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Aliases for PDE4DIP Gene

Aliases for PDE4DIP Gene

  • Phosphodiesterase 4D Interacting Protein 2 3 5
  • Cardiomyopathy-Associated Protein 2 3 4
  • Myomegalin 2 3
  • CMYA2 3 4
  • MMGL 3 4
  • Myomegalin/Phosphodiesterase 4D Interacting Protein Variant 8 3
  • Phosphodiesterase 4D-Interacting Protein 4
  • Cardiomyopathy Associated 2 2
  • KIAA0454 4
  • KIAA0477 4

External Ids for PDE4DIP Gene

Previous HGNC Symbols for PDE4DIP Gene

  • CMYA2

Previous GeneCards Identifiers for PDE4DIP Gene

  • GC01P144477
  • GC01M141455
  • GC01M142582
  • GC01M142604
  • GC01M142606
  • GC01M142189
  • GC01M143563
  • GC01M144833
  • GC01M119142
  • GC01M144836

Summaries for PDE4DIP Gene

Entrez Gene Summary for PDE4DIP Gene

  • The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for PDE4DIP Gene

PDE4DIP (Phosphodiesterase 4D Interacting Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and enzyme binding. An important paralog of this gene is CDK5RAP2.

UniProtKB/Swiss-Prot for PDE4DIP Gene

  • Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Forms a complex with AKAP9: the complex recruits CAMSAP2 to the Golgi apparatus, leading to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570).

Gene Wiki entry for PDE4DIP Gene

Additional gene information for PDE4DIP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE4DIP Gene

Genomics for PDE4DIP Gene

GeneHancer (GH) Regulatory Elements for PDE4DIP Gene

Promoters and enhancers for PDE4DIP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I148950 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 570.5 +148.7 148733 13.5 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC ZC3H11A PDE4DIP LOC647481 SF3B4 LOC101927468 HIST2H2AB ENSG00000227700 HIST2H2BC SV2A PIR31643 PIR33316
GH01I148887 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562 +84.7 84679 10.5 HDGF PKNOX1 FOXA2 SIN3A DMAP1 YY1 ZNF213 FOS DEK REST PDE4DIP GPR89B LOC647481 HIST2H2BD HIST2H2BC ENSG00000261716 GC01M148879 RNU2-38P
GH01I148842 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.3 +36.3 36253 3.5 HDGF ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF263 SP3 ZHX2 MXD4 PDE4DIP GPR89B LOC647481 RN7SKP88 GC01M148879
GH01I148808 Enhancer 1.3 Ensembl ENCODE dbSUPER 550.8 +0.7 690 1.4 PKNOX1 SREBF2 SIN3A DMAP1 ZNF48 ZNF280A E2F8 ARID2 ZNF207 RCOR1 PDE4DIP LOC647481 GPR89B RN7SKP88
GH01I148793 Enhancer 1.4 FANTOM5 Ensembl ENCODE 29.7 -14.2 -14209 1.3 PKNOX1 ATF1 ZNF493 GLI4 TCF12 ZNF766 ZNF416 CAVIN1 YY2 ZNF592 ENSG00000271546 PDE4DIP GPR89B LOC647481 ENSG00000227700 LOC101927468 LOC100996517
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PDE4DIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PDE4DIP gene promoter:

Genomic Locations for PDE4DIP Gene

Genomic Locations for PDE4DIP Gene
240,120 bases
Plus strand

Genomic View for PDE4DIP Gene

Genes around PDE4DIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE4DIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE4DIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE4DIP Gene

Proteins for PDE4DIP Gene

  • Protein details for PDE4DIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A2RU15
    • O75042
    • O75065
    • Q2YDC1
    • Q5VU42
    • Q5VU44
    • Q5VU45
    • Q5VU46
    • Q5VU47
    • Q5VU48
    • Q5VU49
    • Q68DU2
    • Q6AZ93
    • Q6PK88
    • Q86T40
    • Q86TB2
    • Q8N3W0
    • Q8TAY9
    • Q9HCP2
    • Q9HCP3
    • Q9HCP4
    • Q9HCP5

