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Aliases for CD70 Gene

Aliases for CD70 Gene

  • CD70 Molecule 2 3 5
  • Tumor Necrosis Factor Ligand Superfamily Member 7 3 4
  • CD70 Antigen 3 4
  • CD27 Ligand 3 4
  • CD27LG 3 4
  • TNFSF7 3 4
  • CD27-L 3 4
  • CD27L 3 4
  • Tumor Necrosis Factor (Ligand) Superfamily, Member 7 2
  • Tumor Necrosis Factor Ligand 8A 3
  • Surface Antigen CD70 3
  • Ki-24 Antigen 3
  • TNLG8A 3

External Ids for CD70 Gene

Previous HGNC Symbols for CD70 Gene

  • CD27LG
  • TNFSF7

Previous GeneCards Identifiers for CD70 Gene

  • GC19M006537
  • GC19M006538
  • GC19M006346

Summaries for CD70 Gene

Entrez Gene Summary for CD70 Gene

  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CD70 Gene

CD70 (CD70 Molecule) is a Protein Coding gene. Diseases associated with CD70 include Acute Myocarditis and Lymphoproliferative Syndrome 2. Among its related pathways are Akt Signaling and 4-1BB Pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protease binding.

UniProtKB/Swiss-Prot for CD70 Gene

  • Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Additional gene information for CD70 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD70 Gene

Genomics for CD70 Gene

GeneHancer (GH) Regulatory Elements for CD70 Gene

Promoters and enhancers for CD70 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J006588 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 657.2 +13.8 13833 3.1 HDGF PKNOX1 SMAD1 SIN3A YBX1 KLF5 ZNF335 POLR2B GLIS2 ZNF366 CD70 TNFSF9 PSPN RPL7P50 GC19P006581
GH19J006599 Enhancer 1.4 Ensembl ENCODE dbSUPER 650.7 +1.8 1843 5 HDGF PKNOX1 SMAD1 ARNT POLR2B ZNF766 ZNF207 ZNF143 FOS NFYC GC19M006592 CD70 SAFB KHSRP DUS3L GTF2F1 ZNF557 ENSG00000267571 VMAC SAFB2
GH19J006592 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 18.5 +11.5 11534 0.7 HDGF SMAD1 RELA ZNF335 EED ZNF143 ATF7 ETV6 BCLAF1 IKZF2 GC19P006595 RPL7P50 CD70 TNFSF9 DENND1C ZNF557 GC19P006581
GH19J006575 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +25.7 25656 5.5 HDGF PKNOX1 SMAD1 ARNT IRF4 ZNF280A TCF12 ZNF207 ATF7 FOS GC19P006580 GC19P006581 TNFSF14 TNFSF9 CD70 DENND1C ZNF557 ENSG00000199223 GC19M006573
GH19J006517 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 7.6 +85.8 85827 1.1 HDGF SMAD1 STAT5A YBX1 BATF IRF4 ATF7 ETV6 IKZF2 RUNX3 KHSRP ZNF557 RANBP3 SNRPEP4 SAFB DUS3L ENSG00000267571 CD70 TNFSF9 RFX2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CD70 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CD70 gene promoter:
  • c-Jun
  • ATF-2
  • AP-1
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for CD70 Gene

Genomic Locations for CD70 Gene
20,921 bases
Minus strand
20,921 bases
Minus strand

Genomic View for CD70 Gene

Genes around CD70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CD70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CD70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD70 Gene

Proteins for CD70 Gene

  • Protein details for CD70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CD70 antigen
    Protein Accession:
    Secondary Accessions:
    • B4DPR8
    • Q53XX4
    • Q96J57

    Protein attributes for CD70 Gene

    193 amino acids
    Molecular mass:
    21118 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for CD70 Gene


neXtProt entry for CD70 Gene

Post-translational modifications for CD70 Gene

  • Glycosylation at posLast=170170, posLast=7474, and Asn63
  • Modification sites at PhosphoSitePlus

Other Protein References for CD70 Gene

No data available for DME Specific Peptides for CD70 Gene

Domains & Families for CD70 Gene

Gene Families for CD70 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CD70 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tumor necrosis factor family.
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with CD70: view

Function for CD70 Gene

Molecular function for CD70 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Gene Ontology (GO) - Molecular Function for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 12777399
GO:0005102 signaling receptor binding TAS 8120384
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 12324477
genes like me logo Genes that share ontologies with CD70: view
genes like me logo Genes that share phenotypes with CD70: view

