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Aliases for RASSF2 Gene

Aliases for RASSF2 Gene

  • Ras Association Domain Family Member 2 2 3 5
  • Ras Association (RalGDS/AF-6) Domain Family Member 2 2 3
  • Centromere Protein 34 2 3
  • CENP-34 3 4
  • Ras Association (RalGDS/AF-6) Domain Family 2 3
  • Ras Association Domain-Containing Protein 2 3
  • KIAA0168 4

External Ids for RASSF2 Gene

Previous GeneCards Identifiers for RASSF2 Gene

  • GC20M004748
  • GC20M004755
  • GC20M004708

Summaries for RASSF2 Gene

Entrez Gene Summary for RASSF2 Gene

  • This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for RASSF2 Gene

RASSF2 (Ras Association Domain Family Member 2) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway - multiple species. An important paralog of this gene is RASSF4.

UniProtKB/Swiss-Prot for RASSF2 Gene

  • Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Gene Wiki entry for RASSF2 Gene

Additional gene information for RASSF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RASSF2 Gene

Genomics for RASSF2 Gene

GeneHancer (GH) Regulatory Elements for RASSF2 Gene

Promoters and enhancers for RASSF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J004808 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 676.4 +11.1 11096 8 HDGF PKNOX1 IRF4 ZNF48 ATF7 FOS RUNX3 JUNB REST ZNF592 RASSF2 PRNT LOC100421361 CDS2 SLC23A2 LOC105372511
GH20J004820 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 655.5 +0.8 829 5 HDGF PKNOX1 SIN3A FEZF1 ZNF121 GLIS2 ZNF213 ZNF143 ATF7 RUNX3 RASSF2 LOC105372511
GH20J004828 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -6.0 -5996 2.1 CTCF PKNOX1 HLF MAX FEZF1 REST PRDM6 ZNF692 POLR2A CEBPA RASSF2 CDS2 SLC23A2 ENSG00000252096
GH20J004760 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +62.6 62557 1.8 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ARID2 ZNF207 ZNF143 FOS ENSG00000278595 PRNT RASSF2 TMEM230 SLC23A2 PRNP
GH20J004961 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -138.4 -138369 1.6 ATF1 FOXA2 MLX ZFP64 ARID4B DMAP1 ETS1 YY1 SLC30A9 ATF7 MCM8 RASSF2 LOC100421361 PRNT TMEM230 PRND CDS2 SLC23A2 GC20M004944
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RASSF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RASSF2 gene promoter:
  • SRY
  • IRF-1
  • NF-AT4
  • NF-AT
  • NF-AT1
  • NF-AT2

Genomic Locations for RASSF2 Gene

Genomic Locations for RASSF2 Gene
43,623 bases
Minus strand
43,623 bases
Minus strand

Genomic View for RASSF2 Gene

Genes around RASSF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RASSF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RASSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RASSF2 Gene

Proteins for RASSF2 Gene

  • Protein details for RASSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras association domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A6NIX9
    • A8K5Z3
    • Q17S06
    • Q53HD0
    • Q6AHZ2
    • Q8IZA5

    Protein attributes for RASSF2 Gene

    326 amino acids
    Molecular mass:
    37790 Da
    Quaternary structure:
    • Interacts directly with activated KRAS in a GTP-dependent manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.
    • Sequence=BAA11485.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RASSF2 Gene


neXtProt entry for RASSF2 Gene

Post-translational modifications for RASSF2 Gene

Antibody Products

  • Abcam antibodies for RASSF2
  • Santa Cruz Biotechnology (SCBT) Antibodies for RASSF2

No data available for DME Specific Peptides for RASSF2 Gene

Domains & Families for RASSF2 Gene

Gene Families for RASSF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RASSF2 Gene

Suggested Antigen Peptide Sequences for RASSF2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RASSF2: view

No data available for UniProtKB/Swiss-Prot for RASSF2 Gene

Function for RASSF2 Gene

Molecular function for RASSF2 Gene

UniProtKB/Swiss-Prot Function:
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

Phenotypes From GWAS Catalog for RASSF2 Gene

Gene Ontology (GO) - Molecular Function for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IGI 19962960
GO:0005515 protein binding IPI 12732644
genes like me logo Genes that share ontologies with RASSF2: view
genes like me logo Genes that share phenotypes with RASSF2: view

Animal Models for RASSF2 Gene

MGI Knock Outs for RASSF2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RASSF2 Gene

Localization for RASSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RASSF2 Gene

Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RASSF2 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA,IEA 20813266
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA 19525978
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with RASSF2: view

