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Aliases for SCARB2 Gene

Aliases for SCARB2 Gene

  • Scavenger Receptor Class B Member 2 2 3 4 5
  • CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 2 (Lysosomal Integral Membrane Protein II) 2 3
  • 85 KDa Lysosomal Membrane Sialoglycoprotein 3 4
  • Lysosome Membrane Protein II 3 4
  • CD36 Antigen-Like 2 3 4
  • LIMP II 3 4
  • CD36L2 3 4
  • LIMPII 3 4
  • LGP85 3 4
  • 85 KDa Lysosomal Sialoglycoprotein Scavenger Receptor Class B, Member 2 3
  • Scavenger Receptor Class B, Member 2 2
  • Lysosome Membrane Protein 2 3
  • CD36 Antigen 4
  • HLGP85 3
  • LIMP-2 3
  • SR-BII 3
  • LIMP2 4
  • AMRF 3
  • EPM4 3

External Ids for SCARB2 Gene

Previous HGNC Symbols for SCARB2 Gene

  • CD36L2

Previous GeneCards Identifiers for SCARB2 Gene

  • GC04M076978
  • GC04M077272
  • GC04M077472
  • GC04M077540
  • GC04M077538
  • GC04M077437
  • GC04M077298
  • GC04M077079
  • GC04M072831

Summaries for SCARB2 Gene

Entrez Gene Summary for SCARB2 Gene

  • The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GeneCards Summary for SCARB2 Gene

SCARB2 (Scavenger Receptor Class B Member 2) is a Protein Coding gene. Diseases associated with SCARB2 include Epilepsy, Progressive Myoclonic, 4, With Or Without Renal Failure and Unverricht-Lundborg Syndrome. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include enzyme binding and receptor activity. An important paralog of this gene is CD36.

UniProtKB/Swiss-Prot for SCARB2 Gene

  • Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.

  • (Microbial infection) Acts as a receptor for enterovirus 71.

Gene Wiki entry for SCARB2 Gene

Additional gene information for SCARB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCARB2 Gene

Genomics for SCARB2 Gene

GeneHancer (GH) Regulatory Elements for SCARB2 Gene

Promoters and enhancers for SCARB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I076205 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.9 +23.7 23742 10.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 FAM47E SCARB2 GC04P076210 NUP54 THAP6 SDAD1 ART3 NAAA G3BP2 STBD1
GH04I076233 Enhancer 1.3 Ensembl ENCODE dbSUPER 565.1 -1.4 -1383 5.5 SMAD1 ATF1 TAF9B NEUROD1 ZBTB40 CHAMP1 TCF12 POLR2B ZNF766 EGR1 SCARB2 FAM47E NUP54 THAP6 SDAD1 ENSG00000251185 STBD1 LOC105377286
GH04I076192 Enhancer 1.5 Ensembl ENCODE dbSUPER 22.8 +36.7 36743 9.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B FEZF1 YBX1 ZNF2 IRF4 NUP54 SCARB2 RCHY1 THAP6 ART3 NAAA GC04P076210
GH04I076304 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 11.7 -72.4 -72447 4.4 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ETS1 GLIS2 STBD1 CCDC158 SCARB2 FAM47E RNU6-1000P NUP54 GC04M076318 GC04M076287 FAM47E-STBD1
GH04I075989 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 +244.0 243978 2.1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 ZNF766 E2F8 SDAD1 NAAA SCARB2 ART3 LOC101928809 GC04M075923
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SCARB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SCARB2 gene promoter:

Genomic Locations for SCARB2 Gene

Genomic Locations for SCARB2 Gene
75,804 bases
Minus strand

Genomic View for SCARB2 Gene

Genes around SCARB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCARB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCARB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCARB2 Gene

Proteins for SCARB2 Gene

  • Protein details for SCARB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lysosome membrane protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DKD8
    • E7EM68
    • Q53Y63

    Protein attributes for SCARB2 Gene

    478 amino acids
    Molecular mass:
    54290 Da
    Quaternary structure:
    • Interacts with GBA.
    • (Microbial infection) Interacts with enterovirus 71 capsid proteins.

