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Aliases for DLGAP5 Gene

Aliases for DLGAP5 Gene

  • DLG Associated Protein 5 2 3 5
  • Discs Large Homolog Associated Protein 5 2 3
  • Disks Large-Associated Protein DLG7 3 4
  • Hepatoma Up-Regulated Protein 3 4
  • DAP-5 3 4
  • DLG7 3 4
  • HURP 3 4
  • Discs, Large (Drosophila) Homolog-Associated Protein 5 2
  • Discs, Large Homolog 7 (Drosophila) 2
  • Disks Large-Associated Protein 5 3
  • Discs, Large Homolog 7 3
  • Discs Large Homolog 7 4
  • KIAA0008 4

External Ids for DLGAP5 Gene

Previous HGNC Symbols for DLGAP5 Gene

  • DLG7

Previous GeneCards Identifiers for DLGAP5 Gene

  • GC14M054685
  • GC14M055614
  • GC14M035777

Summaries for DLGAP5 Gene

GeneCards Summary for DLGAP5 Gene

DLGAP5 (DLG Associated Protein 5) is a Protein Coding gene. Among its related pathways are Aurora A signaling. Gene Ontology (GO) annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is DLGAP2.

UniProtKB/Swiss-Prot for DLGAP5 Gene

  • Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Gene Wiki entry for DLGAP5 Gene

Additional gene information for DLGAP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLGAP5 Gene

Genomics for DLGAP5 Gene

GeneHancer (GH) Regulatory Elements for DLGAP5 Gene

Promoters and enhancers for DLGAP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J055189 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.8 827 3.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FOS DLGAP5 LOC105370508 FBXO34 MAPK1IP1L LOC105370509 ATG14 GCH1 LGALS3 GC14M054989
GH14J055113 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.8 +67.7 67695 21.7 PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF766 FOS LGALS3 LOC105370509 GCH1 FBXO34 DLGAP5 ATG14 ENSG00000259318 MAPK1IP1L GC14M055059 GC14M055058
GH14J055097 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +88.3 88274 12.7 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 MEF2D GLIS1 LGALS3 LOC105370509 MAPK1IP1L ATG14 SOCS4 GCH1 DLGAP5 FBXO34 ENSG00000259318 GC14M055059
GH14J055135 Enhancer 1 Ensembl ENCODE dbSUPER 11.7 +54.5 54485 2.7 MEIS2 CTCF PKNOX1 TAL1 CBFA2T3 RAD21 JUND ZNF143 KDM1A PRDM1 LOC105370509 DLGAP5 LGALS3 GC14M054989
GH14J055373 Enhancer 1 FANTOM5 Ensembl ENCODE 10.6 -182.6 -182591 1.9 FOSL1 JUND NFATC1 IKZF1 FOS ATF7 RUNX3 IKZF2 LOC105370509 DLGAP5 ATG14 FBXO34 MAPK1IP1L PIR34697 PIR35307 GC14M054989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DLGAP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DLGAP5 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • IRF-2
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • STAT5B
  • CBF(2)

Genomic Locations for DLGAP5 Gene

Genomic Locations for DLGAP5 Gene
chr14:55,148,112-55,191,678
(GRCh38/hg38)
Size:
43,567 bases
Orientation:
Minus strand
chr14:55,614,830-55,658,396
(GRCh37/hg19)
Size:
43,567 bases
Orientation:
Minus strand

Genomic View for DLGAP5 Gene

Genes around DLGAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DLGAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DLGAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLGAP5 Gene

Proteins for DLGAP5 Gene

  • Protein details for DLGAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15398-DLGP5_HUMAN
    Recommended name:
    Disks large-associated protein 5
    Protein Accession:
    Q15398
    Secondary Accessions:
    • A8MTM6
    • B4DRM8
    • Q86T11
    • Q8NG58

    Protein attributes for DLGAP5 Gene

    Size:
    846 amino acids
    Molecular mass:
    95115 Da
    Quaternary structure:
    • Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.
    SequenceCaution:
    • Sequence=BAA02797.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62583.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DLGAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DLGAP5 Gene

Post-translational modifications for DLGAP5 Gene

  • Ubiquitinated, leading to its degradation.
  • Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DLGAP5 Gene

No data available for DME Specific Peptides for DLGAP5 Gene

Domains & Families for DLGAP5 Gene

Gene Families for DLGAP5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for DLGAP5 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DLGAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15398

UniProtKB/Swiss-Prot:

DLGP5_HUMAN :
  • Belongs to the SAPAP family.
Family:
  • Belongs to the SAPAP family.
genes like me logo Genes that share domains with DLGAP5: view

Function for DLGAP5 Gene

Molecular function for DLGAP5 Gene

UniProtKB/Swiss-Prot Function:
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Phenotypes From GWAS Catalog for DLGAP5 Gene

Gene Ontology (GO) - Molecular Function for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity ISS --
GO:0005515 protein binding IPI 15145941
genes like me logo Genes that share ontologies with DLGAP5: view
genes like me logo Genes that share phenotypes with DLGAP5: view

Animal Models for DLGAP5 Gene

MGI Knock Outs for DLGAP5:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DLGAP5 Gene