Pathways & Interactions for RASSF2 Gene

genes like me logo Genes that share pathways with RASSF2: view

Pathways by source for RASSF2 Gene

1 KEGG pathway for RASSF2 Gene

Gene Ontology (GO) - Biological Process for RASSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001503 ossification IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RASSF2: view

No data available for SIGNOR curated interactions for RASSF2 Gene

Drugs & Compounds for RASSF2 Gene

(1) Drugs for RASSF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RASSF2: view

Transcripts for RASSF2 Gene

mRNA/cDNA for RASSF2 Gene

Unigene Clusters for RASSF2 Gene

Ras association (RalGDS/AF-6) domain family member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RASSF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP8: - - -
SP9: - -
SP10: -

Relevant External Links for RASSF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RASSF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RASSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RASSF2 Gene

This gene is overexpressed in Whole Blood (x11.0), Brain - Spinal cord (cervical c-1) (x9.6), and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for RASSF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.6), Lymph node (10.7), Monocytes (10.1), CD8 Tcells (6.9), and Blymphocyte (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RASSF2 Gene

Protein tissue co-expression partners for RASSF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RASSF2 Gene:


SOURCE GeneReport for Unigene cluster for RASSF2 Gene:


mRNA Expression by UniProt/SwissProt for RASSF2 Gene:

Tissue specificity: Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines.

Evidence on tissue expression from TISSUES for RASSF2 Gene

  • Eye(4.9)
  • Nervous system(4.9)
  • Bone marrow(4.3)
  • Liver(2.6)
  • Intestine(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with RASSF2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RASSF2 Gene

Orthologs for RASSF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RASSF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RASSF2 34 33
  • 99.28 (n)
(Bos Taurus)
Mammalia RASSF2 34
  • 95 (a)
(Canis familiaris)
Mammalia RASSF2 34 33
  • 91 (n)
(Rattus norvegicus)
Mammalia Rassf2 33
  • 87.63 (n)
(Mus musculus)
Mammalia Rassf2 16 34 33
  • 87.32 (n)
(Monodelphis domestica)
Mammalia RASSF2 34
  • 87 (a)
(Gallus gallus)
Aves RASSF2 34 33
  • 78.19 (n)
(Anolis carolinensis)
Reptilia RASSF2 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rassf2 33
  • 69.9 (n)
Str.8222 33
(Danio rerio)
Actinopterygii rassf2a 34 33
  • 66.78 (n)
rassf2b 34
  • 52 (a)
wufa04h12 33
fruit fly
(Drosophila melanogaster)
Insecta CG4656 35
  • 35 (a)
Rassf 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
Species where no ortholog for RASSF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RASSF2 Gene

Gene Tree for RASSF2 (if available)
Gene Tree for RASSF2 (if available)
Evolutionary constrained regions (ECRs) for RASSF2: view image

Paralogs for RASSF2 Gene

Paralogs for RASSF2 Gene

(2) SIMAP similar genes for RASSF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RASSF2: view

Variants for RASSF2 Gene

Sequence variations from dbSNP and Humsavar for RASSF2 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs758816530 A colorectal cancer sample 4,790,557(-) C/A/T coding_sequence_variant, missense_variant
rs1000001972 -- 4,780,974(-) A/T 3_prime_UTR_variant
rs1000050122 -- 4,803,053(-) G/C intron_variant
rs1000144710 -- 4,818,949(-) TCTTTTCTTTTCTTTT/TCTTTTCTTTT genic_upstream_transcript_variant, intron_variant
rs1000153425 -- 4,822,273(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RASSF2 Gene

Variant ID Type Subtype PubMed ID
esv1413742 CNV insertion 17803354
esv274965 CNV loss 21479260
esv29645 CNV loss 19812545
esv3383156 CNV insertion 20981092
esv3418342 CNV insertion 20981092
esv3584433 CNV loss 25503493
esv3645074 CNV gain 21293372
esv3893273 CNV loss 25118596
nsv1061866 CNV gain 25217958
nsv526507 CNV loss 19592680
nsv585310 CNV gain 21841781

Variation tolerance for RASSF2 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RASSF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RASSF2 Gene

Disorders for RASSF2 Gene

Additional Disease Information for RASSF2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RASSF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RASSF2 Gene

Publications for RASSF2 Gene

  1. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. (PMID: 16012945) Akino K … Tokino T (Gastroenterology 2005) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8724849) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 3 4 58
  5. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. (PMID: 19525978) Cooper WN … Latif F (Oncogene 2009) 3 4 58

Products for RASSF2 Gene

Sources for RASSF2 Gene

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