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Aliases for CD81 Gene

Aliases for CD81 Gene

  • CD81 Molecule 2 3 5
  • CD81 Antigen (Target Of Antiproliferative Antibody 1) 2 3
  • 26 KDa Cell Surface Protein TAPA-1 3 4
  • Tetraspanin-28 3 4
  • CD81 Antigen 3 4
  • Tspan-28 3 4
  • TSPAN28 3 4
  • TAPA1 3 4
  • Target Of The Antiproliferative Antibody 1 4
  • CVID6 3
  • S5.7 3

External Ids for CD81 Gene

Previous HGNC Symbols for CD81 Gene

  • TAPA1

Previous GeneCards Identifiers for CD81 Gene

  • GC11P002460
  • GC11P002599
  • GC11P002356
  • GC11P002363
  • GC11P002355
  • GC11P002188

Summaries for CD81 Gene

Entrez Gene Summary for CD81 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for CD81 Gene

CD81 (CD81 Molecule) is a Protein Coding gene. Diseases associated with CD81 include Immunodeficiency, Common Variable, 6 and Common Variable Immunodeficiency. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is CD9.

UniProtKB/Swiss-Prot for CD81 Gene

  • May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.

  • (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.

Gene Wiki entry for CD81 Gene

Additional gene information for CD81 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD81 Gene

Genomics for CD81 Gene

GeneHancer (GH) Regulatory Elements for CD81 Gene

Promoters and enhancers for CD81 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J002376 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 658.7 +8.6 8579 15.9 HDGF PKNOX1 FOXA2 ATF1 SIN3A ZNF2 YY1 GTF3C2 GLIS2 ZNF143 CD81 ENSG00000199550 KCNQ1 CD81-AS1 PIR51817
GH11J002374 Enhancer 1 VISTA ENCODE dbSUPER 658.7 -1.3 -1293 1.4 CTCF KLF1 RXRA MAX RAD21 GABPA YY1 JUND CD81 LOC105376520 ENSG00000199550 CD81-AS1
GH11J002375 Enhancer 0.8 ENCODE dbSUPER 650.7 -0.1 -111 0.2 CTCF FOXA2 RXRA MAX REST GABPA YY1 SP1 JUND CD81 CD81-AS1 LOC105376520
GH11J002139 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11 -230.0 -230038 13 ELF3 RB1 MZF1 BATF ZNF48 RAD21 ZEB1 ZNF335 GLIS2 SCRT2 IGF2 INS-IGF2 TSSC4 ENSG00000199550 CD81 LSP1 LOC100505570 KRTAP5-6 FAM99B KRTAP5-5
GH11J002398 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.5 +24.3 24267 4.5 PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 GC11M002398 TSSC4 CD81 PIR51817
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD81 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD81 gene promoter:
  • Pax-4a
  • Lmo2
  • Brachyury
  • ZIC2
  • Gfi-1
  • Pax-5
  • MAZR
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for CD81 Gene

Genomic Locations for CD81 Gene
21,243 bases
Plus strand
21,243 bases
Plus strand

Genomic View for CD81 Gene

Genes around CD81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD81 Gene

Proteins for CD81 Gene

  • Protein details for CD81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD81 antigen
    Protein Accession:
    Secondary Accessions:
    • P18582
    • Q5U0J6

    Protein attributes for CD81 Gene

    236 amino acids
    Molecular mass:
    25809 Da
    Quaternary structure:
    • Homodimer (PubMed:20375010). Interacts directly with IGSF8 (PubMed:11504738). Interacts with CD53 and SCIMP (PubMed:21930792). Interacts with IFITM1 (PubMed:2398277). Interacts with IFITM2 and IFITM3 (By similarity). Part of a GPCR-tetraspanin complex consisting at least of ADGRG1, CD81, eventually CD9, and GNA11 in which CD81 enhances the association of ADGRG1 with GNA11 (PubMed:15004227). Interacts with CLDN1 (PubMed:20375010, PubMed:21516087). Interacts with CLDN6 and CLDN9 (PubMed:20375010). Interacts (via the second extracellular domain) with integrin ITGAV:ITGB3 (PubMed:27993971).
    • (Microbial infection) Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer.

