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Aliases for SPATA2 Gene

Aliases for SPATA2 Gene

  • Spermatogenesis Associated 2 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 145 2 3
  • Spermatogenesis-Associated Protein PD1 3 4
  • PD1 3 4
  • Spermatogenesis-Associated Protein 2 3
  • Spermatogenesis Associated PD1 3
  • PPP1R145 3
  • KIAA0757 4
  • Tamo 3

External Ids for SPATA2 Gene

Previous GeneCards Identifiers for SPATA2 Gene

  • GC20M048248
  • GC20M049158
  • GC20M049205
  • GC20M047953
  • GC20M048519
  • GC20M045269

Summaries for SPATA2 Gene

GeneCards Summary for SPATA2 Gene

SPATA2 (Spermatogenesis Associated 2) is a Protein Coding gene. Among its related pathways are Necroptosis. An important paralog of this gene is SPATA2L.

UniProtKB/Swiss-Prot for SPATA2 Gene

  • May have a role in the regulation of spermatogenesis.

Gene Wiki entry for SPATA2 Gene

Additional gene information for SPATA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPATA2 Gene

Genomics for SPATA2 Gene

GeneHancer (GH) Regulatory Elements for SPATA2 Gene

Promoters and enhancers for SPATA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J049914 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 680.4 -1.0 -1019 4.9 MLX YBX1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 MEF2D ZNF610 SPATA2 LOC105372653 DDX27 SLC9A8 ENSG00000232043 RNF114 PSMD10P1 LINC01273 CSE1L SNORD12B
GH20J049913 Enhancer 0.6 ENCODE dbSUPER 650.7 +1.7 1704 0.2 ZNF362 REST ATF2 LOC105372653 SPATA2 SLC9A8 PIR47085
GH20J049934 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 27.3 -21.5 -21493 4.7 HDGF PKNOX1 ARNT ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZNF2 ZBTB7B RNF114 DDX27 ADNP PSMD10P1 SPATA2 ENSG00000232043 SLC9A8 CEBPB SNAI1 PIR42769
GH20J049810 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.3 +102.5 102514 4.5 HDGF PKNOX1 CLOCK SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 SLC9A8 DDX27 ENSG00000232043 RNF114 SPATA2 ARFGEF2 RNU7-72P
GH20J049945 Enhancer 1.1 ENCODE dbSUPER 35.2 -30.6 -30572 1.6 ELF3 FOXA2 MLX ARID4B THRB ZNF48 ZSCAN9 RARA ZNF614 ZFP91 SPATA2 RNU6-147P ENSG00000199490 SNAI1 RNF114 PIR42769 GC20M049939
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SPATA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPATA2 gene promoter:
  • CREB
  • deltaCREB
  • p53

Genomic Locations for SPATA2 Gene

Genomic Locations for SPATA2 Gene
chr20:49,903,391-49,915,543
(GRCh38/hg38)
Size:
12,153 bases
Orientation:
Minus strand
chr20:48,519,928-48,532,080
(GRCh37/hg19)
Size:
12,153 bases
Orientation:
Minus strand

Genomic View for SPATA2 Gene

Genes around SPATA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPATA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPATA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPATA2 Gene

Proteins for SPATA2 Gene

  • Protein details for SPATA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM82-SPAT2_HUMAN
    Recommended name:
    Spermatogenesis-associated protein 2
    Protein Accession:
    Q9UM82
    Secondary Accessions:
    • E1P626
    • O94857

    Protein attributes for SPATA2 Gene

    Size:
    520 amino acids
    Molecular mass:
    58427 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34477.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPATA2 Gene

neXtProt entry for SPATA2 Gene

Post-translational modifications for SPATA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPATA2 Gene

No data available for DME Specific Peptides for SPATA2 Gene

Domains & Families for SPATA2 Gene

Gene Families for SPATA2 Gene

Protein Domains for SPATA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPATA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UM82

UniProtKB/Swiss-Prot:

SPAT2_HUMAN :
  • Belongs to the SPATA2 family.
Family:
  • Belongs to the SPATA2 family.
genes like me logo Genes that share domains with SPATA2: view

Function for SPATA2 Gene

Molecular function for SPATA2 Gene

UniProtKB/Swiss-Prot Function:
May have a role in the regulation of spermatogenesis.

