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Aliases for BAG5 Gene

Aliases for BAG5 Gene

  • BCL2 Associated Athanogene 5 2 3 5
  • Bcl-2-Associated Athanogene 5 3 4
  • BAG-5 3 4
  • BAG Family Molecular Chaperone Regulator 5 3
  • KIAA0873 4

External Ids for BAG5 Gene

Previous GeneCards Identifiers for BAG5 Gene

  • GC14M101414
  • GC14M097838
  • GC14M102013
  • GC14M103093
  • GC14M104022
  • GC14M084201

Summaries for BAG5 Gene

Entrez Gene Summary for BAG5 Gene

  • The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BAG5 Gene

BAG5 (BCL2 Associated Athanogene 5) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include protein kinase binding and chaperone binding. An important paralog of this gene is BAG3.

UniProtKB/Swiss-Prot for BAG5 Gene

  • Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.

Gene Wiki entry for BAG5 Gene

Additional gene information for BAG5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BAG5 Gene

Genomics for BAG5 Gene

GeneHancer (GH) Regulatory Elements for BAG5 Gene

Promoters and enhancers for BAG5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J103560 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 661.3 +0.2 158 3.6 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 E2F8 ZNF207 ZNF143 APOPT1 KLC1 BAG5 ENSG00000256500 CKB XRCC3 RCOR1 ENSG00000258851 GC14P103445
GH14J103576 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.4 -14.0 -14007 1.6 SIN3A FEZF1 BMI1 ZNF2 RAD21 YY1 ZNF335 ZNF366 RCOR1 EGR2 BAG5 KLC1 APOPT1 CKB RNU4-68P ENSG00000256500 LOC105370688 GC14P103445
GH14J103332 Promoter/Enhancer 2.7 UCNEbase EPDnew Ensembl ENCODE dbSUPER 28.7 +228.5 228473 4.7 CLOCK ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 ENSG00000259775 EIF5 BAG5 XRCC3 CKB KLC1 MARK3 ENSG00000260285 ZFYVE21 PIR56134
GH14J103517 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19.9 +42.2 42163 6.4 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF213 CKB GC14M103376 XRCC3 MARK3 BAG5 RPL23AP11 CDC42BPB RNU7-160P ENSG00000269940 ENSG00000260285
GH14J103103 Enhancer 1.5 Ensembl ENCODE dbSUPER 30.7 +458.0 458004 3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 YBX1 XRCC3 WDR20 RCOR1 BAG5 CDC42BPB ZNF839 ENSG00000259444 ENSG00000269940 RPL23AP11 KLC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around BAG5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BAG5 gene promoter:
  • AREB6
  • PPAR-alpha
  • Nkx2-2
  • GATA-1

Genomic Locations for BAG5 Gene

Genomic Locations for BAG5 Gene
6,288 bases
Minus strand
6,288 bases
Minus strand

Genomic View for BAG5 Gene

Genes around BAG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BAG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BAG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BAG5 Gene

Proteins for BAG5 Gene

  • Protein details for BAG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BAG family molecular chaperone regulator 5
    Protein Accession:
    Secondary Accessions:
    • O94950
    • Q86W59

    Protein attributes for BAG5 Gene

    447 amino acids
    Molecular mass:
    51200 Da
    Quaternary structure:
    • Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PRKN.
    • Sequence=BAA74896.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BAG5 Gene

    Alternative splice isoforms for BAG5 Gene


neXtProt entry for BAG5 Gene

Post-translational modifications for BAG5 Gene

  • Ubiquitination at Lys48
  • Modification sites at PhosphoSitePlus

Other Protein References for BAG5 Gene

No data available for DME Specific Peptides for BAG5 Gene

Domains & Families for BAG5 Gene

Gene Families for BAG5 Gene

Protein Domains for BAG5 Gene

Suggested Antigen Peptide Sequences for BAG5 Gene

Graphical View of Domain Structure for InterPro Entry



  • The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
  • The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
genes like me logo Genes that share domains with BAG5: view

Function for BAG5 Gene

Molecular function for BAG5 Gene

UniProtKB/Swiss-Prot Function:
Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
GENATLAS Biochemistry:
BCL2-associated athanogene 5 (antiapoptotic). Negative regulator of Hsp70 chaperone activity

Phenotypes From GWAS Catalog for BAG5 Gene

Gene Ontology (GO) - Molecular Function for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000774 adenyl-nucleotide exchange factor activity TAS --
GO:0005515 protein binding IPI 24510904
GO:0019901 protein kinase binding IPI 24475098
GO:0031625 ubiquitin protein ligase binding IPI,ISS 15603737
GO:0051087 chaperone binding IPI 15603737
genes like me logo Genes that share ontologies with BAG5: view
genes like me logo Genes that share phenotypes with BAG5: view

