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Aliases for STX8 Gene

Aliases for STX8 Gene

  • Syntaxin 8 2 3 5
  • CIP-1-Associated Regulator Of Cyclin B 3
  • Syntaxin-8 3
  • CARB 3

External Ids for STX8 Gene

Previous GeneCards Identifiers for STX8 Gene

  • GC17M009501
  • GC17M010245
  • GC17M009096
  • GC17M009354
  • GC17M009094
  • GC17M009153

Summaries for STX8 Gene

Entrez Gene Summary for STX8 Gene

  • The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for STX8 Gene

STX8 (Syntaxin 8) is a Protein Coding gene. Among its related pathways are wtCFTR and deltaF508 traffic / Late endosome and Lysosome (norm and CF) and Delta508-CFTR traffic / ER-to-Golgi in CF. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and SNAP receptor activity.

UniProtKB/Swiss-Prot for STX8 Gene

  • Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Gene Wiki entry for STX8 Gene

Additional gene information for STX8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX8 Gene

Genomics for STX8 Gene

GeneHancer (GH) Regulatory Elements for STX8 Gene

Promoters and enhancers for STX8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I009574 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 474 2.6 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 DEK SP3 SP5 ZHX2 CFAP52 STX8 ENSG00000271851
GH17I008628 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.4 +946.1 946081 4.3 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF207 MYH10 ENSG00000265749 CNTROB WRAP53 PFAS STX8 CYB5D1 CTC1 SLC25A35 VAMP2
GH17I009643 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 10.6 -70.2 -70176 5.9 PKNOX1 CLOCK FOXA2 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ENSG00000262296 ENSG00000265349 USP43 STX8 CFAP52
GH17I009431 Enhancer 0.8 Ensembl ENCODE 13.8 +143.9 143945 2.3 PKNOX1 NR2F1 JUNB BATF NR2F2 RELA BCL11A SCRT2 ATF7 ETV6 STX8 GC17P009447 GC17M009366
GH17I009676 Enhancer 0.7 ENCODE 11.2 -100.7 -100727 1.9 CTCF JUN BATF RAD21 FOSL1 NFE2 FOS FOSL2 RUNX3 STAT1 USP43 STX8 CFAP52 GC17P009688 ENSG00000262296
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around STX8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the STX8 gene promoter:

Genomic Locations for STX8 Gene

Genomic Locations for STX8 Gene
326,121 bases
Minus strand

Genomic View for STX8 Gene

Genes around STX8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX8 Gene

Proteins for STX8 Gene

  • Protein details for STX8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O60712
    • Q53XT8

    Protein attributes for STX8 Gene

    236 amino acids
    Molecular mass:
    26907 Da
    Quaternary structure:
    • Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8 (By similarity). Interacts with HECTD3 (By similarity).

neXtProt entry for STX8 Gene

Post-translational modifications for STX8 Gene

  • Ubiquitinated by HECTD3.
  • Ubiquitination at isoforms=59, posLast=9898, and isoforms=146
  • Modification sites at PhosphoSitePlus

Other Protein References for STX8 Gene

No data available for DME Specific Peptides for STX8 Gene

Domains & Families for STX8 Gene

Gene Families for STX8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for STX8 Gene


Suggested Antigen Peptide Sequences for STX8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the syntaxin family.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX8: view

Function for STX8 Gene

Molecular function for STX8 Gene

GENATLAS Biochemistry:
syntaxin 8,forming a synaptic core complex with synaptosome associated proteins,binding to N-type Ca2+ channels,involved in the intracellular membrane transport and exocytosis,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE protein
UniProtKB/Swiss-Prot Function:
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Phenotypes From GWAS Catalog for STX8 Gene

Gene Ontology (GO) - Molecular Function for STX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 16189514
GO:0019869 chloride channel inhibitor activity IDA 18570918
GO:0019905 syntaxin binding IPI 10564279
GO:0031625 ubiquitin protein ligase binding IEA --
genes like me logo Genes that share ontologies with STX8: view
genes like me logo Genes that share phenotypes with STX8: view

Animal Models for STX8 Gene

MGI Knock Outs for STX8:
  • Stx8 tm2a(EUCOMM)Wtsi

Animal Model Products

miRNA for STX8 Gene

miRTarBase miRNAs that target STX8

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for STX8 Gene

Localization for STX8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX8 Gene

Membrane; Single-pass type IV membrane protein. Note=Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STX8 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
endosome 5
endoplasmic reticulum 4
lysosome 3
cytoskeleton 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (1)
  • Cytosol (1)
  • Golgi apparatus (1)
  • Nuclear bodies (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for STX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome IDA 10564279
GO:0005769 early endosome IDA 10564279
GO:0005770 late endosome IDA 10564279
GO:0005783 endoplasmic reticulum TAS 9852078
genes like me logo Genes that share ontologies with STX8: view

Pathways & Interactions for STX8 Gene

genes like me logo Genes that share pathways with STX8: view

Gene Ontology (GO) - Biological Process for STX8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 10198254
GO:0006886 intracellular protein transport IBA --
GO:0006906 vesicle fusion IEA,IBA --
GO:0008333 endosome to lysosome transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with STX8: view

No data available for SIGNOR curated interactions for STX8 Gene

Drugs & Compounds for STX8 Gene

(3) Additional Compounds for STX8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with STX8: view

Transcripts for STX8 Gene

Unigene Clusters for STX8 Gene

Syntaxin 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STX8 Gene

No ASD Table

Relevant External Links for STX8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STX8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for STX8 Gene