    Protein attributes for PDE4DIP Gene

    2346 amino acids
    Molecular mass:
    265080 Da
    Quaternary structure:
    • Interacts with PDE4D (By similarity). Interacts with AKAP9; forming a complex that recruit CAMSAP2 to the Golgi (PubMed:27666745). Interacts with MAPRE1 (PubMed:28814570). Interacts with MAPRE3 (PubMed:28814570). Interacts with CAMSAP2 (PubMed:27666745).
    • Sequence=AAH04860.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA32299.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA32322.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD91152.1; Type=Frameshift; Positions=1507; Evidence={ECO:0000305}; Sequence=CAH18128.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for PDE4DIP Gene

neXtProt entry for PDE4DIP Gene

Post-translational modifications for PDE4DIP Gene

No data available for DME Specific Peptides for PDE4DIP Gene

Domains & Families for PDE4DIP Gene

Gene Families for PDE4DIP Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for PDE4DIP Gene

Suggested Antigen Peptide Sequences for PDE4DIP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PDE4DIP: view

No data available for UniProtKB/Swiss-Prot for PDE4DIP Gene

Function for PDE4DIP Gene

Molecular function for PDE4DIP Gene

UniProtKB/Swiss-Prot Function:
Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Forms a complex with AKAP9: the complex recruits CAMSAP2 to the Golgi apparatus, leading to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570).

Phenotypes From GWAS Catalog for PDE4DIP Gene

Gene Ontology (GO) - Molecular Function for PDE4DIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17923693
GO:0019899 enzyme binding ISS 11134006
GO:0032947 protein complex scaffold activity IDA 27666745
genes like me logo Genes that share ontologies with PDE4DIP: view
genes like me logo Genes that share phenotypes with PDE4DIP: view

Animal Models for PDE4DIP Gene

MGI Knock Outs for PDE4DIP:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PDE4DIP Gene

Localization for PDE4DIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDE4DIP Gene

Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PDE4DIP gene
Compartment Confidence
cytoskeleton 5
nucleus 5
golgi apparatus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PDE4DIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11374908
GO:0005737 cytoplasm IDA,IEA 11374908
GO:0005794 Golgi apparatus ISS 11134006
GO:0005813 centrosome ISS 11134006
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with PDE4DIP: view

Pathways & Interactions for PDE4DIP Gene

SuperPathways for PDE4DIP Gene

No Data Available

SIGNOR curated interactions for PDE4DIP Gene


Gene Ontology (GO) - Biological Process for PDE4DIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043623 cellular protein complex assembly ISS 11134006
GO:1903358 regulation of Golgi organization IDA 27666745
genes like me logo Genes that share ontologies with PDE4DIP: view

No data available for Pathways by source for PDE4DIP Gene

Drugs & Compounds for PDE4DIP Gene

(1) Drugs for PDE4DIP Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with PDE4DIP: view

Transcripts for PDE4DIP Gene

Unigene Clusters for PDE4DIP Gene

Phosphodiesterase 4D interacting protein:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE4DIP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1: - - - - - - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP9: - - - - - - -
SP11: - - -
SP13: - -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - -

ExUns: 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a · 47b ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51 ^ 52 ^ 53 ^ 54 ^ 55a · 55b
SP1: - - -
SP2: - - -
SP3: - -
SP8: -

Relevant External Links for PDE4DIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PDE4DIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PDE4DIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE4DIP Gene

This gene is overexpressed in Muscle - Skeletal (x14.8) and Heart - Left Ventricle (x7.4).

Protein differential expression in normal tissues from HIPED for PDE4DIP Gene

This gene is overexpressed in Frontal cortex (46.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PDE4DIP Gene

NURSA nuclear receptor signaling pathways regulating expression of PDE4DIP Gene:


SOURCE GeneReport for Unigene cluster for PDE4DIP Gene:


mRNA Expression by UniProt/SwissProt for PDE4DIP Gene:

Tissue specificity: Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta.

