Aliases for PLCH2 Gene
External Ids for PLCH2 Gene
Previous HGNC Symbols for PLCH2 Gene
Previous GeneCards Identifiers for PLCH2 Gene
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
GeneCards Summary for PLCH2 Gene
PLCH2 (Phospholipase C Eta 2) is a Protein Coding gene. Diseases associated with PLCH2 include Peroxisome Biogenesis Disorder 6B and Chromosome 1P36 Deletion Syndrome. Among its related pathways are Metabolism and superpathway of inositol phosphate compounds. Gene Ontology (GO) annotations related to this gene include calcium ion binding and phosphoric diester hydrolase activity. An important paralog of this gene is PLCH1.
UniProtKB/Swiss-Prot for PLCH2 Gene
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.