Animal Models for CD70 Gene

MGI Knock Outs for CD70:
  • Cd70 Cd70<tm1.1Jda>

Animal Model Products

  • Taconic Biosciences Mouse Models for CD70

miRNA for CD70 Gene

miRTarBase miRNAs that target CD70

Clone Products

  • Addgene plasmids for CD70
  • R&D Systems cDNA Clones for CD70 (CD27 Ligand/TNFSF7)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CD70 Gene

Localization for CD70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD70 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CD70 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane IDA,TAS --
GO:0005887 integral component of plasma membrane TAS 8120384
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CD70: view

Pathways & Interactions for CD70 Gene

genes like me logo Genes that share pathways with CD70: view

Interacting Proteins for CD70 Gene

SIGNOR curated interactions for CD70 Gene


Gene Ontology (GO) - Biological Process for CD70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 8387892
GO:0007267 cell-cell signaling TAS 8387892
GO:0008283 cell proliferation TAS 8120384
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with CD70: view

Drugs & Compounds for CD70 Gene

(7) Drugs for CD70 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MDX-1203 Pharma 0
MDX-1411 Pharma 0
SGN-70 Pharma antibody 0
SGN-75 Pharma antibody 0

(1) Additional Compounds for CD70 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CD70: view

Transcripts for CD70 Gene

mRNA/cDNA for CD70 Gene

Unigene Clusters for CD70 Gene

CD70 molecule:
Representative Sequences:

Clone Products

  • Addgene plasmids for CD70
  • R&D Systems cDNA Clones for CD70 (CD27 Ligand/TNFSF7)

Alternative Splicing Database (ASD) splice patterns (SP) for CD70 Gene

No ASD Table

Relevant External Links for CD70 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CD70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CD70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD70 Gene

This gene is overexpressed in Liver (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CD70 Gene

Protein tissue co-expression partners for CD70 Gene

NURSA nuclear receptor signaling pathways regulating expression of CD70 Gene:


SOURCE GeneReport for Unigene cluster for CD70 Gene:


Evidence on tissue expression from TISSUES for CD70 Gene

  • Kidney(4.2)
  • Blood(3.2)
  • Lymph node(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with CD70: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CD70 Gene

Orthologs for CD70 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CD70 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CD70 34 33
  • 77.37 (n)
(Bos Taurus)
Mammalia CD70 34 33
  • 72.87 (n)
(Rattus norvegicus)
Mammalia Cd70 33
  • 64.59 (n)
(Mus musculus)
Mammalia Cd70 16 34 33
  • 64.25 (n)
(Pan troglodytes)
Mammalia CD70 34
  • 64 (a)
(Monodelphis domestica)
Mammalia CD70 34
  • 35 (a)
Species where no ortholog for CD70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD70 Gene

Gene Tree for CD70 (if available)
Gene Tree for CD70 (if available)
Evolutionary constrained regions (ECRs) for CD70: view image

Paralogs for CD70 Gene

No data available for Paralogs for CD70 Gene

Variants for CD70 Gene

Sequence variations from dbSNP and Humsavar for CD70 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000117334 -- 6,585,301(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000189840 -- 6,581,438(-) C/T downstream_transcript_variant
rs1000340785 -- 6,587,814(-) A/G intron_variant
rs1000350920 -- 6,587,561(-) T/C intron_variant
rs1000446032 -- 6,592,423(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CD70 Gene

Variant ID Type Subtype PubMed ID
esv3893161 CNV gain 25118596
nsv833728 CNV loss 17160897
nsv978762 CNV duplication 23825009

Variation tolerance for CD70 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CD70 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD70 Gene

Disorders for CD70 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CD70 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acute myocarditis
lymphoproliferative syndrome 2
  • lpfs2
  • waldenstrom macroglobulinemia
corneal dystrophy, congenital stromal
  • cscd
common variable immunodeficiency
  • acquired agammaglobulinemia
- elite association - COSMIC cancer census association via MalaCards
Search CD70 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CD70

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CD70: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD70 Gene

Publications for CD70 Gene

  1. The cloning of CD70 and its identification as the ligand for CD27. (PMID: 8120384) Bowman MR … Herrmann S (Journal of immunology (Baltimore, Md. : 1950) 1994) 2 3 4 58
  2. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. (PMID: 8387892) Goodwin RG … Hennen K (Cell 1993) 2 3 4 58
  3. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PMID: 20568250) Lee KM … Lan Q (American journal of hematology 2010) 3 44 58
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  5. Fyn and CD70 expression in CD4+ T cells from patients with systemic lupus erythematosus. (PMID: 19955046) Kozlowska A … Jagodzinski PP (The Journal of rheumatology 2010) 3 22 58

Products for CD70 Gene

  • Addgene plasmids for CD70
  • Boster Bio Antibodies for CD70
  • Boster Bio ELISA Kits for CD70

Sources for CD70 Gene

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