    Three dimensional structures from OCA and Proteopedia for CD81 Gene

neXtProt entry for CD81 Gene

Post-translational modifications for CD81 Gene

Antibody Products

No data available for DME Specific Peptides for CD81 Gene

Domains & Families for CD81 Gene

Gene Families for CD81 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for CD81 Gene

Suggested Antigen Peptide Sequences for CD81 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with CD81: view

Function for CD81 Gene

Molecular function for CD81 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.
GENATLAS Biochemistry:
integral membrane protein (26kDa),associated with CD19,B cell surface molecule,expressed on many cell types,target of an antiproliferative antibody

Phenotypes From GWAS Catalog for CD81 Gene

Gene Ontology (GO) - Molecular Function for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IMP 20375010
GO:0005178 integrin binding IDA 27993971
GO:0005515 protein binding IPI 2398277
GO:0023026 MHC class II protein complex binding HDA 20458337
GO:1990459 transferrin receptor binding IPI 25635054
genes like me logo Genes that share ontologies with CD81: view
genes like me logo Genes that share phenotypes with CD81: view

Human Phenotype Ontology for CD81 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CD81 Gene

MGI Knock Outs for CD81:

Animal Model Products

  • Taconic Biosciences Mouse Models for CD81

Clone Products

  • Addgene plasmids for CD81

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CD81 Gene

Localization for CD81 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD81 Gene

Basolateral cell membrane; Multi-pass membrane protein. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000269 PubMed:20375010}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD81 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
endosome 2
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 21930792
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 14676841
GO:0005925 focal adhesion HDA 21423176
GO:0016020 membrane HDA,IEA 19946888
genes like me logo Genes that share ontologies with CD81: view

Pathways & Interactions for CD81 Gene

genes like me logo Genes that share pathways with CD81: view

Pathways by source for CD81 Gene

1 GeneGo (Thomson Reuters) pathway for CD81 Gene
1 Qiagen pathway for CD81 Gene

Gene Ontology (GO) - Biological Process for CD81 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 14676841
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008104 protein localization IDA 14676841
GO:0008283 cell proliferation TAS 1695320
GO:0008284 positive regulation of cell proliferation IDA 14676841
genes like me logo Genes that share ontologies with CD81: view

No data available for SIGNOR curated interactions for CD81 Gene

Drugs & Compounds for CD81 Gene

(5) Drugs for CD81 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for CD81 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD81: view

Transcripts for CD81 Gene

mRNA/cDNA for CD81 Gene

Unigene Clusters for CD81 Gene

CD81 molecule:
Representative Sequences:

Clone Products

  • Addgene plasmids for CD81

Alternative Splicing Database (ASD) splice patterns (SP) for CD81 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - -
SP10: -
SP11: - - - - - - - - - -
SP12: -

Relevant External Links for CD81 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD81 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD81 Gene

This gene is overexpressed in Frontal cortex (7.5) and Spinal cord (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD81 Gene

Protein tissue co-expression partners for CD81 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CD81 Gene:


SOURCE GeneReport for Unigene cluster for CD81 Gene:


mRNA Expression by UniProt/SwissProt for CD81 Gene:

Tissue specificity: Hematolymphoid, neuroectodermal and mesenchymal tumor cell lines.

Evidence on tissue expression from TISSUES for CD81 Gene

  • Nervous system(4.9)
  • Lung(4.3)
  • Skin(3.7)
  • Liver(3.6)
  • Lymph node(3.3)
  • Pancreas(3.3)
  • Spleen(3.2)
  • Heart(3)
  • Muscle(2.9)
  • Blood(2.8)
  • Intestine(2.8)
  • Kidney(2.7)
  • Bone marrow(2.5)
  • Gall bladder(2.5)
  • Eye(2.4)
  • Thyroid gland(2.4)
  • Adrenal gland(2.2)
  • Stomach(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CD81 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • ear
  • eye
  • head
  • hypothalamus
  • meninges
  • middle ear
  • neck
  • pituitary gland
  • sinus
  • skull
  • thyroid
  • bronchus
  • heart
  • lung
  • adrenal gland
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
  • anus
  • rectum
  • uterus
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • lymph node
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with CD81: view

No data available for mRNA differential expression in normal tissues for CD81 Gene

Orthologs for CD81 Gene

This gene was present in the common ancestor of animals.

