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Aliases for TRAM2 Gene

Aliases for TRAM2 Gene

  • Translocation Associated Membrane Protein 2 2 3 5
  • KIAA0057 4

External Ids for TRAM2 Gene

Previous GeneCards Identifiers for TRAM2 Gene

  • GC06M052358
  • GC06M052409
  • GC06M052414
  • GC06U900790
  • GC06M052193
  • GC06M052363

Summaries for TRAM2 Gene

Entrez Gene Summary for TRAM2 Gene

  • TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]

GeneCards Summary for TRAM2 Gene

TRAM2 (Translocation Associated Membrane Protein 2) is a Protein Coding gene. Diseases associated with TRAM2 include Polycystic Kidney Disease 4 With Or Without Hepatic Disease and Epilepsy, Idiopathic Generalized 10. An important paralog of this gene is TRAM1.

UniProtKB/Swiss-Prot for TRAM2 Gene

  • Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).

Gene Wiki entry for TRAM2 Gene

Additional gene information for TRAM2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAM2 Gene

Genomics for TRAM2 Gene

GeneHancer (GH) Regulatory Elements for TRAM2 Gene

Promoters and enhancers for TRAM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I052563 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.6 +5.8 5845 14.5 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 TRAM2 EFHC1 MCM3 TRAM2-AS1 PAQR8 LOC730101 GC06P052544
GH06I053054 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 -481.6 -481596 9.3 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ICK MCM3 TRAM2 GSTA3 FBXO9
GH06I052670 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 -94.3 -94256 1.8 HDGF SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 TMEM14A LOC730101 MCM3 TRAM2 ENSG00000271227
GH06I052549 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +25.1 25124 5 FOXA2 NFIB INSM2 ARID4B KLF17 SIN3A BATF RAD21 YY1 ZSCAN5C TRAM2-AS1 TRAM2 EFHC1 PAQR8 GSTA5 GC06P052544
GH06I052663 Promoter/Enhancer 1.5 Ensembl ENCODE 11.6 -87.3 -87330 2.5 PKNOX1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 POLR2B E2F8 ZNF207 LOC730101 MCM3 EFHC1 TRAM2-AS1 TRAM2 ICK TMEM14A GC06P052657
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRAM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAM2 gene promoter:

Genomic Locations for TRAM2 Gene

Genomic Locations for TRAM2 Gene
chr6:52,497,402-52,577,064
(GRCh38/hg38)
Size:
79,663 bases
Orientation:
Minus strand
chr6:52,362,200-52,441,862
(GRCh37/hg19)

Genomic View for TRAM2 Gene

Genes around TRAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAM2 Gene

Proteins for TRAM2 Gene

  • Protein details for TRAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15035-TRAM2_HUMAN
    Recommended name:
    Translocating chain-associated membrane protein 2
    Protein Accession:
    Q15035
    Secondary Accessions:
    • A8K6T6

    Protein attributes for TRAM2 Gene

    Size:
    370 amino acids
    Molecular mass:
    43328 Da
    Quaternary structure:
    • Interacts with SERCA2B and COL1A1.
    SequenceCaution:
    • Sequence=BAA06540.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TRAM2 Gene

Post-translational modifications for TRAM2 Gene

  • Glycosylation at posLast=5555
  • Modification sites at PhosphoSitePlus

Other Protein References for TRAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRAM2 Gene

Domains & Families for TRAM2 Gene

Gene Families for TRAM2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TRAM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15035

UniProtKB/Swiss-Prot:

TRAM2_HUMAN :
  • Belongs to the TRAM family.
Family:
  • Belongs to the TRAM family.
genes like me logo Genes that share domains with TRAM2: view

Function for TRAM2 Gene

Molecular function for TRAM2 Gene

UniProtKB/Swiss-Prot Function:
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293).

