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Aliases for LZTS3 Gene

Aliases for LZTS3 Gene

  • Leucine Zipper Tumor Suppressor Family Member 3 2 3 5
  • ProSAP/Shank-Interacting Protein 1 2 3
  • ProSAP-Interacting Protein 1 3 4
  • PROSAPIP1 3 4
  • Proline Rich Synapse Associated Protein Interacting Protein 1 3
  • Leucine Zipper, Putative Tumor Suppressor Family Member 3 3
  • Leucine Zipper Putative Tumor Suppressor 3 3
  • ProSAPiP1 4
  • KIAA0552 4

External Ids for LZTS3 Gene

Summaries for LZTS3 Gene

GeneCards Summary for LZTS3 Gene

LZTS3 (Leucine Zipper Tumor Suppressor Family Member 3) is a Protein Coding gene. An important paralog of this gene is LZTS2.

UniProtKB/Swiss-Prot for LZTS3 Gene

  • May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.

Additional gene information for LZTS3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LZTS3 Gene

Genomics for LZTS3 Gene

GeneHancer (GH) Regulatory Elements for LZTS3 Gene

Promoters and enhancers for LZTS3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J003172 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 657.8 -0.7 -680 3.3 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 LZTS3 GC20P003173 ITPA ENSG00000229539 DDRGK1 ZNF343 VPS16 NOP56 UBOX5-AS1 SNRPB
GH20J003170 Promoter 0.6 EPDnew 650.7 +3.1 3087 0.1 ZNF362 LZTS3 DDRGK1 PIR60125
GH20J003106 Enhancer 1.1 Ensembl ENCODE 12.3 +66.5 66498 0.9 ELF3 MLX ARID4B DMAP1 THRB ZNF48 RARA CREM THAP11 MIXL1 UBOX5-AS1 LZTS3 MRPS26 GNRH2 OXT UBOX5 ITPA GC20P003124
GH20J003202 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.8 -30.3 -30298 2.7 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B E2F8 ZNF207 KLF13 ITPA DDRGK1 SNRPB VPS16 ZNF343 NOP56 MAVS LZTS3 PIR45599
GH20J003221 Enhancer 1.4 Ensembl ENCODE dbSUPER 6.6 -49.4 -49387 3.9 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ETS1 SLC30A9 GLIS2 ITPA DDRGK1 LZTS3 C20orf194 ENSG00000277287
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around LZTS3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LZTS3 Gene

Genomic Locations for LZTS3 Gene
10,976 bases
Minus strand
10,930 bases
Minus strand

Genomic View for LZTS3 Gene

Genes around LZTS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LZTS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LZTS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LZTS3 Gene

Proteins for LZTS3 Gene

  • Protein details for LZTS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine zipper putative tumor suppressor 3
    Protein Accession:
    Secondary Accessions:
    • A2A2Q7
    • D3DVX6
    • Q8IXX8

    Protein attributes for LZTS3 Gene

    673 amino acids
    Molecular mass:
    71791 Da
    Quaternary structure:
    • Interacts (via C-terminus) with SHANK3 (via PDZ domain). Interacts (via coiled coil) with SIPA1L1. Can form homooligomers.
    • Sequence=BAA25478.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for LZTS3 Gene


neXtProt entry for LZTS3 Gene

Post-translational modifications for LZTS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LZTS3 Gene

Domains & Families for LZTS3 Gene

Gene Families for LZTS3 Gene

Protein Domains for LZTS3 Gene


Suggested Antigen Peptide Sequences for LZTS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LZTS3 family.
  • Belongs to the LZTS3 family.
genes like me logo Genes that share domains with LZTS3: view

Function for LZTS3 Gene

Molecular function for LZTS3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.

