protein details for UBAP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-associated protein 2-like
    Protein Accession:
    Secondary Accessions:
    • B4E0U8
    • Q5VU75
    • Q5VU76
    • Q9BTU3
    • Q9UGL2
    • Q9UGL3
    • Q9UGL4
    • Q9UGL5

    Protein attributes for UBAP2L Gene

    1087 amino acids
    Molecular mass:
    114535 Da
    Quaternary structure:
    • Interacts with BMI1 (PubMed:25185265). Part of a complex consisting of UBAP2L, BMI1 and RNF2(PubMed:25185265).
    • Sequence=CAB65100.2; Type=Frameshift; Positions=1085; Evidence={ECO:0000305};

    Alternative splice isoforms for UBAP2L Gene


neXtProt entry for UBAP2L Gene

Post-translational modifications for UBAP2L Gene

  • Acetylated.
  • Ubiquitination at posLast=976976, isoforms=4970, isoforms=2, 3, 4, 5864, posLast=420420, and posLast=353353
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for UBAP2L
  • Boster Bio Antibodies for UBAP2L

No data available for DME Specific Peptides for UBAP2L Gene

Domains & Families for UBAP2L Gene

Gene Families for UBAP2L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for UBAP2L Gene

Suggested Antigen Peptide Sequences for UBAP2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBAP2L: view

No data available for UniProtKB/Swiss-Prot for UBAP2L Gene

Function for UBAP2L Gene

Molecular function for UBAP2L Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).

Phenotypes From GWAS Catalog for UBAP2L Gene

Gene Ontology (GO) - Molecular Function for UBAP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 19945174
genes like me logo Genes that share ontologies with UBAP2L: view
genes like me logo Genes that share phenotypes with UBAP2L: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBAP2L Gene

Localization for UBAP2L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBAP2L gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBAP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005671 colocalizes_with Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0005737 cytoplasm IBA --
GO:0031519 PcG protein complex IDA 25185265
genes like me logo Genes that share ontologies with UBAP2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBAP2L Gene

Pathways & Interactions for UBAP2L Gene

SuperPathways for UBAP2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBAP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida IMP 19945174
GO:0010628 positive regulation of gene expression IBA --
GO:0061484 hematopoietic stem cell homeostasis IGI 25185265
genes like me logo Genes that share ontologies with UBAP2L: view

No data available for Pathways by source and SIGNOR curated interactions for UBAP2L Gene

Drugs & Compounds for UBAP2L Gene

No Compound Related Data Available

Transcripts for UBAP2L Gene

Unigene Clusters for UBAP2L Gene

Ubiquitin associated protein 2-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a ·
SP1: - - -
SP2: - - - -
SP5: - -
SP6: -
SP8: -

ExUns: 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31a · 31b
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP7: - - - - - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP14: - - - - -
SP16: -

Relevant External Links for UBAP2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBAP2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBAP2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBAP2L Gene

This gene is overexpressed in Bone marrow stromal cell (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UBAP2L Gene

Protein tissue co-expression partners for UBAP2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBAP2L Gene:


SOURCE GeneReport for Unigene cluster for UBAP2L Gene:


mRNA Expression by UniProt/SwissProt for UBAP2L Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for UBAP2L Gene

  • Nervous system(4.7)
  • Skin(4.6)
  • Bone marrow(4.3)
  • Liver(4.3)
  • Lung(3.1)
  • Intestine(2.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with UBAP2L: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBAP2L Gene

Orthologs for UBAP2L Gene

This gene was present in the common ancestor of animals.

Orthologs for UBAP2L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBAP2L 34 33
  • 99.82 (n)
(Canis familiaris)
Mammalia UBAP2L 34
  • 98 (a)
(Bos Taurus)
Mammalia UBAP2L 34 33
  • 96.18 (n)
(Mus musculus)
Mammalia Ubap2l 34
  • 96 (a)
(Monodelphis domestica)
Mammalia UBAP2L 34
  • 96 (a)
(Rattus norvegicus)
Mammalia Atp8b2 33
  • 94.44 (n)
(Gallus gallus)
Aves UBAP2L 34
  • 88 (a)
(Anolis carolinensis)
Reptilia UBAP2L 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubap2l 33
  • 71.46 (n)
Str.5318 33
(Danio rerio)
Actinopterygii ubap2l 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta lig 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1157 34
  • 36 (a)
-- 34
  • 28 (a)
Species where no ortholog for UBAP2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAP2L Gene

Gene Tree for UBAP2L (if available)
Gene Tree for UBAP2L (if available)
Evolutionary constrained regions (ECRs) for UBAP2L: view image

Paralogs for UBAP2L Gene

Paralogs for UBAP2L Gene

(1) SIMAP similar genes for UBAP2L Gene using alignment to 9 proteins:

  • F8W726_HUMAN
  • H0Y5H6_HUMAN
  • H7C2T8_HUMAN
  • Q5VU77_HUMAN
  • Q5VU78_HUMAN
  • Q5VU79_HUMAN
  • Q5VU80_HUMAN
  • Q5VU81_HUMAN
genes like me logo Genes that share paralogs with UBAP2L: view

Variants for UBAP2L Gene

Sequence variations from dbSNP and Humsavar for UBAP2L Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000086133 -- 154,269,193(+) CTCCTCCT/CTCCT genic_downstream_transcript_variant, intron_variant
rs1000152606 -- 154,223,333(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000161222 -- 154,243,601(+) C/G intron_variant
rs1000173291 -- 154,270,776(+) /G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000212624 -- 154,237,302(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBAP2L Gene

Variant ID Type Subtype PubMed ID
esv2672763 CNV deletion 23128226
nsv1143469 CNV deletion 24896259
nsv2954 CNV insertion 18451855
nsv521887 CNV gain 19592680

Variation tolerance for UBAP2L Gene

Residual Variation Intolerance Score: 2.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBAP2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBAP2L Gene

Disorders for UBAP2L Gene

Additional Disease Information for UBAP2L

No disorders were found for UBAP2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBAP2L Gene

Publications for UBAP2L Gene

  1. Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I … Mischke D (Genome research 2001) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 58
  3. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. (PMID: 25185265) Bordeleau ME … Sauvageau G (Blood 2014) 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58

Products for UBAP2L Gene

Sources for UBAP2L Gene

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