Phenotypes From GWAS Catalog for SPATA2 Gene

Gene Ontology (GO) - Molecular Function for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPATA2: view
genes like me logo Genes that share phenotypes with SPATA2: view

Animal Models for SPATA2 Gene

MGI Knock Outs for SPATA2:
  • Spata2 Spata2<tm1(KOMP)Vlcg>

Animal Model Products

miRNA for SPATA2 Gene

miRTarBase miRNAs that target SPATA2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPATA2 Gene

Localization for SPATA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPATA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPATA2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA 10222154
genes like me logo Genes that share ontologies with SPATA2: view

Pathways & Interactions for SPATA2 Gene

SuperPathways for SPATA2 Gene

SuperPathway Contained pathways
1 Necroptosis
genes like me logo Genes that share pathways with SPATA2: view

Pathways by source for SPATA2 Gene

1 KEGG pathway for SPATA2 Gene

Gene Ontology (GO) - Biological Process for SPATA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis NAS 10222154
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SPATA2: view

No data available for SIGNOR curated interactions for SPATA2 Gene

Drugs & Compounds for SPATA2 Gene

No Compound Related Data Available

Transcripts for SPATA2 Gene

mRNA/cDNA for SPATA2 Gene

Unigene Clusters for SPATA2 Gene

Spermatogenesis associated 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPATA2 Gene

No ASD Table

Relevant External Links for SPATA2 Gene

GeneLoc Exon Structure for
SPATA2
ECgene alternative splicing isoforms for
SPATA2

Expression for SPATA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPATA2 Gene

Protein differential expression in normal tissues from HIPED for SPATA2 Gene

This gene is overexpressed in Brain (48.3) and Frontal cortex (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SPATA2 Gene



Protein tissue co-expression partners for SPATA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPATA2 Gene:

SPATA2

SOURCE GeneReport for Unigene cluster for SPATA2 Gene:

Hs.48513

mRNA Expression by UniProt/SwissProt for SPATA2 Gene:

Q9UM82-SPAT2_HUMAN
Tissue specificity: Highly expressed in Sertoli cells, but not detected in spermatogenic cells. Low expression in spleen, thymus and prostate.

Evidence on tissue expression from TISSUES for SPATA2 Gene

  • Nervous system(4.7)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with SPATA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPATA2 Gene

Orthologs for SPATA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPATA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPATA2 34 33
  • 99.62 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SPATA2 34 33
  • 89.49 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SPATA2 34 33
  • 85.31 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spata2 33
  • 85.26 (n)
mouse
(Mus musculus)
Mammalia Spata2 16 34 33
  • 85.21 (n)
oppossum
(Monodelphis domestica)
Mammalia SPATA2 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPATA2 34 33
  • 65.88 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPATA2 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spata2 33
  • 64.04 (n)
Str.7351 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64409 33
zebrafish
(Danio rerio)
Actinopterygii spata2 34 33
  • 55.33 (n)
OneToOne
Species where no ortholog for SPATA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPATA2 Gene

ENSEMBL:
Gene Tree for SPATA2 (if available)
TreeFam:
Gene Tree for SPATA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SPATA2: view image

Paralogs for SPATA2 Gene

Paralogs for SPATA2 Gene

Pseudogenes.org Pseudogenes for SPATA2 Gene

genes like me logo Genes that share paralogs with SPATA2: view

Variants for SPATA2 Gene

Sequence variations from dbSNP and Humsavar for SPATA2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000364560 -- 49,904,839(-) TATTTATTTA/TATTTA 3_prime_UTR_variant
rs1000421471 -- 49,904,720(-) G/A 3_prime_UTR_variant
rs1000511776 -- 49,914,707(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000614847 -- 49,915,538(-) C/A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000972951 -- 49,905,895(-) C/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for SPATA2 Gene

Variant ID Type Subtype PubMed ID
esv2722492 CNV deletion 23290073

Variation tolerance for SPATA2 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.34; 70.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPATA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPATA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPATA2 Gene

Disorders for SPATA2 Gene

Additional Disease Information for SPATA2

No disorders were found for SPATA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPATA2 Gene

Publications for SPATA2 Gene

  1. Genome-wide association analysis identifies three psoriasis susceptibility loci. (PMID: 20953189) Stuart PE … Elder JT (Nature genetics 2010) 3 44 58
  2. Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. (PMID: 18364390) Capon F … Trembath RC (Human molecular genetics 2008) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. cDNA cloning and characterization of PD1: a novel human testicular protein with different expressions in various testiculopathies. (PMID: 10222154) Graziotto R … Onisto M (Experimental cell research 1999) 3 4 58

Products for SPATA2 Gene

Sources for SPATA2 Gene

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