Phenotypes From GWAS Catalog for LZTS3 Gene

genes like me logo Genes that share phenotypes with LZTS3: view

Animal Model Products

CRISPR Products

miRNA for LZTS3 Gene

miRTarBase miRNAs that target LZTS3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZTS3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LZTS3 Gene

Localization for LZTS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LZTS3 Gene

Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, cytoskeleton. Note=Detected at synapses, postsynaptic density, synaptic spines and dendrites. Rather found at excitatory than inhibitory synapses. {ECO:0000250 UniProtKB:Q8K1Q4}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LZTS3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 3
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LZTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LZTS3: view

Pathways & Interactions for LZTS3 Gene

SuperPathways for LZTS3 Gene

No Data Available

Interacting Proteins for LZTS3 Gene

Gene Ontology (GO) - Biological Process for LZTS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061001 regulation of dendritic spine morphogenesis ISS --
genes like me logo Genes that share ontologies with LZTS3: view

No data available for Pathways by source and SIGNOR curated interactions for LZTS3 Gene

Drugs & Compounds for LZTS3 Gene

No Compound Related Data Available

Transcripts for LZTS3 Gene

mRNA/cDNA for LZTS3 Gene

Unigene Clusters for LZTS3 Gene

Leucine zipper, putative tumor suppressor family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for LZTS3

Alternative Splicing Database (ASD) splice patterns (SP) for LZTS3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6
SP1: -
SP2: - -

Relevant External Links for LZTS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LZTS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LZTS3 Gene

mRNA differential expression in normal tissues according to GTEx for LZTS3 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8), Brain - Cerebellar Hemisphere (x5.1), and Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for LZTS3 Gene

This gene is overexpressed in Heart (26.2), Retina (18.2), Brain (8.4), Pancreas (8.0), and Stomach (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LZTS3 Gene

Protein tissue co-expression partners for LZTS3 Gene

NURSA nuclear receptor signaling pathways regulating expression of LZTS3 Gene:


SOURCE GeneReport for Unigene cluster for LZTS3 Gene:


Evidence on tissue expression from TISSUES for LZTS3 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with LZTS3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LZTS3 Gene

Orthologs for LZTS3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LZTS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
LOC469865 33
  • 99.42 (n)
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
  • 90.83 (n)
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
  • 91.92 (n)
(Mus musculus)
Mammalia Lzts3 16 34 33
  • 88.73 (n)
(Rattus norvegicus)
Mammalia Lzts3 33
  • 88.14 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
(Gallus gallus)
  • 65.61 (n)
-- 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485228 33
  • 59.18 (n)
(Danio rerio)
Actinopterygii lzts3b 34 33
  • 57.38 (n)
CABZ01087549.1 34
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3837 34
  • 27 (a)
Species where no ortholog for LZTS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LZTS3 Gene

Gene Tree for LZTS3 (if available)
Gene Tree for LZTS3 (if available)

Paralogs for LZTS3 Gene

Paralogs for LZTS3 Gene

(2) SIMAP similar genes for LZTS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LZTS3: view

Variants for LZTS3 Gene

Sequence variations from dbSNP and Humsavar for LZTS3 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000252118 -- 3,172,938(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000302802 -- 3,173,258(-) GCCGCC/GCC genic_upstream_transcript_variant, intron_variant
rs1000384379 -- 3,169,135(-) G/A 5_prime_UTR_variant, intron_variant
rs1000656697 -- 3,174,175(-) G/C upstream_transcript_variant
rs1000777077 -- 3,172,954(-) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LZTS3 Gene

Variant ID Type Subtype PubMed ID
nsv585276 CNV gain 21841781
nsv833897 CNV loss 17160897
nsv833898 CNV gain+loss 17160897

Variation tolerance for LZTS3 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LZTS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LZTS3 Gene

Disorders for LZTS3 Gene

Additional Disease Information for LZTS3

No disorders were found for LZTS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LZTS3 Gene

Publications for LZTS3 Gene

  1. ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. (PMID: 16522626) Wendholt D … Boeckers TM (The Journal of biological chemistry 2006) 2 3 58
  2. In silico characterization of LZTS3, a potential tumor suppressor. (PMID: 16012743) Teufel A … Lohse AW (Oncology reports 2005) 2 3 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for LZTS3 Gene

Sources for LZTS3 Gene

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