Aliases for BAG5 Gene
External Ids for BAG5 Gene
Previous GeneCards Identifiers for BAG5 Gene
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for BAG5 Gene
BAG5 (BCL2 Associated Athanogene 5) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include protein kinase binding and chaperone binding. An important paralog of this gene is BAG3.
UniProtKB/Swiss-Prot for BAG5 Gene
Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.