Orthologs for CD81 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CD81 34 33
  • 99.29 (n)
(Bos Taurus)
Mammalia CD81 34 33
  • 90.68 (n)
(Canis familiaris)
Mammalia LOC611606 33
  • 90.67 (n)
CD81 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Cd81 33
  • 87.01 (n)
(Mus musculus)
Mammalia Cd81 16 34 33
  • 86.72 (n)
(Gallus gallus)
Aves TAPA1 34
  • 83 (a)
CD81 33
  • 78.32 (n)
(Anolis carolinensis)
Reptilia CD81 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cd81 33
  • 70.5 (n)
MGC75667 33
African clawed frog
(Xenopus laevis)
Amphibia cd81-prov 33
(Danio rerio)
Actinopterygii cd81 34 33 33
  • 67.53 (n)
CD81 (1 of 2) 34
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000823 33
  • 52.36 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tsp96F 34 33
  • 47.58 (n)
(Caenorhabditis elegans)
Secernentea tsp-9 34
  • 26 (a)
Species where no ortholog for CD81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CD81 Gene

Gene Tree for CD81 (if available)
Gene Tree for CD81 (if available)
Evolutionary constrained regions (ECRs) for CD81: view image

Paralogs for CD81 Gene

(10) SIMAP similar genes for CD81 Gene using alignment to 11 proteins:

  • CD81_HUMAN
  • E9PM31_HUMAN
genes like me logo Genes that share paralogs with CD81: view

Variants for CD81 Gene

Sequence variations from dbSNP and Humsavar for CD81 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs587776775 pathogenic, Common variable immunodeficiency 6 2,395,971(+) G/A splice_donor_variant
rs143644902 likely-benign, not specified 2,395,475(+) T/C coding_sequence_variant, synonymous_variant
rs1000018888 -- 2,391,973(+) C/T intron_variant
rs1000045433 -- 2,377,012(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000131388 -- 2,392,198(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CD81 Gene

Variant ID Type Subtype PubMed ID
dgv1568n54 CNV loss 21841781
dgv1569n54 CNV loss 21841781
esv1007864 CNV deletion 20482838
esv1285833 CNV deletion 17803354
esv2744006 CNV deletion 23290073
nsv1070001 CNV deletion 25765185
nsv1115318 CNV deletion 24896259
nsv1151445 CNV deletion 26484159
nsv467645 CNV gain 19166990
nsv469928 CNV loss 18288195
nsv509382 CNV insertion 20534489
nsv553047 CNV gain 21841781
nsv553089 CNV gain 21841781
nsv951286 CNV deletion 24416366
nsv951287 CNV deletion 24416366

Variation tolerance for CD81 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD81 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD81 Gene

Disorders for CD81 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CD81 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency, common variable, 6
  • cvid6
common variable immunodeficiency
  • acquired agammaglobulinemia
hepatitis c
  • chronic hepatitis c
  • hepatitis a
  • cryoimmunoglobulinaemia
- elite association - COSMIC cancer census association via MalaCards
Search CD81 in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency, common variable, 6 (CVID6) [MIM:613496]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:20237408}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CD81

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD81: view

No data available for Genatlas for CD81 Gene

Publications for CD81 Gene

  1. Subunit association and conformational flexibility in the head subdomain of human CD81 large extracellular loop. (PMID: 12437138) Kitadokoro K … Bolognesi M (Biological chemistry 2002) 3 4 22 58
  2. TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins. (PMID: 1695320) Oren R … Levy S (Molecular and cellular biology 1990) 3 4 22 58
  3. The CD9, CD81, and CD151 EC2 domains bind to the classical RGD-binding site of integrin αvβ3. (PMID: 27993971) Yu J … Takada Y (The Biochemical journal 2017) 3 4 58
  4. SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling. (PMID: 21930792) Draber P … Brdicka T (Molecular and cellular biology 2011) 3 4 58
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58

Products for CD81 Gene

  • Addgene plasmids for CD81

Sources for CD81 Gene

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