    Three dimensional structures from OCA and Proteopedia for SCARB2 Gene

    Alternative splice isoforms for SCARB2 Gene


neXtProt entry for SCARB2 Gene

Post-translational modifications for SCARB2 Gene

  • Glycosylation at posLast=4545, isoforms=268, posLast=105105, isoforms=206, isoforms=224, isoforms=2249, isoforms=2304, isoforms=2325, isoforms=2412, and posLast=430430
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SCARB2 Gene

Domains & Families for SCARB2 Gene

Gene Families for SCARB2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SCARB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD36 family.
  • Belongs to the CD36 family.
genes like me logo Genes that share domains with SCARB2: view

Function for SCARB2 Gene

Molecular function for SCARB2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for enterovirus 71.

Phenotypes From GWAS Catalog for SCARB2 Gene

Gene Ontology (GO) - Molecular Function for SCARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity IEA --
GO:0005515 protein binding IPI 14570588
GO:0019899 enzyme binding IPI 18022370
genes like me logo Genes that share ontologies with SCARB2: view
genes like me logo Genes that share phenotypes with SCARB2: view

Human Phenotype Ontology for SCARB2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SCARB2 Gene

MGI Knock Outs for SCARB2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SCARB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SCARB2 Gene

Localization for SCARB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCARB2 Gene

Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCARB2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
endosome 5
cytosol 3
endoplasmic reticulum 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SCARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane TAS 12356916
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion HDA,IDA 21423176
GO:0016020 membrane HDA,IEA 19946888
genes like me logo Genes that share ontologies with SCARB2: view

Pathways & Interactions for SCARB2 Gene

genes like me logo Genes that share pathways with SCARB2: view

Pathways by source for SCARB2 Gene

Gene Ontology (GO) - Biological Process for SCARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006622 protein targeting to lysosome IMP 18022370
GO:0010976 positive regulation of neuron projection development IEA --
GO:0016032 viral process IEA --
GO:0046718 viral entry into host cell IEA --
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with SCARB2: view

No data available for SIGNOR curated interactions for SCARB2 Gene

Drugs & Compounds for SCARB2 Gene

(6) Drugs for SCARB2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SCARB2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCARB2: view

Transcripts for SCARB2 Gene

Unigene Clusters for SCARB2 Gene

Scavenger receptor class B, member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCARB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - -
SP3: -
SP4: -

Relevant External Links for SCARB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SCARB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCARB2 Gene

Protein differential expression in normal tissues from HIPED for SCARB2 Gene

This gene is overexpressed in Bone (13.4) and Nasal epithelium (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SCARB2 Gene

Protein tissue co-expression partners for SCARB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SCARB2 Gene:


SOURCE GeneReport for Unigene cluster for SCARB2 Gene:


Evidence on tissue expression from TISSUES for SCARB2 Gene

  • Nervous system(4.9)
  • Eye(4.6)
  • Liver(4.6)
  • Lung(3.7)
  • Spleen(3)
  • Kidney(2.9)
  • Pancreas(2.9)
  • Heart(2.4)
  • Blood(2.1)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SCARB2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cerebellum
  • ear
  • eye
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • chest wall
  • clavicle
  • esophagus
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
  • pelvis
  • ureter
  • urinary bladder
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with SCARB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SCARB2 Gene