Animal Model Products

Clone Products

  • Addgene plasmids for BAG5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BAG5 Gene

Localization for BAG5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BAG5 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24510904
GO:0005739 mitochondrion IDA 24475098
GO:0005829 cytosol IDA,TAS --
GO:0016020 membrane HDA 19946888
GO:0016234 inclusion body IDA 15603737
genes like me logo Genes that share ontologies with BAG5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BAG5 Gene

Pathways & Interactions for BAG5 Gene

genes like me logo Genes that share pathways with BAG5: view

Gene Ontology (GO) - Biological Process for BAG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS 9873016
GO:0007030 Golgi organization IMP 24510904
GO:0010977 negative regulation of neuron projection development IDA 24510904
GO:0031397 negative regulation of protein ubiquitination ISS,IMP 15603737
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA 24475098
genes like me logo Genes that share ontologies with BAG5: view

No data available for SIGNOR curated interactions for BAG5 Gene

Drugs & Compounds for BAG5 Gene

No Compound Related Data Available

Transcripts for BAG5 Gene

mRNA/cDNA for BAG5 Gene

Unigene Clusters for BAG5 Gene

BCL2-associated athanogene 5:
Representative Sequences:

Clone Products

  • Addgene plasmids for BAG5

Alternative Splicing Database (ASD) splice patterns (SP) for BAG5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - - -
SP2: -

Relevant External Links for BAG5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BAG5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BAG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BAG5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BAG5 Gene

Protein tissue co-expression partners for BAG5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BAG5 Gene:


SOURCE GeneReport for Unigene cluster for BAG5 Gene:


Evidence on tissue expression from TISSUES for BAG5 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with BAG5: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BAG5 Gene

Orthologs for BAG5 Gene

This gene was present in the common ancestor of animals.

Orthologs for BAG5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BAG5 34 33
  • 99.33 (n)
(Canis familiaris)
Mammalia BAG5 34 33
  • 90.08 (n)
(Bos Taurus)
Mammalia BAG5 34 33
  • 87.47 (n)
(Rattus norvegicus)
Mammalia Bag5 33
  • 84.94 (n)
(Mus musculus)
Mammalia Bag5 16 34 33
  • 83.82 (n)
(Ornithorhynchus anatinus)
Mammalia BAG5 34
  • 83 (a)
(Monodelphis domestica)
Mammalia BAG5 34
  • 76 (a)
(Gallus gallus)
Aves BAG5 34 33
  • 73.75 (n)
(Anolis carolinensis)
Reptilia BAG5 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bag5 33
  • 64.94 (n)
Str.13078 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.33765 33
(Danio rerio)
Actinopterygii bag5 34 33
  • 56.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta stv 34
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5020 34
  • 17 (a)
Species where no ortholog for BAG5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BAG5 Gene

Gene Tree for BAG5 (if available)
Gene Tree for BAG5 (if available)
Evolutionary constrained regions (ECRs) for BAG5: view image

Paralogs for BAG5 Gene

Paralogs for BAG5 Gene

genes like me logo Genes that share paralogs with BAG5: view

Variants for BAG5 Gene

Sequence variations from dbSNP and Humsavar for BAG5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs190920873 benign, not provided, not specified 103,563,024(-) A/G upstream_transcript_variant
rs2274268 likely-benign, benign, not specified 103,563,041(-) C/A/G/T upstream_transcript_variant
rs74917403 likely-benign, not specified 103,563,042(-) C/A/G/T upstream_transcript_variant
rs767933232 likely-benign, not specified 103,563,136(-) C/A/T upstream_transcript_variant
rs185675160 benign, not specified 103,562,952(-) G/A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for BAG5 Gene

Variant ID Type Subtype PubMed ID
dgv389n67 CNV gain 20364138
esv3635599 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv566022 CNV loss 21841781
nsv832883 CNV loss 17160897

Variation tolerance for BAG5 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BAG5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BAG5 Gene

Disorders for BAG5 Gene

Additional Disease Information for BAG5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for BAG5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BAG5 Gene

Publications for BAG5 Gene

  1. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. (PMID: 9873016) Takayama S … Reed JC (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson SA … Youle RJ (Nature 2013) 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58
  5. Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma. (PMID: 20855536) Kelly JL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58

Products for BAG5 Gene

Sources for BAG5 Gene

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