Evidence on tissue expression from TISSUES for PDE4DIP Gene

  • Nervous system(5)
  • Muscle(4.9)
  • Heart(4.7)
  • Lung(4.4)
  • Liver(4.3)
  • Pancreas(3.9)
  • Eye(2.7)
  • Skin(2.7)
  • Kidney(2)
genes like me logo Genes that share expression patterns with PDE4DIP: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PDE4DIP Gene

Orthologs for PDE4DIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDE4DIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PDE4DIP 34
  • 99 (a)
(Bos Taurus)
Mammalia PDE4DIP 33 34
  • 88.34 (n)
(Canis familiaris)
Mammalia PDE4DIP 33 34
  • 87.65 (n)
(Mus musculus)
Mammalia Pde4dip 33 16 34
  • 83.13 (n)
(Rattus norvegicus)
Mammalia Pde4dip 33
  • 82.38 (n)
(Monodelphis domestica)
Mammalia PDE4DIP 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia PDE4DIP 34
  • 50 (a)
(Gallus gallus)
Aves PDE4DIP 33 34
  • 62.22 (n)
(Anolis carolinensis)
Reptilia PDE4DIP 34
  • 45 (a)
(Danio rerio)
Actinopterygii si:ch211-242b18.1 33
  • 54.93 (n)
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
Species where no ortholog for PDE4DIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE4DIP Gene

Gene Tree for PDE4DIP (if available)
Gene Tree for PDE4DIP (if available)

Paralogs for PDE4DIP Gene

Paralogs for PDE4DIP Gene

genes like me logo Genes that share paralogs with PDE4DIP: view

Variants for PDE4DIP Gene

Sequence variations from dbSNP and Humsavar for PDE4DIP Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs3215779 benign, not specified 148,960,745(+) AA/A coding_sequence_variant, frameshift, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1002928 -- 148,952,088(+) C/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs10045281 -- 148,833,292(+) A/G genic_upstream_transcript_variant, intron_variant
rs10157122 -- 148,841,590(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs10158139 -- 148,928,075(+) C/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PDE4DIP Gene