Orthologs for SCARB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SCARB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SCARB2 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia SCARB2 33 34
  • 89.4 (n)
(Bos Taurus)
Mammalia SCARB2 33 34
  • 89.05 (n)
(Rattus norvegicus)
Mammalia Scarb2 33
  • 84.73 (n)
(Mus musculus)
Mammalia Scarb2 33 16 34
  • 84.52 (n)
(Monodelphis domestica)
Mammalia SCARB2 34
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SCARB2 34
  • 70 (a)
(Gallus gallus)
Aves SCARB2 33 34
  • 65.9 (n)
(Anolis carolinensis)
Reptilia SCARB2 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia scarb2 33
  • 61.32 (n)
Str.13862 33
African clawed frog
(Xenopus laevis)
Amphibia cd36l2-prov 33
(Danio rerio)
Actinopterygii scarb2 33
  • 56.3 (n)
  • 49 (a)
cd36l2 33
fruit fly
(Drosophila melanogaster)
Insecta emp 33
  • 47.36 (n)
Snmp2 34
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta SCRB9 33
  • 46.75 (n)
(Caenorhabditis elegans)
Secernentea scav-1 34
  • 23 (a)
scav-2 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for SCARB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SCARB2 Gene

Gene Tree for SCARB2 (if available)
Gene Tree for SCARB2 (if available)

Paralogs for SCARB2 Gene

Paralogs for SCARB2 Gene

(2) SIMAP similar genes for SCARB2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCARB2: view

Variants for SCARB2 Gene

Sequence variations from dbSNP and Humsavar for SCARB2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs121909118 pathogenic, Epilepsy, progressive myoclonic 4, with or without renal failure, not provided 76,174,276(-) G/A coding_sequence_variant, stop_gained
rs121909119 pathogenic, Epilepsy, progressive myoclonic 4, with or without renal failure 76,179,596(-) C/T coding_sequence_variant, intron_variant, stop_gained
rs141208366 benign, likely-benign, not specified, Progressive myoclonic epilepsy 76,179,562(-) A/G coding_sequence_variant, intron_variant, synonymous_variant
rs142392473 uncertain-significance, not specified, Progressive myoclonic epilepsy 76,174,219(-) C/T coding_sequence_variant, missense_variant
rs142690468 uncertain-significance, Progressive myoclonic epilepsy 76,195,738(-) G/A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for SCARB2 Gene

Variant ID Type Subtype PubMed ID
dgv9136n54 CNV gain 21841781
dgv958e199 CNV deletion 23128226
esv3601046 CNV loss 21293372
esv3601047 CNV loss 21293372
esv3601048 CNV loss 21293372
esv995458 CNV deletion 20482838
nsv1000178 CNV gain 25217958
nsv461558 CNV gain 19166990
nsv470047 CNV gain 18288195
nsv7363 OTHER inversion 18451855
nsv818244 CNV loss 17921354

Variation tolerance for SCARB2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SCARB2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCARB2 Gene

Disorders for SCARB2 Gene

MalaCards: The human disease database

(14) MalaCards diseases for SCARB2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
epilepsy, progressive myoclonic, 4, with or without renal failure
  • epm4
unverricht-lundborg syndrome
  • unverricht - lundborg disease
hand, foot and mouth disease
  • vesicular stomatitis and exanthem
gaucher's disease
  • acid beta-glucosidase deficiency
- elite association - COSMIC cancer census association via MalaCards


  • Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4) [MIM:254900]: An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. {ECO:0000269 PubMed:18308289, ECO:0000269 PubMed:18424452, ECO:0000269 PubMed:19454373, ECO:0000269 PubMed:21670406}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. {ECO:0000269 PubMed:21796727}.

Additional Disease Information for SCARB2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SCARB2: view

No data available for Genatlas for SCARB2 Gene

Publications for SCARB2 Gene

  1. Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells. (PMID: 1374238) Fujita H … Kato K (Biochemical and biophysical research communications 1992) 2 3 4 22 58
  2. Scavenger receptor B2 is a cellular receptor for enterovirus 71. (PMID: 19543282) Yamayoshi S … Koike S (Nature medicine 2009) 3 4 22 58
  3. The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution. (PMID: 7539776) Calvo D … Vega MA (Genomics 1995) 3 4 22 58
  4. The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes. (PMID: 7509809) Sandoval IV … Rico M (The Journal of biological chemistry 1994) 3 4 22 58
  5. Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. (PMID: 24162852) Neculai D … Dhe-Paganon S (Nature 2013) 3 4 58

Products for SCARB2 Gene

Sources for SCARB2 Gene

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