Phenotypes From GWAS Catalog for TRAM2 Gene

Gene Ontology (GO) - Molecular Function for TRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14749390
genes like me logo Genes that share ontologies with TRAM2: view
genes like me logo Genes that share phenotypes with TRAM2: view

Animal Models for TRAM2 Gene

MGI Knock Outs for TRAM2:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAM2 Gene

Localization for TRAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAM2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAM2 gene
Compartment Confidence
plasma membrane 3
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRAM2: view

Pathways & Interactions for TRAM2 Gene

SuperPathways for TRAM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0032964 collagen biosynthetic process IMP 14749390
GO:0045048 protein insertion into ER membrane IDA 27499293
genes like me logo Genes that share ontologies with TRAM2: view

No data available for Pathways by source and SIGNOR curated interactions for TRAM2 Gene

Drugs & Compounds for TRAM2 Gene

No Compound Related Data Available

Transcripts for TRAM2 Gene

mRNA/cDNA for TRAM2 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRAM2 Gene

Translocation associated membrane protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAM2 Gene

No ASD Table

Relevant External Links for TRAM2 Gene

GeneLoc Exon Structure for
TRAM2
ECgene alternative splicing isoforms for
TRAM2

Expression for TRAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAM2 Gene

Protein differential expression in normal tissues from HIPED for TRAM2 Gene

This gene is overexpressed in Placenta (42.9) and Pancreas (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRAM2 Gene



Protein tissue co-expression partners for TRAM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRAM2 Gene:

TRAM2

SOURCE GeneReport for Unigene cluster for TRAM2 Gene:

Hs.520182

Evidence on tissue expression from TISSUES for TRAM2 Gene

  • Nervous system(4.3)
  • Bone marrow(4.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with TRAM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAM2 Gene

Orthologs for TRAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRAM2 33 34
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia TRAM2 33 34
  • 93 (n)
cow
(Bos Taurus)
Mammalia TRAM2 33 34
  • 89.82 (n)
mouse
(Mus musculus)
Mammalia Tram2 33 16 34
  • 88.65 (n)
rat
(Rattus norvegicus)
Mammalia LOC100361830 33
  • 88.56 (n)
oppossum
(Monodelphis domestica)
Mammalia TRAM2 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRAM2 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRAM2 33 34
  • 77.95 (n)
lizard
(Anolis carolinensis)
Reptilia TRAM2 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tram2 33
  • 73.08 (n)
zebrafish
(Danio rerio)
Actinopterygii tram2 33 34
  • 64.68 (n)
Dr.4811 33
fruit fly
(Drosophila melanogaster)
Insecta TRAM 34
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tram-1 34
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for TRAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAM2 Gene

ENSEMBL:
Gene Tree for TRAM2 (if available)
TreeFam:
Gene Tree for TRAM2 (if available)

Paralogs for TRAM2 Gene

Paralogs for TRAM2 Gene

(2) SIMAP similar genes for TRAM2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRAM2: view

Variants for TRAM2 Gene

Sequence variations from dbSNP and Humsavar for TRAM2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000020715 -- 52,535,105(-) AAAA/AAA intron_variant
rs1000021770 -- 52,529,415(-) C/T intron_variant
rs1000082424 -- 52,523,465(-) A/G intron_variant
rs1000139462 -- 52,567,149(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000264472 -- 52,529,151(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAM2 Gene

Variant ID Type Subtype PubMed ID
esv2732081 CNV deletion 23290073
esv2732082 CNV deletion 23290073
esv3608999 CNV loss 21293372
nsv518713 CNV loss 19592680
nsv522674 CNV loss 19592680
nsv527895 CNV loss 19592680
nsv830663 CNV loss 17160897

Variation tolerance for TRAM2 Gene

Residual Variation Intolerance Score: 21.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRAM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAM2 Gene

Disorders for TRAM2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRAM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
polycystic kidney disease 4 with or without hepatic disease
  • pkd4
epilepsy, idiopathic generalized 10
  • epilepsy, idiopathic generalized, susceptibility to, 10
- elite association - COSMIC cancer census association via MalaCards
Search TRAM2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TRAM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAM2 Gene

Publications for TRAM2 Gene

  1. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. (PMID: 14749390) Stefanovic B … Brenner DA (Molecular and cellular biology 2004) 3 4 22 58
  2. Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene. (PMID: 10594243) Onuchic LF … Guay-Woodford LM (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 22 58
  3. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 2 3 4 58
  4. Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix. (PMID: 27499293) Chen Q … Ye J (Molecular cell 2016) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for TRAM2 Gene

Sources for TRAM2 Gene

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