Aliases for RGS6 Gene
External Ids for RGS6 Gene
Previous GeneCards Identifiers for RGS6 Gene
This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
GeneCards Summary for RGS6 Gene
RGS6 (Regulator Of G Protein Signaling 6) is a Protein Coding gene. Diseases associated with RGS6 include Hirschsprung Disease 1 and Early-Onset Familial Alzheimer Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and protein domain specific binding. An important paralog of this gene is RGS7.
UniProtKB/Swiss-Prot for RGS6 Gene
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509).