This gene is overexpressed in Liver (19.5), Peripheral blood mononuclear cells (17.3), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for STX8 Gene

Protein tissue co-expression partners for STX8 Gene

NURSA nuclear receptor signaling pathways regulating expression of STX8 Gene:


SOURCE GeneReport for Unigene cluster for STX8 Gene:


mRNA Expression by UniProt/SwissProt for STX8 Gene:

Tissue specificity: Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

Evidence on tissue expression from TISSUES for STX8 Gene

  • Lung(4.4)
  • Pancreas(4.3)
  • Nervous system(2.6)
  • Muscle(2.5)
  • Heart(2.4)
  • Skin(2.3)
  • Blood(2)
  • Liver(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with STX8: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for STX8 Gene

Orthologs for STX8 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STX8 33 34
  • 99.86 (n)
(Bos Taurus)
Mammalia STX8 33 34
  • 92.2 (n)
(Mus musculus)
Mammalia Stx8 33 16 34
  • 88.84 (n)
(Rattus norvegicus)
Mammalia Stx8 33
  • 88.56 (n)
(Canis familiaris)
Mammalia STX8 33 34
  • 87.46 (n)
(Monodelphis domestica)
Mammalia STX8 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia STX8 34
  • 76 (a)
(Gallus gallus)
Aves STX8 33 34
  • 70.5 (n)
(Anolis carolinensis)
Reptilia STX8 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stx8 33
  • 65.96 (n)
Str.2166 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17307 33
(Danio rerio)
Actinopterygii stx8 33 34
  • 62.54 (n)
zgc64079 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006100 33
  • 43.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta Syx8 33 34
  • 39.71 (n)
Species where no ortholog for STX8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for STX8 Gene

Gene Tree for STX8 (if available)
Gene Tree for STX8 (if available)

Paralogs for STX8 Gene Pseudogenes for STX8 Gene

genes like me logo Genes that share paralogs with STX8: view

No data available for Paralogs for STX8 Gene

Variants for STX8 Gene

Sequence variations from dbSNP and Humsavar for STX8 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs193920742 uncertain-significance, Malignant tumor of prostate 9,505,052(-) T/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000000024 -- 9,264,852(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000003369 -- 9,385,261(-) G/A intron_variant
rs1000013017 -- 9,399,100(-) C/T intron_variant
rs1000014621 -- 9,551,749(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STX8 Gene

Variant ID Type Subtype PubMed ID
dgv175n21 CNV loss 19592680
esv2533392 CNV insertion 19546169
esv2661151 CNV deletion 23128226
esv2661306 CNV deletion 23128226
esv2663291 CNV deletion 23128226
esv2715631 CNV deletion 23290073
esv2715632 CNV deletion 23290073
esv27693 CNV loss 19812545
esv29207 CNV gain 19812545
esv29975 CNV loss 17803354
esv33701 CNV loss 17666407
esv3385077 CNV insertion 20981092
esv3432025 CNV insertion 20981092
esv3639896 CNV loss 21293372
esv3639897 CNV loss 21293372
esv3639898 CNV loss 21293372
esv3639899 CNV loss 21293372
esv3639900 CNV loss 21293372
esv3639901 CNV loss 21293372
esv3639902 CNV loss 21293372
esv3639903 CNV loss 21293372
esv3639904 CNV loss 21293372
esv3639905 CNV loss 21293372
esv3639906 CNV loss 21293372
esv3639908 CNV loss 21293372
esv3639909 CNV gain 21293372
esv3639910 CNV loss 21293372
esv3639911 CNV loss 21293372
esv3639912 CNV loss 21293372
esv3639915 CNV loss 21293372
esv3639916 CNV loss 21293372
esv3639917 CNV gain 21293372
esv3639918 CNV loss 21293372
nsv1064011 CNV gain 25217958
nsv1070388 CNV deletion 25765185
nsv111672 CNV deletion 16902084
nsv1142212 CNV tandem duplication 24896259
nsv153 CNV insertion 15895083
nsv1972 CNV insertion 18451855
nsv1973 CNV insertion 18451855
nsv1974 CNV insertion 18451855
nsv436063 CNV insertion 17901297
nsv473779 CNV novel sequence insertion 20440878
nsv509652 CNV insertion 20534489
nsv519249 CNV loss 19592680
nsv521947 CNV gain 19592680
nsv524312 CNV loss 19592680
nsv528692 CNV gain 19592680
nsv528816 CNV loss 19592680
nsv574341 CNV gain 21841781
nsv7289 OTHER inversion 18451855
nsv833356 CNV gain 17160897
nsv833357 CNV loss 17160897

Variation tolerance for STX8 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STX8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STX8 Gene

Disorders for STX8 Gene

Additional Disease Information for STX8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for STX8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX8 Gene

Publications for STX8 Gene

  1. Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). (PMID: 10198254) Thoreau V … Chomel JC (Biochemical and biophysical research communications 1999) 2 3 4 22 58
  2. Three novel proteins of the syntaxin/SNAP-25 family. (PMID: 9852078) Steegmaier M … Scheller RH (The Journal of biological chemistry 1998) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Molecular reclassification of Crohn's disease by cluster analysis of genetic variants. (PMID: 20886065) Cleynen I … Vermeire S (PloS one 2010) 3 44 58
  5. Differential palmitoylation of the endosomal SNAREs syntaxin 7 and syntaxin 8. (PMID: 18980942) He Y … Linder ME (Journal of lipid research 2009) 3 22 58

Products for STX8 Gene

Sources for STX8 Gene

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