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Aliases for TOMM70 Gene

Aliases for TOMM70 Gene

  • Translocase Of Outer Mitochondrial Membrane 70 2 3 5
  • Translocase Of Outer Mitochondrial Membrane Protein 70 3 4
  • Mitochondrial Precursor Proteins Import Receptor 3 4
  • Translocase Of Outer Membrane 70 KDa Subunit 3 4
  • TOMM70A 3 4
  • Translocase Of Outer Mitochondrial Membrane 70 Homolog A (S. Cerevisiae) 2
  • Translocase Of Outer Mitochondrial Membrane 70 (Yeast) Homolog A 2
  • Translocase Of Outer Mitochondrial Membrane 70 Homolog A (Yeast) 2
  • Translocase Of Outer Mitochondrial Membrane 70 Homolog A 3
  • Mitochondrial Import Receptor Subunit TOM70 3
  • KIAA0719 4
  • Tom70 3
  • TOM70 4

External Ids for TOMM70 Gene

Previous HGNC Symbols for TOMM70 Gene

  • TOMM70A

Summaries for TOMM70 Gene

Entrez Gene Summary for TOMM70 Gene

  • This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]

GeneCards Summary for TOMM70 Gene

TOMM70 (Translocase Of Outer Mitochondrial Membrane 70) is a Protein Coding gene. Among its related pathways are Pink/Parkin Mediated Mitophagy and Metabolism of proteins. An important paralog of this gene is SPAG1.

UniProtKB/Swiss-Prot for TOMM70 Gene

  • Receptor that accelerates the import of all mitochondrial precursor proteins.

Gene Wiki entry for TOMM70 Gene

Additional gene information for TOMM70 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TOMM70 Gene

Genomics for TOMM70 Gene

GeneHancer (GH) Regulatory Elements for TOMM70 Gene

Promoters and enhancers for TOMM70 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J100399 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 658.5 -0.4 -442 4.9 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 POLR2B LNP1 TOMM70 PIR48705 TBC1D23 TFG GC03P100464
GH03J100333 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.2 +66.0 66003 3.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 NIT2 LNP1 TOMM70 TBC1D23
GH03J100590 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 -189.3 -189282 0.6 ELF3 CTCF CEBPG RAD21 RFX5 ZNF366 ZNF143 SMC3 ZNF444 BCLAF1 GC03P100589 TOMM70 LNP1 TMEM45A ADGRG7 GC03M100588
GH03J100591 Enhancer 0.8 ENCODE dbSUPER 11 -190.2 -190237 1.1 CTCF SP1 GATA3 FOXA2 RXRA ZNF843 RAD21 YY1 TFG LNP1 TOMM70 TMEM45A GC03P100589 ADGRG7 GC03M100588
GH03J100608 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 5.8 -211.1 -211054 7.2 HDAC1 FOXA2 RAD21 RARA YY1 TCF12 ZNF366 EGR2 RXRA REST ADGRG7 TFG ENSG00000252989 TOMM70 TMEM45A LNP1 GC03M100588
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TOMM70 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TOMM70 Gene

Genomic Locations for TOMM70 Gene
chr3:100,363,431-100,401,398
(GRCh38/hg38)
Size:
37,968 bases
Orientation:
Minus strand
chr3:100,082,275-100,120,242
(GRCh37/hg19)
Size:
37,968 bases
Orientation:
Minus strand

Genomic View for TOMM70 Gene

Genes around TOMM70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TOMM70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TOMM70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TOMM70 Gene

Proteins for TOMM70 Gene

  • Protein details for TOMM70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94826-TOM70_HUMAN
    Recommended name:
    Mitochondrial import receptor subunit TOM70
    Protein Accession:
    O94826
    Secondary Accessions:
    • D3DN48

    Protein attributes for TOMM70 Gene

    Size:
    608 amino acids
    Molecular mass:
    67455 Da
    Quaternary structure:
    • Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with CAPN8 (By similarity).
    SequenceCaution:
    • Sequence=BAA34439.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TOMM70 Gene

Post-translational modifications for TOMM70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TOMM70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TOMM70 Gene

Domains & Families for TOMM70 Gene

Protein Domains for TOMM70 Gene

Suggested Antigen Peptide Sequences for TOMM70 Gene

Graphical View of Domain Structure for InterPro Entry

O94826

UniProtKB/Swiss-Prot:

TOM70_HUMAN :
  • Belongs to the Tom70 family.
Family:
  • Belongs to the Tom70 family.
genes like me logo Genes that share domains with TOMM70: view

Function for TOMM70 Gene

Molecular function for TOMM70 Gene

UniProtKB/Swiss-Prot Function:
Receptor that accelerates the import of all mitochondrial precursor proteins.