Localization for DLGAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLGAP5 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DLGAP5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0005815 microtubule organizing center IDA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with DLGAP5: view

Pathways & Interactions for DLGAP5 Gene

SuperPathways for DLGAP5 Gene

SuperPathway Contained pathways
1 Aurora A signaling
genes like me logo Genes that share pathways with DLGAP5: view

Pathways by source for DLGAP5 Gene

1 BioSystems pathway for DLGAP5 Gene

Gene Ontology (GO) - Biological Process for DLGAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007079 mitotic chromosome movement towards spindle pole NAS 12527899
GO:0007221 positive regulation of transcription of Notch receptor target TAS --
GO:0008283 cell proliferation NAS 12527899
genes like me logo Genes that share ontologies with DLGAP5: view

No data available for SIGNOR curated interactions for DLGAP5 Gene

Drugs & Compounds for DLGAP5 Gene

(1) Additional Compounds for DLGAP5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DLGAP5: view

Transcripts for DLGAP5 Gene

mRNA/cDNA for DLGAP5 Gene

Unigene Clusters for DLGAP5 Gene

Discs, large (Drosophila) homolog-associated protein 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLGAP5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
SP1: -
SP2:
SP3: - - - -
SP4:
SP5:
SP6:

ExUns: 20 ^ 21a · 21b · 21c
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for DLGAP5 Gene

GeneLoc Exon Structure for
DLGAP5
ECgene alternative splicing isoforms for
DLGAP5

Expression for DLGAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DLGAP5 Gene

mRNA differential expression in normal tissues according to GTEx for DLGAP5 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for DLGAP5 Gene

This gene is overexpressed in Testis (28.1), Plasma (24.7), and Heart (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DLGAP5 Gene



Protein tissue co-expression partners for DLGAP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DLGAP5 Gene:

DLGAP5

SOURCE GeneReport for Unigene cluster for DLGAP5 Gene:

Hs.77695

mRNA Expression by UniProt/SwissProt for DLGAP5 Gene:

Q15398-DLGP5_HUMAN
Tissue specificity: Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.

Evidence on tissue expression from TISSUES for DLGAP5 Gene

  • Blood(4.2)
  • Bone marrow(4.2)
  • Lung(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with DLGAP5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DLGAP5 Gene

Orthologs for DLGAP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLGAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DLGAP5 34 33
  • 99.29 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DLGAP5 34 33
  • 87.54 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DLGAP5 34 33
  • 85.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dlgap5 16 34 33
  • 72.13 (n)
rat
(Rattus norvegicus)
Mammalia Dlgap5 33
  • 71 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
OneToMany
-- 34
  • 49 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DLGAP5 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves DLGAP5 34 33
  • 56.72 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DLGAP5 34
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.531 33
zebrafish
(Danio rerio)
Actinopterygii dlgap5 34 33
  • 48.78 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mars 34
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1632 34
  • 28 (a)
OneToOne
Species where no ortholog for DLGAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLGAP5 Gene

ENSEMBL:
Gene Tree for DLGAP5 (if available)
TreeFam:
Gene Tree for DLGAP5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DLGAP5: view image

Paralogs for DLGAP5 Gene

Paralogs for DLGAP5 Gene

Pseudogenes.org Pseudogenes for DLGAP5 Gene

genes like me logo Genes that share paralogs with DLGAP5: view

Variants for DLGAP5 Gene

Sequence variations from dbSNP and Humsavar for DLGAP5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000024557 -- 55,155,829(-) C/T intron_variant
rs1000158824 -- 55,159,318(-) AAGAA/AA intron_variant
rs1000176051 -- 55,153,268(-) C/T intron_variant
rs1000180046 -- 55,162,353(-) C/T intron_variant
rs1000211073 -- 55,162,520(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DLGAP5 Gene

Variant ID Type Subtype PubMed ID
esv2673073 CNV deletion 23128226
esv3584459 CNV gain 25503493
esv3634572 CNV loss 21293372
esv3634573 CNV gain 21293372
esv3634575 CNV gain 21293372
nsv1035158 CNV gain 25217958
nsv1113654 CNV deletion 24896259
nsv474886 CNV novel sequence insertion 20440878

Variation tolerance for DLGAP5 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.22; 95.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DLGAP5 Gene

Human Gene Mutation Database (HGMD)
DLGAP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DLGAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLGAP5 Gene

Disorders for DLGAP5 Gene

Additional Disease Information for DLGAP5

No disorders were found for DLGAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DLGAP5 Gene

Publications for DLGAP5 Gene

  1. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. (PMID: 15987997) Yu CT … Huang CY (Molecular and cellular biology 2005) 3 4 22 58
  2. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. (PMID: 15145941) Hsu JM … Huang CY (The Journal of biological chemistry 2004) 3 4 22 58
  3. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. (PMID: 12527899) Tsou AP … Chou CK (Oncogene 2003) 3 4 22 58
  4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 2 3 4 58
  5. Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene. (PMID: 17322106) Gudmundsson KO … Rafnar T (Stem cells (Dayton, Ohio) 2007) 3 22 58

Products for DLGAP5 Gene

Sources for DLGAP5 Gene

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