Variant ID Type Subtype PubMed ID
esv8887 CNV loss 19470904
esv9122 CNV gain 19470904
nsv1001908 CNV loss 25217958
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1005230 CNV gain 25217958
nsv1006036 CNV gain 25217958
nsv1009283 CNV gain 25217958
nsv1009955 CNV loss 25217958
nsv1011358 CNV loss 25217958
nsv1076337 CNV duplication 25765185
nsv1076338 CNV duplication 25765185
nsv1152455 CNV duplication 26484159
nsv1151380 CNV duplication 26484159
nsv1151226 CNV duplication 26484159
nsv1148615 CNV duplication 26484159
nsv1146989 CNV duplication 26484159
nsv1140265 OTHER inversion 24896259
nsv1139498 CNV duplication 24896259
nsv1137808 CNV deletion 24896259
nsv1137807 CNV deletion 24896259
nsv1132304 CNV duplication 24896259
nsv1122399 CNV deletion 24896259
nsv1122398 CNV deletion 24896259
nsv1122397 CNV deletion 24896259
nsv1119721 CNV deletion 24896259
nsv1113168 CNV deletion 24896259
nsv1113167 CNV deletion 24896259
nsv1113166 CNV deletion 24896259
nsv1078719 CNV deletion 25765185
nsv1077617 CNV deletion 25765185
nsv1077615 CNV deletion 25765185
esv7886 CNV gain 19470904
esv7067 CNV loss 19470904
esv7052 CNV loss 19470904
esv6817 CNV loss 19470904
esv6514 CNV gain 19470904
esv6218 CNV loss 19470904
esv3587405 CNV gain 21293372
esv3587404 CNV loss 21293372
esv3587402 CNV loss 21293372
esv3587397 CNV gain 21293372
esv3578142 CNV loss 25503493
esv3578141 CNV loss 25503493
esv3570675 CNV gain 25503493
esv3570008 CNV gain 25503493
esv3569897 CNV gain 25503493
esv3540333 CNV deletion 23714750
esv3540311 CNV deletion 23714750
esv3540300 CNV deletion 23714750
esv3414198 CNV duplication 20981092
esv3387252 CNV duplication 20981092
esv3380599 CNV duplication 20981092
esv3368223 CNV duplication 20981092
esv3361392 CNV insertion 20981092
esv3360116 CNV duplication 20981092
esv3352814 CNV duplication 20981092
esv32934 CNV gain+loss 17666407
esv2874901 CNV duplication 24192839
esv2850013 CNV deletion 24192839
esv2849902 CNV deletion 24192839
esv2762189 CNV gain 21179565
esv2761854 CNV gain 21179565
esv2761299 CNV gain+loss 21179565
esv27392 CNV gain 19812545
esv2670878 CNV deletion 23128226
esv2649952 CNV deletion 19546169
esv2630464 CNV gain 19546169
esv2582001 CNV deletion 19546169
esv2522501 CNV deletion 19546169
esv2455158 CNV gain 19546169
esv2431887 CNV gain 19546169
esv2391656 CNV deletion 18987734
esv23161 CNV gain 19812545
esv2191629 CNV deletion 18987734
esv2124797 CNV deletion 18987734
esv1963892 CNV deletion 18987734
esv1943257 CNV deletion 18987734
esv1942033 CNV deletion 18987734
esv1010993 CNV deletion 20482838
esv1004968 CNV deletion 20482838
dgv92e212 CNV gain 25503493
dgv91e212 CNV gain 25503493
dgv90e212 CNV gain 25503493
dgv70n67 CNV gain 20364138
dgv66e199 CNV deletion 23128226
dgv44e214 CNV gain 21293372
dgv43e214 CNV gain 21293372
dgv327n100 CNV gain 25217958
dgv326n100 CNV gain 25217958
dgv325n100 CNV gain 25217958
dgv324n100 CNV gain 25217958
dgv323n100 CNV gain 25217958
dgv322n100 CNV loss 25217958
dgv321n100 CNV gain 25217958
dgv320n100 CNV gain 25217958
dgv319n100 CNV loss 25217958
dgv200e59 CNV duplication 20981092
dgv199e59 CNV duplication 20981092
dgv177n106 CNV duplication 24896259
dgv16n16 CNV deletion 17901297
nsv999288 CNV loss 25217958
nsv957525 CNV deletion 24416366
nsv957358 CNV deletion 24416366
nsv957357 CNV deletion 24416366
nsv955904 CNV deletion 24416366
nsv950944 CNV duplication 24416366
nsv946952 CNV duplication 23825009
nsv946253 CNV duplication 23825009
nsv946252 CNV duplication 23825009
nsv946251 CNV duplication 23825009
nsv946250 CNV duplication 23825009
nsv946249 CNV duplication 23825009
nsv946248 CNV duplication 23825009
nsv946246 CNV duplication 23825009
nsv946244 CNV duplication 23825009
nsv831326 CNV loss 17160897
nsv831315 CNV loss 17160897
nsv824365 CNV gain 20364138
nsv821620 CNV loss 15273396
nsv821349 CNV duplication 20802225
nsv819024 CNV gain 19587683
nsv8069 CNV gain 18304495
nsv8058 CNV loss 18304495
nsv514005 CNV gain 21397061
nsv511712 CNV loss 21212237
nsv510962 OTHER complex 20534489
nsv509457 CNV insertion 20534489
nsv498686 CNV loss 21111241
nsv2644 CNV deletion 18451855
nsv2633 CNV deletion 18451855
nsv2 CNV deletion 15895083
nsv158975 CNV insertion 16902084
nsv1161492 CNV deletion 26073780
nsv1153254 CNV duplication 26484159

Variation tolerance for PDE4DIP Gene

Residual Variation Intolerance Score: 100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.35; 98.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PDE4DIP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE4DIP Gene

Disorders for PDE4DIP Gene


  • Note=A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein. {ECO:0000269 PubMed:12907457}.

Additional Disease Information for PDE4DIP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PDE4DIP Gene.

No data available for MalaCards and Genatlas for PDE4DIP Gene

Publications for PDE4DIP Gene

  1. Isolation of novel heart-specific genes using the BodyMap database. (PMID: 11374908) Soejima H … Mukai T (Genomics 2001) 3 4 22 58
  2. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 2 3 4 58
  3. Molecular Pathway of Microtubule Organization at the Golgi Apparatus. (PMID: 27666745) Wu J … Akhmanova A (Developmental cell 2016) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. (PMID: 17923693) Faul C … Mundel P (Molecular and cellular biology 2007) 3 22 58

Products for PDE4DIP Gene

Sources for PDE4DIP Gene