Gene Ontology (GO) - Molecular Function for TOMM70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12526792
GO:0008320 protein transmembrane transporter activity TAS 15644312
genes like me logo Genes that share ontologies with TOMM70: view
genes like me logo Genes that share phenotypes with TOMM70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOMM70

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TOMM70 Gene

Localization for TOMM70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TOMM70 Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TOMM70 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 3
endoplasmic reticulum 2
plasma membrane 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TOMM70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IDA,IEA 20531390
GO:0005741 mitochondrial outer membrane TAS --
GO:0005742 mitochondrial outer membrane translocase complex TAS 15644312
GO:0016020 membrane IEA,HDA 19946888
genes like me logo Genes that share ontologies with TOMM70: view

Pathways & Interactions for TOMM70 Gene

genes like me logo Genes that share pathways with TOMM70: view

Gene Ontology (GO) - Biological Process for TOMM70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IBA --
GO:0006626 protein targeting to mitochondrion TAS 15644312
GO:0016236 macroautophagy TAS --
GO:0071806 protein transmembrane transport IEA --
genes like me logo Genes that share ontologies with TOMM70: view

No data available for SIGNOR curated interactions for TOMM70 Gene

Drugs & Compounds for TOMM70 Gene

No Compound Related Data Available

Transcripts for TOMM70 Gene

mRNA/cDNA for TOMM70 Gene

(1) REFSEQ mRNAs :
(318) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TOMM70

Alternative Splicing Database (ASD) splice patterns (SP) for TOMM70 Gene

No ASD Table

Relevant External Links for TOMM70 Gene

GeneLoc Exon Structure for
TOMM70
ECgene alternative splicing isoforms for
TOMM70

Expression for TOMM70 Gene

NURSA nuclear receptor signaling pathways regulating expression of TOMM70 Gene:

TOMM70

Evidence on tissue expression from TISSUES for TOMM70 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Blood(4.2)
  • Skin(4.2)
  • Heart(2.5)
  • Muscle(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TOMM70 Gene

Orthologs for TOMM70 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TOMM70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TOMM70A 34 33
  • 99.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TOMM70A 34 33
  • 93.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TOMM70A 34 33
  • 93.48 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TOMM70A 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TOMM70A 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tomm70a 33
  • 88.96 (n)
mouse
(Mus musculus)
Mammalia Tomm70a 16 34 33
  • 88.6 (n)
chicken
(Gallus gallus)
Aves TOMM70A 34 33
  • 82.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TOMM70A 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tomm70a 33
  • 76.47 (n)
Str.2314 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68780 33
zebrafish
(Danio rerio)
Actinopterygii tomm70a 34 33
  • 73.3 (n)
OneToOne
wufj58b04 33
fruit fly
(Drosophila melanogaster)
Insecta Tom70 34 33
  • 50.28 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009497 33
  • 49.91 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24046g 33
  • 45.99 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM70 36 34 33
  • 44.3 (n)
TOM71 34
  • 15 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR131W 33
  • 41.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1056 34
  • 49 (a)
OneToOne
Cin.4827 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tom70 33
  • 47.2 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04245 33
  • 44.29 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4827 33
Species where no ortholog for TOMM70 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TOMM70 Gene

ENSEMBL:
Gene Tree for TOMM70 (if available)
TreeFam:
Gene Tree for TOMM70 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TOMM70: view image

Paralogs for TOMM70 Gene

Paralogs for TOMM70 Gene

genes like me logo Genes that share paralogs with TOMM70: view

Variants for TOMM70 Gene

Sequence variations from dbSNP and Humsavar for TOMM70 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000111890 -- 100,388,461(-) G/A intron_variant
rs1000165746 -- 100,388,491(-) C/A intron_variant
rs1000243281 -- 100,367,773(-) T/C intron_variant
rs1000431382 -- 100,395,489(-) G/A intron_variant
rs1000521171 -- 100,400,805(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TOMM70 Gene

Variant ID Type Subtype PubMed ID
esv2725694 CNV deletion 23290073
esv3309821 CNV mobile element insertion 20981092
esv3429571 CNV insertion 20981092

Variation tolerance for TOMM70 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TOMM70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TOMM70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TOMM70 Gene

Disorders for TOMM70 Gene

Additional Disease Information for TOMM70

No disorders were found for TOMM70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TOMM70 Gene

Publications for TOMM70 Gene

  1. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. (PMID: 10582581) Alvarez-Dolado M … Muñoz A (Journal of neurochemistry 1999) 2 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Characterization of a human import component of the mitochondrial outer membrane, TOMM70A. (PMID: 12200962) Edmonson AM … Argyropoulos G (Cell communication & adhesion 2002) 3 22 58
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58

Products for TOMM70 Gene

Sources for TOMM70 Gene

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